Details for: TGM1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 22.1800
Cell Significance Index: -3.4500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 13.8383
Cell Significance Index: -3.5100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 4.9254
Cell Significance Index: 67.2000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 3.4355
Cell Significance Index: -3.2800 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.9260
Cell Significance Index: 16.5500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.1325
Cell Significance Index: 31.6500 - Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.8947
Cell Significance Index: 1.0300 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.8405
Cell Significance Index: 7.2700 - Cell Name: epidermal cell (CL0000362)
Fold Change: 0.7141
Cell Significance Index: 1.6100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.6905
Cell Significance Index: 9.8300 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.6208
Cell Significance Index: 6.7900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.4249
Cell Significance Index: -0.9300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3817
Cell Significance Index: 72.6400 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.2712
Cell Significance Index: 1.8000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2240
Cell Significance Index: 22.1600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2095
Cell Significance Index: 189.1500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1463
Cell Significance Index: 3.1200 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1441
Cell Significance Index: 2.2300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1309
Cell Significance Index: 21.2900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1221
Cell Significance Index: 13.2800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0909
Cell Significance Index: 1.9900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0796
Cell Significance Index: 4.7800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0634
Cell Significance Index: 1.7300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0596
Cell Significance Index: 4.1300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0467
Cell Significance Index: 9.3600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0351
Cell Significance Index: 1.0100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0249
Cell Significance Index: 1.1300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0236
Cell Significance Index: 16.3000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0159
Cell Significance Index: 5.7200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0149
Cell Significance Index: 2.9600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0103
Cell Significance Index: 0.7300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0079
Cell Significance Index: 5.8200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0061
Cell Significance Index: 0.7100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0047
Cell Significance Index: 2.0800 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.0030
Cell Significance Index: 0.0300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0028
Cell Significance Index: 4.3400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0004
Cell Significance Index: 0.0700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0001
Cell Significance Index: -0.0500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0006
Cell Significance Index: -0.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0007
Cell Significance Index: -1.4000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0008
Cell Significance Index: -1.1300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0009
Cell Significance Index: -1.6500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0025
Cell Significance Index: -1.8900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0044
Cell Significance Index: -2.7800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0045
Cell Significance Index: -0.5600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0050
Cell Significance Index: -1.4400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0050
Cell Significance Index: -3.7300 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.0058
Cell Significance Index: -0.0700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0060
Cell Significance Index: -3.3800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0069
Cell Significance Index: -0.1500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0072
Cell Significance Index: -0.1800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0076
Cell Significance Index: -3.4600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0078
Cell Significance Index: -0.2100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0099
Cell Significance Index: -0.7900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0101
Cell Significance Index: -1.3000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0101
Cell Significance Index: -1.2900 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.0108
Cell Significance Index: -0.1100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0143
Cell Significance Index: -2.0800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0155
Cell Significance Index: -0.9500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0175
Cell Significance Index: -2.4100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0179
Cell Significance Index: -3.0500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0184
Cell Significance Index: -0.5900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0184
Cell Significance Index: -2.1100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0185
Cell Significance Index: -3.8900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0186
Cell Significance Index: -0.9400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0250
Cell Significance Index: -2.5500 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0289
Cell Significance Index: -0.7200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0297
Cell Significance Index: -0.8000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0342
Cell Significance Index: -0.7100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0344
Cell Significance Index: -3.5800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0352
Cell Significance Index: -0.5300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0356
Cell Significance Index: -1.6600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0359
Cell Significance Index: -4.2300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0386
Cell Significance Index: -1.0300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0415
Cell Significance Index: -1.7000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0422
Cell Significance Index: -3.2400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0423
Cell Significance Index: -1.9900 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0441
Cell Significance Index: -1.0200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0447
Cell Significance Index: -0.6400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0462
Cell Significance Index: -1.6200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0474
Cell Significance Index: -1.5100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0496
Cell Significance Index: -2.5800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0503
Cell Significance Index: -2.8200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0519
Cell Significance Index: -3.8700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0534
Cell Significance Index: -2.3600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0543
Cell Significance Index: -2.8500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0546
Cell Significance Index: -3.4400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0556
Cell Significance Index: -3.5900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0561
Cell Significance Index: -1.1900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0565
Cell Significance Index: -2.9500 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0613
Cell Significance Index: -1.5300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0634
Cell Significance Index: -2.4000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0637
Cell Significance Index: -2.0900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0640
Cell Significance Index: -2.3500 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0740
Cell Significance Index: -1.0600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0794
Cell Significance Index: -2.0400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0852
Cell Significance Index: -3.7000 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0865
Cell Significance Index: -2.1600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0961
Cell Significance Index: -3.3400 - Cell Name: secretory cell (CL0000151)
Fold Change: -0.0966
Cell Significance Index: -0.6700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1028394790
Symbol: TGM1_HUMAN
Name: Protein-glutamine gamma-glutamyltransferase K
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1979171
Title: Primary structure of keratinocyte transglutaminase.
PubMed ID: 1979171
PubMed ID: 1673840
Title: Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture.
PubMed ID: 1673840
PubMed ID: 1670769
Title: The complete amino acid sequence of the human transglutaminase K enzyme deduced from the nucleic acid sequences of cDNA clones.
PubMed ID: 1670769
PubMed ID: 1346394
Title: Genomic structure of keratinocyte transglutaminase. Recruitment of new exon for modified function.
PubMed ID: 1346394
PubMed ID: 1348508
Title: Structure and organization of the human transglutaminase 1 gene.
PubMed ID: 1348508
PubMed ID: 1381356
Title: Structure of the gene for human transglutaminase 1.
PubMed ID: 1381356
PubMed ID: 1350092
Title: Organization and evolution of the human epidermal keratinocyte transglutaminase I gene.
PubMed ID: 1350092
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1704039
Title: Isolation of cDNA for human epidermal type I transglutaminase.
PubMed ID: 1704039
PubMed ID: 1351505
Title: Type I keratinocyte transglutaminase: expression in human skin and psoriasis.
PubMed ID: 1351505
PubMed ID: 8973564
Title: Identification of phosphorylation sites in keratinocyte transglutaminase.
PubMed ID: 8973564
DOI: 10.1042/bj3200547
PubMed ID: 17762858
Title: Localization of the TIG3 transglutaminase interaction domain and demonstration that the amino-terminal region is required for TIG3 function as a keratinocyte differentiation regulator.
PubMed ID: 17762858
PubMed ID: 19241467
Title: Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1.
PubMed ID: 19241467
DOI: 10.1002/humu.20952
PubMed ID: 7824952
Title: Mutations of keratinocyte transglutaminase in lamellar ichthyosis.
PubMed ID: 7824952
PubMed ID: 7773290
Title: Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis.
PubMed ID: 7773290
DOI: 10.1038/ng0395-279
PubMed ID: 9326318
Title: Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population.
PubMed ID: 9326318
DOI: 10.1086/515498
PubMed ID: 11251583
Title: Novel mutations of TGM1 in a child with congenital ichthyosiform erythroderma.
PubMed ID: 11251583
PubMed ID: 11511296
Title: Novel mutations of the transglutaminase 1 gene in lamellar ichthyosis.
PubMed ID: 11511296
PubMed ID: 19890349
Title: Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients.
PubMed ID: 19890349
DOI: 10.1038/jid.2009.346
PubMed ID: 26220141
Title: Identification and functional characterization of a novel transglutaminase 1 gene mutation associated with autosomal recessive congenital ichthyosis.
PubMed ID: 26220141
DOI: 10.1111/ijd.12806
Sequence Information:
- Length: 817
- Mass: 89787
- Checksum: 4732F28234F5D5F1
- Sequence:
MMDGPRSDVG RWGGNPLQPP TTPSPEPEPE PDGRSRRGGG RSFWARCCGC CSCRNAADDD WGPEPSDSRG RGSSSGTRRP GSRGSDSRRP VSRGSGVNAA GDGTIREGML VVNGVDLLSS RSDQNRREHH TDEYEYDELI VRRGQPFHML LLLSRTYESS DRITLELLIG NNPEVGKGTH VIIPVGKGGS GGWKAQVVKA SGQNLNLRVH TSPNAIIGKF QFTVRTQSDA GEFQLPFDPR NEIYILFNPW CPEDIVYVDH EDWRQEYVLN ESGRIYYGTE AQIGERTWNY GQFDHGVLDA CLYILDRRGM PYGGRGDPVN VSRVISAMVN SLDDNGVLIG NWSGDYSRGT NPSAWVGSVE ILLSYLRTGY SVPYGQCWVF AGVTTTVLRC LGLATRTVTN FNSAHDTDTS LTMDIYFDEN MKPLEHLNHD SVWNFHVWND CWMKRPDLPS GFDGWQVVDA TPQETSSGIF CCGPCSVESI KNGLVYMKYD TPFIFAEVNS DKVYWQRQDD GSFKIVYVEE KAIGTLIVTK AISSNMREDI TYLYKHPEGS DAERKAVETA AAHGSKPNVY ANRGSAEDVA MQVEAQDAVM GQDLMVSVML INHSSSRRTV KLHLYLSVTF YTGVSGTIFK ETKKEVELAP GASDRVTMPV AYKEYRPHLV DQGAMLLNVS GHVKESGQVL AKQHTFRLRT PDLSLTLLGA AVVGQECEVQ IVFKNPLPVT LTNVVFRLEG SGLQRPKILN VGDIGGNETV TLRQSFVPVR PGPRQLIASL DSPQLSQVHG VIQVDVAPAP GDGGFFSDAG GDSHLGETIP MASRGGA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.