Details for: TCTA

Gene ID: 6988

Symbol: TCTA

Ensembl ID: ENSG00000145022

Description: T cell leukemia translocation altered

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.12
    Marker Score: 895
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.01
    Marker Score: 1758
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71723
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47947
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.98
    Marker Score: 395
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.92
    Marker Score: 618
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.91
    Marker Score: 3117
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2708
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13968
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5239
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4877.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.81
    Marker Score: 271
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.8
    Marker Score: 893
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 474
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.78
    Marker Score: 7944
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.77
    Marker Score: 7992
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.77
    Marker Score: 2066
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.77
    Marker Score: 1931
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.76
    Marker Score: 1256
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.75
    Marker Score: 544
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.74
    Marker Score: 277
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.74
    Marker Score: 754
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.73
    Marker Score: 228
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.73
    Marker Score: 1708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.72
    Marker Score: 2837
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1465.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.71
    Marker Score: 229
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.71
    Marker Score: 1139
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.71
    Marker Score: 1737
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2930.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.7
    Marker Score: 749
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.69
    Marker Score: 1070
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.69
    Marker Score: 5911
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.68
    Marker Score: 400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.68
    Marker Score: 353
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 610
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.66
    Marker Score: 2860
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.66
    Marker Score: 5746
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.65
    Marker Score: 7563
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.64
    Marker Score: 1217
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.63
    Marker Score: 401
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.63
    Marker Score: 2241.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.63
    Marker Score: 4008
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.62
    Marker Score: 622
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.62
    Marker Score: 307
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.61
    Marker Score: 318
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.61
    Marker Score: 409
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.61
    Marker Score: 644
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.61
    Marker Score: 2913
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.61
    Marker Score: 5753
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.61
    Marker Score: 1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6
    Marker Score: 37030
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.6
    Marker Score: 552.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.6
    Marker Score: 289
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.59
    Marker Score: 241
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 389
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.59
    Marker Score: 964
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.59
    Marker Score: 255
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.58
    Marker Score: 599
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.58
    Marker Score: 135
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3403
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.56
    Marker Score: 311
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.56
    Marker Score: 7587
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.56
    Marker Score: 163
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.56
    Marker Score: 144
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.56
    Marker Score: 328
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.56
    Marker Score: 139
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.56
    Marker Score: 126
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.56
    Marker Score: 308
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.56
    Marker Score: 138
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.56
    Marker Score: 790
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.55
    Marker Score: 2229
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.54
    Marker Score: 2013
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.54
    Marker Score: 187
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 346
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.54
    Marker Score: 186
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.54
    Marker Score: 232
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.53
    Marker Score: 1033
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 249
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.52
    Marker Score: 506
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.52
    Marker Score: 1424
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.51
    Marker Score: 266
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.5
    Marker Score: 260
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5
    Marker Score: 232
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.5
    Marker Score: 742
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.5
    Marker Score: 295
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.5
    Marker Score: 799

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Other Information

**Key Characteristics** The TCTA gene is a non-coding gene, meaning it does not encode a protein. Instead, it is involved in the regulation of gene expression through various mechanisms, including transcriptional control and chromatin remodeling. Its expression is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders. The TCTA gene has been identified as a key player in the negative regulation of osteoclast differentiation, a process critical for bone resorption. Additionally, it has been shown to interact with other proteins, such as BEST4, to regulate cellular processes. **Pathways and Functions** The TCTA gene is involved in several key pathways, including: 1. **Negative regulation of osteoclast differentiation**: The TCTA gene plays a crucial role in the regulation of osteoclast differentiation, a process that is essential for bone resorption. Dysregulation of this process has been implicated in various bone diseases, including osteoporosis and Paget's disease. 2. **Osteoclast fusion**: The TCTA gene is also involved in the regulation of osteoclast fusion, a process that is critical for the formation of multinucleated osteoclasts. This process is essential for bone resorption and has been implicated in various bone diseases. 3. **Protein binding**: The TCTA gene has been shown to interact with other proteins, such as BEST4, to regulate cellular processes. These interactions are critical for the regulation of gene expression and cellular differentiation. **Clinical Significance** The TCTA gene has significant clinical implications, particularly in the context of bone diseases. Dysregulation of the TCTA gene has been implicated in various bone diseases, including osteoporosis and Paget's disease. Additionally, the TCTA gene has been shown to play a role in the regulation of immune responses, particularly in the context of autoimmune disorders. Furthermore, the TCTA gene has been identified as a potential therapeutic target for the treatment of various diseases, including cancer and autoimmune disorders. Its dysregulation has been implicated in the development of various cancers, including leukemia and lymphoma. Therefore, further research is needed to fully understand the clinical significance of the TCTA gene and its potential as a therapeutic target. In conclusion, the TCTA gene is a complex and multifaceted gene that plays a critical role in various cellular processes, including negative regulation of osteoclast differentiation, osteoclast fusion, and protein binding. Its dysregulation has significant clinical implications, particularly in the context of bone diseases and autoimmune disorders. Further research is needed to fully understand the clinical significance of the TCTA gene and its potential as a therapeutic target.

Genular Protein ID: 3859134829

Symbol: TCTA_HUMAN

Name: T-cell leukemia translocation-altered gene protein

UniProtKB Accession Codes:

P57738 B2R4I4 Q6I9U4 Q9BSB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7728759

Title: Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.

PubMed ID: 7728759

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19560569

Title: T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis.

PubMed ID: 19560569

DOI: 10.1016/j.bone.2009.06.019

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 103
  • Mass: 11341
  • Checksum: 62FA7ECC2241D85E
  • Sequence:
    • MAESWSGQAL QALPATVLGA LGSEFLREWE AQDMRVTLFK LLLLWLVLSL LGIQLAWGFY 
GNTVTGLYHR PGLGGQNGST PDGSTHFPSW EMAANEPLKT HRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.