Details for: GPR137B
Gene ID: 7107
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GPR137B
Ensembl ID: ENSG00000077585
Description: G protein-coupled receptor 137B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 13.27rCSI 25.05%PRS 75.96
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CSI 13.11rCSI 36.88%PRS 61.95
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CSI 8.37rCSI 19.09%PRS 57.32
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CSI 6.9rCSI 12.16%PRS 62.28
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CSI 6.35rCSI 8.7%PRS 58.55
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CSI 5.35rCSI 4.93%PRS 67.32
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CSI 4.95rCSI 7.57%PRS 80.57
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CSI 4.77rCSI 12.43%PRS 65.42
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CSI 4.31rCSI 3.19%PRS 58.41
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CSI 4.1rCSI 10.54%PRS 64.36
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CSI 4.05rCSI 14.56%PRS 45.33
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CSI 3.72rCSI 5.8%PRS 87.32
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CSI 3.63rCSI 40.88%PRS 81.74
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CSI 3.6rCSI 8.61%PRS 52.72
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CSI 3.54rCSI 2.46%PRS 76.96
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CSI 3.35rCSI 9.68%PRS 76.6
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CSI 3.32rCSI 5.58%PRS 47.03
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CSI 3.25rCSI 3.4%PRS 69.25
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CSI 3.11rCSI 10.66%PRS 54.02
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CSI 2.74rCSI 3.67%PRS 74.28
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CSI 2.62rCSI 3.8%PRS 81.13
-
CSI 2.62rCSI 2.4%PRS 74.66
-
CSI 2.59rCSI 2.25%PRS 76.34
-
CSI 2.57rCSI 4.39%PRS 86.82
-
CSI 2.48rCSI 3.69%PRS 66.79
-
CSI 2.48rCSI 5.56%PRS 81.81
-
CSI 2.47rCSI 3.11%PRS 77.37
-
CSI 2.47rCSI 5.65%PRS 65.75
-
CSI 2.45rCSI 4.92%PRS 54.66
-
CSI 2.33rCSI 6.04%PRS 60.64
-
CSI 2.28rCSI 1.54%PRS 79.03
-
CSI 2.22rCSI 3.98%PRS 65.03
-
CSI 2.21rCSI 2.65%PRS 63.79
-
CSI 2.21rCSI 3.07%PRS 64.19
-
CSI 2.21rCSI 1.74%PRS 52.54
-
CSI 2.19rCSI 52.32%PRS 46.11
-
CSI 2.16rCSI 52.17%PRS 46.88
-
CSI 2.11rCSI 2.99%PRS 62
-
CSI 2.09rCSI 4.24%PRS 44.39
-
CSI 2.07rCSI 2.66%PRS 62.56
-
CSI 1.9rCSI 7.12%PRS 57.53
-
CSI 1.87rCSI 2.16%PRS 58.54
-
CSI 1.84rCSI 2.82%PRS 74.78
-
CSI 1.72rCSI 3.02%PRS 57.83
-
CSI 1.69rCSI 1.66%PRS 68.48
-
CSI 1.6rCSI 3.17%PRS 62.7
-
CSI 1.58rCSI 3.5%PRS 63.85
-
CSI 1.57rCSI 2.3%PRS 61
-
CSI 1.57rCSI 3.51%PRS 47.68
-
CSI 1.54rCSI 1.19%PRS 66.66
-
CSI 1.53rCSI 2.44%PRS 57.92
-
CSI 1.53rCSI 2.33%PRS 74.91
-
CSI 1.52rCSI 1.9%PRS 45.17
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CSI 1.5rCSI 3.66%PRS 58.71
-
CSI 1.49rCSI 3.29%PRS 69.56
-
CSI 1.49rCSI 4.75%PRS 62.7
-
CSI 1.47rCSI 2.93%PRS 82.13
-
CSI 1.45rCSI 2.22%PRS 69.9
-
CSI 1.44rCSI 4.09%PRS 63.32
-
CSI 1.43rCSI 1.71%PRS 46.79
-
CSI 1.42rCSI 4.08%PRS 84.81
-
CSI 1.41rCSI 2.15%PRS 61.99
-
CSI 1.41rCSI 2.64%PRS 53.7
-
CSI 1.41rCSI 2.26%PRS 49.01
-
CSI 1.36rCSI 1.76%PRS 48.29
-
CSI 1.36rCSI 2.39%PRS 46.12
-
CSI 1.32rCSI 1.73%PRS 78.88
-
CSI 1.32rCSI 8.24%PRS 57.32
-
CSI 1.31rCSI 3.39%PRS 88.45
-
CSI 1.31rCSI 1.58%PRS 74.49
-
CSI 1.29rCSI 5.95%PRS 82.99
-
CSI 1.27rCSI 1.92%PRS 70.29
-
CSI 1.27rCSI 2.42%PRS 83.99
-
CSI 1.26rCSI 2.15%PRS 82.57
-
CSI 1.25rCSI 3.35%PRS 56.57
-
CSI 1.23rCSI 1.77%PRS 55.12
-
CSI 1.23rCSI 2.03%PRS 70.9
-
CSI 1.22rCSI 3.94%PRS 63.37
-
CSI 1.16rCSI 3.35%PRS 55.09
-
CSI 1.12rCSI 2.84%PRS 55.1
-
CSI 1.1rCSI 2.86%PRS 62.4
-
CSI 0.98rCSI 2.29%PRS 75.93
-
CSI 0.94rCSI 1.92%PRS 55.37
-
CSI 0.92rCSI 2.05%PRS 73.4
-
CSI 0.9rCSI 3.42%PRS 56.2
-
CSI 0.86rCSI 1.91%PRS 51.59
-
CSI 0.86rCSI 3.78%PRS 55.59
-
CSI 0.82rCSI 4.05%PRS 62.35
-
CSI 0.8rCSI 1.23%PRS 64.12
-
CSI 0.75rCSI 1.21%PRS 55.16
-
CSI 0.69rCSI 2.62%PRS 47.68
-
CSI 0.68rCSI 1.66%PRS 45.5
-
CSI 0.68rCSI 5.7%PRS 56.07
-
CSI 0.66rCSI 2.63%PRS 64.17
-
CSI 0.65rCSI 2.09%PRS 70.16
-
CSI 0.49rCSI 2.48%PRS 78.27
-
CSI 0.49rCSI 3.61%PRS 52.18
-
CSI 0.48rCSI 1.51%PRS 51.16
-
CSI 0.47rCSI 1.46%PRS 48.74
-
CSI 0.47rCSI 6.61%PRS 56.5
-
CSI 0.3rCSI 5.4%PRS 56.1%
-
CSI 0.3rCSI 2.0%PRS 48.2%
-
CSI 0.5rCSI 6.6%PRS 56.5%
-
CSI 0.5rCSI 1.5%PRS 48.7%
-
CSI 0.5rCSI 1.5%PRS 51.2%
-
CSI 0.5rCSI 3.6%PRS 52.2%
-
CSI 0.5rCSI 2.5%PRS 78.3%
-
CSI 0.7rCSI 2.1%PRS 70.2%
-
CSI 0.7rCSI 2.6%PRS 64.2%
-
CSI 0.7rCSI 5.7%PRS 56.1%
-
CSI 0.7rCSI 1.7%PRS 45.5%
-
CSI 0.7rCSI 2.6%PRS 47.7%
-
CSI 0.8rCSI 1.2%PRS 55.2%
-
CSI 0.8rCSI 1.2%PRS 64.1%
-
CSI 0.8rCSI 4.1%PRS 62.4%
-
CSI 0.9rCSI 3.8%PRS 55.6%
-
CSI 0.9rCSI 1.9%PRS 51.6%
-
CSI 0.9rCSI 3.4%PRS 56.2%
-
CSI 0.9rCSI 2.1%PRS 73.4%
-
CSI 0.9rCSI 1.9%PRS 55.4%
-
CSI 1.0rCSI 2.3%PRS 75.9%
-
CSI 1.1rCSI 2.9%PRS 62.4%
-
CSI 1.1rCSI 2.8%PRS 55.1%
-
CSI 1.2rCSI 3.4%PRS 55.1%
-
CSI 1.2rCSI 3.9%PRS 63.4%
-
CSI 1.2rCSI 2.0%PRS 70.9%
-
CSI 1.2rCSI 1.8%PRS 55.1%
-
CSI 1.3rCSI 3.4%PRS 56.6%
-
CSI 1.3rCSI 2.2%PRS 82.6%
-
CSI 1.3rCSI 2.4%PRS 84.0%
-
CSI 1.3rCSI 1.9%PRS 70.3%
-
CSI 1.3rCSI 6.0%PRS 83.0%
-
CSI 1.3rCSI 1.6%PRS 74.5%
-
CSI 1.3rCSI 3.4%PRS 88.5%
-
CSI 1.3rCSI 8.2%PRS 57.3%
-
CSI 1.3rCSI 1.7%PRS 78.9%
-
CSI 1.4rCSI 2.4%PRS 46.1%
-
CSI 1.4rCSI 1.8%PRS 48.3%
-
CSI 1.4rCSI 2.3%PRS 49.0%
-
CSI 1.4rCSI 2.6%PRS 53.7%
-
CSI 1.4rCSI 2.2%PRS 62.0%
-
CSI 1.4rCSI 4.1%PRS 84.8%
-
CSI 1.4rCSI 1.7%PRS 46.8%
-
CSI 1.4rCSI 4.1%PRS 63.3%
-
CSI 1.5rCSI 2.2%PRS 69.9%
-
CSI 1.5rCSI 2.9%PRS 82.1%
-
CSI 1.5rCSI 4.8%PRS 62.7%
-
CSI 1.5rCSI 3.3%PRS 69.6%
-
CSI 1.5rCSI 3.7%PRS 58.7%
-
CSI 1.5rCSI 1.9%PRS 45.2%
-
CSI 1.5rCSI 2.3%PRS 74.9%
-
CSI 1.5rCSI 2.4%PRS 57.9%
-
CSI 1.5rCSI 1.2%PRS 66.7%
-
CSI 1.6rCSI 3.5%PRS 47.7%
-
CSI 1.6rCSI 2.3%PRS 61.0%
-
CSI 1.6rCSI 3.5%PRS 63.9%
-
CSI 1.6rCSI 3.2%PRS 62.7%
-
CSI 1.7rCSI 1.7%PRS 68.5%
-
CSI 1.7rCSI 3.0%PRS 57.8%
-
CSI 1.8rCSI 2.8%PRS 74.8%
-
CSI 1.9rCSI 2.2%PRS 58.5%
-
CSI 1.9rCSI 7.1%PRS 57.5%
-
CSI 2.1rCSI 2.7%PRS 62.6%
-
CSI 2.1rCSI 4.2%PRS 44.4%
-
CSI 2.1rCSI 3.0%PRS 62.0%
-
CSI 2.2rCSI 52.2%PRS 46.9%
-
CSI 2.2rCSI 52.3%PRS 46.1%
-
CSI 2.2rCSI 1.7%PRS 52.5%
-
CSI 2.2rCSI 3.1%PRS 64.2%
-
CSI 2.2rCSI 2.7%PRS 63.8%
-
CSI 2.2rCSI 4.0%PRS 65.0%
-
CSI 2.3rCSI 1.5%PRS 79.0%
-
CSI 2.3rCSI 6.0%PRS 60.6%
-
CSI 2.5rCSI 4.9%PRS 54.7%
-
CSI 2.5rCSI 5.7%PRS 65.8%
-
CSI 2.5rCSI 3.1%PRS 77.4%
-
CSI 2.5rCSI 5.6%PRS 81.8%
-
CSI 2.5rCSI 3.7%PRS 66.8%
-
CSI 2.6rCSI 4.4%PRS 86.8%
-
CSI 2.6rCSI 2.3%PRS 76.3%
-
CSI 2.6rCSI 2.4%PRS 74.7%
-
CSI 2.6rCSI 3.8%PRS 81.1%
-
CSI 2.7rCSI 3.7%PRS 74.3%
-
CSI 3.1rCSI 10.7%PRS 54.0%
-
CSI 3.3rCSI 3.4%PRS 69.3%
-
CSI 3.3rCSI 5.6%PRS 47.0%
-
CSI 3.4rCSI 9.7%PRS 76.6%
-
CSI 3.5rCSI 2.5%PRS 77.0%
-
CSI 3.6rCSI 8.6%PRS 52.7%
-
CSI 3.6rCSI 40.9%PRS 81.7%
-
CSI 3.7rCSI 5.8%PRS 87.3%
-
CSI 4.1rCSI 14.6%PRS 45.3%
-
CSI 4.1rCSI 10.5%PRS 64.4%
-
CSI 4.3rCSI 3.2%PRS 58.4%
-
CSI 4.8rCSI 12.4%PRS 65.4%
-
CSI 5.0rCSI 7.6%PRS 80.6%
-
CSI 5.4rCSI 4.9%PRS 67.3%
-
CSI 6.4rCSI 8.7%PRS 58.6%
-
CSI 6.9rCSI 12.2%PRS 62.3%
-
CSI 8.4rCSI 19.1%PRS 57.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 1099924895
Symbol: G137B_HUMAN
Name: Integral membrane protein GPR137B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9521871
Title: Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development.
PubMed ID: 9521871
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 22729905
Title: TM7SF1 (GPR137B): a novel lysosome integral membrane protein.
PubMed ID: 22729905
PubMed ID: 31036939
Title: The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.
PubMed ID: 31036939
Sequence Information:
- Length: 399
- Mass: 45599
- Checksum: FE788D618A590604
- Sequence:
MRPERPRPRG SAPGPMETPP WDPARNDSLP PTLTPAVPPY VKLGLTVVYT VFYALLFVFI YVQLWLVLRY RHKRLSYQSV FLFLCLFWAS LRTVLFSFYF KDFVAANSLS PFVFWLLYCF PVCLQFFTLT LMNLYFTQVI FKAKSKYSPE LLKYRLPLYL ASLFISLVFL LVNLTCAVLV KTGNWERKVI VSVRVAINDT LFVLCAVSLS ICLYKISKMS LANIYLESKG SSVCQVTAIG VTVILLYTSR ACYNLFILSF SQNKSVHSFD YDWYNVSDQA DLKNQLGDAG YVLFGVVLFV WELLPTTLVV YFFRVRNPTK DLTNPGMVPS HGFSPRSYFF DNPRRYDSDD DLAWNIAPQG LQGGFAPDYY DWGQQTNSFL AQAGTLQDST LDPDKPSLG