Details for: UPF1

Gene ID: 5976

Symbol: UPF1

Ensembl ID: ENSG00000005007

Description: UPF1 RNA helicase and ATPase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 164.3895
    Cell Significance Index: -25.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.4864
    Cell Significance Index: -26.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.1929
    Cell Significance Index: -21.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.5069
    Cell Significance Index: -25.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.8177
    Cell Significance Index: -21.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3471
    Cell Significance Index: -26.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8101
    Cell Significance Index: -26.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7168
    Cell Significance Index: -26.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4237
    Cell Significance Index: -19.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8342
    Cell Significance Index: -10.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4920
    Cell Significance Index: 34.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9726
    Cell Significance Index: 229.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9346
    Cell Significance Index: 314.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2868
    Cell Significance Index: 77.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2389
    Cell Significance Index: 134.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0791
    Cell Significance Index: 48.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9191
    Cell Significance Index: 47.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7650
    Cell Significance Index: 22.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7190
    Cell Significance Index: 129.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7141
    Cell Significance Index: 19.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7118
    Cell Significance Index: 87.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7106
    Cell Significance Index: 141.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6488
    Cell Significance Index: 44.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6373
    Cell Significance Index: 575.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6265
    Cell Significance Index: 125.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6131
    Cell Significance Index: 31.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5681
    Cell Significance Index: 15.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4829
    Cell Significance Index: 12.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4192
    Cell Significance Index: 11.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3745
    Cell Significance Index: 17.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3297
    Cell Significance Index: 180.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3183
    Cell Significance Index: 43.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3067
    Cell Significance Index: 58.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2920
    Cell Significance Index: 129.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2752
    Cell Significance Index: 27.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2731
    Cell Significance Index: 97.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2472
    Cell Significance Index: 17.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2127
    Cell Significance Index: 13.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1847
    Cell Significance Index: 5.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1814
    Cell Significance Index: 5.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1783
    Cell Significance Index: 123.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1745
    Cell Significance Index: 11.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1506
    Cell Significance Index: 7.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0822
    Cell Significance Index: 1.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0747
    Cell Significance Index: 1.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0561
    Cell Significance Index: 7.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0176
    Cell Significance Index: 2.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0064
    Cell Significance Index: 11.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0049
    Cell Significance Index: 3.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0045
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0152
    Cell Significance Index: -2.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0191
    Cell Significance Index: -25.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0209
    Cell Significance Index: -1.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0235
    Cell Significance Index: -17.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0315
    Cell Significance Index: -23.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0494
    Cell Significance Index: -27.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0516
    Cell Significance Index: -32.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0555
    Cell Significance Index: -6.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0573
    Cell Significance Index: -5.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0714
    Cell Significance Index: -20.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0754
    Cell Significance Index: -5.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0887
    Cell Significance Index: -11.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1101
    Cell Significance Index: -16.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1134
    Cell Significance Index: -3.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1149
    Cell Significance Index: -8.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1189
    Cell Significance Index: -7.3100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1248
    Cell Significance Index: -1.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1280
    Cell Significance Index: -4.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1329
    Cell Significance Index: -2.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1527
    Cell Significance Index: -32.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2016
    Cell Significance Index: -11.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2167
    Cell Significance Index: -10.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2169
    Cell Significance Index: -17.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2256
    Cell Significance Index: -3.3800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2348
    Cell Significance Index: -1.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2382
    Cell Significance Index: -24.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2512
    Cell Significance Index: -11.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2880
    Cell Significance Index: -6.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2948
    Cell Significance Index: -18.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2992
    Cell Significance Index: -2.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3096
    Cell Significance Index: -8.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3214
    Cell Significance Index: -2.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3225
    Cell Significance Index: -16.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3319
    Cell Significance Index: -12.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3770
    Cell Significance Index: -8.7100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3857
    Cell Significance Index: -5.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3956
    Cell Significance Index: -10.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4856
    Cell Significance Index: -12.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5142
    Cell Significance Index: -11.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5217
    Cell Significance Index: -18.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5217
    Cell Significance Index: -8.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5236
    Cell Significance Index: -5.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5557
    Cell Significance Index: -10.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5563
    Cell Significance Index: -9.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5694
    Cell Significance Index: -3.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5710
    Cell Significance Index: -20.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5760
    Cell Significance Index: -20.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UPF1 is a dual-function protein that exhibits both helicase and ATPase activities. The helicase activity allows UPF1 to unwind double-stranded DNA, while the ATPase activity enables it to hydrolyze ATP, driving the unwinding process. This duality is essential for its role in regulating RNA degradation and telomere maintenance. UPF1's ability to bind to specific RNA sequences and its interaction with other proteins, such as RENT1, further underscore its importance in maintaining cellular homeostasis. **Pathways and Functions:** UPF1 is integral to several key cellular pathways, including: 1. **Nonsense-mediated decay (NMD):** UPF1's helicase activity is crucial for unwinding aberrant mRNAs, allowing for their degradation and preventing the translation of aberrant proteins. 2. **Telomere maintenance:** UPF1's ATPase activity is necessary for the unwinding of telomeres, allowing for their maintenance and preventing telomere shortening. 3. **RNA degradation:** UPF1's helicase activity is involved in the degradation of stable RNAs, ensuring the clearance of aberrant transcripts. 4. **Translation regulation:** UPF1's interaction with other proteins, such as RENT1, regulates the translation of specific mRNAs, ensuring the accurate translation of essential proteins. 5. **Chromatin and histone regulation:** UPF1's binding to chromatin and histones modulates chromatin structure and regulates gene expression. **Clinical Significance:** Dysregulation of UPF1 has been implicated in various diseases, including: 1. **Cancer:** Mutations in UPF1 have been observed in various types of cancer, including lung, breast, and colon cancer. 2. **Neurodegenerative diseases:** UPF1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation can lead to aberrant RNA processing and protein aggregation. 3. **Telomere-related disorders:** UPF1's role in telomere maintenance highlights its significance in diseases related to telomere shortening, such as premature aging and telomere-related disorders. In conclusion, UPF1 is a vital gene that plays a central role in maintaining cellular homeostasis through its involvement in RNA degradation, translation regulation, and telomere maintenance. Its dysregulation has significant implications for various diseases, highlighting the importance of UPF1 in maintaining genome stability and preventing disease.

Genular Protein ID: 3508377753

Symbol: RENT1_HUMAN

Name: Up-frameshift suppressor 1 homolog

UniProtKB Accession Codes:

Q92900 O00239 O43343 Q86Z25 Q92842

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CORUM 1 CTD 1 ChEBI 27 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 EMDB 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8855285

Title: Mammalian orthologues of a yeast regulator of nonsense transcript stability.

PubMed ID: 8855285

DOI: 10.1073/pnas.93.20.10928

PubMed ID: 9064659

Title: Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein.

PubMed ID: 9064659

DOI: 10.1093/nar/25.4.814

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 10454541

Title: SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast.

PubMed ID: 10454541

DOI: 10.1128/mcb.19.9.5943

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11163187

Title: Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.

PubMed ID: 11163187

DOI: 10.1016/s0092-8674(00)00214-2

PubMed ID: 11073994

Title: Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.

PubMed ID: 11073994

DOI: 10.1128/mcb.20.23.8944-8957.2000

PubMed ID: 10999600

Title: Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.

PubMed ID: 10999600

DOI: 10.1017/s1355838200000546

PubMed ID: 11544179

Title: Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.

PubMed ID: 11544179

DOI: 10.1101/gad.913001

PubMed ID: 11331269

Title: Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.

PubMed ID: 11331269

DOI: 10.1074/jbc.c100144200

PubMed ID: 11113196

Title: Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).

PubMed ID: 11113196

DOI: 10.1128/mcb.21.1.209-223.2001

PubMed ID: 11546874

Title: Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.

PubMed ID: 11546874

DOI: 10.1126/science.1062786

PubMed ID: 14636577

Title: Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.

PubMed ID: 14636577

DOI: 10.1016/s1097-2765(03)00443-x

PubMed ID: 12554878

Title: Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

PubMed ID: 12554878

DOI: 10.1261/rna.2137903

PubMed ID: 15721257

Title: SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.

PubMed ID: 15721257

DOI: 10.1016/j.molcel.2005.01.010

PubMed ID: 16086026

Title: Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.

PubMed ID: 16086026

DOI: 10.1038/nsmb972

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16452507

Title: Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.

PubMed ID: 16452507

DOI: 10.1101/gad.1389006

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18172165

Title: Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.

PubMed ID: 18172165

DOI: 10.1101/gad.1622708

PubMed ID: 18447585

Title: A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.

PubMed ID: 18447585

DOI: 10.1371/journal.pbio.0060111

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18362360

Title: The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.

PubMed ID: 18362360

DOI: 10.1073/pnas.0710576105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 19864460

Title: Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.

PubMed ID: 19864460

DOI: 10.1091/mbc.e09-05-0389

PubMed ID: 19150429

Title: Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex.

PubMed ID: 19150429

DOI: 10.1016/j.molcel.2008.11.022

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21145460

Title: Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.

PubMed ID: 21145460

DOI: 10.1016/j.cell.2010.11.043

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25220460

Title: The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

PubMed ID: 25220460

DOI: 10.1016/j.celrep.2014.08.020

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24726324

Title: MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

PubMed ID: 24726324

DOI: 10.1016/j.molcel.2014.03.017

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26000482

Title: Regnase-1 and Roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms.

PubMed ID: 26000482

DOI: 10.1016/j.cell.2015.04.029

PubMed ID: 26841701

Title: The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.

PubMed ID: 26841701

DOI: 10.1038/ncomms10585

PubMed ID: 27974568

Title: IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10.

PubMed ID: 27974568

DOI: 10.1128/jvi.01606-16

PubMed ID: 29382845

Title: HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition.

PubMed ID: 29382845

DOI: 10.1038/s41467-017-02793-6

PubMed ID: 30218034

Title: UPF1-like helicase grip on nucleic acids dictates processivity.

PubMed ID: 30218034

DOI: 10.1038/s41467-018-06313-y

PubMed ID: 17159905

Title: Structural and functional insights into the human Upf1 helicase core.

PubMed ID: 17159905

DOI: 10.1038/sj.emboj.7601464

PubMed ID: 19556969

Title: Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.

PubMed ID: 19556969

DOI: 10.1038/emboj.2009.175

PubMed ID: 21419344

Title: Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.

PubMed ID: 21419344

DOI: 10.1016/j.molcel.2011.02.010

Sequence Information:

  • Length: 1129
  • Mass: 124345
  • Checksum: 6CCA6FE42B15BA28
  • Sequence:
    • MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG PGGPGGGGAG 
GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL AELNFEEDEE DTYYTKDLPI 
HACSYCGIHD PACVVYCNTS KKWFCNGRGN TSGSHIVNHL VRAKCKEVTL HKDGPLGETV 
LECYNCGCRN VFLLGFIPAK ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS 
WLVKIPSEQE QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY 
QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT DSGNEDLVII 
WLRDMRLMQG DEICLRYKGD LAPLWKGIGH VIKVPDNYGD EIAIELRSSV GAPVEVTHNF 
QVDFVWKSTS FDRMQSALKT FAVDETSVSG YIYHKLLGHE VEDVIIKCQL PKRFTAQGLP 
DLNHSQVYAV KTVLQRPLSL IQGPPGTGKT VTSATIVYHL ARQGNGPVLV CAPSNIAVDQ 
LTEKIHQTGL KVVRLCAKSR EAIDSPVSFL ALHNQIRNMD SMPELQKLQQ LKDETGELSS 
ADEKRYRALK RTAERELLMN ADVICCTCVG AGDPRLAKMQ FRSILIDEST QATEPECMVP 
VVLGAKQLIL VGDHCQLGPV VMCKKAAKAG LSQSLFERLV VLGIRPIRLQ VQYRMHPALS 
AFPSNIFYEG SLQNGVTAAD RVKKGFDFQW PQPDKPMFFY VTQGQEEIAS SGTSYLNRTE 
AANVEKITTK LLKAGAKPDQ IGIITPYEGQ RSYLVQYMQF SGSLHTKLYQ EVEIASVDAF 
QGREKDFIIL SCVRANEHQG IGFLNDPRRL NVALTRARYG VIIVGNPKAL SKQPLWNHLL 
NYYKEQKVLV EGPLNNLRES LMQFSKPRKL VNTINPGARF MTTAMYDARE AIIPGSVYDR 
SSQGRPSSMY FQTHDQIGMI SAGPSHVAAM NIPIPFNLVM PPMPPPGYFG QANGPAAGRG 
TPKGKTGRGG RQKNRFGLPG PSQTNLPNSQ ASQDVASQPF SQGALTQGYI SMSQPSQMSQ 
PGLSQPELSQ DSYLGDEFKS QIDVALSQDS TYQGERAYQH GGVTGLSQY

Genular Protein ID: 1737285506

Symbol: A0A024R7L5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024R7L5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 10 Gene3D 3 HOGENOM 1 InterPro 8 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 5 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 1118
  • Mass: 123036
  • Checksum: A485D3ED52C39D06
  • Sequence:
    • MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG PGGPGGGGAG 
GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL AELNFEEDEE DTYYTKDLPI 
HACSYCGIHD PACVVYCNTS KKWFCNGRGN TSGSHIVNHL VRAKCKEVTL HKDGPLGETV 
LECYNCGCRN VFLLGFIPAK ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS 
WLVKIPSEQE QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY 
QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT DSDMRLMQGD 
EICLRYKGDL APLWKGIGHV IKVPDNYGDE IAIELRSSVG APVEVTHNFQ VDFVWKSTSF 
DRMQSALKTF AVDETSVSGY IYHKLLGHEV EDVIIKCQLP KRFTAQGLPD LNHSQVYAVK 
TVLQRPLSLI QGPPGTGKTV TSATIVYHLA RQGNGPVLVC APSNIAVDQL TEKIHQTGLK 
VVRLCAKSRE AIDSPVSFLA LHNQIRNMDS MPELQKLQQL KDETGELSSA DEKRYRALKR 
TAERELLMNA DVICCTCVGA GDPRLAKMQF RSILIDESTQ ATEPECMVPV VLGAKQLILV 
GDHCQLGPVV MCKKAAKAGL SQSLFERLVV LGIRPIRLQV QYRMHPALSA FPSNIFYEGS 
LQNGVTAADR VKKGFDFQWP QPDKPMFFYV TQGQEEIASS GTSYLNRTEA ANVEKITTKL 
LKAGAKPDQI GIITPYEGQR SYLVQYMQFS GSLHTKLYQE VEIASVDAFQ GREKDFIILS 
CVRANEHQGI GFLNDPRRLN VALTRARYGV IIVGNPKALS KQPLWNHLLN YYKEQKVLVE 
GPLNNLRESL MQFSKPRKLV NTINPGARFM TTAMYDAREA IIPGSVYDRS SQGRPSSMYF 
QTHDQIGMIS AGPSHVAAMN IPIPFNLVMP PMPPPGYFGQ ANGPAAGRGT PKGKTGRGGR 
QKNRFGLPGP SQTNLPNSQA SQDVASQPFS QGALTQGYIS MSQPSQMSQP GLSQPELSQD 
SYLGDEFKSQ IDVALSQDST YQGERAYQHG GVTGLSQY

Genular Protein ID: 406002354

Symbol: B3KY55_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KY55

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 373
  • Mass: 40970
  • Checksum: 2C3F3105EB48AA33
  • Sequence:
    • MFFYVTQGQE EIASSGTSYL NRTEAANVEK ITTKLLKAGA KPDQIGIITP YEGQRSYLVQ 
YMQFSGSLHT KLYQEVEIAS VDAFQGREKD FIILSCVRAN EHQGIGFLND PRRLNVALTR 
ARYGVIIVGN PKALSKQPLW NHLLNYYKEQ KVLVEGPLNN LRESLMQFSK PRKLVNTINP 
GARFMTTAMY DAREAIIPGS VYDRSSQGRP SSMYFQTHDQ IGMISAGPSH VAAMNIPIPF 
NLVMPPMPPP GYFGQANGPA AGRGTPKGKT GRGGRQKNRF GLPGPSQTNL PNSQASQDVA 
SQPFSQGALT QGYISMSQPS QMSQPGLSQP ELSQDSYLGD EFKSQIDVAL SQDSTYQGER 
AYQHGGVTGL SQY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.