Details for: TFPI

Gene ID: 7035

Symbol: TFPI

Ensembl ID: ENSG00000003436

Description: tissue factor pathway inhibitor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 270.7894
    Cell Significance Index: -42.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.5427
    Cell Significance Index: -36.1600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 99.5758
    Cell Significance Index: -41.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.7013
    Cell Significance Index: -42.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.6292
    Cell Significance Index: -35.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.4080
    Cell Significance Index: -35.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.5106
    Cell Significance Index: -42.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.8648
    Cell Significance Index: -36.9100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 12.3876
    Cell Significance Index: 76.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7386
    Cell Significance Index: -42.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.4889
    Cell Significance Index: 143.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.6076
    Cell Significance Index: 44.7700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.4733
    Cell Significance Index: 32.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.1006
    Cell Significance Index: 99.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.2211
    Cell Significance Index: 121.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.0488
    Cell Significance Index: 108.1100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.8728
    Cell Significance Index: 23.9600
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 3.4335
    Cell Significance Index: 11.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.4018
    Cell Significance Index: 60.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3428
    Cell Significance Index: 663.3900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.4776
    Cell Significance Index: 19.5600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.1727
    Cell Significance Index: 31.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9531
    Cell Significance Index: 250.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.7298
    Cell Significance Index: 87.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6748
    Cell Significance Index: 272.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3061
    Cell Significance Index: 1179.3100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.2965
    Cell Significance Index: 12.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.2711
    Cell Significance Index: 7.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2636
    Cell Significance Index: 65.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2455
    Cell Significance Index: 30.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1346
    Cell Significance Index: 12.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0258
    Cell Significance Index: 119.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7960
    Cell Significance Index: 151.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7462
    Cell Significance Index: 102.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6056
    Cell Significance Index: 45.1400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5987
    Cell Significance Index: 6.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4561
    Cell Significance Index: 345.2100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4245
    Cell Significance Index: 1.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2992
    Cell Significance Index: 7.4800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2961
    Cell Significance Index: 4.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2215
    Cell Significance Index: 21.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1305
    Cell Significance Index: 6.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1173
    Cell Significance Index: 64.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0660
    Cell Significance Index: 8.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0302
    Cell Significance Index: 1.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0135
    Cell Significance Index: 2.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0087
    Cell Significance Index: 0.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0074
    Cell Significance Index: -0.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0097
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0125
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.3300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0157
    Cell Significance Index: -0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0166
    Cell Significance Index: -31.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0199
    Cell Significance Index: -36.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0216
    Cell Significance Index: -3.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0275
    Cell Significance Index: -42.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0325
    Cell Significance Index: -44.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0450
    Cell Significance Index: -2.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0505
    Cell Significance Index: -34.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0521
    Cell Significance Index: -29.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0570
    Cell Significance Index: -36.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0691
    Cell Significance Index: -30.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0713
    Cell Significance Index: -32.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0836
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0928
    Cell Significance Index: -19.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1022
    Cell Significance Index: -11.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1124
    Cell Significance Index: -40.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1465
    Cell Significance Index: -42.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1584
    Cell Significance Index: -31.7700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1967
    Cell Significance Index: -3.3800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1976
    Cell Significance Index: -1.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1979
    Cell Significance Index: -20.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2043
    Cell Significance Index: -22.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2126
    Cell Significance Index: -16.3200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2496
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2604
    Cell Significance Index: -29.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2760
    Cell Significance Index: -5.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2870
    Cell Significance Index: -41.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3054
    Cell Significance Index: -39.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3110
    Cell Significance Index: -19.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3297
    Cell Significance Index: -9.5000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3674
    Cell Significance Index: -3.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4123
    Cell Significance Index: -42.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4191
    Cell Significance Index: -11.2300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.4515
    Cell Significance Index: -2.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4537
    Cell Significance Index: -32.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4656
    Cell Significance Index: -28.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4731
    Cell Significance Index: -37.4700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.4758
    Cell Significance Index: -2.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4922
    Cell Significance Index: -10.5200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.5446
    Cell Significance Index: -6.6300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.5462
    Cell Significance Index: -7.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5583
    Cell Significance Index: -26.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6059
    Cell Significance Index: -15.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6152
    Cell Significance Index: -19.7100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6191
    Cell Significance Index: -3.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6429
    Cell Significance Index: -43.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6811
    Cell Significance Index: -42.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6895
    Cell Significance Index: -44.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** TFPI is a serine protease inhibitor that contains three conserved cysteine residues and exhibits a unique structural fold, which allows it to bind to and inhibit the activity of various proteases, including tissue factor factor VIIa. 2. **Cellular Expression:** TFPI is expressed in a variety of cell types, including endothelial cells, fibroblasts, and enterocytes, which highlights its widespread role in maintaining tissue homeostasis. 3. **Regulation of Blood Coagulation:** TFPI acts as a negative regulator of the extrinsic pathway of fibrin clot formation by inhibiting the conversion of tissue factor to activated factor VIIa, thereby preventing excessive thrombin generation and clot formation. **Pathways and Functions:** 1. **Blood Coagulation:** TFPI regulates the extrinsic pathway of fibrin clot formation by inhibiting the activity of tissue factor factor VIIa, thereby preventing excessive thrombin generation and clot formation. 2. **Cellular Response to Steroid Hormone Stimulus:** TFPI has been implicated in the regulation of cellular response to steroid hormone stimulus, suggesting a potential role in the modulation of cellular growth and differentiation. 3. **Endopeptidase Inhibition:** TFPI exhibits endopeptidase inhibitor activity, which may contribute to its role in regulating cellular growth and differentiation. 4. **Extracellular Matrix Deposition:** TFPI has been implicated in the regulation of extracellular matrix deposition, suggesting a potential role in maintaining tissue homeostasis. **Clinical Significance:** Dysregulation of TFPI has been implicated in various pathological conditions, including: 1. **Thrombosis:** Excessive TFPI activity has been linked to an increased risk of thrombosis, highlighting the importance of TFPI in maintaining vascular homeostasis. 2. **Cancer:** TFPI has been implicated in the regulation of cellular growth and differentiation, and its dysregulation has been linked to various types of cancer. 3. **Cardiovascular Disease:** TFPI has been implicated in the regulation of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. In conclusion, TFPI is a multifunctional protein that plays a crucial role in regulating blood coagulation and maintaining vascular homeostasis. Its dysregulation has been implicated in various pathological conditions, highlighting the importance of further research into the mechanisms and clinical significance of TFPI.

Genular Protein ID: 2355120815

Symbol: TFPI1_HUMAN

Name: Tissue factor pathway inhibitor

UniProtKB Accession Codes:

P10646 O95103 Q53TS4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 21 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 3 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2452157

Title: Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains.

PubMed ID: 2452157

DOI: 10.1016/s0021-9258(18)68737-x

PubMed ID: 2781520

Title: Identification of the 1.4 kb and 4.0 kb messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein.

PubMed ID: 2781520

DOI: 10.1016/0049-3848(89)90454-4

PubMed ID: 1993173

Title: Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation.

PubMed ID: 1993173

DOI: 10.1021/bi00220a018

PubMed ID: 2002045

Title: Structure of the human lipoprotein-associated coagulation inhibitor gene. Intro/exon gene organization and localization of the gene to chromosome 2.

PubMed ID: 2002045

DOI: 10.1016/s0021-9258(19)67752-5

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19017259

Title: Biochemical characterization of plasma-derived tissue factor pathway inhibitor: post-translational modification of free, full-length form with particular reference to the sugar chain.

PubMed ID: 19017259

DOI: 10.1111/j.1538-7836.2008.03222.x

PubMed ID: 2553722

Title: Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma.

PubMed ID: 2553722

DOI: 10.1016/s0021-9258(18)51542-8

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2927510

Title: Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor.

PubMed ID: 2927510

DOI: 10.1038/338518a0

PubMed ID: 8639592

Title: Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N- and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2.

PubMed ID: 8639592

DOI: 10.1021/bi9524880

PubMed ID: 2271516

Title: Regulation of coagulation by a multivalent Kunitz-type inhibitor.

PubMed ID: 2271516

DOI: 10.1021/bi00485a001

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22144186

Title: TFPIbeta is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes.

PubMed ID: 22144186

DOI: 10.1182/blood-2011-10-388512

PubMed ID: 9242660

Title: The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition.

PubMed ID: 9242660

DOI: 10.1074/jbc.272.32.19931

PubMed ID: 9199408

Title: The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.

PubMed ID: 9199408

DOI: 10.1006/jmbi.1997.1029

PubMed ID: 11772005

Title: Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor.

PubMed ID: 11772005

DOI: 10.1021/bi011299g

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 304
  • Mass: 35015
  • Checksum: 5281E32B758B44FE
  • Sequence:
    • MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD 
GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTRDNAN RIIKTTLQQE 
KPDFCFLEED PGICRGYITR YFYNNQTKQC ERFKYGGCLG NMNNFETLEE CKNICEDGPN 
GFQVDNYGTQ LNAVNNSLTP QSTKVPSLFE FHGPSWCLTP ADRGLCRANE NRFYYNSVIG 
KCRPFKYSGC GGNENNFTSK QECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEIF 
VKNM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.