Details for: ST3GAL1

Gene ID: 6482

Symbol: ST3GAL1

Ensembl ID: ENSG00000008513

Description: ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 250.4095
    Cell Significance Index: -38.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.0819
    Cell Significance Index: -37.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.7984
    Cell Significance Index: -37.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 90.4108
    Cell Significance Index: -42.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.8149
    Cell Significance Index: -41.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.6566
    Cell Significance Index: -42.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.7803
    Cell Significance Index: -37.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.5235
    Cell Significance Index: -40.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.6607
    Cell Significance Index: -36.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3269
    Cell Significance Index: -34.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.6917
    Cell Significance Index: -42.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.8868
    Cell Significance Index: 298.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2304
    Cell Significance Index: 116.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.0558
    Cell Significance Index: 34.6300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.0223
    Cell Significance Index: 32.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2168
    Cell Significance Index: 17.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1834
    Cell Significance Index: 234.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0259
    Cell Significance Index: 26.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8244
    Cell Significance Index: 148.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8121
    Cell Significance Index: 15.8500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8041
    Cell Significance Index: 19.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7818
    Cell Significance Index: 36.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7599
    Cell Significance Index: 152.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7021
    Cell Significance Index: 133.6100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.6941
    Cell Significance Index: 5.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6227
    Cell Significance Index: 340.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5749
    Cell Significance Index: 70.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5290
    Cell Significance Index: 14.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5255
    Cell Significance Index: 27.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4887
    Cell Significance Index: 7.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4306
    Cell Significance Index: 388.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3776
    Cell Significance Index: 8.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3668
    Cell Significance Index: 10.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3561
    Cell Significance Index: 35.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3536
    Cell Significance Index: 22.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3518
    Cell Significance Index: 3.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2737
    Cell Significance Index: 37.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2595
    Cell Significance Index: 33.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1951
    Cell Significance Index: 134.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1444
    Cell Significance Index: 4.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1334
    Cell Significance Index: 21.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1271
    Cell Significance Index: 45.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0661
    Cell Significance Index: 30.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0557
    Cell Significance Index: 2.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0461
    Cell Significance Index: 86.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0432
    Cell Significance Index: 5.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0195
    Cell Significance Index: 8.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0176
    Cell Significance Index: 32.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0161
    Cell Significance Index: 10.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0047
    Cell Significance Index: -0.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0159
    Cell Significance Index: -0.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0171
    Cell Significance Index: -0.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0209
    Cell Significance Index: -15.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0295
    Cell Significance Index: -16.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0319
    Cell Significance Index: -43.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0346
    Cell Significance Index: -5.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0348
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0351
    Cell Significance Index: -21.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0492
    Cell Significance Index: -36.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0649
    Cell Significance Index: -7.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0682
    Cell Significance Index: -6.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0784
    Cell Significance Index: -2.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0984
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1016
    Cell Significance Index: -21.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1159
    Cell Significance Index: -1.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1250
    Cell Significance Index: -35.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1274
    Cell Significance Index: -15.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1297
    Cell Significance Index: -18.8600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1316
    Cell Significance Index: -1.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1338
    Cell Significance Index: -9.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1480
    Cell Significance Index: -9.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1661
    Cell Significance Index: -19.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1743
    Cell Significance Index: -7.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1746
    Cell Significance Index: -11.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2337
    Cell Significance Index: -13.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2551
    Cell Significance Index: -19.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2822
    Cell Significance Index: -32.2100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2848
    Cell Significance Index: -1.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3029
    Cell Significance Index: -21.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3037
    Cell Significance Index: -21.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3339
    Cell Significance Index: -34.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4692
    Cell Significance Index: -28.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4853
    Cell Significance Index: -8.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4876
    Cell Significance Index: -38.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5083
    Cell Significance Index: -8.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5099
    Cell Significance Index: -16.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5296
    Cell Significance Index: -15.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5467
    Cell Significance Index: -14.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5485
    Cell Significance Index: -9.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6320
    Cell Significance Index: -9.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6625
    Cell Significance Index: -21.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6662
    Cell Significance Index: -21.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6935
    Cell Significance Index: -14.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7018
    Cell Significance Index: -14.6900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7280
    Cell Significance Index: -9.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7366
    Cell Significance Index: -10.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7649
    Cell Significance Index: -40.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7932
    Cell Significance Index: -34.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glycosylation enzyme**: ST3GAL1 is a type II transmembrane glycosyltransferase that catalyzes the transfer of sialic acid residues to galactose-containing molecules. 2. **Specificity**: The enzyme has a high specificity for the transfer of sialic acid residues to galactose-containing molecules, resulting in the formation of sialylated glycoconjugates. 3. **Cellular localization**: ST3GAL1 is primarily expressed in the Golgi apparatus, where it plays a critical role in the biosynthesis of glycoproteins and glycolipids. 4. **Tissue distribution**: The enzyme is widely expressed in various tissues, including the heart, skeletal muscle, kidney, lung, and brain. **Pathways and Functions:** 1. **Glycosylation**: ST3GAL1 is involved in the biosynthesis of glycoproteins and glycolipids, which play critical roles in cell signaling, cell adhesion, and immune response. 2. **Immune response**: The enzyme has been implicated in the regulation of immune responses, including the modulation of T cell activation and the suppression of inflammatory responses. 3. **Cell signaling**: ST3GAL1 has been shown to regulate cell signaling pathways, including the Notch and Wnt signaling pathways. 4. **Cancer**: The enzyme has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 5. **Infectious diseases**: ST3GAL1 has been implicated in the regulation of immune responses to infectious diseases, including influenza and COVID-19. **Clinical Significance:** 1. **Cancer diagnosis and treatment**: ST3GAL1 has been identified as a potential biomarker for cancer diagnosis and treatment. 2. **Infectious disease treatment**: The enzyme has been found to be involved in the regulation of immune responses to infectious diseases, making it a potential target for therapeutic interventions. 3. **Neurological disorders**: ST3GAL1 has been implicated in the regulation of immune responses in neurological disorders, including multiple sclerosis and Alzheimer's disease. 4. **Vaccine development**: The enzyme has been identified as a potential target for vaccine development, particularly for the treatment of infectious diseases. In conclusion, ST3GAL1 is a critical enzyme involved in the biosynthesis of glycoproteins and glycolipids, and its dysregulation has been implicated in various physiological and pathological processes, including cancer, inflammation, and infectious diseases. Further research is needed to fully elucidate the role of ST3GAL1 in immune response and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 480226734

Symbol: SIA4A_HUMAN

Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

UniProtKB Accession Codes:

Q11201 O60677 Q9UN51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 35 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 7 Rhea 14 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8027041

Title: Differential expression of five sialyltransferase genes in human tissues.

PubMed ID: 8027041

DOI: 10.1016/s0021-9258(17)32390-6

PubMed ID: 7655169

Title: Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies.

PubMed ID: 7655169

DOI: 10.1093/glycob/5.3.319

PubMed ID: 10504389

Title: Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver.

PubMed ID: 10504389

DOI: 10.1046/j.1432-1327.1999.00733.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9182658

Title: A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core-2-based O-glycans.

PubMed ID: 9182658

DOI: 10.1083/jcb.137.6.1229

PubMed ID: 31784620

Title: Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1).

PubMed ID: 31784620

DOI: 10.1038/s41598-019-54384-8

Sequence Information:

  • Length: 340
  • Mass: 39075
  • Checksum: A3E81D9C85446843
  • Sequence:
    • MVTLRKRTLK VLTFLVLFIF LTSFFLNYSH TMVATTWFPK QMVLELSENL KRLIKHRPCT 
CTHCIGQRKL SAWFDERFNQ TMQPLLTAQN ALLEDDTYRW WLRLQREKKP NNLNDTIKEL 
FRVVPGNVDP MLEKRSVGCR RCAVVGNSGN LRESSYGPEI DSHDFVLRMN KAPTAGFEAD 
VGTKTTHHLV YPESFRELGD NVSMILVPFK TIDLEWVVSA ITTGTISHTY IPVPAKIRVK 
QDKILIYHPA FIKYVFDNWL QGHGRYPSTG ILSVIFSMHV CDEVDLYGFG ADSKGNWHHY 
WENNPSAGAF RKTGVHDADF ESNVTATLAS INKIRIFKGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.