Details for: SRPRA
Gene ID: 6734
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SRPRA
Ensembl ID: ENSG00000182934
Description: SRP receptor subunit alpha
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 49.27rCSI 38.76%PRS 65.12
-
CSI 16.24rCSI 26.6%PRS 48.07
-
CSI 13.2rCSI 19.31%PRS 62.68
-
CSI 11.48rCSI 12.03%PRS 61.96
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CSI 10.66rCSI 12.73%PRS 78.22
-
CSI 9.99rCSI 13.09%PRS 84.89
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CSI 9.71rCSI 10.13%PRS 58.75
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CSI 9.33rCSI 20.6%PRS 44.92
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CSI 9.02rCSI 8.28%PRS 67.22
-
CSI 7.82rCSI 6.48%PRS 57.52
-
CSI 6.94rCSI 13.38%PRS 84.88
-
CSI 6.89rCSI 11%PRS 62.55
-
CSI 6.88rCSI 10.38%PRS 62.29
-
CSI 6.73rCSI 8.56%PRS 64.89
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CSI 6.56rCSI 7.86%PRS 75.95
-
CSI 6.15rCSI 6.42%PRS 81.59
-
CSI 5.66rCSI 25.18%PRS 90.7
-
CSI 5.56rCSI 3.71%PRS 79.27
-
CSI 5.26rCSI 3.95%PRS 63.55
-
CSI 5.14rCSI 4.75%PRS 78.21
-
CSI 5.03rCSI 5.15%PRS 73.73
-
CSI 4.9rCSI 7.49%PRS 72.43
-
CSI 4.77rCSI 3.63%PRS 71.31
-
CSI 4.74rCSI 3.76%PRS 80.08
-
CSI 4.59rCSI 23.67%PRS 80.27
-
CSI 4.15rCSI 3.75%PRS 55.3
-
CSI 4.14rCSI 13.43%PRS 59.37
-
CSI 4.04rCSI 9.03%PRS 66.16
-
CSI 3.94rCSI 11.29%PRS 78.09
-
CSI 3.9rCSI 5.21%PRS 67.62
-
CSI 3.82rCSI 13.82%PRS 77.96
-
CSI 3.78rCSI 3.18%PRS 75.83
-
CSI 3.78rCSI 5.81%PRS 55.54
-
CSI 3.55rCSI 2.84%PRS 79.09
-
CSI 3.41rCSI 8.66%PRS 52.99
-
CSI 3.37rCSI 2.34%PRS 69.25
-
CSI 3.21rCSI 7.29%PRS 62.85
-
CSI 3.2rCSI 5.75%PRS 51.58
-
CSI 3.17rCSI 7.1%PRS 41.43
-
CSI 3.14rCSI 2.35%PRS 73.47
-
CSI 3.11rCSI 4.46%PRS 62.94
-
CSI 3.08rCSI 4.57%PRS 60.18
-
CSI 3rCSI 2.83%PRS 58.21
-
CSI 2.96rCSI 5.07%PRS 67.48
-
CSI 2.94rCSI 3.63%PRS 73.98
-
CSI 2.94rCSI 4.49%PRS 59.17
-
CSI 2.93rCSI 2.27%PRS 60.12
-
CSI 2.92rCSI 6.44%PRS 62.58
-
CSI 2.92rCSI 2.17%PRS 71.91
-
CSI 2.89rCSI 4.59%PRS 69.69
-
CSI 2.87rCSI 3.97%PRS 60.19
-
CSI 2.86rCSI 28.09%PRS 78.72
-
CSI 2.85rCSI 1.68%PRS 75.73
-
CSI 2.83rCSI 16.49%PRS 67.98
-
CSI 2.76rCSI 14.86%PRS 71.39
-
CSI 2.71rCSI 2.03%PRS 85.55
-
CSI 2.69rCSI 3.38%PRS 68.9
-
CSI 2.69rCSI 2.77%PRS 75.35
-
CSI 2.67rCSI 1.92%PRS 72.77
-
CSI 2.64rCSI 2.05%PRS 76.42
-
CSI 2.59rCSI 6.07%PRS 64.52
-
CSI 2.58rCSI 1.8%PRS 61.26
-
CSI 2.57rCSI 3.72%PRS 74.51
-
CSI 2.55rCSI 2.51%PRS 61.11
-
CSI 2.5rCSI 2.19%PRS 68.53
-
CSI 2.47rCSI 3.65%PRS 63.92
-
CSI 2.47rCSI 1.72%PRS 73.54
-
CSI 2.44rCSI 56.86%PRS 78.62
-
CSI 2.43rCSI 1.97%PRS 59.09
-
CSI 2.39rCSI 3.27%PRS 64.33
-
CSI 2.37rCSI 5.71%PRS 76.43
-
CSI 2.36rCSI 2.65%PRS 74.87
-
CSI 2.33rCSI 3.99%PRS 82.18
-
CSI 2.32rCSI 1.83%PRS 45.44
-
CSI 2.31rCSI 2.15%PRS 58.78
-
CSI 2.21rCSI 2.17%PRS 74.31
-
CSI 2.14rCSI 3.47%PRS 55.44
-
CSI 2.1rCSI 2.86%PRS 70.46
-
CSI 2.1rCSI 4.79%PRS 58.36
-
CSI 2.06rCSI 4.92%PRS 59.79
-
CSI 2.06rCSI 2.26%PRS 62.48
-
CSI 2.06rCSI 1.58%PRS 58.7
-
CSI 2.06rCSI 1.98%PRS 58.82
-
CSI 2.04rCSI 3.89%PRS 73.92
-
CSI 2.04rCSI 5.37%PRS 77.84
-
CSI 2.02rCSI 1.53%PRS 72.26
-
CSI 1.99rCSI 3.03%PRS 54.92
-
CSI 1.98rCSI 8.79%PRS 57.83
-
CSI 1.96rCSI 2.1%PRS 57.61
-
CSI 1.95rCSI 1.71%PRS 63.81
-
CSI 1.95rCSI 5.61%PRS 72.82
-
CSI 1.92rCSI 1.29%PRS 71.41
-
CSI 1.92rCSI 2.62%PRS 60.34
-
CSI 1.91rCSI 2.23%PRS 74.95
-
CSI 1.9rCSI 1.64%PRS 64.55
-
CSI 1.89rCSI 4.8%PRS 48.1
-
CSI 1.89rCSI 5.32%PRS 55.68
-
CSI 1.89rCSI 2.51%PRS 64.79
-
CSI 1.86rCSI 1.9%PRS 71.78
-
CSI 1.86rCSI 2.16%PRS 66.59
-
CSI 0.2rCSI 1.1%PRS 68.2%
-
CSI 0.3rCSI 1.7%PRS 75.2%
-
CSI 0.3rCSI 1.2%PRS 78.8%
-
CSI 0.4rCSI 1.6%PRS 89.3%
-
CSI 0.4rCSI 2.7%PRS 85.2%
-
CSI 0.4rCSI 2.8%PRS 85.0%
-
CSI 0.4rCSI 1.6%PRS 68.1%
-
CSI 0.5rCSI 1.7%PRS 39.1%
-
CSI 0.5rCSI 2.1%PRS 71.4%
-
CSI 0.6rCSI 0.7%PRS 47.0%
-
CSI 0.6rCSI 1.7%PRS 60.0%
-
CSI 0.6rCSI 0.8%PRS 64.5%
-
CSI 0.6rCSI 1.4%PRS 68.3%
-
CSI 0.6rCSI 3.3%PRS 71.4%
-
CSI 0.6rCSI 2.9%PRS 76.3%
-
CSI 0.7rCSI 1.7%PRS 39.3%
-
CSI 0.7rCSI 2.3%PRS 42.2%
-
CSI 0.8rCSI 3.0%PRS 75.4%
-
CSI 0.8rCSI 3.9%PRS 70.9%
-
CSI 0.9rCSI 1.8%PRS 76.9%
-
CSI 0.9rCSI 1.4%PRS 67.3%
-
CSI 0.9rCSI 1.8%PRS 61.3%
-
CSI 1.0rCSI 1.6%PRS 40.7%
-
CSI 1.0rCSI 2.1%PRS 67.2%
-
CSI 1.0rCSI 2.3%PRS 56.4%
-
CSI 1.1rCSI 1.9%PRS 57.7%
-
CSI 1.1rCSI 1.3%PRS 67.2%
-
CSI 1.1rCSI 1.1%PRS 51.9%
-
CSI 1.1rCSI 5.8%PRS 84.2%
-
CSI 1.1rCSI 3.1%PRS 71.7%
-
CSI 1.1rCSI 2.0%PRS 76.9%
-
CSI 1.2rCSI 5.8%PRS 69.9%
-
CSI 1.2rCSI 1.5%PRS 41.8%
-
CSI 1.2rCSI 3.1%PRS 67.4%
-
CSI 1.2rCSI 1.7%PRS 78.3%
-
CSI 1.2rCSI 3.0%PRS 56.9%
-
CSI 1.2rCSI 1.8%PRS 74.8%
-
CSI 1.3rCSI 1.0%PRS 75.6%
-
CSI 1.3rCSI 1.9%PRS 68.1%
-
CSI 1.3rCSI 5.1%PRS 64.6%
-
CSI 1.3rCSI 2.7%PRS 38.4%
-
CSI 1.4rCSI 1.7%PRS 54.7%
-
CSI 1.4rCSI 1.9%PRS 59.0%
-
CSI 1.4rCSI 2.6%PRS 74.4%
-
CSI 1.4rCSI 2.2%PRS 56.5%
-
CSI 1.5rCSI 2.2%PRS 74.3%
-
CSI 1.5rCSI 1.9%PRS 70.6%
-
CSI 1.5rCSI 2.3%PRS 50.9%
-
CSI 1.5rCSI 3.1%PRS 55.9%
-
CSI 1.5rCSI 1.4%PRS 59.8%
-
CSI 1.5rCSI 1.9%PRS 60.5%
-
CSI 1.5rCSI 2.3%PRS 55.0%
-
CSI 1.5rCSI 3.7%PRS 67.6%
-
CSI 1.6rCSI 1.8%PRS 70.9%
-
CSI 1.6rCSI 1.4%PRS 73.2%
-
CSI 1.6rCSI 2.4%PRS 67.8%
-
CSI 1.6rCSI 6.3%PRS 71.8%
-
CSI 1.6rCSI 1.7%PRS 55.0%
-
CSI 1.6rCSI 2.6%PRS 60.5%
-
CSI 1.6rCSI 1.6%PRS 80.5%
-
CSI 1.7rCSI 3.3%PRS 76.3%
-
CSI 1.7rCSI 4.0%PRS 66.7%
-
CSI 1.7rCSI 2.0%PRS 66.2%
-
CSI 1.7rCSI 2.5%PRS 62.8%
-
CSI 1.7rCSI 1.5%PRS 46.5%
-
CSI 1.7rCSI 3.9%PRS 77.7%
-
CSI 1.7rCSI 1.7%PRS 49.0%
-
CSI 1.7rCSI 1.5%PRS 69.1%
-
CSI 1.7rCSI 1.4%PRS 60.3%
-
CSI 1.7rCSI 2.0%PRS 61.1%
-
CSI 1.8rCSI 4.6%PRS 63.3%
-
CSI 1.8rCSI 1.8%PRS 64.0%
-
CSI 1.8rCSI 1.6%PRS 56.6%
-
CSI 1.8rCSI 2.0%PRS 48.6%
-
CSI 1.8rCSI 1.5%PRS 63.3%
-
CSI 1.8rCSI 2.6%PRS 69.7%
-
CSI 1.8rCSI 1.8%PRS 80.7%
-
CSI 1.8rCSI 4.0%PRS 73.2%
-
CSI 1.8rCSI 2.7%PRS 70.1%
-
CSI 1.9rCSI 2.2%PRS 66.6%
-
CSI 1.9rCSI 1.9%PRS 71.8%
-
CSI 1.9rCSI 2.5%PRS 64.8%
-
CSI 1.9rCSI 5.3%PRS 55.7%
-
CSI 1.9rCSI 4.8%PRS 48.1%
-
CSI 1.9rCSI 1.6%PRS 64.6%
-
CSI 1.9rCSI 2.2%PRS 75.0%
-
CSI 1.9rCSI 2.6%PRS 60.3%
-
CSI 1.9rCSI 1.3%PRS 71.4%
-
CSI 2.0rCSI 5.6%PRS 72.8%
-
CSI 2.0rCSI 1.7%PRS 63.8%
-
CSI 2.0rCSI 2.1%PRS 57.6%
-
CSI 2.0rCSI 8.8%PRS 57.8%
-
CSI 2.0rCSI 3.0%PRS 54.9%
-
CSI 2.0rCSI 1.5%PRS 72.3%
-
CSI 2.0rCSI 5.4%PRS 77.8%
-
CSI 2.0rCSI 3.9%PRS 73.9%
-
CSI 2.1rCSI 2.0%PRS 58.8%
-
CSI 2.1rCSI 1.6%PRS 58.7%
-
CSI 2.1rCSI 2.3%PRS 62.5%
-
CSI 2.1rCSI 4.9%PRS 59.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3291640407
Symbol: SRPRA_HUMAN
Name: Signal recognition particle receptor subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3340536
Title: Complete cDNA sequence coding for human docking protein.
PubMed ID: 3340536
DOI: 10.1093/nar/16.1.361
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30550790
Title: Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.
PubMed ID: 30550790
PubMed ID: 16439358
Title: The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains.
PubMed ID: 16439358
PubMed ID: 16675701
Title: Signal recognition particle receptor exposes the ribosomal translocon binding site.
PubMed ID: 16675701
PubMed ID: 34020957
Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
PubMed ID: 34020957
Sequence Information:
- Length: 638
- Mass: 69811
- Checksum: 967F943CEE3FA79E
- Sequence:
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR SMIETRGEKP KEKAKNSKKK GAKKEGSDGP LATSKPVPAE KSGLPVGPEN GVELSKEELI RRKREEFIQK HGRGMEKSNK STKSDAPKEK GKKAPRVWEL GGCANKEVLD YSTPTTNGTP EAALSEDINL IRGTGSGGQL QDLDCSSSDD EGAAQNSTKP SATKGTLGGM FGMLKGLVGS KSLSREDMES VLDKMRDHLI AKNVAADIAV QLCESVANKL EGKVMGTFST VTSTVKQALQ ESLVQILQPQ RRVDMLRDIM DAQRRQRPYV VTFCGVNGVG KSTNLAKISF WLLENGFSVL IAACDTFRAG AVEQLRTHTR RLSALHPPEK HGGRTMVQLF EKGYGKDAAG IAMEAIAFAR NQGFDVVLVD TAGRMQDNAP LMTALAKLIT VNTPDLVLFV GEALVGNEAV DQLVKFNRAL ADHSMAQTPR LIDGIVLTKF DTIDDKVGAA ISMTYITSKP IVFVGTGQTY CDLRSLNAKA VVAALMKA