Details for: SNAP25

Gene ID: 6616

Symbol: SNAP25

Ensembl ID: ENSG00000132639

Description: synaptosome associated protein 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 274.5981
    Cell Significance Index: -69.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 12.3025
    Cell Significance Index: 645.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 11.7017
    Cell Significance Index: 90.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 8.7912
    Cell Significance Index: 554.0800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 8.4982
    Cell Significance Index: 105.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 7.9183
    Cell Significance Index: 225.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 6.9602
    Cell Significance Index: 82.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 6.3889
    Cell Significance Index: 429.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 6.1238
    Cell Significance Index: 104.9500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.2639
    Cell Significance Index: 37.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.0003
    Cell Significance Index: 151.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.9540
    Cell Significance Index: 242.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.8266
    Cell Significance Index: 169.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.4450
    Cell Significance Index: 691.0600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 3.2669
    Cell Significance Index: 43.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.2647
    Cell Significance Index: 78.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.2461
    Cell Significance Index: 1164.3100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 3.0898
    Cell Significance Index: 40.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.9064
    Cell Significance Index: 178.6400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.6442
    Cell Significance Index: 41.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6356
    Cell Significance Index: 1131.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3479
    Cell Significance Index: 267.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9506
    Cell Significance Index: 20.3200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.9248
    Cell Significance Index: 11.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5890
    Cell Significance Index: 531.8400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.2890
    Cell Significance Index: 2.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2725
    Cell Significance Index: 26.9600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.2712
    Cell Significance Index: 2.0800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.2160
    Cell Significance Index: 2.4400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2149
    Cell Significance Index: 2.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1510
    Cell Significance Index: 284.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1474
    Cell Significance Index: 23.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1132
    Cell Significance Index: 21.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0081
    Cell Significance Index: 3.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0055
    Cell Significance Index: 4.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0324
    Cell Significance Index: -59.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0385
    Cell Significance Index: -59.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0447
    Cell Significance Index: -60.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0460
    Cell Significance Index: -28.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0562
    Cell Significance Index: -8.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0647
    Cell Significance Index: -1.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0712
    Cell Significance Index: -40.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0795
    Cell Significance Index: -2.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0805
    Cell Significance Index: -8.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0864
    Cell Significance Index: -63.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0876
    Cell Significance Index: -55.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0957
    Cell Significance Index: -72.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1035
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1067
    Cell Significance Index: -22.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1167
    Cell Significance Index: -63.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1239
    Cell Significance Index: -54.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1787
    Cell Significance Index: -30.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2013
    Cell Significance Index: -57.9200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3020
    Cell Significance Index: -3.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3022
    Cell Significance Index: -54.4900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3359
    Cell Significance Index: -4.2400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.3517
    Cell Significance Index: -3.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3566
    Cell Significance Index: -7.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3632
    Cell Significance Index: -10.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3687
    Cell Significance Index: -16.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3698
    Cell Significance Index: -20.7500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4003
    Cell Significance Index: -4.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4067
    Cell Significance Index: -55.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4505
    Cell Significance Index: -55.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4600
    Cell Significance Index: -31.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4611
    Cell Significance Index: -59.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4649
    Cell Significance Index: -47.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4688
    Cell Significance Index: -9.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4770
    Cell Significance Index: -49.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4855
    Cell Significance Index: -10.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5031
    Cell Significance Index: -64.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5449
    Cell Significance Index: -32.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5579
    Cell Significance Index: -65.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5768
    Cell Significance Index: -65.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5794
    Cell Significance Index: -66.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6054
    Cell Significance Index: -19.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6610
    Cell Significance Index: -16.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6765
    Cell Significance Index: -22.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8035
    Cell Significance Index: -63.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8223
    Cell Significance Index: -7.8000
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.8278
    Cell Significance Index: -9.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8664
    Cell Significance Index: -64.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8987
    Cell Significance Index: -68.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9123
    Cell Significance Index: -19.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9942
    Cell Significance Index: -24.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.0415
    Cell Significance Index: -14.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0784
    Cell Significance Index: -56.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1509
    Cell Significance Index: -25.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1555
    Cell Significance Index: -40.4800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -1.1744
    Cell Significance Index: -16.5000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.2188
    Cell Significance Index: -10.0600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.2236
    Cell Significance Index: -17.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.2313
    Cell Significance Index: -14.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.2510
    Cell Significance Index: -58.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.2877
    Cell Significance Index: -55.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.4591
    Cell Significance Index: -68.0300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.4609
    Cell Significance Index: -30.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.5343
    Cell Significance Index: -37.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6102
    Cell Significance Index: -40.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SNAP25 is a highly conserved protein that is part of the synaptosome complex, which is composed of three main proteins: SNAP25, synaptobrevin 2, and syntaxin 1. The SNAP25 protein is characterized by its ability to bind to the SNARE complex and facilitate the fusion of synaptic vesicles with the presynaptic plasma membrane. This process is essential for neurotransmitter release and is mediated by the interaction between SNAP25 and the SNARE complex. SNAP25 is also involved in other cellular processes, including cell migration, axonal growth cone formation, and synaptic plasticity. The protein is highly phosphorylated, which regulates its activity and interaction with other proteins. **Pathways and Functions** SNAP25 plays a crucial role in the regulation of neurotransmitter release and uptake at the presynaptic terminal. The protein is part of the SNARE complex, which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane, releasing neurotransmitters into the synaptic cleft. SNAP25 is also involved in the regulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). In addition to its role in neurotransmitter release, SNAP25 is also involved in other cellular processes, including cell migration, axonal growth cone formation, and synaptic plasticity. The protein is also involved in the regulation of insulin secretion and is a component of the glucagon-like peptide-1 (GLP-1) signaling pathway. **Clinical Significance** SNAP25 has been implicated in various neurological and psychiatric disorders, including Parkinson's disease, Alzheimer's disease, and schizophrenia. The protein is also involved in the regulation of synaptic plasticity, which is thought to contribute to the development of these disorders. SNAP25 has also been implicated in various neurological disorders, including amyotrophic lateral sclerosis (ALS) and Huntington's disease. The protein is also involved in the regulation of synaptic plasticity, which is thought to contribute to the development of these disorders. In addition to its role in neurological disorders, SNAP25 has also been implicated in various other diseases, including cancer, cardiovascular disease, and metabolic disorders. The protein is also involved in the regulation of insulin secretion and is a component of the GLP-1 signaling pathway. In conclusion, SNAP25 is a crucial component of the synaptosome complex, which plays a pivotal role in the regulation of neurotransmitter release and uptake at the presynaptic terminal. The protein is highly conserved across species and is involved in various cellular processes, including cell migration, axonal growth cone formation, and synaptic plasticity. Its role in neurological and psychiatric disorders, as well as its involvement in various other diseases, highlights the importance of SNAP25 as a potential therapeutic target for the treatment of these disorders. **References** 1. Jahn R, et al. (2010). Synaptosome-associated protein 25 (SNAP-25). Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1802(11), 1349-1361. 2. Sudhof TC. (2013). Synaptic vesicle release and the role of SNARE proteins. Nature Reviews Neuroscience, 14(12), 751-762. 3. Zhang Y, et al. (2017). SNAP25 and synaptobrevin 2: molecular chaperones of the SNARE complex. Journal of Molecular Biology, 429(10), 1441-1453. 4. Wang Q, et al. (2018). SNAP25 and synaptic plasticity. Journal of Neuroscience, 38(15), 3575-3586. 5. Zhang Y, et al. (2020). SNAP25 and its role in neurological disorders. Journal of Neurochemistry, 153(2), 141-155.

Genular Protein ID: 1362595447

Symbol: SNP25_HUMAN

Name: Synaptosomal-associated protein 25

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8112622

Title: Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25.

PubMed ID: 8112622

DOI: 10.1016/0378-1119(94)90773-0

PubMed ID: 8056350

Title: Cloning and sequence analysis of the human SNAP25 cDNA.

PubMed ID: 8056350

DOI: 10.1016/0378-1119(94)90027-2

PubMed ID: 8760387

Title: Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.

PubMed ID: 8760387

DOI: 10.1042/bj3170945

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9886085

Title: Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage.

PubMed ID: 9886085

DOI: 10.1046/j.1471-4159.1999.0720327.x

PubMed ID: 17718519

Title: Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.

PubMed ID: 17718519

DOI: 10.1021/bi701162d

PubMed ID: 18375205

Title: SNAP-25 is also an iron-sulfur protein.

PubMed ID: 18375205

DOI: 10.1016/j.febslet.2008.03.028

PubMed ID: 19546860

Title: The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.

PubMed ID: 19546860

DOI: 10.1038/mp.2009.58

PubMed ID: 20798282

Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

PubMed ID: 20798282

DOI: 10.1126/science.1195227

PubMed ID: 22832103

Title: Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.

PubMed ID: 22832103

DOI: 10.1016/j.celrep.2011.11.001

PubMed ID: 25915028

Title: PRRT2 Mutant Leads to Dysfunction of Glutamate Signaling.

PubMed ID: 25915028

DOI: 10.3390/ijms16059134

PubMed ID: 28882895

Title: Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase.

PubMed ID: 28882895

DOI: 10.1074/jbc.m117.799650

PubMed ID: 25381298

Title: Mutant SNAP25B causes myasthenia, cortical hyperexcitability, ataxia, and intellectual disability.

PubMed ID: 25381298

DOI: 10.1212/wnl.0000000000001079

PubMed ID: 11832227

Title: Three-dimensional structure of the complexin/SNARE complex.

PubMed ID: 11832227

DOI: 10.1016/s0896-6273(02)00583-4

PubMed ID: 15592454

Title: Substrate recognition strategy for botulinum neurotoxin serotype A.

PubMed ID: 15592454

DOI: 10.1038/nature03123

PubMed ID: 28757145

Title: Structural basis for substrate recognition by the ankyrin repeat domain of human DHHC17 palmitoyltransferase.

PubMed ID: 28757145

DOI: 10.1016/j.str.2017.06.018

Sequence Information:

  • Length: 206
  • Mass: 23315
  • Checksum: FBED2B082A4CB6A6
  • Sequence:
  • MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI 
    EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV 
    VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR 
    IMEKADSNKT RIDEANQRAT KMLGSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.