Details for: DYNLT2

Gene ID: 6991

Symbol: DYNLT2

Ensembl ID: ENSG00000184786

Description: dynein light chain Tctex-type 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5173
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.8
    Marker Score: 1003.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.78
    Marker Score: 947
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.78
    Marker Score: 1050
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.73
    Marker Score: 296.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 532.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 275
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2816
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.67
    Marker Score: 392
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.66
    Marker Score: 208
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.56
    Marker Score: 2355
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.55
    Marker Score: 403
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 318
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 2979
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.48
    Marker Score: 1359
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.45
    Marker Score: 163
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.44
    Marker Score: 1046
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.38
    Marker Score: 592
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 253
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.36
    Marker Score: 116
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.35
    Marker Score: 3012
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.32
    Marker Score: 298
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.32
    Marker Score: 309
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 311
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.31
    Marker Score: 2900
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.3
    Marker Score: 147
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3
    Marker Score: 89
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 119
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.29
    Marker Score: 163
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.28
    Marker Score: 2863
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.28
    Marker Score: 267
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.28
    Marker Score: 2796
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.27
    Marker Score: 16800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.27
    Marker Score: 184
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.27
    Marker Score: 183
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.26
    Marker Score: 106
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.26
    Marker Score: 207
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.25
    Marker Score: 110
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.25
    Marker Score: 518
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.25
    Marker Score: 454
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.24
    Marker Score: 2286
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.23
    Marker Score: 659
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.23
    Marker Score: 250
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.23
    Marker Score: 71
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.23
    Marker Score: 548
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.23
    Marker Score: 241
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.22
    Marker Score: 395
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 133
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.22
    Marker Score: 165
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.22
    Marker Score: 85
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.22
    Marker Score: 251
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.22
    Marker Score: 279
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.21
    Marker Score: 7260
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.21
    Marker Score: 864
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.21
    Marker Score: 46
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.21
    Marker Score: 106
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.21
    Marker Score: 73
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.21
    Marker Score: 104
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.21
    Marker Score: 7637
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.21
    Marker Score: 48
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.21
    Marker Score: 102
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.2
    Marker Score: 174
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2
    Marker Score: 353
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 180
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.2
    Marker Score: 217
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.2
    Marker Score: 43
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.19
    Marker Score: 242
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.19
    Marker Score: 53
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.19
    Marker Score: 226

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Other Information

**Key Characteristics:** DYNLT2 is a member of the dynein light chain family, which is essential for the assembly and function of the cytoplasmic dynein complex. This complex is composed of multiple subunits, including heavy chains (DYNC1H1-4), light chains (DYNC1I1-3), and intermediate chains (DYNC1I1-4). DYNLT2 is specifically associated with the Tctex-type subunit, which is distinct from the more commonly studied dynein heavy chains. The Tctex-type subunit is thought to play a crucial role in the regulation of dynein function and its interaction with other motor proteins. **Pathways and Functions:** DYNLT2 is involved in various cellular processes, including: 1. **Intraflagellar transport (IFT):** DYNLT2 is essential for the transport of cilia and flagella along microtubules, which is critical for sensory perception and motility. 2. **Organelle biogenesis and maintenance:** DYNLT2 is involved in the movement and positioning of organelles, such as peroxisomes and mitochondria, within the cell. 3. **Membrane trafficking:** DYNLT2 contributes to the transport of vesicles and cargo along microtubules, which is essential for cell signaling, protein secretion, and cell migration. 4. **Cilium assembly and maintenance:** DYNLT2 is required for the assembly and maintenance of cilia, which is critical for sensory perception and motility. **Clinical Significance:** DYNLT2 has been implicated in various human diseases, including: 1. **Cilia-related disorders:** Mutations in DYNLT2 have been associated with ciliary dyskinesia, a group of disorders characterized by impaired cilia function and motility. 2. **Neurological disorders:** DYNLT2 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** DYNLT2 has been implicated in cancer progression and metastasis, particularly in epithelial cancers. 4. **Immune system disorders:** DYNLT2 has been linked to immune system disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, DYNLT2 is a critical component of the cytoplasmic dynein complex, involved in various cellular processes, including intraflagellar transport, organelle biogenesis, and membrane trafficking. Its dysregulation has been implicated in various human diseases, highlighting the importance of this gene in human health and disease. Further research is necessary to fully elucidate the role of DYNLT2 in human disease and to develop therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 1314898701

Symbol: DYLT2_HUMAN

Name: T-complex testis-specific protein 3

UniProtKB Accession Codes:

Q8IZS6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12584439

Title: Identification of the human ortholog of the T-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia.

PubMed ID: 12584439

DOI: 10.1159/000068545

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278908

Title: The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family.

PubMed ID: 11278908

DOI: 10.1074/jbc.m011456200

Sequence Information:

  • Length: 198
  • Mass: 23176
  • Checksum: FC20E7C32510111D
  • Sequence:
    • MEKRGRGVKS SPIQTPNQTP QQAPVTPRKE RRPSMFEKEA YTQILRERLR ESIHNVQYVE 
PPFDDSIADI GKEWKSALAK LKFANSYRME PLKKFQAHSV ETKVQQILTE SLKDVKYDDK 
VFSHLSLELA DRILLAVKEF GYHRYKFIIK VLFIQKTGQA INIASRWIWD IAWDSWVAAK 
HEAESYVALV LVFALYYE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.