Details for: SYT5

Gene ID: 6861

Symbol: SYT5

Ensembl ID: ENSG00000129990

Description: synaptotagmin 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.3537
    Cell Significance Index: -8.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.3576
    Cell Significance Index: -7.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.0490
    Cell Significance Index: -6.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9913
    Cell Significance Index: -8.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.9767
    Cell Significance Index: 182.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.6653
    Cell Significance Index: -7.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.6511
    Cell Significance Index: 58.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.0451
    Cell Significance Index: 65.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2545
    Cell Significance Index: 35.8000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.7901
    Cell Significance Index: 6.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7655
    Cell Significance Index: 153.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5443
    Cell Significance Index: 24.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5429
    Cell Significance Index: 20.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5103
    Cell Significance Index: 34.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4746
    Cell Significance Index: 46.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4567
    Cell Significance Index: 28.0700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.4483
    Cell Significance Index: 4.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4419
    Cell Significance Index: 398.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3714
    Cell Significance Index: 7.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3386
    Cell Significance Index: 64.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3143
    Cell Significance Index: 34.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2953
    Cell Significance Index: 17.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2650
    Cell Significance Index: 43.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2270
    Cell Significance Index: 5.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2211
    Cell Significance Index: 4.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2135
    Cell Significance Index: 6.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1999
    Cell Significance Index: 71.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1493
    Cell Significance Index: 10.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1423
    Cell Significance Index: 7.4700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0863
    Cell Significance Index: 1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0716
    Cell Significance Index: 4.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0665
    Cell Significance Index: 1.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0507
    Cell Significance Index: 2.3000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0368
    Cell Significance Index: 0.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0368
    Cell Significance Index: 20.1000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.0348
    Cell Significance Index: 0.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0340
    Cell Significance Index: 2.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0330
    Cell Significance Index: 1.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0275
    Cell Significance Index: 0.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0238
    Cell Significance Index: 0.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0156
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0056
    Cell Significance Index: 1.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0027
    Cell Significance Index: 2.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0017
    Cell Significance Index: 1.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0099
    Cell Significance Index: -1.6900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0103
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0112
    Cell Significance Index: -7.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0118
    Cell Significance Index: -5.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0141
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0152
    Cell Significance Index: -1.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0165
    Cell Significance Index: -7.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0183
    Cell Significance Index: -3.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0220
    Cell Significance Index: -6.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0230
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0380
    Cell Significance Index: -4.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0395
    Cell Significance Index: -4.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0397
    Cell Significance Index: -7.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0419
    Cell Significance Index: -1.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0459
    Cell Significance Index: -1.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0502
    Cell Significance Index: -6.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0511
    Cell Significance Index: -7.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0513
    Cell Significance Index: -7.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0569
    Cell Significance Index: -7.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0588
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0635
    Cell Significance Index: -7.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0644
    Cell Significance Index: -7.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0678
    Cell Significance Index: -1.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0696
    Cell Significance Index: -7.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0780
    Cell Significance Index: -4.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0810
    Cell Significance Index: -2.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0817
    Cell Significance Index: -0.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0855
    Cell Significance Index: -8.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0942
    Cell Significance Index: -6.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0947
    Cell Significance Index: -1.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0964
    Cell Significance Index: -6.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0990
    Cell Significance Index: -7.3800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1076
    Cell Significance Index: -0.7000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1110
    Cell Significance Index: -1.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1122
    Cell Significance Index: -3.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1129
    Cell Significance Index: -1.5400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1143
    Cell Significance Index: -2.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1182
    Cell Significance Index: -1.1200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1272
    Cell Significance Index: -1.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1304
    Cell Significance Index: -6.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1410
    Cell Significance Index: -6.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1474
    Cell Significance Index: -6.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1491
    Cell Significance Index: -6.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1513
    Cell Significance Index: -2.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1742
    Cell Significance Index: -1.1800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1816
    Cell Significance Index: -3.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1902
    Cell Significance Index: -4.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding protein:** SYT5 is a calcium-binding protein that interacts with calcium ions to regulate neurotransmitter release. 2. **Synaptic vesicle membrane protein:** SYT5 is a transmembrane protein that anchors synaptic vesicles to the plasma membrane, facilitating their fusion and neurotransmitter release. 3. **Protein heterodimerization activity:** SYT5 can interact with other proteins, such as syntaxin, to regulate neurotransmitter release and synaptic plasticity. 4. **Metabolic regulation:** SYT5 is involved in the regulation of energy metabolism, insulin secretion, and dopamine release, highlighting its role in metabolic processes beyond neurotransmission. **Pathways and Functions:** 1. **Calcium-dependent phospholipid binding:** SYT5 binds to phosphatidylinositol-4,5-bisphosphate (PIP2) and phosphatidylserine (PS) to regulate calcium-dependent phospholipid binding and neurotransmitter release. 2. **Calcium ion-regulated exocytosis of neurotransmitter:** SYT5 mediates calcium-dependent exocytosis of neurotransmitters, facilitating their release from synaptic vesicles. 3. **Cellular response to calcium ion:** SYT5 is involved in the cellular response to calcium ions, regulating various cellular processes, including metabolism and neurotransmission. 4. **Chemical synaptic transmission:** SYT5 plays a crucial role in chemical synaptic transmission, regulating neurotransmitter release and synaptic plasticity. 5. **Integration of energy metabolism:** SYT5 is implicated in the integration of energy metabolism, regulating glucose and lipid metabolism in neurons. **Clinical Significance:** 1. **Neurological disorders:** SYT5 has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and autism spectrum disorder. 2. **Metabolic disorders:** SYT5 is involved in metabolic disorders, such as type 2 diabetes and obesity, highlighting its role in regulating energy metabolism. 3. **Cancer:** SYT5 has been identified as a potential biomarker for cancer diagnosis and prognosis, particularly in neuroendocrine tumors. 4. **Neurodegenerative diseases:** SYT5 has been implicated in neurodegenerative diseases, such as Huntington's disease and amyotrophic lateral sclerosis (ALS). In conclusion, SYT5 is a complex protein involved in calcium-dependent neurotransmitter release and metabolic regulation. Its dysregulation has been implicated in various neurological and metabolic disorders, highlighting the need for further research into the molecular mechanisms underlying SYT5 function and its role in human disease.

Genular Protein ID: 2870188917

Symbol: SYT5_HUMAN

Name: Synaptotagmin-5

UniProtKB Accession Codes:

O00445 B3KWJ8 B7Z300 Q86X72

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 18 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177789

Title: Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location.

PubMed ID: 9177789

DOI: 10.1006/geno.1997.4722

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27793683

Title: Structural analysis of Ca2+-binding pocket of synaptotagmin 5 C2A domain.

PubMed ID: 27793683

DOI: 10.1016/j.ijbiomac.2016.10.083

Sequence Information:

  • Length: 386
  • Mass: 42900
  • Checksum: 96A36792D177FD55
  • Sequence:
    • MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL YRKSCRRRTG 
KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG QQVADKHELG RLQYSLDYDF 
QSGQLLVGIL QAMGLAALDL GGSSDPYVRV YLLPDKRRRY ETKVHRQTLN PHFGETFAFK 
VPYVELGGRV LVMAVYDFDR FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL 
GDICFSLRYV PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN 
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG GAGLRHWADM 
LANPRRPIAQ WHSLRPPDRV RLLPAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.