Details for: MOK

Gene ID: 5891

Symbol: MOK

Ensembl ID: ENSG00000080823

Description: MOK protein kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 197.3381
    Cell Significance Index: -30.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.2369
    Cell Significance Index: -29.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 77.9468
    Cell Significance Index: -32.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.9282
    Cell Significance Index: -23.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.3456
    Cell Significance Index: -31.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.0434
    Cell Significance Index: -23.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0084
    Cell Significance Index: -29.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9523
    Cell Significance Index: -31.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 5.8401
    Cell Significance Index: 368.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3041
    Cell Significance Index: -9.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0281
    Cell Significance Index: 406.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1918
    Cell Significance Index: 226.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0671
    Cell Significance Index: 47.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0262
    Cell Significance Index: 38.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8685
    Cell Significance Index: 311.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7628
    Cell Significance Index: 51.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7533
    Cell Significance Index: 149.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7158
    Cell Significance Index: 70.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6808
    Cell Significance Index: 52.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6218
    Cell Significance Index: 34.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6119
    Cell Significance Index: 552.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6099
    Cell Significance Index: 17.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5493
    Cell Significance Index: 379.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4731
    Cell Significance Index: 21.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4489
    Cell Significance Index: 245.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3818
    Cell Significance Index: 62.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3632
    Cell Significance Index: 10.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3388
    Cell Significance Index: 7.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3109
    Cell Significance Index: 33.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2259
    Cell Significance Index: 31.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2172
    Cell Significance Index: 5.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1546
    Cell Significance Index: 9.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1523
    Cell Significance Index: 67.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0922
    Cell Significance Index: 173.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0663
    Cell Significance Index: 0.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0493
    Cell Significance Index: 8.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0447
    Cell Significance Index: 1.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0346
    Cell Significance Index: 21.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0310
    Cell Significance Index: 57.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0309
    Cell Significance Index: 1.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0276
    Cell Significance Index: 42.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0223
    Cell Significance Index: 1.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0126
    Cell Significance Index: 17.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0106
    Cell Significance Index: 4.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0020
    Cell Significance Index: 0.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0211
    Cell Significance Index: -1.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0239
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0321
    Cell Significance Index: -4.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0334
    Cell Significance Index: -2.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0389
    Cell Significance Index: -29.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0476
    Cell Significance Index: -26.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0487
    Cell Significance Index: -0.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0528
    Cell Significance Index: -6.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0536
    Cell Significance Index: -33.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0547
    Cell Significance Index: -4.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0919
    Cell Significance Index: -26.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1092
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1094
    Cell Significance Index: -18.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1352
    Cell Significance Index: -7.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1455
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1501
    Cell Significance Index: -31.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1751
    Cell Significance Index: -20.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1774
    Cell Significance Index: -18.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1807
    Cell Significance Index: -21.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2238
    Cell Significance Index: -26.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2679
    Cell Significance Index: -6.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2730
    Cell Significance Index: -28.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2844
    Cell Significance Index: -7.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2862
    Cell Significance Index: -4.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2885
    Cell Significance Index: -9.2400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2892
    Cell Significance Index: -4.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3045
    Cell Significance Index: -24.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3057
    Cell Significance Index: -19.7300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3161
    Cell Significance Index: -4.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3332
    Cell Significance Index: -20.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3543
    Cell Significance Index: -7.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3667
    Cell Significance Index: -22.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3700
    Cell Significance Index: -9.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3736
    Cell Significance Index: -6.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3896
    Cell Significance Index: -8.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4000
    Cell Significance Index: -12.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4194
    Cell Significance Index: -11.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4236
    Cell Significance Index: -14.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4337
    Cell Significance Index: -14.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4374
    Cell Significance Index: -9.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4496
    Cell Significance Index: -23.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4573
    Cell Significance Index: -9.7800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5062
    Cell Significance Index: -10.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5183
    Cell Significance Index: -15.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5303
    Cell Significance Index: -4.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5338
    Cell Significance Index: -9.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5452
    Cell Significance Index: -9.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5461
    Cell Significance Index: -3.7000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5647
    Cell Significance Index: -4.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5673
    Cell Significance Index: -19.8800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5757
    Cell Significance Index: -8.1800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.5759
    Cell Significance Index: -7.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/Threonine Kinase Activity:** MOK protein kinase exhibits serine/threonine kinase activity, which enables it to phosphorylate and regulate downstream targets. 2. **Cell Cycle Regulation:** MOK has been shown to regulate cell cycle progression, suggesting its involvement in controlling cell growth and proliferation. 3. **Ciliary Function:** MOK is co-localized with cilia in various cell types, indicating its potential role in ciliary function and intracellular signaling. 4. **Neurotransmitter Release:** MOK has been implicated in the regulation of neurotransmitter release, suggesting its involvement in synaptic transmission and neuronal function. 5. **Cellular Localization:** MOK is expressed in multiple cell types, including retinal rod cells, ciliated cells, astrocytes, and neurons, highlighting its wide-ranging cellular distribution. **Pathways and Functions:** 1. **Intracellular Signaling:** MOK is involved in regulating various intracellular signaling pathways, including MAPK, PI3K/AKT, and JNK pathways. 2. **Ciliary Signaling:** MOK is co-localized with cilia and is involved in regulating ciliary function and intracellular signaling. 3. **Cell Cycle Regulation:** MOK regulates cell cycle progression, controlling cell growth and proliferation. 4. **Neurotransmitter Release:** MOK regulates neurotransmitter release, influencing synaptic transmission and neuronal function. 5. **Metal Ion Binding:** MOK exhibits metal ion binding activity, which is essential for its kinase activity and cellular function. **Clinical Significance:** 1. **Neurological Disorders:** Abnormal MOK expression has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** MOK has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in cancer progression. 3. **Retinal Diseases:** MOK has been implicated in retinal diseases, including retinitis pigmentosa and age-related macular degeneration, highlighting its importance in maintaining retinal function. 4. **Ciliary Dyskinesia:** MOK has been implicated in ciliary dyskinesia, a condition characterized by defective ciliary function, suggesting its potential role in regulating ciliary function. In conclusion, MOK protein kinase is a multifunctional kinase that plays a crucial role in regulating various cellular processes, including cell cycle progression, signal transduction, and intracellular signaling. Its wide-ranging expression in multiple cell types and its involvement in various disease states highlight its importance in maintaining cellular homeostasis and overall health.

Genular Protein ID: 1092410175

Symbol: MOK_HUMAN

Name: MAPK/MAK/MRK overlapping kinase

UniProtKB Accession Codes:

Q9UQ07 B2R6Z4 B7Z7P6 E7ER76 E7ERR8 Q92790 Q93067

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 3 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10421840

Title: Molecular cloning and characterization of a novel member of the MAP kinase superfamily.

PubMed ID: 10421840

DOI: 10.1046/j.1365-2443.1999.00261.x

PubMed ID: 8781117

Title: A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma.

PubMed ID: 8781117

DOI: 10.1007/bf02602776

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 419
  • Mass: 48014
  • Checksum: CDA7D9C1E80AAE8F
  • Sequence:
    • MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE IQALRRLNPH 
PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL SEKKIMHYMY QLCKSLDHIH 
RNGIFHRDVK PENILIKQDV LKLGDFGSCR SVYSKQPYTE YISTRWYRAP ECLLTDGFYT 
YKMDLWSAGC VFYEIASLQP LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP 
FKKGSGIPLL TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR 
KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP KLKLSGVVRL 
SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD LKPAPQQCRL PTIVRKGGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.