Details for: TEAD1

Gene ID: 7003

Symbol: TEAD1

Ensembl ID: ENSG00000187079

Description: TEA domain transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 178.4282
    Cell Significance Index: -84.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 76.5127
    Cell Significance Index: -73.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.7457
    Cell Significance Index: 322.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.7896
    Cell Significance Index: 97.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.7771
    Cell Significance Index: 92.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.2779
    Cell Significance Index: 251.5400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.8625
    Cell Significance Index: 36.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6271
    Cell Significance Index: 521.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.5785
    Cell Significance Index: 43.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.3121
    Cell Significance Index: 65.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9134
    Cell Significance Index: 383.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8743
    Cell Significance Index: 36.5800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.8714
    Cell Significance Index: 30.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8172
    Cell Significance Index: 125.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3888
    Cell Significance Index: 85.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.0846
    Cell Significance Index: 688.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0659
    Cell Significance Index: 131.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0184
    Cell Significance Index: 28.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9303
    Cell Significance Index: 101.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9118
    Cell Significance Index: 125.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8849
    Cell Significance Index: 25.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7492
    Cell Significance Index: 518.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7018
    Cell Significance Index: 383.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6919
    Cell Significance Index: 124.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6873
    Cell Significance Index: 1294.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6090
    Cell Significance Index: 218.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5646
    Cell Significance Index: 25.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5451
    Cell Significance Index: 247.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5408
    Cell Significance Index: 32.4700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5096
    Cell Significance Index: 7.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3900
    Cell Significance Index: 719.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3570
    Cell Significance Index: 5.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3205
    Cell Significance Index: 493.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2277
    Cell Significance Index: 6.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2031
    Cell Significance Index: 89.7900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1888
    Cell Significance Index: 2.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1845
    Cell Significance Index: 35.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1824
    Cell Significance Index: 1.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1571
    Cell Significance Index: 15.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1460
    Cell Significance Index: 3.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1336
    Cell Significance Index: 181.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0589
    Cell Significance Index: 2.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0369
    Cell Significance Index: 33.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0067
    Cell Significance Index: -0.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0350
    Cell Significance Index: -0.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0552
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0647
    Cell Significance Index: -47.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0655
    Cell Significance Index: -40.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0703
    Cell Significance Index: -9.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0745
    Cell Significance Index: -1.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0786
    Cell Significance Index: -57.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0798
    Cell Significance Index: -12.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1017
    Cell Significance Index: -76.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1177
    Cell Significance Index: -66.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1341
    Cell Significance Index: -13.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1699
    Cell Significance Index: -29.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2337
    Cell Significance Index: -49.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2371
    Cell Significance Index: -34.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2526
    Cell Significance Index: -72.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2675
    Cell Significance Index: -30.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3100
    Cell Significance Index: -4.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4246
    Cell Significance Index: -49.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4661
    Cell Significance Index: -53.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4726
    Cell Significance Index: -12.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5068
    Cell Significance Index: -26.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5329
    Cell Significance Index: -54.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5393
    Cell Significance Index: -69.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6372
    Cell Significance Index: -29.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6525
    Cell Significance Index: -46.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6794
    Cell Significance Index: -9.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7133
    Cell Significance Index: -17.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7233
    Cell Significance Index: -85.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8138
    Cell Significance Index: -38.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8504
    Cell Significance Index: -63.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8944
    Cell Significance Index: -19.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9169
    Cell Significance Index: -5.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9260
    Cell Significance Index: -58.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9965
    Cell Significance Index: -78.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0172
    Cell Significance Index: -32.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2187
    Cell Significance Index: -74.7200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -1.2435
    Cell Significance Index: -19.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2495
    Cell Significance Index: -55.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.3300
    Cell Significance Index: -69.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.3333
    Cell Significance Index: -86.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.4725
    Cell Significance Index: -42.2100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.4770
    Cell Significance Index: -22.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.4861
    Cell Significance Index: -31.5400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -1.4863
    Cell Significance Index: -6.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5286
    Cell Significance Index: -40.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5778
    Cell Significance Index: -50.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.6292
    Cell Significance Index: -85.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.6310
    Cell Significance Index: -61.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.6339
    Cell Significance Index: -27.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.6491
    Cell Significance Index: -36.1100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.6680
    Cell Significance Index: -28.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.7121
    Cell Significance Index: -45.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.7761
    Cell Significance Index: -58.1500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.7876
    Cell Significance Index: -25.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.8435
    Cell Significance Index: -64.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.0478
    Cell Significance Index: -71.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TEAD1 is a transcription factor that belongs to the TEA domain family, which is characterized by the presence of a TEA domain, a conserved DNA-binding motif. This domain allows TEAD1 to interact with specific DNA sequences, thereby regulating gene expression. TEAD1 is a dimeric transcription factor, consisting of two TEA domains, which cooperate to bind to target DNA sequences. The gene is highly conserved across species, suggesting its essential role in evolutionarily conserved biological processes. **Pathways and Functions** TEAD1 is involved in various signaling pathways, including: 1. **Hippo Signaling**: TEAD1 interacts with YAP1 and WWTR1 (Taz) to regulate gene expression in response to Hippo pathway activation. 2. **Chromatin Regulation**: TEAD1 binds to chromatin, influencing chromatin structure and gene expression. 3. **RNA Polymerase II**: TEAD1 regulates the activity of RNA polymerase II, a key enzyme in transcriptional regulation. 4. **Developmental Biology**: TEAD1 is crucial for embryonic development, nervous system formation, and tissue patterning. 5. **Cell Growth and Proliferation**: TEAD1 promotes cell growth and proliferation by regulating the expression of genes involved in these processes. **Clinical Significance** TEAD1 dysregulation has been implicated in various human diseases, including: 1. **Neurological Disorders**: TEAD1 mutations have been associated with neurological disorders, such as schizophrenia and autism spectrum disorder. 2. **Cancer**: TEAD1 is overexpressed in certain types of cancer, including breast cancer and lung cancer, and is involved in tumor progression and metastasis. 3. **Cardiovascular Diseases**: TEAD1 is involved in cardiac development and function, and its dysregulation has been linked to cardiovascular diseases, such as heart failure and arrhythmias. In conclusion, TEAD1 is a multifunctional transcription factor that plays a critical role in regulating gene expression during embryonic development, nervous system formation, and tissue homeostasis. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the molecular mechanisms underlying TEAD1 function and its clinical significance. **References** [List of references cited in the article] Note: The references listed are not provided in the original text, but they should be included in the article to support the discussion and provide additional evidence for the functions and significance of TEAD1.

Genular Protein ID: 3258424640

Symbol: TEAD1_HUMAN

Name: Transcriptional enhancer factor TEF-1

UniProtKB Accession Codes:

P28347 A4FUP2 E7EV65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1851669

Title: Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1.

PubMed ID: 1851669

DOI: 10.1016/0092-8674(91)90088-g

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2070413

Title: The TEA domain: a novel, highly conserved DNA-binding motif.

PubMed ID: 2070413

DOI: 10.1016/0092-8674(91)90132-i

PubMed ID: 18579750

Title: TEAD mediates YAP-dependent gene induction and growth control.

PubMed ID: 18579750

DOI: 10.1101/gad.1664408

PubMed ID: 19324877

Title: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.

PubMed ID: 19324877

DOI: 10.1074/jbc.m900843200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 38512451

Title: The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.

PubMed ID: 38512451

DOI: 10.1172/jci174587

PubMed ID: 17085591

Title: Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain.

PubMed ID: 17085591

DOI: 10.1073/pnas.0607171103

PubMed ID: 20123905

Title: Structural insights into the YAP and TEAD complex.

PubMed ID: 20123905

DOI: 10.1101/gad.1865810

PubMed ID: 15016762

Title: A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration).

PubMed ID: 15016762

DOI: 10.1093/hmg/ddh106

Sequence Information:

  • Length: 426
  • Mass: 47946
  • Checksum: EFD8067F2770B3C7
  • Sequence:
    • MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL 
SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSRDFHSKLK DQTAKDKALQ 
HMAAMSSAQI VSATAIHNKL GLPGIPRPTF PGAPGFWPGM IQTGQPGSSQ DVKPFVQQAY 
PIQPAVTAPI PGFEPASAPA PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV 
HIGHANHSYS DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD 
DAGAFYGVTS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV YRINRSPMCE 
YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL LCMACVFEVS NSEHGAQHHI 
YRLVKD

Genular Protein ID: 4087379742

Symbol: Q59EF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EF3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 Pfam 2 RefSeq 1

Sequence Information:

  • Length: 371
  • Mass: 41580
  • Checksum: 6031C975B2E7BFE1
  • Sequence:
    • VWFSLLAVLF IHACLLFLAY FVALYFSPCA RGCACVTCLV AMRYVLSWCV TVTFKDQTAK 
DKALQHMAAM SSAQIVSATA IHNKLGLPGI PRPTFPGAPG FWPGMIQTGQ PGSSQDVKPF 
VQQAYPIQPA VTAPIPGFEP ASAPAPSVPA WQGRSIGTTK LRLVEFSAFL EQQRDPDSYN 
KHLFVHIGHA NHSYSDPLLE SVDIRQIYDK FPEKKGGLKE LFGKGPQNAF FLVKFWADLN 
CNIQDDAGAF YGVTSQYESS ENMTVTCSTK VCSFGKQVVE KVETEYARFE NGRFVYRINR 
SPMCEYMINF IHKLKHLPEK YMMNSVLENF TILLVVTNRD TQETLLCMAC VFEVSNSEHG 
AQHHIYRLVK D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.