Details for: SNAP25
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 274.5981
Cell Significance Index: -69.6500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 12.3025
Cell Significance Index: 645.9300 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 11.7017
Cell Significance Index: 90.2000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 8.7912
Cell Significance Index: 554.0800 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 8.4982
Cell Significance Index: 105.4100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 7.9183
Cell Significance Index: 225.9700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 6.9602
Cell Significance Index: 82.9700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 6.3889
Cell Significance Index: 429.5900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 6.1238
Cell Significance Index: 104.9500 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 4.2639
Cell Significance Index: 37.5600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.0003
Cell Significance Index: 151.4800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 3.9540
Cell Significance Index: 242.4200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.8266
Cell Significance Index: 169.2600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.4450
Cell Significance Index: 691.0600 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 3.2669
Cell Significance Index: 43.5800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.2647
Cell Significance Index: 78.3000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.2461
Cell Significance Index: 1164.3100 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 3.0898
Cell Significance Index: 40.0700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.9064
Cell Significance Index: 178.6400 - Cell Name: keratocyte (CL0002363)
Fold Change: 2.6442
Cell Significance Index: 41.9500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.6356
Cell Significance Index: 1131.2500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3479
Cell Significance Index: 267.5000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.9506
Cell Significance Index: 20.3200 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.9248
Cell Significance Index: 11.2100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5890
Cell Significance Index: 531.8400 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.2890
Cell Significance Index: 2.7500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2725
Cell Significance Index: 26.9600 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.2712
Cell Significance Index: 2.0800 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.2160
Cell Significance Index: 2.4400 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.2149
Cell Significance Index: 2.6800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1510
Cell Significance Index: 284.3500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1474
Cell Significance Index: 23.9700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1132
Cell Significance Index: 21.5500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0081
Cell Significance Index: 3.6700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0055
Cell Significance Index: 4.0400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0037
Cell Significance Index: -0.1300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0324
Cell Significance Index: -59.7000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0385
Cell Significance Index: -59.2000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0447
Cell Significance Index: -60.8500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0460
Cell Significance Index: -28.7400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0562
Cell Significance Index: -8.1800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0647
Cell Significance Index: -1.2800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0712
Cell Significance Index: -40.1400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0795
Cell Significance Index: -2.2900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0805
Cell Significance Index: -8.7600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0864
Cell Significance Index: -63.3700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0876
Cell Significance Index: -55.6200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0957
Cell Significance Index: -72.4300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1035
Cell Significance Index: -3.3200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1067
Cell Significance Index: -22.4700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.1167
Cell Significance Index: -63.7100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.1239
Cell Significance Index: -54.7700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1787
Cell Significance Index: -30.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2013
Cell Significance Index: -57.9200 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.3020
Cell Significance Index: -3.2900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.3022
Cell Significance Index: -54.4900 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.3359
Cell Significance Index: -4.2400 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -0.3517
Cell Significance Index: -3.8800 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3566
Cell Significance Index: -7.1600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3632
Cell Significance Index: -10.1500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3687
Cell Significance Index: -16.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3698
Cell Significance Index: -20.7500 - Cell Name: neural cell (CL0002319)
Fold Change: -0.4003
Cell Significance Index: -4.6700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.4067
Cell Significance Index: -55.8500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.4505
Cell Significance Index: -55.4000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4600
Cell Significance Index: -31.8100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.4611
Cell Significance Index: -59.5700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.4649
Cell Significance Index: -47.4900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4688
Cell Significance Index: -9.9500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4770
Cell Significance Index: -49.6700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4855
Cell Significance Index: -10.5200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.5031
Cell Significance Index: -64.4900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5449
Cell Significance Index: -32.7100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5579
Cell Significance Index: -65.0200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5768
Cell Significance Index: -65.8400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5794
Cell Significance Index: -66.3800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6054
Cell Significance Index: -19.2800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6610
Cell Significance Index: -16.9900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6765
Cell Significance Index: -22.1500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8035
Cell Significance Index: -63.6400 - Cell Name: neuron (CL0000540)
Fold Change: -0.8223
Cell Significance Index: -7.8000 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: -0.8278
Cell Significance Index: -9.4900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.8664
Cell Significance Index: -64.5700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.8987
Cell Significance Index: -68.9700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.9123
Cell Significance Index: -19.7100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.9942
Cell Significance Index: -24.8000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -1.0415
Cell Significance Index: -14.9200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.0784
Cell Significance Index: -56.1700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.1509
Cell Significance Index: -25.2000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.1555
Cell Significance Index: -40.4800 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -1.1744
Cell Significance Index: -16.5000 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -1.2188
Cell Significance Index: -10.0600 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -1.2236
Cell Significance Index: -17.1100 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -1.2313
Cell Significance Index: -14.7300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.2510
Cell Significance Index: -58.8000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -1.2877
Cell Significance Index: -55.9900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.4591
Cell Significance Index: -68.0300 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -1.4609
Cell Significance Index: -30.4900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.5343
Cell Significance Index: -37.1700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.6102
Cell Significance Index: -40.2500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1362595447
Symbol: SNP25_HUMAN
Name: Synaptosomal-associated protein 25
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8112622
Title: Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25.
PubMed ID: 8112622
PubMed ID: 8056350
Title: Cloning and sequence analysis of the human SNAP25 cDNA.
PubMed ID: 8056350
PubMed ID: 8760387
Title: Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.
PubMed ID: 8760387
DOI: 10.1042/bj3170945
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9886085
Title: Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage.
PubMed ID: 9886085
PubMed ID: 17718519
Title: Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
PubMed ID: 17718519
DOI: 10.1021/bi701162d
PubMed ID: 18375205
Title: SNAP-25 is also an iron-sulfur protein.
PubMed ID: 18375205
PubMed ID: 19546860
Title: The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.
PubMed ID: 19546860
DOI: 10.1038/mp.2009.58
PubMed ID: 20798282
Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
PubMed ID: 20798282
PubMed ID: 22832103
Title: Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.
PubMed ID: 22832103
PubMed ID: 25915028
Title: PRRT2 Mutant Leads to Dysfunction of Glutamate Signaling.
PubMed ID: 25915028
DOI: 10.3390/ijms16059134
PubMed ID: 28882895
Title: Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase.
PubMed ID: 28882895
PubMed ID: 25381298
Title: Mutant SNAP25B causes myasthenia, cortical hyperexcitability, ataxia, and intellectual disability.
PubMed ID: 25381298
PubMed ID: 11832227
Title: Three-dimensional structure of the complexin/SNARE complex.
PubMed ID: 11832227
PubMed ID: 15592454
Title: Substrate recognition strategy for botulinum neurotoxin serotype A.
PubMed ID: 15592454
DOI: 10.1038/nature03123
PubMed ID: 28757145
Title: Structural basis for substrate recognition by the ankyrin repeat domain of human DHHC17 palmitoyltransferase.
PubMed ID: 28757145
Sequence Information:
- Length: 206
- Mass: 23315
- Checksum: FBED2B082A4CB6A6
- Sequence:
MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR IMEKADSNKT RIDEANQRAT KMLGSG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.