Details for: PSG7

Gene ID: 5676

Symbol: PSG7

Ensembl ID: ENSG00000221878

Description: pregnancy specific beta-1-glycoprotein 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8517
    Cell Significance Index: 20.6300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2593
    Cell Significance Index: 3.7800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.2220
    Cell Significance Index: 1.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2105
    Cell Significance Index: 3.0200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.1696
    Cell Significance Index: 1.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1200
    Cell Significance Index: 2.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0775
    Cell Significance Index: 2.0700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0664
    Cell Significance Index: 0.2500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0469
    Cell Significance Index: 0.5400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0421
    Cell Significance Index: 0.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0406
    Cell Significance Index: 0.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0345
    Cell Significance Index: 0.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0189
    Cell Significance Index: 0.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0102
    Cell Significance Index: 2.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0015
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0029
    Cell Significance Index: -0.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0054
    Cell Significance Index: -1.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0054
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0062
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0080
    Cell Significance Index: -0.5400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0082
    Cell Significance Index: -0.1000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0083
    Cell Significance Index: -0.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0084
    Cell Significance Index: -1.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0104
    Cell Significance Index: -0.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0107
    Cell Significance Index: -0.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0107
    Cell Significance Index: -0.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0132
    Cell Significance Index: -0.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0140
    Cell Significance Index: -0.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0140
    Cell Significance Index: -0.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0143
    Cell Significance Index: -0.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0153
    Cell Significance Index: -0.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0155
    Cell Significance Index: -0.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0160
    Cell Significance Index: -0.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0167
    Cell Significance Index: -0.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0168
    Cell Significance Index: -0.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0191
    Cell Significance Index: -0.2400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0193
    Cell Significance Index: -0.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0206
    Cell Significance Index: -0.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0228
    Cell Significance Index: -0.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0230
    Cell Significance Index: -1.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0251
    Cell Significance Index: -0.7400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0254
    Cell Significance Index: -0.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0279
    Cell Significance Index: -0.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0280
    Cell Significance Index: -0.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0302
    Cell Significance Index: -0.8700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0305
    Cell Significance Index: -0.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0308
    Cell Significance Index: -0.6100
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.0312
    Cell Significance Index: -0.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0325
    Cell Significance Index: -0.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0351
    Cell Significance Index: -0.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0357
    Cell Significance Index: -0.9200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0367
    Cell Significance Index: -1.1600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0369
    Cell Significance Index: -0.4700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0375
    Cell Significance Index: -0.2600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0379
    Cell Significance Index: -0.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0389
    Cell Significance Index: -1.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0393
    Cell Significance Index: -0.8200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0404
    Cell Significance Index: -0.6800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0410
    Cell Significance Index: -0.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0414
    Cell Significance Index: -0.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0416
    Cell Significance Index: -0.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0420
    Cell Significance Index: -0.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0429
    Cell Significance Index: -1.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0434
    Cell Significance Index: -1.0400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0436
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0441
    Cell Significance Index: -0.6700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0457
    Cell Significance Index: -0.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0466
    Cell Significance Index: -0.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0475
    Cell Significance Index: -0.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0476
    Cell Significance Index: -0.5900
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0496
    Cell Significance Index: -0.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0498
    Cell Significance Index: -1.0900
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0506
    Cell Significance Index: -0.5800
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0512
    Cell Significance Index: -0.3900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0513
    Cell Significance Index: -0.7100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0526
    Cell Significance Index: -1.0700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0544
    Cell Significance Index: -0.5900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0547
    Cell Significance Index: -0.7500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0548
    Cell Significance Index: -0.9300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0557
    Cell Significance Index: -1.4200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0560
    Cell Significance Index: -0.6100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0567
    Cell Significance Index: -0.6800
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0573
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0584
    Cell Significance Index: -0.8300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0590
    Cell Significance Index: -1.4400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0595
    Cell Significance Index: -0.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0601
    Cell Significance Index: -0.4900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0622
    Cell Significance Index: -0.7400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0625
    Cell Significance Index: -0.7800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0638
    Cell Significance Index: -0.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PSG7 is a type of glycoprotein, with a molecular weight of approximately 30 kDa, and is composed of a carbohydrate moiety attached to a protein backbone. It is highly glycosylated, with multiple N- and O-linked glycosylation sites. PSG7 is primarily expressed in the extracellular environment, where it interacts with various cell surface receptors and proteins. Its expression is tightly regulated during pregnancy, with significant increases observed in maternal and fetal tissues. **Pathways and Functions** PSG7 is involved in several key pathways and processes, including: 1. **Cell surface interactions**: PSG7 interacts with various cell surface receptors, such as integrins and selectins, to regulate cell adhesion, migration, and signaling. 2. **Immune system regulation**: PSG7 modulates immune responses by interacting with immune cells, including T cells, B cells, and plasma cells, to regulate their activation, proliferation, and differentiation. 3. **Signal transduction**: PSG7 is involved in signal transduction pathways, including the PI3K/Akt and MAPK/ERK pathways, to regulate cell survival, proliferation, and differentiation. 4. **Hemostasis**: PSG7 plays a role in hemostasis by interacting with platelets and endothelial cells to regulate thrombus formation and stability. **Clinical Significance** The dysregulation of PSG7 has been implicated in various diseases, including: 1. **Pregnancy complications**: Abnormal PSG7 expression has been linked to pregnancy complications, such as preeclampsia and placental insufficiency. 2. **Autoimmune diseases**: PSG7 has been implicated in autoimmune diseases, including rheumatoid arthritis and lupus, where it is thought to contribute to immune system dysregulation. 3. **Cancer**: PSG7 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, where it is thought to contribute to tumor progression and metastasis. 4. **Neurological disorders**: PSG7 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it is thought to contribute to neuroinflammation and neuronal damage. In conclusion, PSG7 is a critical regulator of various physiological and pathological processes, particularly during pregnancy and immune system regulation. Further research is needed to fully elucidate the mechanisms of PSG7 and its role in disease, with potential therapeutic applications in the treatment of pregnancy complications, autoimmune diseases, and cancer.

Genular Protein ID: 2327064784

Symbol: PSG7_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 7

UniProtKB Accession Codes:

Q13046 A0A087WSZ1 Q15232

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7794280

Title: Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants.

PubMed ID: 7794280

DOI: 10.1006/bbrc.1995.1862

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 1690992

Title: The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed.

PubMed ID: 1690992

DOI: 10.1016/0006-291x(90)92103-7

Sequence Information:

  • Length: 419
  • Mass: 47027
  • Checksum: 57219C6FB683BF33
  • Sequence:
    • MGPLSAPPCT QHITWKGLLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ 
NLTGYIWYKG QIRDLYHYVT SYIVDGQIIK YGPAYSGRET VYSNASLLIQ NVTQEDTGSY 
TLHIIKRGDG TGGVTGRFTF TLYLETPKPS ISSSNFNPRE ATEAVILTCD PETPDASYLW 
WMNGQSLPMT HSLQLSETNR TLYLFGVTNY TAGPYECEIR NPVSASRSDP VTLNLLPKLP 
KPYITINNLN PRENKDVSTF TCEPKSENYT YIWWLNGQSL PVSPRVKRRI ENRILILPSV 
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYHSGQNL YLSCFADSNP 
PAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSVT VRVSDWTLP

Genular Protein ID: 3491544955

Symbol: A0A096LNM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A096LNM5

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 297
  • Mass: 33402
  • Checksum: 36F473D3E9E26181
  • Sequence:
    • MGPLSAPPCT QHITWKGLLL TVETPKPSIS SSNFNPREAT EAVILTCDPE TPDASYLWWM 
NGQSLPMTHS LQLSETNRTL YLFGVTNYTA GPYECEIRNP VSASRSDPVT LNLLPKLPKP 
YITINNLNPR ENKDVSTFTC EPKSENYTYI WWLNGQSLPV SPRVKRRIEN RILILPSVTR 
NETGPYQCEI RDRYGGIRSD PVTLNVLYGP DLPRIYPSFT YYHSGQNLYL SCFADSNPPA 
QYSWTINGKF QLSGQKLSIP QITTKHSGLY ACSVRNSATG KESSKSVTVR VSDWTLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.