Details for: SIGLEC1

Gene ID: 6614

Symbol: SIGLEC1

Ensembl ID: ENSG00000088827

Description: sialic acid binding Ig like lectin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.15
    Marker Score: 15264
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 4.31
    Marker Score: 13793
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.86
    Marker Score: 8161
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.12
    Marker Score: 2124
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.71
    Marker Score: 942
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169162
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.47
    Marker Score: 612
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.13
    Marker Score: 2296
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.07
    Marker Score: 60085
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251805
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1820
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.82
    Marker Score: 4984
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.8
    Marker Score: 20613
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1175
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.71
    Marker Score: 815
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 9986
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.46
    Marker Score: 1183
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.45
    Marker Score: 461
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.44
    Marker Score: 489
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.43
    Marker Score: 778
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.4
    Marker Score: 4655
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.38
    Marker Score: 266
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 173
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.35
    Marker Score: 1090
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.34
    Marker Score: 654
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.34
    Marker Score: 2231
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.31
    Marker Score: 238
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.26
    Marker Score: 179
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.26
    Marker Score: 128
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 165
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 217
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 142
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 124
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.23
    Marker Score: 176
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.22
    Marker Score: 127
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.2
    Marker Score: 217
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.19
    Marker Score: 459
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.19
    Marker Score: 246
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.18
    Marker Score: 524
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.18
    Marker Score: 755
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.18
    Marker Score: 232
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.18
    Marker Score: 172
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.15
    Marker Score: 193
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.15
    Marker Score: 142
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.15
    Marker Score: 154
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 255
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.15
    Marker Score: 32
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.14
    Marker Score: 175
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.14
    Marker Score: 88.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.13
    Marker Score: 68
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.13
    Marker Score: 349
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 126
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.11
    Marker Score: 249
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.1
    Marker Score: 28

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Other Information

**Key characteristics:** * SIGLEC1 is a glycoprotein with a molecular weight of approximately 150 kDa. * It is expressed on a variety of cell types, including endothelial cells, epithelial cells, and immune cells. * SIGLEC1 is a key molecule in cell-cell adhesion, as it is involved in the formation of cell junctions and the maintenance of tissue integrity. * It is also involved in cell-matrix adhesion, as it binds to extracellular matrix proteins and helps to hold cells together. * SIGLEC1 is also involved in immune responses, as it is expressed on immune cells such as macrophages and dendritic cells. * It is a negative regulator of type I interferon production, which is a protein that is involved in the regulation of inflammation. **Pathways and functions:** * SIGLEC1 is involved in cell-cell adhesion by binding to sialic acids on the surface of other cells. * It is also involved in cell-matrix adhesion by binding to extracellular matrix proteins. * It is involved in immune responses by binding to sialic acids on the surface of infected cells. * It is a negative regulator of type I interferon production, which is a protein that is involved in the regulation of inflammation. **Clinical significance:** SIGLEC1 is a promising target for cancer immunotherapy. Inhibition of SIGLEC1 has been shown to inhibit cancer cell growth and metastasis in animal models of cancer. This suggests that SIGLEC1 is a potential therapeutic target for cancer patients.

Genular Protein ID: 3175592182

Symbol: SN_HUMAN

Name: Sialoadhesin

UniProtKB Accession Codes:

Q9BZZ2 Q96DL4 Q9GZS5 Q9H1H6 Q9H1H7 Q9H7L7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 8 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11133773

Title: Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.

PubMed ID: 11133773

DOI: 10.1182/blood.v97.1.288

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11214971

Title: Characterization of long cDNA clones from human adult spleen.

PubMed ID: 11214971

DOI: 10.1093/dnares/7.6.357

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12940982

Title: Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptake.

PubMed ID: 12940982

DOI: 10.1046/j.1365-2958.2003.03634.x

PubMed ID: 26358190

Title: Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.

PubMed ID: 26358190

DOI: 10.1038/cr.2015.108

PubMed ID: 28129379

Title: Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

PubMed ID: 28129379

DOI: 10.1371/journal.ppat.1006181

PubMed ID: 31160823

Title: Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry.

PubMed ID: 31160823

DOI: 10.1038/s41564-019-0453-2

PubMed ID: 33489013

Title: Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.

PubMed ID: 33489013

DOI: 10.1002/jev2.12046

PubMed ID: 34782760

Title: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells.

PubMed ID: 34782760

DOI: 10.1038/s41423-021-00794-6

Sequence Information:

  • Length: 1709
  • Mass: 182624
  • Checksum: 587C7CCA0B789A6D
  • Sequence:
    • MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY 
YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS 
EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP 
ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG 
VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW 
YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF 
LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD 
LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD 
ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS 
PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ 
EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA 
GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL 
GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC 
QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG 
DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA 
DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT 
VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG 
VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG 
AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS 
HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL 
QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP 
LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG 
SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV 
EMAFQKETTQ LIDPDAATCE TSTCAPPLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.