Details for: RAP2A

Gene ID: 5911

Symbol: RAP2A

Ensembl ID: ENSG00000125249

Description: RAP2A, member of RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 174.6759
    Cell Significance Index: -27.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.8105
    Cell Significance Index: -28.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.7983
    Cell Significance Index: -27.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.9820
    Cell Significance Index: -25.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.9286
    Cell Significance Index: -28.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9053
    Cell Significance Index: -26.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4195
    Cell Significance Index: -25.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2706
    Cell Significance Index: -28.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3054
    Cell Significance Index: -13.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7988
    Cell Significance Index: 360.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2951
    Cell Significance Index: 1169.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0372
    Cell Significance Index: 120.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9300
    Cell Significance Index: 101.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8448
    Cell Significance Index: 137.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8253
    Cell Significance Index: 6.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7947
    Cell Significance Index: 35.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7656
    Cell Significance Index: 28.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7159
    Cell Significance Index: 48.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5516
    Cell Significance Index: 15.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5318
    Cell Significance Index: 29.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4743
    Cell Significance Index: 170.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4566
    Cell Significance Index: 90.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4010
    Cell Significance Index: 24.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2508
    Cell Significance Index: 6.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2447
    Cell Significance Index: 16.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1998
    Cell Significance Index: 38.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1643
    Cell Significance Index: 3.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1475
    Cell Significance Index: 4.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1388
    Cell Significance Index: 75.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1335
    Cell Significance Index: 24.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1214
    Cell Significance Index: 7.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1169
    Cell Significance Index: 51.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1105
    Cell Significance Index: 2.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1027
    Cell Significance Index: 14.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0961
    Cell Significance Index: 11.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0847
    Cell Significance Index: 10.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0605
    Cell Significance Index: 2.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0250
    Cell Significance Index: 33.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0061
    Cell Significance Index: 0.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0059
    Cell Significance Index: 11.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0010
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0127
    Cell Significance Index: -7.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0131
    Cell Significance Index: -20.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0189
    Cell Significance Index: -3.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0266
    Cell Significance Index: -19.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0312
    Cell Significance Index: -23.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0329
    Cell Significance Index: -0.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0356
    Cell Significance Index: -16.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0424
    Cell Significance Index: -6.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0671
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0801
    Cell Significance Index: -16.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0829
    Cell Significance Index: -23.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0919
    Cell Significance Index: -9.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1115
    Cell Significance Index: -5.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1265
    Cell Significance Index: -16.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1379
    Cell Significance Index: -6.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1427
    Cell Significance Index: -16.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1569
    Cell Significance Index: -17.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1624
    Cell Significance Index: -5.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1810
    Cell Significance Index: -13.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1964
    Cell Significance Index: -13.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2110
    Cell Significance Index: -13.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2315
    Cell Significance Index: -5.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2321
    Cell Significance Index: -7.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2382
    Cell Significance Index: -6.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2475
    Cell Significance Index: -5.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2630
    Cell Significance Index: -19.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2661
    Cell Significance Index: -27.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2757
    Cell Significance Index: -14.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2899
    Cell Significance Index: -22.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2916
    Cell Significance Index: -6.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3159
    Cell Significance Index: -10.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3225
    Cell Significance Index: -4.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3248
    Cell Significance Index: -5.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3589
    Cell Significance Index: -9.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3633
    Cell Significance Index: -11.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3786
    Cell Significance Index: -10.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3896
    Cell Significance Index: -20.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3929
    Cell Significance Index: -10.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4658
    Cell Significance Index: -28.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5048
    Cell Significance Index: -17.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5206
    Cell Significance Index: -11.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5309
    Cell Significance Index: -13.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5620
    Cell Significance Index: -15.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5689
    Cell Significance Index: -19.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5833
    Cell Significance Index: -14.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6072
    Cell Significance Index: -12.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6114
    Cell Significance Index: -12.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6118
    Cell Significance Index: -22.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6325
    Cell Significance Index: -18.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7245
    Cell Significance Index: -14.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7301
    Cell Significance Index: -10.4600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7427
    Cell Significance Index: -15.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7484
    Cell Significance Index: -23.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7855
    Cell Significance Index: -9.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7978
    Cell Significance Index: -23.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTPase activity**: Rap2A exhibits GTPase activity, which regulates its activity and interaction with downstream effectors. 2. **Rap protein signal transduction**: Rap2A is involved in regulating signaling pathways that control cell migration, polarity, and morphology. 3. **Cellular localization**: Rap2A is primarily localized to the plasma membrane, where it regulates protein localization and interactions. 4. **Expression pattern**: Rap2A is expressed in various cell types, including neurons, cardiac muscle, and certain epithelial cells. **Pathways and Functions:** 1. **Actin cytoskeleton organization**: Rap2A regulates the organization of the actin cytoskeleton, which is essential for cell migration, shape changes, and intracellular transport. 2. **Cellular response to xenobiotic stimulus**: Rap2A mediates the cellular response to xenobiotics, which involves the regulation of detoxification pathways and cell survival. 3. **Establishment of epithelial cell apical/basal polarity**: Rap2A plays a crucial role in establishing polarity in epithelial cells, which is essential for tissue development and function. 4. **Regulation of dendrite morphogenesis**: Rap2A regulates the morphogenesis of dendrites in neurons, which is essential for synaptic plasticity and learning. 5. **Regulation of protein localization**: Rap2A regulates the localization of proteins to specific compartments, such as the plasma membrane and endosomes. **Clinical Significance:** 1. **Neurological disorders**: Alterations in Rap2A expression and function have been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 2. **Cardiovascular disease**: Rap2A plays a role in regulating cardiac muscle function and may contribute to the development of cardiovascular disease. 3. **Cancer**: Rap2A has been implicated in the development and progression of certain types of cancer, such as breast cancer and leukemia. 4. **Neurodevelopmental disorders**: Rap2A may play a role in neurodevelopmental disorders, such as autism spectrum disorder and attention-deficit/hyperactivity disorder. In conclusion, Rap2A is a critical regulator of cellular processes, including cell migration, polarity establishment, and protein localization. Its expression and function have been implicated in various diseases, highlighting the importance of further research into the role of Rap2A in human health and disease.

Genular Protein ID: 2793338047

Symbol: RAP2A_HUMAN

Name: Ras-related protein Rap-2a

UniProtKB Accession Codes:

P10114 B2RCJ1 Q5JSC1 Q5JSC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3045729

Title: Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

PubMed ID: 3045729

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1900290

Title: The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis.

PubMed ID: 1900290

DOI: 10.1016/s0021-9258(20)64324-1

PubMed ID: 8424780

Title: Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated.

PubMed ID: 8424780

DOI: 10.1042/bj2890349

PubMed ID: 8391995

Title: Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.

PubMed ID: 8391995

DOI: 10.1016/0014-5793(93)81792-x

PubMed ID: 7962206

Title: Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex.

PubMed ID: 7962206

DOI: 10.1242/jcs.107.6.1661

PubMed ID: 8626586

Title: Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

PubMed ID: 8626586

DOI: 10.1074/jbc.271.17.10217

PubMed ID: 10572250

Title: Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments.

PubMed ID: 10572250

DOI: 10.1002/(sici)1097-4644(19991215)75:4<675::aid-jcb13>3.0.co;2-m

PubMed ID: 10777494

Title: Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

PubMed ID: 10777494

DOI: 10.1074/jbc.m001113200

PubMed ID: 12444546

Title: Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon.

PubMed ID: 12444546

DOI: 10.1038/sj.onc.1206003

PubMed ID: 14966141

Title: Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase.

PubMed ID: 14966141

DOI: 10.1074/jbc.c300542200

PubMed ID: 15342639

Title: The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.

PubMed ID: 15342639

DOI: 10.1074/jbc.m406370200

PubMed ID: 15752761

Title: PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector.

PubMed ID: 15752761

DOI: 10.1016/j.bbrc.2005.02.069

PubMed ID: 16246175

Title: Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A.

PubMed ID: 16246175

DOI: 10.1042/bj20051086

PubMed ID: 16540189

Title: Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation.

PubMed ID: 16540189

DOI: 10.1016/j.bbamcr.2006.02.001

PubMed ID: 17509819

Title: Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.

PubMed ID: 17509819

DOI: 10.1016/j.ygeno.2007.03.013

PubMed ID: 18930710

Title: MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1.

PubMed ID: 18930710

DOI: 10.1016/j.bbrc.2008.10.038

PubMed ID: 19061864

Title: Rap2 function requires palmitoylation and recycling endosome localization.

PubMed ID: 19061864

DOI: 10.1016/j.bbrc.2008.11.107

PubMed ID: 19645719

Title: RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange.

PubMed ID: 19645719

DOI: 10.1111/j.1742-4658.2009.07166.x

PubMed ID: 20159449

Title: Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.

PubMed ID: 20159449

DOI: 10.1016/j.neuron.2010.01.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22267739

Title: Structural determinants of Clostridium difficile toxin A glucosyltransferase activity.

PubMed ID: 22267739

DOI: 10.1074/jbc.m111.298414

PubMed ID: 23894443

Title: Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis.

PubMed ID: 23894443

DOI: 10.1371/journal.pone.0069289

PubMed ID: 9312017

Title: Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

PubMed ID: 9312017

DOI: 10.1093/emboj/16.18.5582

PubMed ID: 10591105

Title: Structure of the small G protein Rap2 in a non-catalytic complex with GTP.

PubMed ID: 10591105

DOI: 10.1002/(sici)1097-0134(19991115)37:3<465::aid-prot13>3.0.co;2-o

Sequence Information:

  • Length: 183
  • Mass: 20615
  • Checksum: 047D49762765F0B7
  • Sequence:
    • MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG 
TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYEKVP VILVGNKVDL 
ESEREVSSSE GRALAEEWGC PFMETSAKSK TMVDELFAEI VRQMNYAAQP DKDDPCCSAC 
NIQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.