Details for: TFPI

Gene ID: 7035

Symbol: TFPI

Ensembl ID: ENSG00000003436

Description: tissue factor pathway inhibitor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.65
    Marker Score: 3195
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 4.6
    Marker Score: 7096
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.28
    Marker Score: 10882
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.67
    Marker Score: 3921
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.63
    Marker Score: 3128
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.54
    Marker Score: 2329
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 3.15
    Marker Score: 1795
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.99
    Marker Score: 101807
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.93
    Marker Score: 9600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.86
    Marker Score: 7477
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.83
    Marker Score: 18478
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.8
    Marker Score: 4063
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.79
    Marker Score: 2987.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.69
    Marker Score: 1120
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.62
    Marker Score: 4203
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.53
    Marker Score: 2158
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.46
    Marker Score: 2826
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.41
    Marker Score: 3482
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.36
    Marker Score: 1279
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.3
    Marker Score: 9926
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.28
    Marker Score: 36647
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.26
    Marker Score: 1256
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.21
    Marker Score: 550
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.19
    Marker Score: 550
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.15
    Marker Score: 522
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.12
    Marker Score: 4083.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.03
    Marker Score: 444
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2
    Marker Score: 10742
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.95
    Marker Score: 3826
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.95
    Marker Score: 415
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.83
    Marker Score: 1771
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.79
    Marker Score: 7742
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.79
    Marker Score: 11529
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.78
    Marker Score: 1124.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.77
    Marker Score: 23388
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.76
    Marker Score: 1774
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.73
    Marker Score: 1082
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.73
    Marker Score: 3453
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.72
    Marker Score: 23156
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.7
    Marker Score: 2874.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.69
    Marker Score: 438
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.67
    Marker Score: 5915
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.61
    Marker Score: 455
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.6
    Marker Score: 1974
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.6
    Marker Score: 440
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.6
    Marker Score: 1157
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.56
    Marker Score: 8199
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.54
    Marker Score: 1388
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.5
    Marker Score: 840.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.5
    Marker Score: 582
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.49
    Marker Score: 2200
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.49
    Marker Score: 368
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.45
    Marker Score: 348
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.43
    Marker Score: 835
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.43
    Marker Score: 1959
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.4
    Marker Score: 1746
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.39
    Marker Score: 320
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.37
    Marker Score: 394
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.34
    Marker Score: 378
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.33
    Marker Score: 1348
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.33
    Marker Score: 1266
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.33
    Marker Score: 429
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.32
    Marker Score: 1422
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.32
    Marker Score: 497
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.32
    Marker Score: 11549
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.31
    Marker Score: 1410
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.3
    Marker Score: 682
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 1.29
    Marker Score: 416
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.28
    Marker Score: 1150
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.23
    Marker Score: 527
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.22
    Marker Score: 13719
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.22
    Marker Score: 272
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.21
    Marker Score: 282
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.17
    Marker Score: 800
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.17
    Marker Score: 262
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.13
    Marker Score: 288
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.13
    Marker Score: 297
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.13
    Marker Score: 421
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.12
    Marker Score: 4409
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.11
    Marker Score: 1299
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.11
    Marker Score: 1044
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.11
    Marker Score: 729
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.1
    Marker Score: 321
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.08
    Marker Score: 377
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.05
    Marker Score: 1129
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.04
    Marker Score: 4017
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251720
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.02
    Marker Score: 4881
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.02
    Marker Score: 1056
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1
    Marker Score: 1541
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1
    Marker Score: 254
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71737
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1
    Marker Score: 997
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47963
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.99
    Marker Score: 489
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.99
    Marker Score: 479
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.97
    Marker Score: 8238
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454

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Other Information

**Key Characteristics:** 1. **Structure and Function:** TFPI is a serine protease inhibitor that contains three conserved cysteine residues and exhibits a unique structural fold, which allows it to bind to and inhibit the activity of various proteases, including tissue factor factor VIIa. 2. **Cellular Expression:** TFPI is expressed in a variety of cell types, including endothelial cells, fibroblasts, and enterocytes, which highlights its widespread role in maintaining tissue homeostasis. 3. **Regulation of Blood Coagulation:** TFPI acts as a negative regulator of the extrinsic pathway of fibrin clot formation by inhibiting the conversion of tissue factor to activated factor VIIa, thereby preventing excessive thrombin generation and clot formation. **Pathways and Functions:** 1. **Blood Coagulation:** TFPI regulates the extrinsic pathway of fibrin clot formation by inhibiting the activity of tissue factor factor VIIa, thereby preventing excessive thrombin generation and clot formation. 2. **Cellular Response to Steroid Hormone Stimulus:** TFPI has been implicated in the regulation of cellular response to steroid hormone stimulus, suggesting a potential role in the modulation of cellular growth and differentiation. 3. **Endopeptidase Inhibition:** TFPI exhibits endopeptidase inhibitor activity, which may contribute to its role in regulating cellular growth and differentiation. 4. **Extracellular Matrix Deposition:** TFPI has been implicated in the regulation of extracellular matrix deposition, suggesting a potential role in maintaining tissue homeostasis. **Clinical Significance:** Dysregulation of TFPI has been implicated in various pathological conditions, including: 1. **Thrombosis:** Excessive TFPI activity has been linked to an increased risk of thrombosis, highlighting the importance of TFPI in maintaining vascular homeostasis. 2. **Cancer:** TFPI has been implicated in the regulation of cellular growth and differentiation, and its dysregulation has been linked to various types of cancer. 3. **Cardiovascular Disease:** TFPI has been implicated in the regulation of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. In conclusion, TFPI is a multifunctional protein that plays a crucial role in regulating blood coagulation and maintaining vascular homeostasis. Its dysregulation has been implicated in various pathological conditions, highlighting the importance of further research into the mechanisms and clinical significance of TFPI.

Genular Protein ID: 2355120815

Symbol: TFPI1_HUMAN

Name: Tissue factor pathway inhibitor

UniProtKB Accession Codes:

P10646 O95103 Q53TS4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 21 EMDB 1 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 3 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 8 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2452157

Title: Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains.

PubMed ID: 2452157

DOI: 10.1016/s0021-9258(18)68737-x

PubMed ID: 2781520

Title: Identification of the 1.4 kb and 4.0 kb messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein.

PubMed ID: 2781520

DOI: 10.1016/0049-3848(89)90454-4

PubMed ID: 1993173

Title: Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation.

PubMed ID: 1993173

DOI: 10.1021/bi00220a018

PubMed ID: 2002045

Title: Structure of the human lipoprotein-associated coagulation inhibitor gene. Intro/exon gene organization and localization of the gene to chromosome 2.

PubMed ID: 2002045

DOI: 10.1016/s0021-9258(19)67752-5

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19017259

Title: Biochemical characterization of plasma-derived tissue factor pathway inhibitor: post-translational modification of free, full-length form with particular reference to the sugar chain.

PubMed ID: 19017259

DOI: 10.1111/j.1538-7836.2008.03222.x

PubMed ID: 2553722

Title: Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma.

PubMed ID: 2553722

DOI: 10.1016/s0021-9258(18)51542-8

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2927510

Title: Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor.

PubMed ID: 2927510

DOI: 10.1038/338518a0

PubMed ID: 8639592

Title: Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N- and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2.

PubMed ID: 8639592

DOI: 10.1021/bi9524880

PubMed ID: 2271516

Title: Regulation of coagulation by a multivalent Kunitz-type inhibitor.

PubMed ID: 2271516

DOI: 10.1021/bi00485a001

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22144186

Title: TFPIbeta is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes.

PubMed ID: 22144186

DOI: 10.1182/blood-2011-10-388512

PubMed ID: 9242660

Title: The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition.

PubMed ID: 9242660

DOI: 10.1074/jbc.272.32.19931

PubMed ID: 9199408

Title: The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.

PubMed ID: 9199408

DOI: 10.1006/jmbi.1997.1029

PubMed ID: 11772005

Title: Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor.

PubMed ID: 11772005

DOI: 10.1021/bi011299g

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 304
  • Mass: 35015
  • Checksum: 5281E32B758B44FE
  • Sequence:
    • MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD 
GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTRDNAN RIIKTTLQQE 
KPDFCFLEED PGICRGYITR YFYNNQTKQC ERFKYGGCLG NMNNFETLEE CKNICEDGPN 
GFQVDNYGTQ LNAVNNSLTP QSTKVPSLFE FHGPSWCLTP ADRGLCRANE NRFYYNSVIG 
KCRPFKYSGC GGNENNFTSK QECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEIF 
VKNM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.