Details for: CRIPTO

Gene ID: 6997

Symbol: CRIPTO

Ensembl ID: ENSG00000241186

Description: cripto, EGF-CFC family member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.1091
    Cell Significance Index: 110.1100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.7690
    Cell Significance Index: 14.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4980
    Cell Significance Index: 148.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3147
    Cell Significance Index: 250.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0534
    Cell Significance Index: 22.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.8586
    Cell Significance Index: -2.3000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.7217
    Cell Significance Index: 3.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6909
    Cell Significance Index: 16.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6716
    Cell Significance Index: 40.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6411
    Cell Significance Index: 578.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5897
    Cell Significance Index: 64.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4422
    Cell Significance Index: 71.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3780
    Cell Significance Index: 9.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3086
    Cell Significance Index: 21.3400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.2774
    Cell Significance Index: 1.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2495
    Cell Significance Index: 3.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2450
    Cell Significance Index: 6.1100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2197
    Cell Significance Index: 2.4600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1784
    Cell Significance Index: 2.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1527
    Cell Significance Index: 4.8900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1376
    Cell Significance Index: 1.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1152
    Cell Significance Index: 2.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0620
    Cell Significance Index: 12.3000
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.0546
    Cell Significance Index: 0.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0446
    Cell Significance Index: 1.1500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0444
    Cell Significance Index: 0.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0427
    Cell Significance Index: 1.2300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.0340
    Cell Significance Index: 0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0310
    Cell Significance Index: 22.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0299
    Cell Significance Index: 2.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0208
    Cell Significance Index: 0.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0134
    Cell Significance Index: 0.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0125
    Cell Significance Index: 1.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0113
    Cell Significance Index: 0.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0101
    Cell Significance Index: 2.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0079
    Cell Significance Index: 0.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0055
    Cell Significance Index: 0.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0041
    Cell Significance Index: 0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0029
    Cell Significance Index: -0.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0034
    Cell Significance Index: -2.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0036
    Cell Significance Index: -2.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0047
    Cell Significance Index: -1.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0057
    Cell Significance Index: -1.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0060
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0098
    Cell Significance Index: -2.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0110
    Cell Significance Index: -1.9900
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0132
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0137
    Cell Significance Index: -1.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0139
    Cell Significance Index: -1.7900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.0140
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0148
    Cell Significance Index: -2.1500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0165
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0177
    Cell Significance Index: -2.1800
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: -0.0181
    Cell Significance Index: -0.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0207
    Cell Significance Index: -1.2700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0209
    Cell Significance Index: -0.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0226
    Cell Significance Index: -0.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0243
    Cell Significance Index: -1.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0274
    Cell Significance Index: -2.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0332
    Cell Significance Index: -2.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0350
    Cell Significance Index: -2.1500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0367
    Cell Significance Index: -0.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0382
    Cell Significance Index: -1.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0388
    Cell Significance Index: -2.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0396
    Cell Significance Index: -1.7200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0429
    Cell Significance Index: -0.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0436
    Cell Significance Index: -1.1700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0466
    Cell Significance Index: -0.4200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0469
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0481
    Cell Significance Index: -1.3100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0487
    Cell Significance Index: -0.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0488
    Cell Significance Index: -0.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0498
    Cell Significance Index: -0.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0504
    Cell Significance Index: -2.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0528
    Cell Significance Index: -0.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0535
    Cell Significance Index: -1.9700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0551
    Cell Significance Index: -1.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0553
    Cell Significance Index: -1.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0557
    Cell Significance Index: -1.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0571
    Cell Significance Index: -1.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0581
    Cell Significance Index: -2.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0583
    Cell Significance Index: -0.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0626
    Cell Significance Index: -1.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0628
    Cell Significance Index: -1.8000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0655
    Cell Significance Index: -0.9800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0673
    Cell Significance Index: -0.8700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0718
    Cell Significance Index: -1.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0721
    Cell Significance Index: -1.8000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0722
    Cell Significance Index: -1.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0738
    Cell Significance Index: -1.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Cripto is a secreted protein that interacts with the Epidermal Growth Factor (EGF) receptor, activating signaling pathways involved in cell proliferation, differentiation, and migration. It is highly expressed in various cell types, including embryonic stem cells, cortical thymic epithelial cells, and intestinal crypt stem cells. Cripto's unique structure, comprising two EGF-like domains and a FGF-like domain, allows it to bind to the EGF receptor, triggering a cascade of intracellular signaling events. **Pathways and Functions** Cripto's signaling pathways are involved in various cellular processes, including: 1. **Anterior/posterior axis specification**: Cripto plays a crucial role in the development of the anterior/posterior axis in embryonic development, regulating the specification of left/right symmetry. 2. **Cell differentiation**: Cripto influences the differentiation of various cell types, including epithelial cells, immune cells, and stem cells. 3. **Cell migration**: Cripto promotes cell migration, essential for tissue morphogenesis and angiogenesis. 4. **Apoptosis regulation**: Cripto negatively regulates the apoptotic process, ensuring the survival of cells. 5. **Signaling by Nodal**: Cripto interacts with Nodal, a key ligand in the TGF-β signaling pathway, regulating the activity of this pathway in embryonic development and immune system development. **Clinical Significance** Cripto's dysregulation has been implicated in various diseases, including: 1. **Immune system disorders**: Alterations in Cripto expression have been linked to immune system dysregulation, including autoimmune diseases and immunodeficiency disorders. 2. **Cancer**: Cripto's overexpression has been observed in various types of cancer, where it may contribute to tumorigenesis and metastasis. 3. **Neurological disorders**: Cripto's involvement in neuronal development and function may contribute to the pathogenesis of neurological disorders, such as autism spectrum disorder. 4. **Reproductive disorders**: Cripto's role in embryonic development and implantation may contribute to reproductive disorders, such as recurrent miscarriage. In conclusion, Cripto is a multifunctional protein that plays a crucial role in various developmental and cellular processes, including immune system development and function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding Cripto's signaling pathways and functions in the context of immune system biology.

Genular Protein ID: 389738327

Symbol: TDGF1_HUMAN

Name: Cripto-1 growth factor

UniProtKB Accession Codes:

P13385 Q8TCC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2792079

Title: Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells.

PubMed ID: 2792079

DOI: 10.1002/j.1460-2075.1989.tb03605.x

PubMed ID: 1882841

Title: Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence.

PubMed ID: 1882841

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11909953

Title: Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.

PubMed ID: 11909953

DOI: 10.1128/mcb.22.8.2586-2597.2002

PubMed ID: 12919325

Title: The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto.

PubMed ID: 12919325

DOI: 10.1046/j.1432-1033.2003.03749.x

PubMed ID: 18930707

Title: Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension.

PubMed ID: 18930707

DOI: 10.1016/j.bbamem.2008.09.011

PubMed ID: 18835250

Title: CRIPTO3, a presumed pseudogene, is expressed in cancer.

PubMed ID: 18835250

DOI: 10.1016/j.bbrc.2008.09.113

PubMed ID: 27881714

Title: A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.

PubMed ID: 27881714

DOI: 10.1083/jcb.201605121

Sequence Information:

  • Length: 188
  • Mass: 21169
  • Checksum: AEE8727D0F27D886
  • Sequence:
    • MDCRKMARFS YSVIWIMAIS KVFELGLVAG LGHQEFARPS RGYLAFRDDS IWPQEEPAIR 
PRSSQRVPPM GIQHSKELNR TCCLNGGTCM LGSFCACPPS FYGRNCEHDV RKENCGSVPH 
DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD GLVMDEHLVA SRTPELPPSA RTTTFMLVGI 
CLSIQSYY

Genular Protein ID: 3725319174

Symbol: F5H1T8_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H1T8

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 172
  • Mass: 19180
  • Checksum: 40B9A07836E56D4A
  • Sequence:
    • MAISKVFELG LVAGLGHQEF ARPSRGYLAF RDDSIWPQEE PAIRPRSSQR VPPMGIQHSK 
ELNRTCCLNG GTCMLGSFCA CPPSFYGRNC EHDVRKENCG SVPHDTWLPK KCSLCKCWHG 
QLRCFPQAFL PGCDGLVMDE HLVASRTPEL PPSARTTTFM LVGICLSIQS YY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.