Details for: PSG2

Gene ID: 5670

Symbol: PSG2

Ensembl ID: ENSG00000242221

Description: pregnancy specific beta-1-glycoprotein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 5.06
    Marker Score: 16207.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.63
    Marker Score: 10411
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.36
    Marker Score: 2377
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 2.13
    Marker Score: 689
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.93
    Marker Score: 7482
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1191
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.96
    Marker Score: 1057
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2420
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1379
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 485
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.64
    Marker Score: 1029
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 504
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.62
    Marker Score: 695
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1176.5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.43
    Marker Score: 707
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6694
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 831
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 177
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.29
    Marker Score: 364
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 170
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.28
    Marker Score: 384
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.23
    Marker Score: 299
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.23
    Marker Score: 652
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 143
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.21
    Marker Score: 186
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.19
    Marker Score: 152
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 306
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 129
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.11
    Marker Score: 257
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1
    Marker Score: 872.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.1
    Marker Score: 419
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 177
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.08
    Marker Score: 690
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.08
    Marker Score: 123
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.08
    Marker Score: 4896
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.08
    Marker Score: 122
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 90
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.07
    Marker Score: 653
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 23.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.06
    Marker Score: 413
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.06
    Marker Score: 382
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 113
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 21.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.05
    Marker Score: 192
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.05
    Marker Score: 85
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 68.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.04
    Marker Score: 376
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 23

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Other Information

**Key characteristics:** - It is a glycoprotein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in the placenta, decidua, and other sites in the female reproductive tract. - It is also expressed in low levels in the male reproductive tract. **Pathways and functions:** - PSG2 is a key component of the cell surface adhesion molecule (CAM) family of proteins. - It is involved in cell migration, cell surface interactions at the vascular wall, and cellular communication. - It is expressed on the surface of a variety of cells in the female reproductive tract, including amacrine cells, retinal cone cells, blood vessel endothelial cells, trophoblast giant cells, neural progenitor cells, B cells, goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and absorptive cells. - PSG2 is thought to play a role in maintaining the integrity of the female reproductive tract by regulating cell-cell adhesion and migration. **Clinical significance:** - Mutations in the PSG2 gene have been linked to a number of human diseases, including infertility, miscarriage, and preterm labor. - PSG2 is a potential therapeutic target for these diseases. - By blocking PSG2 signaling, it is possible to inhibit cell migration and cell adhesion, which may lead to the prevention of cancer and other diseases that are caused by abnormal cell behavior.

Genular Protein ID: 2014807344

Symbol: PSG2_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 2

UniProtKB Accession Codes:

P11465 Q8TCD9 Q9UEA4 Q9UQ78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3260773

Title: The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family.

PubMed ID: 3260773

DOI: 10.1016/0006-291x(88)90660-2

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 335
  • Mass: 37216
  • Checksum: C47AFC14DED9C0F8
  • Sequence:
    • MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ 
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY 
TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCD PETPDTSYQW 
WMNGQSLPMT HRFQLSETNR TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD 
LPRIHPSYTN YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV 
CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.