Details for: SRPRA

Gene ID: 6734

Symbol: SRPRA

Ensembl ID: ENSG00000182934

Description: SRP receptor subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.5247
    Cell Significance Index: -33.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.1532
    Cell Significance Index: -37.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.0386
    Cell Significance Index: -37.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.2608
    Cell Significance Index: -33.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9342
    Cell Significance Index: -31.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.7548
    Cell Significance Index: -26.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2225
    Cell Significance Index: -11.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9945
    Cell Significance Index: 54.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9277
    Cell Significance Index: 89.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3006
    Cell Significance Index: 141.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2405
    Cell Significance Index: 28.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1361
    Cell Significance Index: 15.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0957
    Cell Significance Index: 178.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9391
    Cell Significance Index: 169.3000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9372
    Cell Significance Index: 7.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9071
    Cell Significance Index: 124.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8474
    Cell Significance Index: 104.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7261
    Cell Significance Index: 37.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6628
    Cell Significance Index: 34.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6351
    Cell Significance Index: 47.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6061
    Cell Significance Index: 39.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5890
    Cell Significance Index: 69.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5608
    Cell Significance Index: 16.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5571
    Cell Significance Index: 304.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5385
    Cell Significance Index: 486.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4508
    Cell Significance Index: 199.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4108
    Cell Significance Index: 19.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4076
    Cell Significance Index: 52.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3813
    Cell Significance Index: 26.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3420
    Cell Significance Index: 33.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3419
    Cell Significance Index: 68.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3059
    Cell Significance Index: 39.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2788
    Cell Significance Index: 55.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2302
    Cell Significance Index: 14.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2283
    Cell Significance Index: 6.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2121
    Cell Significance Index: 2.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2081
    Cell Significance Index: 23.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1840
    Cell Significance Index: 35.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1641
    Cell Significance Index: 28.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0955
    Cell Significance Index: 34.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0509
    Cell Significance Index: 35.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0474
    Cell Significance Index: 1.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0360
    Cell Significance Index: 1.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0167
    Cell Significance Index: 31.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0125
    Cell Significance Index: 9.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0069
    Cell Significance Index: 0.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0058
    Cell Significance Index: 4.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0101
    Cell Significance Index: -18.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0153
    Cell Significance Index: -23.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0239
    Cell Significance Index: -32.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0261
    Cell Significance Index: -2.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0315
    Cell Significance Index: -20.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0315
    Cell Significance Index: -23.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0373
    Cell Significance Index: -0.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0497
    Cell Significance Index: -2.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0532
    Cell Significance Index: -24.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0550
    Cell Significance Index: -31.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0592
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0616
    Cell Significance Index: -38.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0649
    Cell Significance Index: -2.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0924
    Cell Significance Index: -26.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1028
    Cell Significance Index: -2.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1386
    Cell Significance Index: -10.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1557
    Cell Significance Index: -18.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1617
    Cell Significance Index: -23.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1761
    Cell Significance Index: -37.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1882
    Cell Significance Index: -10.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1972
    Cell Significance Index: -5.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2066
    Cell Significance Index: -5.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2111
    Cell Significance Index: -9.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2338
    Cell Significance Index: -4.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2599
    Cell Significance Index: -8.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3167
    Cell Significance Index: -32.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3263
    Cell Significance Index: -13.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3370
    Cell Significance Index: -5.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3636
    Cell Significance Index: -7.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3681
    Cell Significance Index: -24.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3932
    Cell Significance Index: -24.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4020
    Cell Significance Index: -10.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4424
    Cell Significance Index: -35.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4466
    Cell Significance Index: -15.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4973
    Cell Significance Index: -12.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5392
    Cell Significance Index: -33.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5833
    Cell Significance Index: -25.8000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6687
    Cell Significance Index: -7.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6879
    Cell Significance Index: -13.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6906
    Cell Significance Index: -26.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7007
    Cell Significance Index: -15.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7233
    Cell Significance Index: -26.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8077
    Cell Significance Index: -13.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8259
    Cell Significance Index: -21.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8318
    Cell Significance Index: -29.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8790
    Cell Significance Index: -28.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8795
    Cell Significance Index: -28.0100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.8948
    Cell Significance Index: -9.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9105
    Cell Significance Index: -16.0900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9431
    Cell Significance Index: -5.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9497
    Cell Significance Index: -14.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **SRP complex component:** SRPRA is a subunit of the SRP complex, which recognizes and binds to signal sequences on nascent polypeptide chains, facilitating their targeted membrane insertion. 2. **Cellular expression:** SRPRA is expressed in a wide range of cell types, including pancreatic acinar cells, salivary gland acinar cells, extravillous trophoblasts, IgG plasmablasts, and various immune cells, such as myeloid dendritic cells, CD8-positive T cells, and monocytes. 3. **Protein interactions:** SRPRA interacts with other SRP complex subunits, as well as with various proteins involved in protein homeostasis, including chaperones and unfolded protein response (UPR) regulators. **Pathways and Functions:** 1. **Cotranslational protein targeting:** SRPRA plays a critical role in the targeted membrane insertion of proteins during translation, ensuring proper protein localization and function. 2. **Cellular stress response:** SRPRA is involved in the regulation of the unfolded protein response (UPR), a cellular stress response mechanism that ensures protein homeostasis and prevents cell death. 3. **Immune regulation:** SRPRA has been implicated in the regulation of immune responses, including the activation of immune cells, such as T cells and dendritic cells, and the modulation of cytokine production. 4. **Protein metabolism:** SRPRA is involved in the regulation of protein metabolism, including protein degradation and synthesis, and is connected to various metabolic pathways, including ATP hydrolysis and GTPase activity. **Clinical Significance:** 1. **Immune-related disorders:** Alterations in SRPRA expression or function have been implicated in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** SRPRA has been identified as a tumor suppressor gene, and its downregulation has been associated with cancer progression and metastasis. 3. **Neurological disorders:** SRPRA has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where protein misfolding and aggregation play a critical role. 4. **Infectious diseases:** SRPRA has been shown to play a role in the regulation of immune responses to infections, including the activation of immune cells and the production of cytokines. In conclusion, SRPRA is a critical component of the SRP complex, and its expression and function have significant implications for immune regulation, cellular homeostasis, and protein metabolism. Further research is necessary to fully elucidate the role of SRPRA in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3291640407

Symbol: SRPRA_HUMAN

Name: Signal recognition particle receptor subunit alpha

UniProtKB Accession Codes:

P08240 A6NIB3 B2R5Z8 B4E0H3 E9PJS4 Q9BVJ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 EMDB 1 Ensembl 2 EvolutionaryTrace 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3340536

Title: Complete cDNA sequence coding for human docking protein.

PubMed ID: 3340536

DOI: 10.1093/nar/16.1.361

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30550790

Title: Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

PubMed ID: 30550790

DOI: 10.1016/j.cell.2018.11.028

PubMed ID: 16439358

Title: The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains.

PubMed ID: 16439358

DOI: 10.1074/jbc.m512415200

PubMed ID: 16675701

Title: Signal recognition particle receptor exposes the ribosomal translocon binding site.

PubMed ID: 16675701

DOI: 10.1126/science.1124864

PubMed ID: 34020957

Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

PubMed ID: 34020957

DOI: 10.1126/sciadv.abg0942

Sequence Information:

  • Length: 638
  • Mass: 69811
  • Checksum: 967F943CEE3FA79E
  • Sequence:
    • MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE ALTLKYKLDN 
QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ QSALSLLNGT FDFQNDFLRL 
LREAEESSKI RAPTTMKKFE DSEKAKKPVR SMIETRGEKP KEKAKNSKKK GAKKEGSDGP 
LATSKPVPAE KSGLPVGPEN GVELSKEELI RRKREEFIQK HGRGMEKSNK STKSDAPKEK 
GKKAPRVWEL GGCANKEVLD YSTPTTNGTP EAALSEDINL IRGTGSGGQL QDLDCSSSDD 
EGAAQNSTKP SATKGTLGGM FGMLKGLVGS KSLSREDMES VLDKMRDHLI AKNVAADIAV 
QLCESVANKL EGKVMGTFST VTSTVKQALQ ESLVQILQPQ RRVDMLRDIM DAQRRQRPYV 
VTFCGVNGVG KSTNLAKISF WLLENGFSVL IAACDTFRAG AVEQLRTHTR RLSALHPPEK 
HGGRTMVQLF EKGYGKDAAG IAMEAIAFAR NQGFDVVLVD TAGRMQDNAP LMTALAKLIT 
VNTPDLVLFV GEALVGNEAV DQLVKFNRAL ADHSMAQTPR LIDGIVLTKF DTIDDKVGAA 
ISMTYITSKP IVFVGTGQTY CDLRSLNAKA VVAALMKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.