Details for: TACR3

Gene ID: 6870

Symbol: TACR3

Ensembl ID: ENSG00000169836

Description: tachykinin receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3622
    Cell Significance Index: 10.5000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.3422
    Cell Significance Index: 13.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1444
    Cell Significance Index: 27.7200
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: 1.1052
    Cell Significance Index: 13.5200
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.7937
    Cell Significance Index: 4.4500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6292
    Cell Significance Index: 9.1700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6187
    Cell Significance Index: 5.4500
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.3218
    Cell Significance Index: 0.2300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.2339
    Cell Significance Index: 2.2500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2009
    Cell Significance Index: 5.0100
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.1332
    Cell Significance Index: 0.9100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1147
    Cell Significance Index: 1.3900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1006
    Cell Significance Index: 1.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0721
    Cell Significance Index: 14.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0502
    Cell Significance Index: 34.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0244
    Cell Significance Index: 0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0224
    Cell Significance Index: 4.4500
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.0105
    Cell Significance Index: 0.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0027
    Cell Significance Index: 0.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0015
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0046
    Cell Significance Index: -0.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0057
    Cell Significance Index: -0.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0111
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0112
    Cell Significance Index: -5.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0122
    Cell Significance Index: -2.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0136
    Cell Significance Index: -3.9200
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0193
    Cell Significance Index: -0.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0212
    Cell Significance Index: -1.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0232
    Cell Significance Index: -3.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0239
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0268
    Cell Significance Index: -5.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0346
    Cell Significance Index: -4.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0394
    Cell Significance Index: -4.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0398
    Cell Significance Index: -0.5700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0399
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0478
    Cell Significance Index: -5.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0518
    Cell Significance Index: -3.4800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0522
    Cell Significance Index: -0.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0528
    Cell Significance Index: -5.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0615
    Cell Significance Index: -1.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0680
    Cell Significance Index: -3.0100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0724
    Cell Significance Index: -2.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0751
    Cell Significance Index: -5.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0763
    Cell Significance Index: -1.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0767
    Cell Significance Index: -0.5200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0786
    Cell Significance Index: -0.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0840
    Cell Significance Index: -3.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0866
    Cell Significance Index: -1.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0949
    Cell Significance Index: -4.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1057
    Cell Significance Index: -4.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1089
    Cell Significance Index: -2.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1129
    Cell Significance Index: -4.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1176
    Cell Significance Index: -3.8500
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.1186
    Cell Significance Index: -0.9300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1203
    Cell Significance Index: -1.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1214
    Cell Significance Index: -1.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1273
    Cell Significance Index: -4.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1303
    Cell Significance Index: -4.1500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1317
    Cell Significance Index: -2.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1332
    Cell Significance Index: -3.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1373
    Cell Significance Index: -4.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1387
    Cell Significance Index: -2.2000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1394
    Cell Significance Index: -1.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1425
    Cell Significance Index: -7.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1443
    Cell Significance Index: -3.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1489
    Cell Significance Index: -3.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1504
    Cell Significance Index: -5.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1560
    Cell Significance Index: -4.1700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1602
    Cell Significance Index: -2.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1640
    Cell Significance Index: -3.5900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1675
    Cell Significance Index: -1.8300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1690
    Cell Significance Index: -0.8900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1743
    Cell Significance Index: -2.3700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1751
    Cell Significance Index: -2.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1753
    Cell Significance Index: -5.0500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1781
    Cell Significance Index: -1.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1814
    Cell Significance Index: -3.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1817
    Cell Significance Index: -4.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1826
    Cell Significance Index: -4.5600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1839
    Cell Significance Index: -2.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1866
    Cell Significance Index: -3.9600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1906
    Cell Significance Index: -2.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1940
    Cell Significance Index: -5.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1958
    Cell Significance Index: -4.8900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1972
    Cell Significance Index: -2.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1988
    Cell Significance Index: -3.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2007
    Cell Significance Index: -4.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2008
    Cell Significance Index: -5.9200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2021
    Cell Significance Index: -4.9300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2031
    Cell Significance Index: -2.0100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2115
    Cell Significance Index: -2.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2123
    Cell Significance Index: -5.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TACR3 is a G protein-coupled receptor that belongs to the class A/1 rhodopsin-like receptor family. It is characterized by its high sequence similarity to other tachykinin receptors, such as TACR1 and TACR2. TACR3 is primarily expressed in the plasma membrane of various cell types, including retinal cone cells, cardiac endothelial cells, and immune cells. The receptor is activated by neuromedin-K, a tachykinin peptide, which triggers a signaling cascade involving Gαq proteins and downstream effectors, such as phospholipase C and protein kinase C. **Pathways and Functions** The activation of TACR3 by neuromedin-K triggers a signaling cascade that modulates various physiological processes, including: 1. **Cardiovascular function**: TACR3 activation leads to the regulation of blood pressure, heart rate, and uterine smooth muscle contraction. 2. **Neuronal signaling**: TACR3 is involved in the regulation of neuronal excitability and synaptic transmission, particularly in the cerebral cortex and retinal cone cells. 3. **Immune responses**: TACR3 is expressed on immature innate lymphoid cells and lymphoid lineage-restricted progenitor cells, suggesting its potential role in regulating immune responses. 4. **Regulation of dopamine metabolic process**: TACR3 activation may influence the regulation of dopamine synthesis and release in the brain. **Clinical Significance** TACR3 has been implicated in various diseases and disorders, including: 1. **Hypertension**: TACR3 activation may contribute to the development of hypertension by regulating blood pressure and vascular tone. 2. **Atherosclerosis**: TACR3 expression on cardiac endothelial cells may play a role in the regulation of endothelial function and atherosclerosis development. 3. **Immune-mediated disorders**: TACR3 expression on immune cells may influence the regulation of immune responses and the development of autoimmune diseases. 4. **Neurological disorders**: TACR3 activation may contribute to the regulation of neuronal excitability and synaptic transmission, potentially influencing the development of neurological disorders, such as epilepsy and Parkinson's disease. In conclusion, TACR3 is a complex receptor that plays a crucial role in various physiological processes, including cardiovascular function, neuronal signaling, and immune responses. Further research is needed to fully elucidate the mechanisms of TACR3 signaling and its clinical significance in various diseases and disorders.

Genular Protein ID: 1040876492

Symbol: NK3R_HUMAN

Name: Neuromedin-K receptor

UniProtKB Accession Codes:

P29371 Q0P510

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 13 EMDB 1 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1374246

Title: cDNA sequence and heterologous expression of the human neurokinin-3 receptor.

PubMed ID: 1374246

DOI: 10.1016/0006-291x(92)90685-e

PubMed ID: 1312036

Title: Molecular characterisation, expression and localisation of human neurokinin-3 receptor.

PubMed ID: 1312036

DOI: 10.1016/0014-5793(92)80107-r

PubMed ID: 1312928

Title: The primary structure and gene organization of human substance P and neuromedin K receptors.

PubMed ID: 1312928

DOI: 10.1111/j.1432-1033.1992.tb16724.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19079066

Title: TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.

PubMed ID: 19079066

DOI: 10.1038/ng.306

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

PubMed ID: 25077900

Title: The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients.

PubMed ID: 25077900

DOI: 10.1210/jc.2014-2110

Sequence Information:

  • Length: 465
  • Mass: 52202
  • Checksum: 98E88D4BC9DBD315
  • Sequence:
    • MATLPAAETW IDGGGGVGAD AVNLTASLAA GAATGAVETG WLQLLDQAGN LSSSPSALGL 
PVASPAPSQP WANLTNQFVQ PSWRIALWSL AYGVVVAVAV LGNLIVIWII LAHKRMRTVT 
NYFLVNLAFS DASMAAFNTL VNFIYALHSE WYFGANYCRF QNFFPITAVF ASIYSMTAIA 
VDRYMAIIDP LKPRLSATAT KIVIGSIWIL AFLLAFPQCL YSKTKVMPGR TLCFVQWPEG 
PKQHFTYHII VIILVYCFPL LIMGITYTIV GITLWGGEIP GDTCDKYHEQ LKAKRKVVKM 
MIIVVMTFAI CWLPYHIYFI LTAIYQQLNR WKYIQQVYLA SFWLAMSSTM YNPIIYCCLN 
KRFRAGFKRA FRWCPFIKVS SYDELELKTT RFHPNRQSSM YTVTRMESMT VVFDPNDADT 
TRSSRKKRAT PRDPSFNGCS RRNSKSASAT SSFISSPYTS VDEYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.