Gene TGFA - ENSG00000163235 | NCBI Gene ID: 7039

Details for: TGFA

Gene ID: 7039

Symbol: TGFA

Ensembl ID: ENSG00000163235

Description: transforming growth factor alpha

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Copii-mediated vesicle transport
(R-HSA-204005)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Er to golgi anterograde transport
(R-HSA-199977)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Grb2 events in egfr signaling
(R-HSA-179812)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Raf/map kinase cascade
(R-HSA-5673001)
Rna polymerase ii transcription
(R-HSA-73857)
Shc1 events in egfr signaling
(R-HSA-180336)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tfap2 (ap-2) family regulates transcription of growth factors and their receptors
(R-HSA-8866910)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Angiogenesis
(GO:0001525)
Basolateral plasma membrane
(GO:0016323)
Cell surface
(GO:0009986)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytoplasmic vesicle
(GO:0031410)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Er to golgi transport vesicle membrane
(GO:0012507)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Hepatocyte proliferation
(GO:0072574)
Intracellular signal transduction
(GO:0035556)
Mammary gland alveolus development
(GO:0060749)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 2.12
Marker Score: 823
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.39
Marker Score: 948
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.29
Marker Score: 1423.5
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.25
Marker Score: 2935
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 791
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71814
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48039
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.97
Marker Score: 314
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.97
Marker Score: 766
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.93
Marker Score: 1765
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.92
Marker Score: 14421
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5145
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.86
Marker Score: 1746
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.79
Marker Score: 836
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 312
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.76
Marker Score: 458
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 682
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.74
Marker Score: 765
Cell Name: plasmablast (CL0000980)
Fold Change: 0.73
Marker Score: 973
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.71
Marker Score: 206
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.69
Marker Score: 1747
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.62
Marker Score: 126
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.62
Marker Score: 672.5
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.61
Marker Score: 467
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.59
Marker Score: 394
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.59
Marker Score: 728
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.58
Marker Score: 850
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.54
Marker Score: 546
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.52
Marker Score: 476
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.52
Marker Score: 17922
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.51
Marker Score: 723
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.5
Marker Score: 4342
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.5
Marker Score: 1237
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.5
Marker Score: 145
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.5
Marker Score: 132
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.49
Marker Score: 203
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.48
Marker Score: 1148
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.46
Marker Score: 484
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.45
Marker Score: 403
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.45
Marker Score: 1414
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.45
Marker Score: 141
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 439
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.44
Marker Score: 210
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.4
Marker Score: 105
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.4
Marker Score: 179
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.4
Marker Score: 1153
Cell Name: neutrophil (CL0000775)
Fold Change: 0.39
Marker Score: 239
Cell Name: enterocyte (CL0000584)
Fold Change: 0.37
Marker Score: 1792
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.37
Marker Score: 372
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.36
Marker Score: 2849
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.36
Marker Score: 104
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.35
Marker Score: 290
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.35
Marker Score: 162
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.35
Marker Score: 2207
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.34
Marker Score: 336
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.34
Marker Score: 121
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.34
Marker Score: 228
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.33
Marker Score: 164
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.33
Marker Score: 1167
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.33
Marker Score: 155
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.33
Marker Score: 226
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.32
Marker Score: 187
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.32
Marker Score: 75
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.32
Marker Score: 101
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.31
Marker Score: 155
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.31
Marker Score: 2713
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.31
Marker Score: 142
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.31
Marker Score: 311
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.31
Marker Score: 155
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.29
Marker Score: 773
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.29
Marker Score: 71
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.28
Marker Score: 335
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.27
Marker Score: 625
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.27
Marker Score: 119
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.27
Marker Score: 273
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.27
Marker Score: 692
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.27
Marker Score: 651
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.27
Marker Score: 70
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.26
Marker Score: 169.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.26
Marker Score: 418
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.26
Marker Score: 232
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.26
Marker Score: 433
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.26
Marker Score: 325
Cell Name: oocyte (CL0000023)
Fold Change: 0.26
Marker Score: 64
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.26
Marker Score: 153
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.25
Marker Score: 1889
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.25
Marker Score: 268
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.25
Marker Score: 129

Hover over a box to see details here...

**Key Characteristics:** 1. **Cell Surface Expression**: TGFA is primarily secreted onto the cell surface, where it interacts with its receptor, the Epidermal Growth Factor Receptor (EGFR). 2. **Receptor Binding**: Upon binding to EGFR, TGFA triggers a cascade of intracellular signaling events, leading to the activation of various downstream pathways. 3. **Signaling Pathways**: TGFA is implicated in multiple signaling pathways, including the PI3K/AKT, MAPK, and Rac1/ROCK pathways, which regulate cell growth, survival, migration, and differentiation. 4. **Diverse Cellular Expression**: TGFA is expressed in various cell types, including epithelial cells, neurons, immune cells, and cancer cells, highlighting its role in multiple physiological and pathological processes. **Pathways and Functions:** TGFA's involvement in multiple signaling pathways and cellular processes can be summarized as follows: 1. **Cell Proliferation and Survival**: TGFA regulates cell growth and survival by activating the PI3K/AKT pathway, leading to the phosphorylation and activation of downstream targets, such as BCL-2 and BCL-XL. 2. **Differentiation and Migration**: TGFA influences cell differentiation and migration by activating the MAPK pathway, which regulates the expression of genes involved in these processes. 3. **Apoptosis and Cell Death**: TGFA can also induce apoptosis by activating the caspase cascade, leading to the cleavage and activation of caspase-3 and -9. 4. **Angiogenesis**: TGFA is involved in angiogenesis, the formation of new blood vessels, by regulating the expression of vascular endothelial growth factor (VEGF) and other angiogenic factors. **Clinical Significance:** TGFA's involvement in various diseases and disorders has significant clinical implications: 1. **Cancer**: TGFA's overexpression is associated with various cancers, including breast, lung, and colon cancer, where it contributes to tumor growth, metastasis, and resistance to therapy. 2. **Neurological Disorders**: TGFA's dysregulation has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Inflammatory Diseases**: TGFA's role in inflammation and immune responses makes it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and asthma. 4. **Wound Healing**: TGFA's involvement in wound healing and tissue repair highlights its potential as a therapeutic target for wound closure and tissue regeneration. In conclusion, TGFA is a multifaceted gene that plays a critical role in various cellular processes, including cell signaling, growth, differentiation, and survival. Its dysregulation has significant clinical implications, making it an attractive target for the development of novel therapeutic strategies for various diseases and disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 821531604

Symbol: TGFA_HUMAN

Name: Protransforming growth factor alpha

UniProtKB Accession Codes:

P01135 A8K286 Q15577 Q53SK7 Q9BS56 Q9UEI3 Q9UKM1 Q9UKM2 Q9UKM3

Database IDs:

Citations:

PubMed ID: 6088071

Title: Human transforming growth factor-alpha: precursor structure and expression in E. coli.

PubMed ID: 6088071

DOI: 10.1016/0092-8674(84)90550-6

PubMed ID: 2464748

Title: A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA.

PubMed ID: 2464748

DOI: 10.1210/mend-2-11-1056

PubMed ID: 8224876

Title: Human transforming growth factor alpha: sequence analysis of the 4.5-kb and 1.6-kb mRNA species.

PubMed ID: 8224876

DOI: 10.1016/0378-1119(93)90210-t

PubMed ID: 8100397

Title: Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions.

PubMed ID: 8100397

PubMed ID: 10552925

Title: Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only.

PubMed ID: 10552925

DOI: 10.1006/geno.1999.5962

PubMed ID: 10523832

Title: Human keratinocytes and tumor-derived cell lines express alternatively spliced forms of transforming growth factor-alpha mRNA, encoding precursors lacking carboxyl-terminal valine residues.

PubMed ID: 10523832

DOI: 10.1038/sj.onc.1203091

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2907605

Title: The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

PubMed ID: 2907605

DOI: 10.1128/mcb.8.12.5549-5554.1988

PubMed ID: 10066034

Title: TGFA: exon-intron structure and evaluation as a candidate gene for Alstrom syndrome.

PubMed ID: 10066034

DOI: 10.1034/j.1399-0004.1999.550111.x

PubMed ID: 1632509

Title: Characterization of disulfide bond position in proteins and sequence analysis of cystine-bridged peptides by tandem mass spectrometry.

PubMed ID: 1632509

DOI: 10.1016/0003-2697(92)90331-z

PubMed ID: 8910478

Title: Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.

PubMed ID: 8910478

DOI: 10.1074/jbc.271.45.28502

PubMed ID: 10230395

Title: A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.

PubMed ID: 10230395

DOI: 10.1016/s1097-2765(00)80470-0

PubMed ID: 17607000

Title: Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells.

PubMed ID: 17607000

DOI: 10.1242/jcs.004200

PubMed ID: 18757723

Title: EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.

PubMed ID: 18757723

DOI: 10.1073/pnas.0806298105

PubMed ID: 2261437

Title: Solution structures of human transforming growth factor alpha derived from 1H NMR data.

PubMed ID: 2261437

DOI: 10.1021/bi00486a005

PubMed ID: 2050136

Title: The solution structure of human transforming growth factor alpha.

PubMed ID: 2050136

DOI: 10.1111/j.1432-1033.1991.tb16050.x

PubMed ID: 8338831

Title: Solution structure of human type-alpha transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints.

PubMed ID: 8338831

DOI: 10.1021/bi00080a003

Sequence Information:

Length: 160
Mass: 17006
Checksum: D692184F9353DE47
Sequence:

MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC 
RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL 
IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV

Genular Protein ID: 2075850087

Symbol: E7EPT6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EPT6

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 165
Mass: 17719
Checksum: 3494D4796413D984
Sequence:

MFKIGRGALD LFSELLSFGG IVLAACQALE NSTSPLSDPP VAAAVVSHFN DCPDSHTQFC 
FHGTCRFLVQ EDKPACVCHS GYVGARCEHA DLLAVVAASQ KKQAITALVV VSIVALAVLI 
ITCVLIHCCQ VRKHCEWCRA LICRHEKPSA LLKGRTACCH SETVV

Genular Protein ID: 2656095475

Symbol: F8VNR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VNR3

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 166
Mass: 17790
Checksum: 5557180147111D21
Sequence:

MFKIGRGALD LFSELLSFGG IVLAACQALE NSTSPLSADP PVAAAVVSHF NDCPDSHTQF 
CFHGTCRFLV QEDKPACVCH SGYVGARCEH ADLLAVVAAS QKKQAITALV VVSIVALAVL 
IITCVLIHCC QVRKHCEWCR ALICRHEKPS ALLKGRTACC HSETVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TGFA

Associated with

Cells (max top 100)

Other Information

Human transforming growth factor-alpha: precursor structure and expression in E. coli. PubMed ID: 6088071

A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA. PubMed ID: 2464748

Human transforming growth factor alpha: sequence analysis of the 4.5-kb and 1.6-kb mRNA species. PubMed ID: 8224876

Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. PubMed ID: 8100397

Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only. PubMed ID: 10552925

Human keratinocytes and tumor-derived cell lines express alternatively spliced forms of transforming growth factor-alpha mRNA, encoding precursors lacking carboxyl-terminal valine residues. PubMed ID: 10523832

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. PubMed ID: 2907605

TGFA: exon-intron structure and evaluation as a candidate gene for Alstrom syndrome. PubMed ID: 10066034

Characterization of disulfide bond position in proteins and sequence analysis of cystine-bridged peptides by tandem mass spectrometry. PubMed ID: 1632509

Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association. PubMed ID: 8910478

A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. PubMed ID: 10230395

Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. PubMed ID: 17607000

EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. PubMed ID: 18757723

Solution structures of human transforming growth factor alpha derived from 1H NMR data. PubMed ID: 2261437

The solution structure of human transforming growth factor alpha. PubMed ID: 2050136

Solution structure of human type-alpha transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints. PubMed ID: 8338831

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Database document:

PubMed ID: 6088071

PubMed ID: 2464748

PubMed ID: 8224876

PubMed ID: 8100397

PubMed ID: 10552925

PubMed ID: 10523832

PubMed ID: 14702039

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 2907605

PubMed ID: 10066034

PubMed ID: 1632509

PubMed ID: 8910478

PubMed ID: 10230395

PubMed ID: 17607000

PubMed ID: 18757723

PubMed ID: 2261437

PubMed ID: 2050136

PubMed ID: 8338831

PubMed ID: 15815621

PubMed ID: 15815621