Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 11.6855
Cell Significance Index: 736.5000 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.4646
Cell Significance Index: 42.1300 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.7674
Cell Significance Index: 6.7600 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.5626
Cell Significance Index: 6.8200 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.5377
Cell Significance Index: 13.0300 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.4989
Cell Significance Index: 5.7200 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.4874
Cell Significance Index: 3.7500 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.3701
Cell Significance Index: 4.5900 - Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: 0.2430
Cell Significance Index: 3.0200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2340
Cell Significance Index: 2.7900 - Cell Name: amacrine cell (CL0000561)
Fold Change: 0.2196
Cell Significance Index: 2.7500 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.1805
Cell Significance Index: 1.9400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1002
Cell Significance Index: 5.2600 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.0993
Cell Significance Index: 1.2400 - Cell Name: invaginating midget bipolar cell (CL4033034)
Fold Change: 0.0782
Cell Significance Index: 0.9600 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.0618
Cell Significance Index: 0.5100 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.0383
Cell Significance Index: 0.4800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0017
Cell Significance Index: -3.2200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0021
Cell Significance Index: -3.2200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0030
Cell Significance Index: -5.6400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0050
Cell Significance Index: -0.5900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0070
Cell Significance Index: -3.1800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0081
Cell Significance Index: -5.1400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0081
Cell Significance Index: -6.0100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0097
Cell Significance Index: -5.2900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0098
Cell Significance Index: -1.6700 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.0124
Cell Significance Index: -0.1400 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0130
Cell Significance Index: -0.1000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0158
Cell Significance Index: -5.6600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0163
Cell Significance Index: -0.8200 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0174
Cell Significance Index: -0.2300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0179
Cell Significance Index: -3.5900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0218
Cell Significance Index: -0.8900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0271
Cell Significance Index: -0.3700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0287
Cell Significance Index: -1.7600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0296
Cell Significance Index: -5.8700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0360
Cell Significance Index: -5.2300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0392
Cell Significance Index: -5.3900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0430
Cell Significance Index: -2.6400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0431
Cell Significance Index: -2.0100 - Cell Name: diffuse bipolar 2 cell (CL4033028)
Fold Change: -0.0440
Cell Significance Index: -0.5400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0498
Cell Significance Index: -0.5700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0520
Cell Significance Index: -5.9600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0549
Cell Significance Index: -2.4300 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.0557
Cell Significance Index: -0.6000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0621
Cell Significance Index: -1.7900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0635
Cell Significance Index: -2.4100 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0720
Cell Significance Index: -0.8400 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0746
Cell Significance Index: -0.9300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0796
Cell Significance Index: -5.3500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0852
Cell Significance Index: -2.0800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0941
Cell Significance Index: -5.2800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0961
Cell Significance Index: -2.2200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1018
Cell Significance Index: -3.2200 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1032
Cell Significance Index: -2.6300 - Cell Name: macroglial cell (CL0000126)
Fold Change: -0.1045
Cell Significance Index: -1.2100 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.1049
Cell Significance Index: -1.1500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1068
Cell Significance Index: -1.5300 - Cell Name: diffuse bipolar 4 cell (CL4033031)
Fold Change: -0.1076
Cell Significance Index: -1.3100 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.1096
Cell Significance Index: -1.5100 - Cell Name: neuron (CL0000540)
Fold Change: -0.1097
Cell Significance Index: -1.0400 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.1101
Cell Significance Index: -1.3900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1120
Cell Significance Index: -3.2100 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1144
Cell Significance Index: -1.4800 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1179
Cell Significance Index: -1.9100 - Cell Name: diffuse bipolar 1 cell (CL4033027)
Fold Change: -0.1230
Cell Significance Index: -1.5100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1277
Cell Significance Index: -6.0000 - Cell Name: pericyte (CL0000669)
Fold Change: -0.1301
Cell Significance Index: -1.5600 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1310
Cell Significance Index: -1.9100 - Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.1342
Cell Significance Index: -1.4800 - Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.1348
Cell Significance Index: -1.4800 - Cell Name: H1 horizontal cell (CL0004217)
Fold Change: -0.1420
Cell Significance Index: -1.7900 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1454
Cell Significance Index: -2.2500 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1529
Cell Significance Index: -1.9600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1667
Cell Significance Index: -5.8400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1733
Cell Significance Index: -3.7100 - Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.1737
Cell Significance Index: -1.7000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1833
Cell Significance Index: -6.0000 - Cell Name: memory B cell (CL0000787)
Fold Change: -0.1833
Cell Significance Index: -1.9500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1850
Cell Significance Index: -2.8100 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.1854
Cell Significance Index: -2.8200 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: -0.1886
Cell Significance Index: -1.9900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1890
Cell Significance Index: -2.6900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1906
Cell Significance Index: -5.4400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1912
Cell Significance Index: -6.0900 - Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.1929
Cell Significance Index: -1.8800 - Cell Name: diffuse bipolar 3b cell (CL4033030)
Fold Change: -0.1934
Cell Significance Index: -2.3300 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.1947
Cell Significance Index: -3.1300 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.1956
Cell Significance Index: -2.3800 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.1985
Cell Significance Index: -2.8200 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.2005
Cell Significance Index: -1.8100 - Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
Fold Change: -0.2020
Cell Significance Index: -2.1800 - Cell Name: giant bipolar cell (CL4033035)
Fold Change: -0.2025
Cell Significance Index: -2.3700 - Cell Name: glial cell (CL0000125)
Fold Change: -0.2026
Cell Significance Index: -2.2200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2027
Cell Significance Index: -5.9700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2034
Cell Significance Index: -5.4500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2036
Cell Significance Index: -5.4500 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.2069
Cell Significance Index: -2.9000 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.2079
Cell Significance Index: -2.1700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2092
Cell Significance Index: -5.5000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4173100248
Symbol: OPSD_HUMAN
Name: Rhodopsin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6589631
Title: Isolation and nucleotide sequence of the gene encoding human rhodopsin.
PubMed ID: 6589631
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8566799
Title: Sequence analysis of the 5.34-kb 5' flanking region of the human rhodopsin-encoding gene.
PubMed ID: 8566799
PubMed ID: 25664179
Title: Ultrastructural visualization of trans-ciliary rhodopsin cargoes in mammalian rods.
PubMed ID: 25664179
PubMed ID: 28524165
Title: Molecular assembly of rhodopsin with G protein-coupled receptor kinases.
PubMed ID: 28524165
DOI: 10.1038/cr.2017.72
PubMed ID: 26200343
Title: Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.
PubMed ID: 26200343
DOI: 10.1038/nature14656
PubMed ID: 28753425
Title: Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
PubMed ID: 28753425
PubMed ID: 2239971
Title: Autosomal dominant retinitis pigmentosa: absence of the rhodopsin proline-->histidine substitution (codon 23) in pedigrees from Europe.
PubMed ID: 2239971
PubMed ID: 2137202
Title: A point mutation of the rhodopsin gene in one form of retinitis pigmentosa.
PubMed ID: 2137202
DOI: 10.1038/343364a0
PubMed ID: 2215617
Title: Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.
PubMed ID: 2215617
PubMed ID: 1985460
Title: A 3-bp deletion in the rhodopsin gene in a family with autosomal dominant retinitis pigmentosa.
PubMed ID: 1985460
PubMed ID: 1897520
Title: Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresis.
PubMed ID: 1897520
PubMed ID: 1840561
Title: Pro-347-Arg mutation of the rhodopsin gene in autosomal dominant retinitis pigmentosa.
PubMed ID: 1840561
PubMed ID: 1862076
Title: Rhodopsin mutations in autosomal dominant retinitis pigmentosa.
PubMed ID: 1862076
PubMed ID: 1833777
Title: Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa.
PubMed ID: 1833777
PubMed ID: 1302614
Title: Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family.
PubMed ID: 1302614
DOI: 10.1093/hmg/1.9.769
PubMed ID: 1391967
Title: Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP).
PubMed ID: 1391967
DOI: 10.1007/bf01899733
PubMed ID: 8317502
Title: Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin.
PubMed ID: 8317502
PubMed ID: 8406457
Title: Molecular analysis and genetic mapping of the rhodopsin gene in families with autosomal dominant retinitis pigmentosa.
PubMed ID: 8406457
PubMed ID: 8401533
Title: Rhodopsin mutations in autosomal dominant retinitis pigmentosa.
PubMed ID: 8401533
PubMed ID: 8353500
Title: Autosomal dominant 'sector' retinitis pigmentosa due to a point mutation predicting an Asn-15-Ser substitution of rhodopsin.
PubMed ID: 8353500
DOI: 10.1093/hmg/2.6.813
PubMed ID: 8364589
Title: A leucine to arginine amino acid substitution at codon 46 of rhodopsin is responsible for a severe form of autosomal dominant retinitis pigmentosa.
PubMed ID: 8364589
PubMed ID: 8358437
Title: Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness.
PubMed ID: 8358437
DOI: 10.1038/ng0793-280
PubMed ID: 8088850
Title: Further screening of the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa.
PubMed ID: 8088850
PubMed ID: 8076945
Title: Identification of a novel rhodopsin mutation (Met-44-Thr) in a simplex case of retinitis pigmentosa.
PubMed ID: 8076945
DOI: 10.1007/bf00208284
PubMed ID: 7981701
Title: Three novel rhodopsin mutations (C110F, L131P, A164V) in patients with autosomal dominant retinitis pigmentosa.
PubMed ID: 7981701
DOI: 10.1093/hmg/3.7.1203
PubMed ID: 7987326
Title: Identification of a new mutation at codon 171 of rhodopsin gene causing autosomal dominant retinitis pigmentosa.
PubMed ID: 7987326
DOI: 10.1093/hmg/3.8.1421
PubMed ID: 7987331
Title: Five novel missense mutations of the rhodopsin gene in autosomal dominant retinitis pigmentosa.
PubMed ID: 7987331
DOI: 10.1093/hmg/3.8.1433
PubMed ID: 8081400
Title: Two new rhodopsin transversion mutations (L40R; M216K) in families with autosomal dominant retinitis pigmentosa.
PubMed ID: 8081400
PubMed ID: 8045708
Title: Autosomal dominant retinitis pigmentosa in a large family: a clinical and molecular genetic study.
PubMed ID: 8045708
PubMed ID: 8107847
Title: Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness.
PubMed ID: 8107847
DOI: 10.1038/367639a0
PubMed ID: 7987385
Title: Missense rhodopsin mutation in a family with recessive RP.
PubMed ID: 7987385
DOI: 10.1038/ng0994-10
PubMed ID: 7633434
Title: Rhodopsin mutation proline347-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347.
PubMed ID: 7633434
DOI: 10.1093/hmg/4.4.775
PubMed ID: 7846071
Title: Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation.
PubMed ID: 7846071
PubMed ID: 8554077
Title: Retinitis punctata albescens associated with the Arg135Trp mutation in the rhodopsin gene.
PubMed ID: 8554077
PubMed ID: 9452035
Title: Rhodopsin mutation G109R in a family with autosomal dominant retinitis pigmentosa.
PubMed ID: 9452035
PubMed ID: 9888392
Title: A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindness.
PubMed ID: 9888392
DOI: 10.1002/(sici)1098-1004(1999)13:1<75::aid-humu9>3.0.co;2-4
PubMed ID: 12566452
Title: Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa.
PubMed ID: 12566452
PubMed ID: 19934218
Title: A dual role for EDEM1 in the processing of rod opsin.
PubMed ID: 19934218
DOI: 10.1242/jcs.055228
PubMed ID: 19960070
Title: A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosa.
PubMed ID: 19960070
PubMed ID: 22334370
Title: Next-generation genetic testing for retinitis pigmentosa.
PubMed ID: 22334370
DOI: 10.1002/humu.22045
PubMed ID: 28837730
Title: A novel potentially causative variant of NDUFAF7 revealed by mutation screening in a chinese family with pathologic myopia.
PubMed ID: 28837730
Sequence Information:
- Length: 348
- Mass: 38893
- Checksum: 6F4F6FCBA34265B2
- Sequence:
MNGTEGPNFY VPFSNATGVV RSPFEYPQYY LAEPWQFSML AAYMFLLIVL GFPINFLTLY VTVQHKKLRT PLNYILLNLA VADLFMVLGG FTSTLYTSLH GYFVFGPTGC NLEGFFATLG GEIALWSLVV LAIERYVVVC KPMSNFRFGE NHAIMGVAFT WVMALACAAP PLAGWSRYIP EGLQCSCGID YYTLKPEVNN ESFVIYMFVV HFTIPMIIIF FCYGQLVFTV KEAAAQQQES ATTQKAEKEV TRMVIIMVIA FLICWVPYAS VAFYIFTHQG SNFGPIFMTI PAFFAKSAAI YNPVIYIMMN KQFRNCMLTT ICCGKNPLGD DEASATVSKT ETSQVAPA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.