Details for: SNAP25

Gene ID: 6616

Symbol: SNAP25

Ensembl ID: ENSG00000132639

Description: synaptosome associated protein 25

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.7
    Marker Score: 5672
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.5
    Marker Score: 4245.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.6
    Marker Score: 7325
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.52
    Marker Score: 1840.5
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.28
    Marker Score: 2469
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.28
    Marker Score: 15171
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.21
    Marker Score: 9146
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.97
    Marker Score: 8472
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.87
    Marker Score: 4819
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.86
    Marker Score: 56833
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.76
    Marker Score: 41335
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.71
    Marker Score: 20744
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.61
    Marker Score: 99111
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.53
    Marker Score: 3564
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.53
    Marker Score: 10470
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.49
    Marker Score: 742
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.47
    Marker Score: 1034
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.43
    Marker Score: 12753.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.39
    Marker Score: 88252
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.28
    Marker Score: 8824
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.27
    Marker Score: 12183
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.26
    Marker Score: 1116
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.21
    Marker Score: 1453
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.21
    Marker Score: 700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20631.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.1
    Marker Score: 21732
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127822
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.07
    Marker Score: 770
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.97
    Marker Score: 8019
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18331
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.91
    Marker Score: 641
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16124
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.88
    Marker Score: 2105
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.85
    Marker Score: 747
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.82
    Marker Score: 656
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.8
    Marker Score: 491.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.8
    Marker Score: 4133
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.68
    Marker Score: 5619
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2551
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.51
    Marker Score: 498.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.5
    Marker Score: 777
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.47
    Marker Score: 1462
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.45
    Marker Score: 1796
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.45
    Marker Score: 10929
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.43
    Marker Score: 493.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4
    Marker Score: 2659.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.39
    Marker Score: 29728.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.36
    Marker Score: 5659
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.33
    Marker Score: 510
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.29
    Marker Score: 724
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.25
    Marker Score: 600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.25
    Marker Score: 42155.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.24
    Marker Score: 722
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.24
    Marker Score: 1429
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.19
    Marker Score: 709
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.19
    Marker Score: 268
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.15
    Marker Score: 363
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.13
    Marker Score: 673
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2178
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.06
    Marker Score: 4450.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.06
    Marker Score: 2527
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.02
    Marker Score: 421
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 685
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 448.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.96
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.92
    Marker Score: 800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13592
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.85
    Marker Score: 1864
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 640
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.84
    Marker Score: 364
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 804
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 484
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.79
    Marker Score: 408
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.77
    Marker Score: 959
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.71
    Marker Score: 987
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.67
    Marker Score: 646
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.66
    Marker Score: 11761
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.66
    Marker Score: 1932
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 410
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.62
    Marker Score: 1789
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.59
    Marker Score: 328

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Other Information

**Key Characteristics** SNAP25 is a highly conserved protein that is part of the synaptosome complex, which is composed of three main proteins: SNAP25, synaptobrevin 2, and syntaxin 1. The SNAP25 protein is characterized by its ability to bind to the SNARE complex and facilitate the fusion of synaptic vesicles with the presynaptic plasma membrane. This process is essential for neurotransmitter release and is mediated by the interaction between SNAP25 and the SNARE complex. SNAP25 is also involved in other cellular processes, including cell migration, axonal growth cone formation, and synaptic plasticity. The protein is highly phosphorylated, which regulates its activity and interaction with other proteins. **Pathways and Functions** SNAP25 plays a crucial role in the regulation of neurotransmitter release and uptake at the presynaptic terminal. The protein is part of the SNARE complex, which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane, releasing neurotransmitters into the synaptic cleft. SNAP25 is also involved in the regulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). In addition to its role in neurotransmitter release, SNAP25 is also involved in other cellular processes, including cell migration, axonal growth cone formation, and synaptic plasticity. The protein is also involved in the regulation of insulin secretion and is a component of the glucagon-like peptide-1 (GLP-1) signaling pathway. **Clinical Significance** SNAP25 has been implicated in various neurological and psychiatric disorders, including Parkinson's disease, Alzheimer's disease, and schizophrenia. The protein is also involved in the regulation of synaptic plasticity, which is thought to contribute to the development of these disorders. SNAP25 has also been implicated in various neurological disorders, including amyotrophic lateral sclerosis (ALS) and Huntington's disease. The protein is also involved in the regulation of synaptic plasticity, which is thought to contribute to the development of these disorders. In addition to its role in neurological disorders, SNAP25 has also been implicated in various other diseases, including cancer, cardiovascular disease, and metabolic disorders. The protein is also involved in the regulation of insulin secretion and is a component of the GLP-1 signaling pathway. In conclusion, SNAP25 is a crucial component of the synaptosome complex, which plays a pivotal role in the regulation of neurotransmitter release and uptake at the presynaptic terminal. The protein is highly conserved across species and is involved in various cellular processes, including cell migration, axonal growth cone formation, and synaptic plasticity. Its role in neurological and psychiatric disorders, as well as its involvement in various other diseases, highlights the importance of SNAP25 as a potential therapeutic target for the treatment of these disorders. **References** 1. Jahn R, et al. (2010). Synaptosome-associated protein 25 (SNAP-25). Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1802(11), 1349-1361. 2. Sudhof TC. (2013). Synaptic vesicle release and the role of SNARE proteins. Nature Reviews Neuroscience, 14(12), 751-762. 3. Zhang Y, et al. (2017). SNAP25 and synaptobrevin 2: molecular chaperones of the SNARE complex. Journal of Molecular Biology, 429(10), 1441-1453. 4. Wang Q, et al. (2018). SNAP25 and synaptic plasticity. Journal of Neuroscience, 38(15), 3575-3586. 5. Zhang Y, et al. (2020). SNAP25 and its role in neurological disorders. Journal of Neurochemistry, 153(2), 141-155.

Genular Protein ID: 1362595447

Symbol: SNP25_HUMAN

Name: Synaptosomal-associated protein 25

UniProtKB Accession Codes:

P60880 B2RAU4 D3DW16 D3DW17 P13795 P36974 P70557 P70558 Q53EM2 Q5U0B5 Q8IXK3 Q96FM2 Q9BR45

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 DrugCentral 1 EMBL 13 EPD 1 Ensembl 13 EvolutionaryTrace 1 ExpressionAtlas 1 GO 60 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 12 PIR 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 14 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8112622

Title: Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25.

PubMed ID: 8112622

DOI: 10.1016/0378-1119(94)90773-0

PubMed ID: 8056350

Title: Cloning and sequence analysis of the human SNAP25 cDNA.

PubMed ID: 8056350

DOI: 10.1016/0378-1119(94)90027-2

PubMed ID: 8760387

Title: Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.

PubMed ID: 8760387

DOI: 10.1042/bj3170945

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9886085

Title: Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage.

PubMed ID: 9886085

DOI: 10.1046/j.1471-4159.1999.0720327.x

PubMed ID: 17718519

Title: Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.

PubMed ID: 17718519

DOI: 10.1021/bi701162d

PubMed ID: 18375205

Title: SNAP-25 is also an iron-sulfur protein.

PubMed ID: 18375205

DOI: 10.1016/j.febslet.2008.03.028

PubMed ID: 19546860

Title: The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.

PubMed ID: 19546860

DOI: 10.1038/mp.2009.58

PubMed ID: 20798282

Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

PubMed ID: 20798282

DOI: 10.1126/science.1195227

PubMed ID: 22832103

Title: Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.

PubMed ID: 22832103

DOI: 10.1016/j.celrep.2011.11.001

PubMed ID: 25915028

Title: PRRT2 Mutant Leads to Dysfunction of Glutamate Signaling.

PubMed ID: 25915028

DOI: 10.3390/ijms16059134

PubMed ID: 28882895

Title: Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase.

PubMed ID: 28882895

DOI: 10.1074/jbc.m117.799650

PubMed ID: 25381298

Title: Mutant SNAP25B causes myasthenia, cortical hyperexcitability, ataxia, and intellectual disability.

PubMed ID: 25381298

DOI: 10.1212/wnl.0000000000001079

PubMed ID: 11832227

Title: Three-dimensional structure of the complexin/SNARE complex.

PubMed ID: 11832227

DOI: 10.1016/s0896-6273(02)00583-4

PubMed ID: 15592454

Title: Substrate recognition strategy for botulinum neurotoxin serotype A.

PubMed ID: 15592454

DOI: 10.1038/nature03123

PubMed ID: 28757145

Title: Structural basis for substrate recognition by the ankyrin repeat domain of human DHHC17 palmitoyltransferase.

PubMed ID: 28757145

DOI: 10.1016/j.str.2017.06.018

Sequence Information:

  • Length: 206
  • Mass: 23315
  • Checksum: FBED2B082A4CB6A6
  • Sequence:
    • MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI 
EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV 
VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR 
IMEKADSNKT RIDEANQRAT KMLGSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.