TGFA | ENSG00000163235 | NCBI 7039

Details for: TGFA

Gene ID: 7039

Symbol: TGFA

Ensembl ID: ENSG00000163235

Description: transforming growth factor alpha

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Copii-mediated vesicle transport
(R-HSA-204005)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Er to golgi anterograde transport
(R-HSA-199977)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Grb2 events in egfr signaling
(R-HSA-179812)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Raf/map kinase cascade
(R-HSA-5673001)
Rna polymerase ii transcription
(R-HSA-73857)
Shc1 events in egfr signaling
(R-HSA-180336)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tfap2 (ap-2) family regulates transcription of growth factors and their receptors
(R-HSA-8866910)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Angiogenesis
(GO:0001525)
Basolateral plasma membrane
(GO:0016323)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytoplasmic vesicle
(GO:0031410)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Er to golgi transport vesicle membrane
(GO:0012507)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Hepatocyte proliferation
(GO:0072574)
Intracellular signal transduction
(GO:0035556)
Mammary gland alveolus development
(GO:0060749)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 56.3180
Cell Significance Index: -8.7600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 34.7338
Cell Significance Index: -8.8100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 20.4304
Cell Significance Index: -8.3000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 8.8191
Cell Significance Index: -8.4200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.1049
Cell Significance Index: -8.7600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.1247
Cell Significance Index: -4.6500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.7715
Cell Significance Index: 337.1300
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.4954
Cell Significance Index: 12.7100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2541
Cell Significance Index: 17.1100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0794
Cell Significance Index: 56.0700
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.0369
Cell Significance Index: 15.0600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9571
Cell Significance Index: 94.6800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9421
Cell Significance Index: 153.2200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.8797
Cell Significance Index: 102.5200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8563
Cell Significance Index: 51.4100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8263
Cell Significance Index: 746.0800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7445
Cell Significance Index: 50.0600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.7426
Cell Significance Index: 11.1900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7191
Cell Significance Index: 15.5800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6891
Cell Significance Index: 74.9600
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.6505
Cell Significance Index: 9.2600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6230
Cell Significance Index: 17.9500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5433
Cell Significance Index: 107.8100
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.5094
Cell Significance Index: 8.4000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4862
Cell Significance Index: 22.0400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.3935
Cell Significance Index: 45.0900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3549
Cell Significance Index: 9.6600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3400
Cell Significance Index: 15.9800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3240
Cell Significance Index: 4.8600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3030
Cell Significance Index: 20.9600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2939
Cell Significance Index: 160.5100
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.2075
Cell Significance Index: 2.1400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2025
Cell Significance Index: 1.8700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1978
Cell Significance Index: 22.5800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1929
Cell Significance Index: 5.3900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.1687
Cell Significance Index: 3.5000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1548
Cell Significance Index: 107.0800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1498
Cell Significance Index: 3.1900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1276
Cell Significance Index: 3.1900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1260
Cell Significance Index: 22.7100
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.1168
Cell Significance Index: 0.4400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0931
Cell Significance Index: 4.1200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0929
Cell Significance Index: 11.4200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0759
Cell Significance Index: 3.5400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0658
Cell Significance Index: 2.4900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0593
Cell Significance Index: 7.6600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0576
Cell Significance Index: 9.8300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0511
Cell Significance Index: 10.2500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0332
Cell Significance Index: 21.0900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0244
Cell Significance Index: 1.8800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0133
Cell Significance Index: 4.7700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0012
Cell Significance Index: -0.7300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0022
Cell Significance Index: -4.1400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0033
Cell Significance Index: -6.1200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0035
Cell Significance Index: -2.6000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0043
Cell Significance Index: -1.9000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0060
Cell Significance Index: -9.2900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0061
Cell Significance Index: -4.4400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0074
Cell Significance Index: -4.1600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0077
Cell Significance Index: -10.5100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0083
Cell Significance Index: -6.3000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0167
Cell Significance Index: -3.5200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0195
Cell Significance Index: -8.8400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0219
Cell Significance Index: -0.7000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0325
Cell Significance Index: -9.3600
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.0339
Cell Significance Index: -0.2100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0355
Cell Significance Index: -2.2900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0389
Cell Significance Index: -3.9700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0429
Cell Significance Index: -0.3500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0468
Cell Significance Index: -6.8000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0566
Cell Significance Index: -4.2200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0627
Cell Significance Index: -8.6100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0630
Cell Significance Index: -8.0800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0826
Cell Significance Index: -9.7400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0857
Cell Significance Index: -8.9200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1095
Cell Significance Index: -8.6800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1163
Cell Significance Index: -7.1500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1197
Cell Significance Index: -7.3400
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.1224
Cell Significance Index: -1.5500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1258
Cell Significance Index: -8.9000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1297
Cell Significance Index: -3.8200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1411
Cell Significance Index: -7.9200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1465
Cell Significance Index: -3.9200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1471
Cell Significance Index: -9.2700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1487
Cell Significance Index: -2.1300
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.1531
Cell Significance Index: -1.1700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1572
Cell Significance Index: -8.1900
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.1618
Cell Significance Index: -1.7400
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1636
Cell Significance Index: -2.2700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1646
Cell Significance Index: -5.7200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1682
Cell Significance Index: -4.0800
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.1685
Cell Significance Index: -1.7000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1711
Cell Significance Index: -6.2800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1766
Cell Significance Index: -4.4100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1800
Cell Significance Index: -9.4500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1810
Cell Significance Index: -6.3600
Cell Name: peg cell (CL4033014)
Fold Change: -0.1835
Cell Significance Index: -4.2400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1969
Cell Significance Index: -5.6200
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.2029
Cell Significance Index: -2.1000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2107
Cell Significance Index: -3.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Cell Surface Expression**: TGFA is primarily secreted onto the cell surface, where it interacts with its receptor, the Epidermal Growth Factor Receptor (EGFR). 2. **Receptor Binding**: Upon binding to EGFR, TGFA triggers a cascade of intracellular signaling events, leading to the activation of various downstream pathways. 3. **Signaling Pathways**: TGFA is implicated in multiple signaling pathways, including the PI3K/AKT, MAPK, and Rac1/ROCK pathways, which regulate cell growth, survival, migration, and differentiation. 4. **Diverse Cellular Expression**: TGFA is expressed in various cell types, including epithelial cells, neurons, immune cells, and cancer cells, highlighting its role in multiple physiological and pathological processes. **Pathways and Functions:** TGFA's involvement in multiple signaling pathways and cellular processes can be summarized as follows: 1. **Cell Proliferation and Survival**: TGFA regulates cell growth and survival by activating the PI3K/AKT pathway, leading to the phosphorylation and activation of downstream targets, such as BCL-2 and BCL-XL. 2. **Differentiation and Migration**: TGFA influences cell differentiation and migration by activating the MAPK pathway, which regulates the expression of genes involved in these processes. 3. **Apoptosis and Cell Death**: TGFA can also induce apoptosis by activating the caspase cascade, leading to the cleavage and activation of caspase-3 and -9. 4. **Angiogenesis**: TGFA is involved in angiogenesis, the formation of new blood vessels, by regulating the expression of vascular endothelial growth factor (VEGF) and other angiogenic factors. **Clinical Significance:** TGFA's involvement in various diseases and disorders has significant clinical implications: 1. **Cancer**: TGFA's overexpression is associated with various cancers, including breast, lung, and colon cancer, where it contributes to tumor growth, metastasis, and resistance to therapy. 2. **Neurological Disorders**: TGFA's dysregulation has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Inflammatory Diseases**: TGFA's role in inflammation and immune responses makes it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and asthma. 4. **Wound Healing**: TGFA's involvement in wound healing and tissue repair highlights its potential as a therapeutic target for wound closure and tissue regeneration. In conclusion, TGFA is a multifaceted gene that plays a critical role in various cellular processes, including cell signaling, growth, differentiation, and survival. Its dysregulation has significant clinical implications, making it an attractive target for the development of novel therapeutic strategies for various diseases and disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 821531604

Symbol: TGFA_HUMAN

Name: Protransforming growth factor alpha

UniProtKB Accession Codes:

P01135 A8K286 Q15577 Q53SK7 Q9BS56 Q9UEI3 Q9UKM1 Q9UKM2 Q9UKM3

Database IDs:

Citations:

PubMed ID: 6088071

Title: Human transforming growth factor-alpha: precursor structure and expression in E. coli.

PubMed ID: 6088071

DOI: 10.1016/0092-8674(84)90550-6

PubMed ID: 2464748

Title: A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA.

PubMed ID: 2464748

DOI: 10.1210/mend-2-11-1056

PubMed ID: 8224876

Title: Human transforming growth factor alpha: sequence analysis of the 4.5-kb and 1.6-kb mRNA species.

PubMed ID: 8224876

DOI: 10.1016/0378-1119(93)90210-t

PubMed ID: 8100397

Title: Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions.

PubMed ID: 8100397

PubMed ID: 10552925

Title: Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only.

PubMed ID: 10552925

DOI: 10.1006/geno.1999.5962

PubMed ID: 10523832

Title: Human keratinocytes and tumor-derived cell lines express alternatively spliced forms of transforming growth factor-alpha mRNA, encoding precursors lacking carboxyl-terminal valine residues.

PubMed ID: 10523832

DOI: 10.1038/sj.onc.1203091

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2907605

Title: The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

PubMed ID: 2907605

DOI: 10.1128/mcb.8.12.5549-5554.1988

PubMed ID: 10066034

Title: TGFA: exon-intron structure and evaluation as a candidate gene for Alstrom syndrome.

PubMed ID: 10066034

DOI: 10.1034/j.1399-0004.1999.550111.x

PubMed ID: 1632509

Title: Characterization of disulfide bond position in proteins and sequence analysis of cystine-bridged peptides by tandem mass spectrometry.

PubMed ID: 1632509

DOI: 10.1016/0003-2697(92)90331-z

PubMed ID: 8910478

Title: Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.

PubMed ID: 8910478

DOI: 10.1074/jbc.271.45.28502

PubMed ID: 10230395

Title: A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.

PubMed ID: 10230395

DOI: 10.1016/s1097-2765(00)80470-0

PubMed ID: 17607000

Title: Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells.

PubMed ID: 17607000

DOI: 10.1242/jcs.004200

PubMed ID: 18757723

Title: EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.

PubMed ID: 18757723

DOI: 10.1073/pnas.0806298105

PubMed ID: 2261437

Title: Solution structures of human transforming growth factor alpha derived from 1H NMR data.

PubMed ID: 2261437

DOI: 10.1021/bi00486a005

PubMed ID: 2050136

Title: The solution structure of human transforming growth factor alpha.

PubMed ID: 2050136

DOI: 10.1111/j.1432-1033.1991.tb16050.x

PubMed ID: 8338831

Title: Solution structure of human type-alpha transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints.

PubMed ID: 8338831

DOI: 10.1021/bi00080a003

Sequence Information:

Length: 160
Mass: 17006
Checksum: D692184F9353DE47
Sequence:

MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC 
RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL 
IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV

Genular Protein ID: 2075850087

Symbol: E7EPT6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EPT6

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 165
Mass: 17719
Checksum: 3494D4796413D984
Sequence:

MFKIGRGALD LFSELLSFGG IVLAACQALE NSTSPLSDPP VAAAVVSHFN DCPDSHTQFC 
FHGTCRFLVQ EDKPACVCHS GYVGARCEHA DLLAVVAASQ KKQAITALVV VSIVALAVLI 
ITCVLIHCCQ VRKHCEWCRA LICRHEKPSA LLKGRTACCH SETVV

Genular Protein ID: 2656095475

Symbol: F8VNR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VNR3

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 166
Mass: 17790
Checksum: 5557180147111D21
Sequence:

MFKIGRGALD LFSELLSFGG IVLAACQALE NSTSPLSADP PVAAAVVSHF NDCPDSHTQF 
CFHGTCRFLV QEDKPACVCH SGYVGARCEH ADLLAVVAAS QKKQAITALV VVSIVALAVL 
IITCVLIHCC QVRKHCEWCR ALICRHEKPS ALLKGRTACC HSETVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TGFA

Associated with

Cells (max top 100)

Other Information

Human transforming growth factor-alpha: precursor structure and expression in E. coli. PubMed ID: 6088071

A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA. PubMed ID: 2464748

Human transforming growth factor alpha: sequence analysis of the 4.5-kb and 1.6-kb mRNA species. PubMed ID: 8224876

Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. PubMed ID: 8100397

Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only. PubMed ID: 10552925

Human keratinocytes and tumor-derived cell lines express alternatively spliced forms of transforming growth factor-alpha mRNA, encoding precursors lacking carboxyl-terminal valine residues. PubMed ID: 10523832

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. PubMed ID: 2907605

TGFA: exon-intron structure and evaluation as a candidate gene for Alstrom syndrome. PubMed ID: 10066034

Characterization of disulfide bond position in proteins and sequence analysis of cystine-bridged peptides by tandem mass spectrometry. PubMed ID: 1632509

Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association. PubMed ID: 8910478

A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. PubMed ID: 10230395

Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. PubMed ID: 17607000

EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. PubMed ID: 18757723

Solution structures of human transforming growth factor alpha derived from 1H NMR data. PubMed ID: 2261437

The solution structure of human transforming growth factor alpha. PubMed ID: 2050136

Solution structure of human type-alpha transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints. PubMed ID: 8338831

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Database document:

PubMed ID: 6088071

PubMed ID: 2464748

PubMed ID: 8224876

PubMed ID: 8100397

PubMed ID: 10552925

PubMed ID: 10523832

PubMed ID: 14702039

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 2907605

PubMed ID: 10066034

PubMed ID: 1632509

PubMed ID: 8910478

PubMed ID: 10230395

PubMed ID: 17607000

PubMed ID: 18757723

PubMed ID: 2261437

PubMed ID: 2050136

PubMed ID: 8338831

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 15815621

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 15815621