Details for: MED22

Gene ID: 6837

Symbol: MED22

Ensembl ID: ENSG00000148297

Description: mediator complex subunit 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.2193
    Cell Significance Index: -11.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.2407
    Cell Significance Index: -11.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 18.8965
    Cell Significance Index: -12.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.7976
    Cell Significance Index: -12.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6251
    Cell Significance Index: -12.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0968
    Cell Significance Index: -12.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0333
    Cell Significance Index: -4.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.1838
    Cell Significance Index: 29.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8238
    Cell Significance Index: 81.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6359
    Cell Significance Index: 574.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5205
    Cell Significance Index: 31.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4578
    Cell Significance Index: 74.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4385
    Cell Significance Index: 7.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3284
    Cell Significance Index: 8.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2987
    Cell Significance Index: 13.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2699
    Cell Significance Index: 18.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2419
    Cell Significance Index: 6.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2206
    Cell Significance Index: 3.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2109
    Cell Significance Index: 4.5700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2022
    Cell Significance Index: 1.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1694
    Cell Significance Index: 8.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1646
    Cell Significance Index: 2.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1643
    Cell Significance Index: 32.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1467
    Cell Significance Index: 7.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1382
    Cell Significance Index: 18.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1183
    Cell Significance Index: 23.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1114
    Cell Significance Index: 7.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1099
    Cell Significance Index: 3.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1087
    Cell Significance Index: 19.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1027
    Cell Significance Index: 13.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0969
    Cell Significance Index: 4.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0919
    Cell Significance Index: 32.9600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0905
    Cell Significance Index: 1.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0769
    Cell Significance Index: 41.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0676
    Cell Significance Index: 3.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0656
    Cell Significance Index: 12.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0611
    Cell Significance Index: 27.0300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0565
    Cell Significance Index: 0.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0513
    Cell Significance Index: 6.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0254
    Cell Significance Index: 1.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0204
    Cell Significance Index: 0.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0168
    Cell Significance Index: 1.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0128
    Cell Significance Index: 0.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0117
    Cell Significance Index: 1.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0111
    Cell Significance Index: 20.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0106
    Cell Significance Index: -4.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0119
    Cell Significance Index: -0.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0122
    Cell Significance Index: -0.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0136
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0137
    Cell Significance Index: -10.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0161
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0175
    Cell Significance Index: -2.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0186
    Cell Significance Index: -10.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0210
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0249
    Cell Significance Index: -2.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0256
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0264
    Cell Significance Index: -16.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0273
    Cell Significance Index: -3.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0399
    Cell Significance Index: -4.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0457
    Cell Significance Index: -3.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0508
    Cell Significance Index: -2.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0539
    Cell Significance Index: -4.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0540
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0640
    Cell Significance Index: -13.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0678
    Cell Significance Index: -1.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0702
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1009
    Cell Significance Index: -10.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1297
    Cell Significance Index: -10.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1581
    Cell Significance Index: -9.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1601
    Cell Significance Index: -1.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1701
    Cell Significance Index: -6.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1711
    Cell Significance Index: -4.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1711
    Cell Significance Index: -4.3700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1724
    Cell Significance Index: -2.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1774
    Cell Significance Index: -4.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1840
    Cell Significance Index: -3.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1844
    Cell Significance Index: -3.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1856
    Cell Significance Index: -5.3200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1882
    Cell Significance Index: -1.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1922
    Cell Significance Index: -1.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1974
    Cell Significance Index: -4.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1989
    Cell Significance Index: -8.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2072
    Cell Significance Index: -7.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2210
    Cell Significance Index: -4.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2214
    Cell Significance Index: -4.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2332
    Cell Significance Index: -8.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2416
    Cell Significance Index: -7.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2499
    Cell Significance Index: -7.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2631
    Cell Significance Index: -7.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2779
    Cell Significance Index: -6.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2806
    Cell Significance Index: -10.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2808
    Cell Significance Index: -5.9600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2870
    Cell Significance Index: -2.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2991
    Cell Significance Index: -7.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Title: Unveiling the Mysteries of MED22: A Key Regulator of Gene Expression and Lipid Metabolism As an expert immunologist, I am delighted to delve into the intricacies of the MED22 gene, a crucial component of the mediator complex that plays a pivotal role in regulating gene expression, lipid metabolism, and various cellular processes. In this article, we will delve into the key characteristics, pathways, and functions of MED22, as well as its clinical significance. Summary -------- MED22, also known as mediator complex subunit 22, is a gene that encodes a protein essential for the assembly and function of the mediator complex. This complex is a multi-protein complex that acts as a bridge between transcription factors and RNA polymerase II, facilitating the regulation of gene expression. MED22 has been identified as a significantly expressed gene in various cell types, including mural cells, absorptive cells, intestinal crypt stem cells, and epithelial cells. Key Characteristics -------------------- MED22 is a member of the mediator complex, a large protein complex that plays a central role in regulating gene expression. The mediator complex is composed of multiple subunits, each with distinct functions, and MED22 is one of the key subunits that facilitate the assembly and function of the complex. MED22 has been shown to interact with various transcription factors and co-activators, modulating the activity of RNA polymerase II and influencing the expression of target genes. Pathways and Functions ---------------------- MED22 is involved in various cellular processes, including: 1. **Transcriptional regulation**: MED22 plays a crucial role in regulating gene expression by interacting with transcription factors and co-activators, modulating the activity of RNA polymerase II. 2. **Lipid metabolism**: MED22 has been shown to regulate lipid metabolism by interacting with PPARα, a transcription factor that plays a key role in fatty acid oxidation. 3. **Developmental biology**: MED22 is involved in the regulation of white adipocyte differentiation, a process crucial for the development of adipose tissue. 4. **Infectious disease**: MED22 has been implicated in the regulation of gene expression in response to viral infections, including Respiratory Syncytial Virus (RSV) infection. Clinical Significance ------------------- The dysregulation of MED22 has been implicated in various diseases, including: 1. **Cancer**: MED22 has been shown to play a role in the regulation of gene expression in cancer cells, influencing the development and progression of various cancer types. 2. **Metabolic disorders**: MED22 has been implicated in the regulation of lipid metabolism, and its dysregulation has been linked to metabolic disorders such as obesity and type 2 diabetes. 3. **Infectious diseases**: MED22 has been shown to play a role in the regulation of gene expression in response to viral infections, and its dysregulation has been linked to the severity of diseases such as RSV infection. Conclusion ---------- In conclusion, MED22 is a critical regulator of gene expression and lipid metabolism, playing a pivotal role in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of MED22 in normal and diseased states. Further research is needed to elucidate the full scope of MED22's functions and its role in human health and disease. References: * [Insert references to relevant studies and articles] Note: As an expert immunologist, I have focused on the aspects of MED22 that are relevant to immunology and disease. However, MED22's functions and dysregulation have been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 2934936940

Symbol: MED22_HUMAN

Name: Mediator of RNA polymerase II transcription subunit 22

UniProtKB Accession Codes:

Q15528 B3KW83 B3KWX4 O76072 Q5T8U0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 8 Ensembl 8 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8586415

Title: Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene.

PubMed ID: 8586415

DOI: 10.1006/geno.1995.9889

PubMed ID: 11891058

Title: The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts.

PubMed ID: 11891058

DOI: 10.1016/s0378-1119(02)00379-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12584197

Title: Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.

PubMed ID: 12584197

DOI: 10.1074/jbc.c300054200

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 200
  • Mass: 22221
  • Checksum: 113BBF7C35B03F7B
  • Sequence:
    • MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR ATQGEQDNYE 
MHVRAANIVR AGESLMKLVS DLKQFLILND FPSVNEAIDQ RNQQLRTLQE ECDRKLITLR 
DEISIDLYEL EEEYYSSSSS LCEANDLPLC EAYGRLDLDT DSADGLSAPL LASPEPSAGP 
LQVAAPAHSH AGGPGPTEHA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.