Details for: PXN

Gene ID: 5829

Symbol: PXN

Ensembl ID: ENSG00000089159

Description: paxillin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 182.7764
    Cell Significance Index: -28.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.1045
    Cell Significance Index: -27.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.7958
    Cell Significance Index: -30.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.0990
    Cell Significance Index: -28.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1689
    Cell Significance Index: -29.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2075
    Cell Significance Index: -22.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2648
    Cell Significance Index: -25.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2782
    Cell Significance Index: -28.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.1093
    Cell Significance Index: 44.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9823
    Cell Significance Index: 52.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.5746
    Cell Significance Index: 38.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5699
    Cell Significance Index: 30.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4865
    Cell Significance Index: 40.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4138
    Cell Significance Index: 36.3400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.4051
    Cell Significance Index: 9.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3495
    Cell Significance Index: 81.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.3133
    Cell Significance Index: 8.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2371
    Cell Significance Index: 134.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0781
    Cell Significance Index: 132.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8967
    Cell Significance Index: 45.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8356
    Cell Significance Index: 24.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7960
    Cell Significance Index: 143.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7822
    Cell Significance Index: 706.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7550
    Cell Significance Index: 9.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7338
    Cell Significance Index: 145.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6369
    Cell Significance Index: 17.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5833
    Cell Significance Index: 16.8100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.5795
    Cell Significance Index: 9.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5718
    Cell Significance Index: 25.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5296
    Cell Significance Index: 3.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5294
    Cell Significance Index: 27.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3656
    Cell Significance Index: 9.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3316
    Cell Significance Index: 7.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3169
    Cell Significance Index: 24.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2750
    Cell Significance Index: 17.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2621
    Cell Significance Index: 49.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2195
    Cell Significance Index: 137.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2100
    Cell Significance Index: 114.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2015
    Cell Significance Index: 5.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1842
    Cell Significance Index: 2.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1683
    Cell Significance Index: 16.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1625
    Cell Significance Index: 71.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1497
    Cell Significance Index: 5.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1493
    Cell Significance Index: 275.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1362
    Cell Significance Index: 27.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1290
    Cell Significance Index: 46.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1119
    Cell Significance Index: 8.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1093
    Cell Significance Index: 5.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1004
    Cell Significance Index: 188.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0924
    Cell Significance Index: 142.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0917
    Cell Significance Index: 2.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0653
    Cell Significance Index: 8.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0597
    Cell Significance Index: 37.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0581
    Cell Significance Index: 0.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0565
    Cell Significance Index: 9.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0353
    Cell Significance Index: 47.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0317
    Cell Significance Index: 0.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0204
    Cell Significance Index: 14.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0140
    Cell Significance Index: 6.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0009
    Cell Significance Index: 0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0005
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0235
    Cell Significance Index: -3.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0271
    Cell Significance Index: -2.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0376
    Cell Significance Index: -2.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0405
    Cell Significance Index: -5.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0453
    Cell Significance Index: -2.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0454
    Cell Significance Index: -0.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0687
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0717
    Cell Significance Index: -15.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0853
    Cell Significance Index: -24.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0863
    Cell Significance Index: -0.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0866
    Cell Significance Index: -1.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0898
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0957
    Cell Significance Index: -10.9600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1092
    Cell Significance Index: -1.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1261
    Cell Significance Index: -1.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1360
    Cell Significance Index: -14.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1444
    Cell Significance Index: -16.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1826
    Cell Significance Index: -21.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2006
    Cell Significance Index: -22.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2425
    Cell Significance Index: -3.5800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2467
    Cell Significance Index: -2.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2876
    Cell Significance Index: -22.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2980
    Cell Significance Index: -20.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3110
    Cell Significance Index: -17.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3132
    Cell Significance Index: -19.2500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3593
    Cell Significance Index: -5.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3597
    Cell Significance Index: -11.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3812
    Cell Significance Index: -20.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4376
    Cell Significance Index: -7.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4436
    Cell Significance Index: -28.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4632
    Cell Significance Index: -24.1300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4683
    Cell Significance Index: -7.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4918
    Cell Significance Index: -30.1500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.5111
    Cell Significance Index: -4.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5214
    Cell Significance Index: -18.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5332
    Cell Significance Index: -7.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Paxillin is a cytoplasmic protein that belongs to the paxillin family of proteins. It is a 60-kDa protein that contains four Src homology 2 (SH2) domains, three phosphotyrosine-binding (PTB) domains, and a proline-rich sequence. The SH2 domains enable paxillin to bind to phosphotyrosine residues on activated receptor tyrosine kinases, while the PTB domains facilitate the interaction with other signaling proteins. The proline-rich sequence is involved in the formation of protein complexes and the regulation of cell migration. **Pathways and Functions** Paxillin's involvement in various signaling pathways underscores its importance in regulating cellular responses to external stimuli. Key pathways include: 1. **Cell-cell and cell-ECM interactions**: Paxillin's association with focal adhesions and the ECM enables cells to sense and respond to their environment. 2. **Receptor tyrosine kinase signaling**: Paxillin binds to activated receptor tyrosine kinases, such as EGFR and VEGFR, and modulates their activity. 3. **Cytoskeletal remodeling**: Paxillin's interaction with actin and myosin motors regulates cytoskeletal dynamics and cell shape. 4. **Stress fiber assembly**: Paxillin's involvement in stress fiber formation is essential for maintaining cell shape and structure. 5. **Cell migration**: Paxillin's role in regulating focal adhesion dynamics and cytoskeletal remodeling is critical for cell migration. **Clinical Significance** Paxillin's involvement in various diseases highlights its potential as a therapeutic target. Dysregulation of paxillin has been implicated in: 1. **Cancer**: Paxillin's overexpression has been observed in various cancers, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: Paxillin's role in regulating inflammatory responses has been implicated in diseases such as rheumatoid arthritis and atherosclerosis. 3. **Neurological disorders**: Paxillin's involvement in neuronal signaling and cytoskeletal dynamics has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's. In conclusion, paxillin is a critical protein involved in various cellular processes, including cell adhesion, migration, and signaling. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the role of paxillin in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 1489217478

Symbol: PAXI_HUMAN

Name: Paxillin

UniProtKB Accession Codes:

P49023 B2RAI3 B7ZMB4 O14970 O14971 O60360 Q5HYA4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 4 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 15 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7534286

Title: Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.

PubMed ID: 7534286

DOI: 10.1074/jbc.270.10.5039

PubMed ID: 9054445

Title: Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins.

PubMed ID: 9054445

DOI: 10.1074/jbc.272.11.7437

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10604475

Title: Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses.

PubMed ID: 10604475

DOI: 10.1038/45264

PubMed ID: 11035932

Title: Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells.

PubMed ID: 11035932

DOI: 10.1006/excr.2000.5026

PubMed ID: 10938112

Title: Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.

PubMed ID: 10938112

DOI: 10.1128/mcb.20.17.6354-6363.2000

PubMed ID: 10749932

Title: A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration.

PubMed ID: 10749932

DOI: 10.1091/mbc.11.4.1315

PubMed ID: 11774284

Title: Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.

PubMed ID: 11774284

DOI: 10.1002/ijc.1609

PubMed ID: 12861019

Title: RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.

PubMed ID: 12861019

DOI: 10.1128/mcb.23.15.5331-5345.2003

PubMed ID: 15572663

Title: Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin.

PubMed ID: 15572663

DOI: 10.1128/mcb.24.24.10558-10572.2004

PubMed ID: 15817463

Title: Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.

PubMed ID: 15817463

DOI: 10.1074/jbc.m500752200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18042622

Title: Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin.

PubMed ID: 18042622

DOI: 10.1242/jcs.018218

PubMed ID: 17297458

Title: Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells.

PubMed ID: 17297458

DOI: 10.1038/sj.onc.1210264

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20489202

Title: Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.

PubMed ID: 20489202

DOI: 10.1074/jbc.m110.128470

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23128389

Title: SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration.

PubMed ID: 23128389

DOI: 10.1038/onc.2012.488

PubMed ID: 25015296

Title: TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.

PubMed ID: 25015296

DOI: 10.1242/jcs.143537

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24694988

Title: Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells.

PubMed ID: 24694988

DOI: 10.1038/ki.2014.85

PubMed ID: 14527389

Title: Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.

PubMed ID: 14527389

DOI: 10.1016/j.str.2003.08.010

PubMed ID: 17462669

Title: Paxillin and ponsin interact in nascent costameres of muscle cells.

PubMed ID: 17462669

DOI: 10.1016/j.jmb.2007.03.050

PubMed ID: 18508764

Title: The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly.

PubMed ID: 18508764

DOI: 10.1074/jbc.m801270200

PubMed ID: 18940607

Title: Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.

PubMed ID: 18940607

DOI: 10.1016/j.str.2008.08.007

PubMed ID: 19358827

Title: Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.

PubMed ID: 19358827

DOI: 10.1016/j.bbrc.2009.04.011

PubMed ID: 22869380

Title: Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.

PubMed ID: 22869380

DOI: 10.1074/jbc.m112.367342

Sequence Information:

  • Length: 591
  • Mass: 64505
  • Checksum: ABF6C0BE5939623F
  • Sequence:
    • MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG 
TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF 
PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL 
YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG 
EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG 
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA 
CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH NLFSPRCYYC 
NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA 
RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK 
PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.