Details for: DYNLT2

Gene ID: 6991

Symbol: DYNLT2

Ensembl ID: ENSG00000184786

Description: dynein light chain Tctex-type 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.4817
    Cell Significance Index: -7.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.4849
    Cell Significance Index: -7.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.1803
    Cell Significance Index: -7.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9577
    Cell Significance Index: -7.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3399
    Cell Significance Index: 254.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8195
    Cell Significance Index: 81.0700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.7278
    Cell Significance Index: 23.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6602
    Cell Significance Index: 596.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6033
    Cell Significance Index: 36.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6004
    Cell Significance Index: 17.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5718
    Cell Significance Index: 25.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5636
    Cell Significance Index: 61.3100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5267
    Cell Significance Index: 4.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5234
    Cell Significance Index: 32.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4630
    Cell Significance Index: 75.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2830
    Cell Significance Index: 4.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2824
    Cell Significance Index: 19.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2786
    Cell Significance Index: 14.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2709
    Cell Significance Index: 5.8700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2187
    Cell Significance Index: 3.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1914
    Cell Significance Index: 5.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1900
    Cell Significance Index: 12.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1886
    Cell Significance Index: 37.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1866
    Cell Significance Index: 33.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1527
    Cell Significance Index: 30.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1393
    Cell Significance Index: 1.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1362
    Cell Significance Index: 3.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1088
    Cell Significance Index: 5.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0982
    Cell Significance Index: 1.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0969
    Cell Significance Index: 11.9100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0853
    Cell Significance Index: 0.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0848
    Cell Significance Index: 1.7600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0807
    Cell Significance Index: 1.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0787
    Cell Significance Index: 6.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0730
    Cell Significance Index: 1.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0666
    Cell Significance Index: 1.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0627
    Cell Significance Index: 22.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0617
    Cell Significance Index: 2.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0588
    Cell Significance Index: 8.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0576
    Cell Significance Index: 6.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0531
    Cell Significance Index: 0.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0527
    Cell Significance Index: 81.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0490
    Cell Significance Index: 2.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0479
    Cell Significance Index: 88.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0443
    Cell Significance Index: 83.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0442
    Cell Significance Index: 24.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0417
    Cell Significance Index: 18.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0316
    Cell Significance Index: 0.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0225
    Cell Significance Index: 30.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0206
    Cell Significance Index: 0.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0176
    Cell Significance Index: 0.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0153
    Cell Significance Index: 0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0149
    Cell Significance Index: 9.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0138
    Cell Significance Index: 0.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0122
    Cell Significance Index: 0.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0098
    Cell Significance Index: 1.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0083
    Cell Significance Index: 0.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0064
    Cell Significance Index: 0.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0016
    Cell Significance Index: 0.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0021
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0045
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0105
    Cell Significance Index: -0.4900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0110
    Cell Significance Index: -0.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0115
    Cell Significance Index: -0.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0154
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0175
    Cell Significance Index: -2.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0195
    Cell Significance Index: -5.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0230
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0261
    Cell Significance Index: -2.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0296
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0317
    Cell Significance Index: -2.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0350
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0361
    Cell Significance Index: -7.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0363
    Cell Significance Index: -0.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0649
    Cell Significance Index: -6.7600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0701
    Cell Significance Index: -0.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0712
    Cell Significance Index: -1.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0763
    Cell Significance Index: -2.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0763
    Cell Significance Index: -1.9600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0901
    Cell Significance Index: -1.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0910
    Cell Significance Index: -7.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1040
    Cell Significance Index: -1.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1047
    Cell Significance Index: -1.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1108
    Cell Significance Index: -3.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1151
    Cell Significance Index: -2.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1166
    Cell Significance Index: -2.4400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1201
    Cell Significance Index: -1.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1219
    Cell Significance Index: -6.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1228
    Cell Significance Index: -4.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1235
    Cell Significance Index: -4.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1247
    Cell Significance Index: -4.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1333
    Cell Significance Index: -2.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1357
    Cell Significance Index: -2.8800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1365
    Cell Significance Index: -1.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1394
    Cell Significance Index: -3.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DYNLT2 is a member of the dynein light chain family, which is essential for the assembly and function of the cytoplasmic dynein complex. This complex is composed of multiple subunits, including heavy chains (DYNC1H1-4), light chains (DYNC1I1-3), and intermediate chains (DYNC1I1-4). DYNLT2 is specifically associated with the Tctex-type subunit, which is distinct from the more commonly studied dynein heavy chains. The Tctex-type subunit is thought to play a crucial role in the regulation of dynein function and its interaction with other motor proteins. **Pathways and Functions:** DYNLT2 is involved in various cellular processes, including: 1. **Intraflagellar transport (IFT):** DYNLT2 is essential for the transport of cilia and flagella along microtubules, which is critical for sensory perception and motility. 2. **Organelle biogenesis and maintenance:** DYNLT2 is involved in the movement and positioning of organelles, such as peroxisomes and mitochondria, within the cell. 3. **Membrane trafficking:** DYNLT2 contributes to the transport of vesicles and cargo along microtubules, which is essential for cell signaling, protein secretion, and cell migration. 4. **Cilium assembly and maintenance:** DYNLT2 is required for the assembly and maintenance of cilia, which is critical for sensory perception and motility. **Clinical Significance:** DYNLT2 has been implicated in various human diseases, including: 1. **Cilia-related disorders:** Mutations in DYNLT2 have been associated with ciliary dyskinesia, a group of disorders characterized by impaired cilia function and motility. 2. **Neurological disorders:** DYNLT2 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** DYNLT2 has been implicated in cancer progression and metastasis, particularly in epithelial cancers. 4. **Immune system disorders:** DYNLT2 has been linked to immune system disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, DYNLT2 is a critical component of the cytoplasmic dynein complex, involved in various cellular processes, including intraflagellar transport, organelle biogenesis, and membrane trafficking. Its dysregulation has been implicated in various human diseases, highlighting the importance of this gene in human health and disease. Further research is necessary to fully elucidate the role of DYNLT2 in human disease and to develop therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 1314898701

Symbol: DYLT2_HUMAN

Name: T-complex testis-specific protein 3

UniProtKB Accession Codes:

Q8IZS6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12584439

Title: Identification of the human ortholog of the T-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia.

PubMed ID: 12584439

DOI: 10.1159/000068545

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278908

Title: The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family.

PubMed ID: 11278908

DOI: 10.1074/jbc.m011456200

Sequence Information:

  • Length: 198
  • Mass: 23176
  • Checksum: FC20E7C32510111D
  • Sequence:
    • MEKRGRGVKS SPIQTPNQTP QQAPVTPRKE RRPSMFEKEA YTQILRERLR ESIHNVQYVE 
PPFDDSIADI GKEWKSALAK LKFANSYRME PLKKFQAHSV ETKVQQILTE SLKDVKYDDK 
VFSHLSLELA DRILLAVKEF GYHRYKFIIK VLFIQKTGQA INIASRWIWD IAWDSWVAAK 
HEAESYVALV LVFALYYE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.