Details for: PSG2

Gene ID: 5670

Symbol: PSG2

Ensembl ID: ENSG00000242221

Description: pregnancy specific beta-1-glycoprotein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 6.1970
    Cell Significance Index: 38.5100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.7136
    Cell Significance Index: 9.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4794
    Cell Significance Index: 12.8000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.3602
    Cell Significance Index: 4.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3307
    Cell Significance Index: 8.0100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.1337
    Cell Significance Index: 1.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1198
    Cell Significance Index: 1.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1050
    Cell Significance Index: 1.8000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0419
    Cell Significance Index: 0.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0374
    Cell Significance Index: 0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0312
    Cell Significance Index: 6.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0307
    Cell Significance Index: 0.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0214
    Cell Significance Index: 0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0106
    Cell Significance Index: 3.7900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0069
    Cell Significance Index: 0.0500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0009
    Cell Significance Index: -0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0020
    Cell Significance Index: -0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0050
    Cell Significance Index: -2.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0099
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0124
    Cell Significance Index: -2.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0130
    Cell Significance Index: -1.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0140
    Cell Significance Index: -2.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0140
    Cell Significance Index: -2.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0146
    Cell Significance Index: -0.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0155
    Cell Significance Index: -2.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0168
    Cell Significance Index: -2.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0179
    Cell Significance Index: -0.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0180
    Cell Significance Index: -0.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0227
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0230
    Cell Significance Index: -2.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0233
    Cell Significance Index: -2.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0250
    Cell Significance Index: -1.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0262
    Cell Significance Index: -2.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0280
    Cell Significance Index: -1.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0311
    Cell Significance Index: -2.3900
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.0367
    Cell Significance Index: -0.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0384
    Cell Significance Index: -2.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0423
    Cell Significance Index: -1.8700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0436
    Cell Significance Index: -0.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0498
    Cell Significance Index: -0.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0502
    Cell Significance Index: -1.9000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0513
    Cell Significance Index: -1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0517
    Cell Significance Index: -2.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0549
    Cell Significance Index: -1.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0574
    Cell Significance Index: -1.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0584
    Cell Significance Index: -1.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0612
    Cell Significance Index: -2.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0636
    Cell Significance Index: -1.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0646
    Cell Significance Index: -1.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0652
    Cell Significance Index: -2.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0655
    Cell Significance Index: -1.9300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0681
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0717
    Cell Significance Index: -1.5000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0742
    Cell Significance Index: -1.4600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0757
    Cell Significance Index: -0.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0759
    Cell Significance Index: -1.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0773
    Cell Significance Index: -1.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0778
    Cell Significance Index: -1.9400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0781
    Cell Significance Index: -0.7400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0781
    Cell Significance Index: -1.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0788
    Cell Significance Index: -2.2500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0898
    Cell Significance Index: -2.8400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0932
    Cell Significance Index: -1.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0940
    Cell Significance Index: -2.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0957
    Cell Significance Index: -1.6100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0957
    Cell Significance Index: -1.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0964
    Cell Significance Index: -1.0500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0994
    Cell Significance Index: -1.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1011
    Cell Significance Index: -2.0300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1020
    Cell Significance Index: -1.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1024
    Cell Significance Index: -2.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1030
    Cell Significance Index: -2.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1032
    Cell Significance Index: -2.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1037
    Cell Significance Index: -2.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1041
    Cell Significance Index: -2.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1048
    Cell Significance Index: -1.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1053
    Cell Significance Index: -2.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1091
    Cell Significance Index: -1.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1093
    Cell Significance Index: -1.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1123
    Cell Significance Index: -2.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1142
    Cell Significance Index: -2.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1155
    Cell Significance Index: -2.5300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1216
    Cell Significance Index: -2.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1247
    Cell Significance Index: -2.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1315
    Cell Significance Index: -1.7200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1330
    Cell Significance Index: -2.6000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1349
    Cell Significance Index: -1.4900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1358
    Cell Significance Index: -1.4200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1379
    Cell Significance Index: -2.0100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1380
    Cell Significance Index: -1.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSG2 is a large, glycosylated protein that belongs to the beta-1-glycoprotein family. It is characterized by its high molecular weight (approximately 130 kDa) and its ability to bind to various ligands, including cell surface molecules and extracellular matrix proteins. PSG2 is highly expressed in different cell types, including immune cells (e.g., B cells, goblet cells), neural cells (e.g., amacrine cells, forebrain radial glial cells), and endothelial cells. Its expression is also significantly upregulated during pregnancy, where it plays a crucial role in maintaining immune tolerance and promoting fetal development. **Pathways and Functions:** PSG2's multifunctional nature is reflected in its involvement in various biological pathways, including: 1. **Cell Migration and Adhesion:** PSG2 interacts with cell surface molecules, such as integrins and cadherins, to regulate cell migration, adhesion, and signaling. This function is essential for tissue development, immune cell trafficking, and angiogenesis. 2. **Heterophilic Cell-Cell Adhesion:** PSG2 binds to specific ligands on the surface of adjacent cells, facilitating heterophilic cell-cell adhesion. This interaction is crucial for the formation of tissue structures, such as blood vessels and the placenta. 3. **Cell Surface Interactions at the Vascular Wall:** PSG2 interacts with endothelial cells and blood vessel components, regulating vascular permeability, blood flow, and immune responses. 4. **Molecular Function:** PSG2 exhibits a range of molecular functions, including protein-protein interactions, ligand binding, and signaling. **Clinical Significance:** PSG2's dysregulation has been implicated in various immune-related diseases, including: 1. **Pregnancy Complications:** Alterations in PSG2 expression and function have been linked to pregnancy-related disorders, such as gestational diabetes, preeclampsia, and recurrent miscarriage. 2. **Autoimmune Diseases:** PSG2's role in immune tolerance and regulation has been implicated in autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. 3. **Cancer:** PSG2's involvement in cell migration, adhesion, and signaling has been linked to cancer progression and metastasis. 4. **Neurological Disorders:** PSG2's expression in neural cells has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, PSG2 is a multifunctional glycoprotein that plays a crucial role in immune regulation, tissue development, and disease pathogenesis. Further research is necessary to fully elucidate PSG2's mechanisms of action and its clinical significance in immune-related diseases.

Genular Protein ID: 2014807344

Symbol: PSG2_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 2

UniProtKB Accession Codes:

P11465 Q8TCD9 Q9UEA4 Q9UQ78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3260773

Title: The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family.

PubMed ID: 3260773

DOI: 10.1016/0006-291x(88)90660-2

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 335
  • Mass: 37216
  • Checksum: C47AFC14DED9C0F8
  • Sequence:
    • MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ 
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 
TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCD PETPDTSYQW 
WMNGQSLPMT HRFQLSETNR TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD 
LPRIHPSYTN YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV 
CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.