Details for: THBS2

Gene ID: 7058

Symbol: THBS2

Ensembl ID: ENSG00000186340

Description: thrombospondin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.2792
    Cell Significance Index: 237.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.3402
    Cell Significance Index: 67.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.4054
    Cell Significance Index: 85.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.8297
    Cell Significance Index: 173.4900
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.2673
    Cell Significance Index: 13.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8415
    Cell Significance Index: 58.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5105
    Cell Significance Index: 29.4800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.1879
    Cell Significance Index: 7.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0453
    Cell Significance Index: 52.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9688
    Cell Significance Index: 14.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8415
    Cell Significance Index: 160.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6764
    Cell Significance Index: 92.8900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.6048
    Cell Significance Index: 3.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4716
    Cell Significance Index: 46.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4343
    Cell Significance Index: 392.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2541
    Cell Significance Index: 41.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1996
    Cell Significance Index: 35.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1779
    Cell Significance Index: 78.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1733
    Cell Significance Index: 18.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0707
    Cell Significance Index: 9.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0560
    Cell Significance Index: 3.8800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0171
    Cell Significance Index: 0.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0036
    Cell Significance Index: 0.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0106
    Cell Significance Index: -6.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0149
    Cell Significance Index: -27.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0158
    Cell Significance Index: -8.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0174
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0174
    Cell Significance Index: -1.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0186
    Cell Significance Index: -28.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0204
    Cell Significance Index: -0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0211
    Cell Significance Index: -28.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0269
    Cell Significance Index: -20.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0276
    Cell Significance Index: -20.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0298
    Cell Significance Index: -18.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0309
    Cell Significance Index: -0.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0413
    Cell Significance Index: -22.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0430
    Cell Significance Index: -12.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0430
    Cell Significance Index: -15.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0435
    Cell Significance Index: -1.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0450
    Cell Significance Index: -8.9400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0474
    Cell Significance Index: -0.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0482
    Cell Significance Index: -21.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0504
    Cell Significance Index: -10.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0684
    Cell Significance Index: -11.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0685
    Cell Significance Index: -13.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0706
    Cell Significance Index: -3.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1040
    Cell Significance Index: -1.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1215
    Cell Significance Index: -8.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1251
    Cell Significance Index: -18.1800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1273
    Cell Significance Index: -1.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1285
    Cell Significance Index: -6.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1311
    Cell Significance Index: -16.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1561
    Cell Significance Index: -18.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1757
    Cell Significance Index: -4.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1864
    Cell Significance Index: -19.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2021
    Cell Significance Index: -21.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2121
    Cell Significance Index: -16.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2260
    Cell Significance Index: -25.8900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2438
    Cell Significance Index: -2.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2492
    Cell Significance Index: -5.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2628
    Cell Significance Index: -4.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2824
    Cell Significance Index: -21.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2827
    Cell Significance Index: -19.0100
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.2887
    Cell Significance Index: -2.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3470
    Cell Significance Index: -21.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3832
    Cell Significance Index: -9.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4181
    Cell Significance Index: -23.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4261
    Cell Significance Index: -8.9200
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.4374
    Cell Significance Index: -1.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4595
    Cell Significance Index: -21.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5050
    Cell Significance Index: -26.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5278
    Cell Significance Index: -17.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5476
    Cell Significance Index: -3.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5548
    Cell Significance Index: -24.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5562
    Cell Significance Index: -22.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5623
    Cell Significance Index: -13.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5710
    Cell Significance Index: -20.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5908
    Cell Significance Index: -15.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5957
    Cell Significance Index: -20.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6074
    Cell Significance Index: -21.2800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6136
    Cell Significance Index: -8.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6217
    Cell Significance Index: -17.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6499
    Cell Significance Index: -24.6100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6665
    Cell Significance Index: -16.6200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6751
    Cell Significance Index: -11.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6788
    Cell Significance Index: -21.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6819
    Cell Significance Index: -17.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6987
    Cell Significance Index: -18.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6990
    Cell Significance Index: -20.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7191
    Cell Significance Index: -19.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7255
    Cell Significance Index: -18.1200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.7392
    Cell Significance Index: -12.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7429
    Cell Significance Index: -6.2400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.7554
    Cell Significance Index: -9.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7716
    Cell Significance Index: -16.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7948
    Cell Significance Index: -20.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Glycosylation**: Thrombospondin 2 is heavily glycosylated, with multiple O-glycans attached to its extracellular domain. This post-translational modification plays a crucial role in its interactions with other proteins and cells. 2. **Cell adhesion and signaling**: Thrombospondin 2 mediates cell adhesion through its interaction with integrins, laminins, and other extracellular matrix components. It also regulates signaling pathways, including those involving PDGF and receptor tyrosine kinases. 3. **Angiogenesis regulation**: Thrombospondin 2 acts as a negative regulator of angiogenesis, inhibiting the formation of new blood vessels and promoting vascular stability. 4. **Metabolic homeostasis**: Thrombospondin 2 is involved in the regulation of metabolic processes, including protein metabolism and glycosylation. **Pathways and Functions** 1. **Basement membrane formation**: Thrombospondin 2 contributes to the formation and maintenance of the basement membrane, a critical component of tissue architecture. 2. **Cell migration and proliferation**: Thrombospondin 2 regulates cell migration and proliferation through its interactions with integrins and other extracellular matrix components. 3. **Angiogenesis**: Thrombospondin 2 inhibits angiogenesis by regulating the expression of pro- and anti-angiogenic factors. 4. **Metabolic regulation**: Thrombospondin 2 regulates protein metabolism and glycosylation, which are essential for maintaining cellular homeostasis. **Clinical Significance** 1. **Cancer**: Thrombospondin 2 is overexpressed in various cancers, including breast, lung, and colon cancer, where it promotes tumor growth and metastasis. 2. **Vascular diseases**: Thrombospondin 2 is involved in the pathogenesis of vascular diseases, such as atherosclerosis and hypertension, where it regulates vascular tone and remodeling. 3. **Inflammatory diseases**: Thrombospondin 2 is overexpressed in inflammatory diseases, including rheumatoid arthritis and atherosclerosis, where it regulates immune cell activation and tissue damage. 4. **Neurological disorders**: Thrombospondin 2 is involved in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates synaptic plasticity and neuronal survival. In conclusion, the THBS2 gene plays a multifaceted role in regulating immune responses, angiogenesis, and metabolic homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying its functions and the development of therapeutic strategies to modulate its activity.

Genular Protein ID: 2923212884

Symbol: TSP2_HUMAN

Name: Thrombospondin-2

UniProtKB Accession Codes:

P35442 A6H8N1 A7E232 Q5RI52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8406456

Title: Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region.

PubMed ID: 8406456

DOI: 10.1006/geno.1993.1308

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1559694

Title: Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans.

PubMed ID: 1559694

DOI: 10.1016/0888-7543(92)90430-z

PubMed ID: 1371676

Title: Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding.

PubMed ID: 1371676

DOI: 10.1016/0006-291x(92)91860-s

PubMed ID: 11590138

Title: Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2.

PubMed ID: 11590138

DOI: 10.1074/jbc.m104218200

PubMed ID: 18455130

Title: A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.

PubMed ID: 18455130

DOI: 10.1016/j.ajhg.2008.03.013

PubMed ID: 20714802

Title: CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo.

PubMed ID: 20714802

DOI: 10.1007/s10549-010-1085-7

PubMed ID: 16186819

Title: Structure of the calcium-rich signature domain of human thrombospondin-2.

PubMed ID: 16186819

DOI: 10.1038/nsmb997

PubMed ID: 18499674

Title: Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability.

PubMed ID: 18499674

DOI: 10.1074/jbc.m800223200

Sequence Information:

  • Length: 1172
  • Mass: 129991
  • Checksum: 415BF376F4669F6A
  • Sequence:
    • MVWRLVLLAL WVWPSTQAGH QDKDTTFDLF SISNINRKTI GAKQFRGPDP GVPAYRFVRF 
DYIPPVNADD LSKITKIMRQ KEGFFLTAQL KQDGKSRGTL LALEGPGLSQ RQFEIVSNGP 
ADTLDLTYWI DGTRHVVSLE DVGLADSQWK NVTVQVAGET YSLHVGCDLI DSFALDEPFY 
EHLQAEKSRM YVAKGSARES HFRGLLQNVH LVFENSVEDI LSKKGCQQGQ GAEINAISEN 
TETLRLGPHV TTEYVGPSSE RRPEVCERSC EELGNMVQEL SGLHVLVNQL SENLKRVSND 
NQFLWELIGG PPKTRNMSAC WQDGRFFAEN ETWVVDSCTT CTCKKFKTIC HQITCPPATC 
ASPSFVEGEC CPSCLHSVDG EEGWSPWAEW TQCSVTCGSG TQQRGRSCDV TSNTCLGPSI 
QTRACSLSKC DTRIRQDGGW SHWSPWSSCS VTCGVGNITR IRLCNSPVPQ MGGKNCKGSG 
RETKACQGAP CPIDGRWSPW SPWSACTVTC AGGIRERTRV CNSPEPQYGG KACVGDVQER 
QMCNKRSCPV DGCLSNPCFP GAQCSSFPDG SWSCGSCPVG FLGNGTHCED LDECALVPDI 
CFSTSKVPRC VNTQPGFHCL PCPPRYRGNQ PVGVGLEAAK TEKQVCEPEN PCKDKTHNCH 
KHAECIYLGH FSDPMYKCEC QTGYAGDGLI CGEDSDLDGW PNLNLVCATN ATYHCIKDNC 
PHLPNSGQED FDKDGIGDAC DDDDDNDGVT DEKDNCQLLF NPRQADYDKD EVGDRCDNCP 
YVHNPAQIDT DNNGEGDACS VDIDGDDVFN ERDNCPYVYN TDQRDTDGDG VGDHCDNCPL 
VHNPDQTDVD NDLVGDQCDN NEDIDDDGHQ NNQDNCPYIS NANQADHDRD GQGDACDPDD 
DNDGVPDDRD NCRLVFNPDQ EDLDGDGRGD ICKDDFDNDN IPDIDDVCPE NNAISETDFR 
NFQMVPLDPK GTTQIDPNWV IRHQGKELVQ TANSDPGIAV GFDEFGSVDF SGTFYVNTDR 
DDDYAGFVFG YQSSSRFYVV MWKQVTQTYW EDQPTRAYGY SGVSLKVVNS TTGTGEHLRN 
ALWHTGNTPG QVRTLWHDPR NIGWKDYTAY RWHLTHRPKT GYIRVLVHEG KQVMADSGPI 
YDQTYAGGRL GLFVFSQEMV YFSDLKYECR DI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.