Details for: TCTA

Gene ID: 6988

Symbol: TCTA

Ensembl ID: ENSG00000145022

Description: T cell leukemia translocation altered

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.1001
    Cell Significance Index: -16.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.3496
    Cell Significance Index: -14.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.6915
    Cell Significance Index: -17.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 26.4447
    Cell Significance Index: -17.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.3639
    Cell Significance Index: -17.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9125
    Cell Significance Index: -13.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5641
    Cell Significance Index: -18.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.4159
    Cell Significance Index: 56.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3035
    Cell Significance Index: -7.2300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.9457
    Cell Significance Index: 47.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2292
    Cell Significance Index: 10.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9754
    Cell Significance Index: 44.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9092
    Cell Significance Index: 26.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8371
    Cell Significance Index: 91.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7088
    Cell Significance Index: 115.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6260
    Cell Significance Index: 40.3900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6193
    Cell Significance Index: 6.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5419
    Cell Significance Index: 8.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4534
    Cell Significance Index: 31.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3766
    Cell Significance Index: 10.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3382
    Cell Significance Index: 64.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3204
    Cell Significance Index: 64.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3156
    Cell Significance Index: 43.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2646
    Cell Significance Index: 12.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2615
    Cell Significance Index: 51.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2300
    Cell Significance Index: 41.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2290
    Cell Significance Index: 8.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2144
    Cell Significance Index: 11.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1810
    Cell Significance Index: 21.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1693
    Cell Significance Index: 60.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1599
    Cell Significance Index: 19.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1532
    Cell Significance Index: 15.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1420
    Cell Significance Index: 77.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1168
    Cell Significance Index: 15.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1165
    Cell Significance Index: 14.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1063
    Cell Significance Index: 8.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0787
    Cell Significance Index: 34.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0753
    Cell Significance Index: 8.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0512
    Cell Significance Index: 1.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0488
    Cell Significance Index: 1.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0468
    Cell Significance Index: 1.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0432
    Cell Significance Index: 2.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0376
    Cell Significance Index: 6.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0309
    Cell Significance Index: 1.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0259
    Cell Significance Index: 1.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0236
    Cell Significance Index: 16.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0157
    Cell Significance Index: 21.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0110
    Cell Significance Index: 8.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0104
    Cell Significance Index: 7.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0090
    Cell Significance Index: 16.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0034
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0051
    Cell Significance Index: -3.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0101
    Cell Significance Index: -5.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0120
    Cell Significance Index: -5.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0164
    Cell Significance Index: -1.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0199
    Cell Significance Index: -2.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0266
    Cell Significance Index: -0.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0270
    Cell Significance Index: -1.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0327
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0350
    Cell Significance Index: -7.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0467
    Cell Significance Index: -13.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0532
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0601
    Cell Significance Index: -6.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0644
    Cell Significance Index: -3.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0716
    Cell Significance Index: -2.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0733
    Cell Significance Index: -8.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0759
    Cell Significance Index: -11.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0872
    Cell Significance Index: -2.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0923
    Cell Significance Index: -2.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1112
    Cell Significance Index: -2.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1117
    Cell Significance Index: -7.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1125
    Cell Significance Index: -2.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1266
    Cell Significance Index: -4.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1375
    Cell Significance Index: -6.0800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1528
    Cell Significance Index: -2.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1558
    Cell Significance Index: -3.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1597
    Cell Significance Index: -12.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1597
    Cell Significance Index: -16.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1629
    Cell Significance Index: -6.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1871
    Cell Significance Index: -10.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2009
    Cell Significance Index: -4.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2089
    Cell Significance Index: -2.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2094
    Cell Significance Index: -12.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2130
    Cell Significance Index: -5.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2723
    Cell Significance Index: -7.0000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2909
    Cell Significance Index: -3.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3035
    Cell Significance Index: -5.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3100
    Cell Significance Index: -9.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3156
    Cell Significance Index: -4.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3322
    Cell Significance Index: -9.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3376
    Cell Significance Index: -8.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3386
    Cell Significance Index: -10.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3604
    Cell Significance Index: -11.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3675
    Cell Significance Index: -9.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3731
    Cell Significance Index: -13.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3817
    Cell Significance Index: -7.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TCTA gene is a non-coding gene, meaning it does not encode a protein. Instead, it is involved in the regulation of gene expression through various mechanisms, including transcriptional control and chromatin remodeling. Its expression is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders. The TCTA gene has been identified as a key player in the negative regulation of osteoclast differentiation, a process critical for bone resorption. Additionally, it has been shown to interact with other proteins, such as BEST4, to regulate cellular processes. **Pathways and Functions** The TCTA gene is involved in several key pathways, including: 1. **Negative regulation of osteoclast differentiation**: The TCTA gene plays a crucial role in the regulation of osteoclast differentiation, a process that is essential for bone resorption. Dysregulation of this process has been implicated in various bone diseases, including osteoporosis and Paget's disease. 2. **Osteoclast fusion**: The TCTA gene is also involved in the regulation of osteoclast fusion, a process that is critical for the formation of multinucleated osteoclasts. This process is essential for bone resorption and has been implicated in various bone diseases. 3. **Protein binding**: The TCTA gene has been shown to interact with other proteins, such as BEST4, to regulate cellular processes. These interactions are critical for the regulation of gene expression and cellular differentiation. **Clinical Significance** The TCTA gene has significant clinical implications, particularly in the context of bone diseases. Dysregulation of the TCTA gene has been implicated in various bone diseases, including osteoporosis and Paget's disease. Additionally, the TCTA gene has been shown to play a role in the regulation of immune responses, particularly in the context of autoimmune disorders. Furthermore, the TCTA gene has been identified as a potential therapeutic target for the treatment of various diseases, including cancer and autoimmune disorders. Its dysregulation has been implicated in the development of various cancers, including leukemia and lymphoma. Therefore, further research is needed to fully understand the clinical significance of the TCTA gene and its potential as a therapeutic target. In conclusion, the TCTA gene is a complex and multifaceted gene that plays a critical role in various cellular processes, including negative regulation of osteoclast differentiation, osteoclast fusion, and protein binding. Its dysregulation has significant clinical implications, particularly in the context of bone diseases and autoimmune disorders. Further research is needed to fully understand the clinical significance of the TCTA gene and its potential as a therapeutic target.

Genular Protein ID: 3859134829

Symbol: TCTA_HUMAN

Name: T-cell leukemia translocation-altered gene protein

UniProtKB Accession Codes:

P57738 B2R4I4 Q6I9U4 Q9BSB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7728759

Title: Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.

PubMed ID: 7728759

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19560569

Title: T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis.

PubMed ID: 19560569

DOI: 10.1016/j.bone.2009.06.019

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 103
  • Mass: 11341
  • Checksum: 62FA7ECC2241D85E
  • Sequence:
    • MAESWSGQAL QALPATVLGA LGSEFLREWE AQDMRVTLFK LLLLWLVLSL LGIQLAWGFY 
GNTVTGLYHR PGLGGQNGST PDGSTHFPSW EMAANEPLKT HRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.