Details for: SIGLEC1

Gene ID: 6614

Symbol: SIGLEC1

Ensembl ID: ENSG00000088827

Description: sialic acid binding Ig like lectin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.5639
    Cell Significance Index: -6.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.7856
    Cell Significance Index: 74.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 4.3289
    Cell Significance Index: 35.3000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 3.0551
    Cell Significance Index: 37.7900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.3844
    Cell Significance Index: 6.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4028
    Cell Significance Index: 7.4500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0630
    Cell Significance Index: 0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0048
    Cell Significance Index: -8.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0084
    Cell Significance Index: -3.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0086
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0096
    Cell Significance Index: -0.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0116
    Cell Significance Index: -6.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0140
    Cell Significance Index: -6.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0145
    Cell Significance Index: -2.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0153
    Cell Significance Index: -4.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0273
    Cell Significance Index: -4.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0349
    Cell Significance Index: -5.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0364
    Cell Significance Index: -4.6600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0369
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0387
    Cell Significance Index: -2.9700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0424
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0450
    Cell Significance Index: -7.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0478
    Cell Significance Index: -5.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0539
    Cell Significance Index: -7.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0590
    Cell Significance Index: -6.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0663
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0688
    Cell Significance Index: -7.8800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0754
    Cell Significance Index: -0.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0905
    Cell Significance Index: -2.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0984
    Cell Significance Index: -6.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0993
    Cell Significance Index: -6.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1033
    Cell Significance Index: -5.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1070
    Cell Significance Index: -5.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1102
    Cell Significance Index: -7.1100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1130
    Cell Significance Index: -1.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1154
    Cell Significance Index: -3.2300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1192
    Cell Significance Index: -1.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1208
    Cell Significance Index: -1.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1243
    Cell Significance Index: -7.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1304
    Cell Significance Index: -3.5500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1325
    Cell Significance Index: -1.1200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1440
    Cell Significance Index: -2.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1451
    Cell Significance Index: -2.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1498
    Cell Significance Index: -4.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1508
    Cell Significance Index: -8.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1579
    Cell Significance Index: -4.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1662
    Cell Significance Index: -8.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1702
    Cell Significance Index: -7.5300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1724
    Cell Significance Index: -1.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1747
    Cell Significance Index: -6.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1778
    Cell Significance Index: -8.2900
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1825
    Cell Significance Index: -1.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1878
    Cell Significance Index: -6.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1966
    Cell Significance Index: -6.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1986
    Cell Significance Index: -7.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2064
    Cell Significance Index: -5.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2190
    Cell Significance Index: -6.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2212
    Cell Significance Index: -8.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2226
    Cell Significance Index: -4.6600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2294
    Cell Significance Index: -2.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2365
    Cell Significance Index: -5.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2382
    Cell Significance Index: -8.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2386
    Cell Significance Index: -5.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2421
    Cell Significance Index: -6.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2452
    Cell Significance Index: -7.0300
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.2466
    Cell Significance Index: -1.8100
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.2470
    Cell Significance Index: -2.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2588
    Cell Significance Index: -3.0900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2593
    Cell Significance Index: -5.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2606
    Cell Significance Index: -5.6300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2618
    Cell Significance Index: -2.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2681
    Cell Significance Index: -6.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2691
    Cell Significance Index: -6.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2693
    Cell Significance Index: -7.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2757
    Cell Significance Index: -5.6100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2808
    Cell Significance Index: -5.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2881
    Cell Significance Index: -8.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2914
    Cell Significance Index: -6.3800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2915
    Cell Significance Index: -9.2200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2961
    Cell Significance Index: -3.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3023
    Cell Significance Index: -6.4200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3092
    Cell Significance Index: -3.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3110
    Cell Significance Index: -6.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3123
    Cell Significance Index: -6.2700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3185
    Cell Significance Index: -4.5300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3209
    Cell Significance Index: -3.4500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3247
    Cell Significance Index: -6.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3247
    Cell Significance Index: -6.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3299
    Cell Significance Index: -8.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3302
    Cell Significance Index: -7.9200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3342
    Cell Significance Index: -4.3300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3365
    Cell Significance Index: -5.4500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.3411
    Cell Significance Index: -2.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIGLEC1 is a type II transmembrane protein, consisting of an extracellular domain with two Ig-like domains and a cytoplasmic tail. The extracellular domain is responsible for binding to sialic acid, which is a key component of cell surface glycoproteins. This binding is thought to regulate the adhesion and migration of immune cells, such as macrophages and T cells. SIGLEC1 has been shown to be highly expressed in various immune cells, including Kupffer cells, Hofbauer cells, and alternatively activated macrophages. **Pathways and Functions:** SIGLEC1 is involved in several immune-related pathways, including: 1. **Cell-cell adhesion:** SIGLEC1 mediates the adhesion of immune cells to each other and to endothelial cells, facilitating their migration to sites of inflammation. 2. **Immune system regulation:** SIGLEC1 has been shown to regulate the production of type I interferons, which are key players in the antiviral response. 3. **Inflammatory response:** SIGLEC1 has been implicated in the regulation of inflammatory responses, including the production of pro-inflammatory cytokines. 4. **Cell-matrix adhesion:** SIGLEC1 has been shown to regulate the adhesion of immune cells to the extracellular matrix, which is important for their migration and tissue homing. **Clinical Significance:** SIGLEC1 has been implicated in several diseases, including: 1. **Autoimmune diseases:** SIGLEC1 has been shown to play a role in the regulation of autoimmune responses, including rheumatoid arthritis and multiple sclerosis. 2. **Infectious diseases:** SIGLEC1 has been implicated in the regulation of antiviral responses, including the production of type I interferons. 3. **Cancer:** SIGLEC1 has been shown to be overexpressed in certain types of cancer, including melanoma and lung cancer. 4. **Neurological disorders:** SIGLEC1 has been implicated in the regulation of inflammatory responses in neurological disorders, including multiple sclerosis and Alzheimer's disease. In conclusion, SIGLEC1 is a key regulator of the immune system, involved in various immune-related pathways, including cell-cell adhesion, immune system regulation, inflammatory response, and cell-matrix adhesion. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the role of SIGLEC1 in human health and disease. **Signaling Pathways:** 1. **Clathrin-dependent endocytosis of virus by host cell:** SIGLEC1 has been shown to regulate the endocytosis of viruses by host cells, which is an important mechanism for the regulation of antiviral responses. 2. **Immune system:** SIGLEC1 has been implicated in the regulation of immune responses, including the activation of T cells and B cells. 3. **Inflammatory response:** SIGLEC1 has been shown to regulate the production of pro-inflammatory cytokines, which is an important mechanism for the regulation of inflammatory responses. 4. **Negative regulation of type I interferon production:** SIGLEC1 has been shown to regulate the production of type I interferons, which are key players in the antiviral response. **Signaling Molecules:** 1. **CD14:** SIGLEC1 has been shown to interact with CD14, a receptor on the surface of macrophages, which is involved in the regulation of immune responses. 2. **CD16:** SIGLEC1 has been shown to interact with CD16, a receptor on the surface of natural killer cells, which is involved in the regulation of antiviral responses. 3. **T cells:** SIGLEC1 has been shown to interact with T cells, which are key players in the regulation of immune responses. 4. **B cells:** SIGLEC1 has been shown to interact with B cells, which are key players in the regulation of immune responses. **Enzymes:** 1. **Tyrosine kinases:** SIGLEC1 has been shown to interact with tyrosine kinases, which are enzymes involved in the regulation of cell signaling pathways. 2. **Phosphatases:** SIGLEC1 has been shown to interact with phosphatases, which are enzymes involved in the regulation of cell signaling pathways. 3. **Proteases:** SIGLEC1 has been shown to interact with proteases, which are enzymes involved in the regulation of cell signaling pathways. **Cell Types:** 1. **Kupffer cells:** SIGLEC1 has been shown to be highly expressed in Kupffer cells, which are macrophages in the liver. 2. **Hofbauer cells:** SIGLEC1 has been shown to be highly expressed in Hofbauer cells, which are macrophages in the kidney. 3. **Alternatively activated macrophages:** SIGLEC1 has been shown to be highly expressed in alternatively activated macrophages, which are involved in the regulation of immune responses. 4. **Immature innate lymphoid cells:** SIGLEC1 has been shown to be highly expressed in immature innate lymphoid cells, which are involved in the regulation of immune responses. **Protein-Protein Interactions:** 1. **CD14:** SIGLEC1 has been shown to interact with CD14, a receptor on the surface of macrophages. 2. **CD16:** SIGLEC1 has been shown to interact with CD16, a receptor on the surface of natural killer cells. 3. **T cells:** SIGLEC1 has been shown to interact with T cells, which are key players in the regulation of immune responses. 4. **B cells:** SIGLEC1 has been shown to interact with B cells, which are key players in the regulation of immune responses. **Regulatory Elements:** 1. **Promoter:** The promoter of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 2. **Enhancer:** The enhancer of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 3. **Silencer:** The silencer of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. **Gene Regulation:** 1. **Transcriptional regulation:** The transcriptional regulation of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 2. **Post-transcriptional regulation:** The post-transcriptional regulation of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 3. **Epigenetic regulation:** The epigenetic regulation of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. **Gene Expression:** 1. **Tissue-specific expression:** The SIGLEC1 gene has been shown to be tissue-specifically expressed in various tissues, including the liver, kidney, and immune cells. 2. **Developmental expression:** The SIGLEC1 gene has been shown to be developmentally expressed in various tissues, including the liver, kidney, and immune cells. 3. **Cell-type specific expression:** The SIGLEC1 gene has been shown to be cell-type specifically expressed in various cell types, including immune cells and non-immune cells. **Gene Expression Analysis:** 1. **Microarray analysis:** The microarray analysis of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 2. **RT-PCR analysis:** The RT-PCR analysis of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 3. **ChIP-seq analysis:** The ChIP-seq analysis of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. **Gene Expression Regulation:** 1. **Transcriptional regulation:** The transcriptional regulation of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 2. **Post-transcriptional regulation:** The post-transcriptional regulation of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 3. **Epigenetic regulation:** The epigenetic regulation of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. **Gene Expression Analysis Tools:** 1. **Microarray analysis:** The microarray analysis of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 2. **RT-PCR analysis:** The RT-PCR analysis of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 3. **ChIP-seq analysis:** The ChIP-seq analysis of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. **Gene Expression Bioinformatics Tools:** 1. **Gene expression profiling:** The gene expression profiling of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 2. **Transcriptome analysis:** The transcriptome analysis of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. 3. **ChIP-seq analysis:** The ChIP-seq analysis of the SIGLEC1 gene has been shown to be involved in the regulation of its expression. **Gene Expression Regulation:

Genular Protein ID: 3175592182

Symbol: SN_HUMAN

Name: Sialoadhesin

UniProtKB Accession Codes:

Q9BZZ2 Q96DL4 Q9GZS5 Q9H1H6 Q9H1H7 Q9H7L7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 8 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11133773

Title: Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.

PubMed ID: 11133773

DOI: 10.1182/blood.v97.1.288

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11214971

Title: Characterization of long cDNA clones from human adult spleen.

PubMed ID: 11214971

DOI: 10.1093/dnares/7.6.357

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12940982

Title: Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptake.

PubMed ID: 12940982

DOI: 10.1046/j.1365-2958.2003.03634.x

PubMed ID: 26358190

Title: Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.

PubMed ID: 26358190

DOI: 10.1038/cr.2015.108

PubMed ID: 28129379

Title: Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

PubMed ID: 28129379

DOI: 10.1371/journal.ppat.1006181

PubMed ID: 31160823

Title: Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry.

PubMed ID: 31160823

DOI: 10.1038/s41564-019-0453-2

PubMed ID: 33489013

Title: Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.

PubMed ID: 33489013

DOI: 10.1002/jev2.12046

PubMed ID: 34782760

Title: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells.

PubMed ID: 34782760

DOI: 10.1038/s41423-021-00794-6

Sequence Information:

  • Length: 1709
  • Mass: 182624
  • Checksum: 587C7CCA0B789A6D
  • Sequence:
    • MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY 
YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS 
EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP 
ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG 
VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW 
YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF 
LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD 
LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD 
ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS 
PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ 
EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA 
GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL 
GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC 
QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG 
DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA 
DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT 
VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG 
VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG 
AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS 
HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL 
QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP 
LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG 
SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV 
EMAFQKETTQ LIDPDAATCE TSTCAPPLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.