Details for: TLR1

Gene ID: 7096

Symbol: TLR1

Ensembl ID: ENSG00000174125

Description: toll like receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1152
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.48
    Marker Score: 734
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 838
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.18
    Marker Score: 1430
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.16
    Marker Score: 419
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251779
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.01
    Marker Score: 2625
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48021
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.96
    Marker Score: 310
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2730
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1838
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5143
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.82
    Marker Score: 3171
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1248
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 451
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.69
    Marker Score: 685.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.62
    Marker Score: 1138
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.6
    Marker Score: 964
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.59
    Marker Score: 674
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.58
    Marker Score: 32663
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.58
    Marker Score: 1128
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.54
    Marker Score: 1306
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 951
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.5
    Marker Score: 1238
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.5
    Marker Score: 5758
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.48
    Marker Score: 194
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.46
    Marker Score: 1058
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2761
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.46
    Marker Score: 467
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.45
    Marker Score: 504
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.41
    Marker Score: 10587
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.39
    Marker Score: 159
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.36
    Marker Score: 217
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.35
    Marker Score: 264
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.34
    Marker Score: 714
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.34
    Marker Score: 5320
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 139
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.33
    Marker Score: 326
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 141
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 319
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.31
    Marker Score: 933
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.31
    Marker Score: 1906.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.31
    Marker Score: 214
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.31
    Marker Score: 126
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.31
    Marker Score: 298
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.31
    Marker Score: 143
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.31
    Marker Score: 132
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 709
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.29
    Marker Score: 158
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.29
    Marker Score: 99
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.28
    Marker Score: 978
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.28
    Marker Score: 2638
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.28
    Marker Score: 250
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.28
    Marker Score: 679
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.27
    Marker Score: 1126
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.27
    Marker Score: 94
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.27
    Marker Score: 292
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 148
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.26
    Marker Score: 173
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.26
    Marker Score: 128
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.25
    Marker Score: 242
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.25
    Marker Score: 152
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.25
    Marker Score: 321
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.24
    Marker Score: 165
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.24
    Marker Score: 48
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.24
    Marker Score: 107.5
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.24
    Marker Score: 53
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.23
    Marker Score: 134
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.23
    Marker Score: 164
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.23
    Marker Score: 54
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.23
    Marker Score: 296
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.23
    Marker Score: 116.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.22
    Marker Score: 473
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.22
    Marker Score: 113
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.22
    Marker Score: 77
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.22
    Marker Score: 54

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Other Information

**Key Characteristics** TLR1 exhibits several key characteristics that enable its function as a pattern recognition receptor (PRR). These include: 1. **Ligand recognition**: TLR1 is capable of recognizing a variety of ligands, including bacterial lipopeptides, triacyl lipopeptides, and other PAMPs. 2. **Receptor complex formation**: TLR1 forms a receptor complex with other TLRs, such as TLR2, to enhance its ligand recognition and signaling capabilities. 3. **Signaling pathway activation**: Upon ligand binding, TLR1 activates downstream signaling pathways, leading to the production of pro-inflammatory cytokines, chemokines, and type I interferons. 4. **Cellular localization**: TLR1 is expressed on various cell types, including myeloid leukocytes, macrophages, and dendritic cells, allowing it to survey the body for pathogens and initiate an immune response. 5. **Expression regulation**: TLR1 expression is tightly regulated by various factors, including transcriptional and post-transcriptional mechanisms, to ensure proper immune function. **Pathways and Functions** The TLR1 signaling pathway involves the activation of several key molecules, including: 1. **MyD88**: A critical adapter protein that mediates the signaling from TLR1 to downstream effectors. 2. **IRAK4**: A protein that interacts with MyD88 to enhance the signaling from TLR1. 3. **TRAF6**: A protein that interacts with MyD88 to activate the NF-κB transcription factor, leading to the production of pro-inflammatory cytokines and chemokines. 4. **NF-κB**: A transcription factor that regulates the expression of genes involved in inflammation and immune response. The TLR1 signaling pathway plays a critical role in the regulation of various immune responses, including: 1. **Innate immune response**: TLR1 helps to recognize and eliminate pathogens, such as bacteria and viruses. 2. **Adaptive immune response**: TLR1 can also activate the adaptive immune response by stimulating the production of cytokines and chemokines that recruit immune cells to the site of infection. 3. **Autoimmunity**: Dysregulation of TLR1 signaling has been implicated in various autoimmune diseases, such as rheumatoid arthritis and lupus. **Clinical Significance** Dysregulation of TLR1 signaling has been implicated in various diseases, including: 1. **Infectious diseases**: TLR1 plays a critical role in the recognition and elimination of pathogens, such as bacteria and viruses. 2. **Autoimmune diseases**: Dysregulation of TLR1 signaling has been implicated in various autoimmune diseases, including rheumatoid arthritis and lupus. 3. **Cancer**: TLR1 has been shown to play a role in the regulation of tumor progression and immune evasion. 4. **Neurological diseases**: TLR1 has been implicated in the pathogenesis of various neurological diseases, including Alzheimer's disease and multiple sclerosis. In conclusion, TLR1 is a critical component of the innate immune system, playing a pivotal role in the recognition and response to microbial pathogens. Its dysregulation has been implicated in various diseases, highlighting the importance of TLR1 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 819199836

Symbol: TLR1_HUMAN

Name: Toll-like receptor 1

UniProtKB Accession Codes:

Q15399 D1CS39 D1CS41 O15452 Q32MK3 Q32MK4 Q9UG90

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 8 RefSeq 8 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9435236

Title: A family of human receptors structurally related to Drosophila Toll.

PubMed ID: 9435236

DOI: 10.1073/pnas.95.2.588

PubMed ID: 18810425

Title: Natural selection in the TLR-related genes in the course of primate evolution.

PubMed ID: 18810425

DOI: 10.1007/s00251-008-0332-0

PubMed ID: 19924287

Title: The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.

PubMed ID: 19924287

DOI: 10.1371/journal.pone.0007803

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16880211

Title: Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.

PubMed ID: 16880211

DOI: 10.1074/jbc.m602794200

PubMed ID: 17548585

Title: Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy.

PubMed ID: 17548585

DOI: 10.4049/jimmunol.178.12.7520

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21078852

Title: Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.

PubMed ID: 21078852

DOI: 10.1128/iai.00806-10

PubMed ID: 11081518

Title: Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.

PubMed ID: 11081518

DOI: 10.1038/35040600

PubMed ID: 17889651

Title: Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.

PubMed ID: 17889651

DOI: 10.1016/j.cell.2007.09.008

PubMed ID: 19456232

Title: Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions.

PubMed ID: 19456232

DOI: 10.1086/599121

PubMed ID: 21618349

Title: Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.

PubMed ID: 21618349

DOI: 10.1002/humu.21486

Sequence Information:

  • Length: 786
  • Mass: 90291
  • Checksum: 1BFCCC5E42EA5242
  • Sequence:
    • MTSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL NISQNYISEL 
WTSDILSLSK LRILIISHNR IQYLDISVFK FNQELEYLDL SHNKLVKISC HPTVNLKHLD 
LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH LEKSSVLPIA HLNISKVLLV LGETYGEKED 
PEGLQDFNTE SLHIVFPTNK EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL 
QTNPKLSNLT LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK 
ALSIHQVVSD VFGFPQSYIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF LHLDFSNNLL 
TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL QQLDISQNSV SYDEKKGDCS 
WTKSLLSLNM SSNILTDTIF RCLPPRIKVL DLHSNKIKSI PKQVVKLEAL QELNVAFNSL 
TDLPGCGSFS SLSVLIIDHN SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELGEFVKNID 
QVSSEVLEGW PDSYKCDYPE SYRGTLLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL 
CSYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW VKNELLPNLE 
KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN FVQSEWCHYE LYFAHHNLFH 
EGSNSLILIL LEPIPQYSIP SSYHKLKSLM ARRTYLEWPK EKSKRGLFWA NLRAAINIKL 
TEQAKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.