Details for: GPR137B

Gene ID: 7107

Symbol: GPR137B

Ensembl ID: ENSG00000077585

Description: G protein-coupled receptor 137B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.78
    Marker Score: 3370
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.66
    Marker Score: 1555
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.07
    Marker Score: 654
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.06
    Marker Score: 5877
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.96
    Marker Score: 2634
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.91
    Marker Score: 569
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.73
    Marker Score: 7259
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.6
    Marker Score: 2225.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.46
    Marker Score: 37512
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3348
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2783
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.34
    Marker Score: 51052
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.34
    Marker Score: 1617
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.31
    Marker Score: 27955
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.28
    Marker Score: 13221
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.25
    Marker Score: 2534
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.24
    Marker Score: 76563
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.23
    Marker Score: 677
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18633
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.17
    Marker Score: 1173
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.17
    Marker Score: 1810
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.16
    Marker Score: 4473
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.11
    Marker Score: 1230
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.11
    Marker Score: 9497
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.09
    Marker Score: 1352
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.08
    Marker Score: 539
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.07
    Marker Score: 10096
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.04
    Marker Score: 9909
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.01
    Marker Score: 3583
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.01
    Marker Score: 1485
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.01
    Marker Score: 3953
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47961
  • Cell Name: neuron (CL0000540)
    Fold Change: 1
    Marker Score: 4056
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.98
    Marker Score: 36207
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.98
    Marker Score: 311
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.97
    Marker Score: 19369
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.96
    Marker Score: 7386
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.95
    Marker Score: 4105
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.91
    Marker Score: 309
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.9
    Marker Score: 365
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.9
    Marker Score: 3714
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.88
    Marker Score: 1064
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4967
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.85
    Marker Score: 1638.5
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.84
    Marker Score: 352
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.84
    Marker Score: 265
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.84
    Marker Score: 5081.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.81
    Marker Score: 2874
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.8
    Marker Score: 758
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.79
    Marker Score: 11835
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.78
    Marker Score: 17499
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.78
    Marker Score: 1886
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.78
    Marker Score: 278
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.76
    Marker Score: 319
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3170
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1225
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 302
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.75
    Marker Score: 420
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.75
    Marker Score: 923
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.74
    Marker Score: 777
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.73
    Marker Score: 836.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.71
    Marker Score: 1850
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.71
    Marker Score: 705
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 423
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.7
    Marker Score: 527.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.7
    Marker Score: 605
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.69
    Marker Score: 1955
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.68
    Marker Score: 219
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.67
    Marker Score: 747
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.66
    Marker Score: 570
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.65
    Marker Score: 1037
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.64
    Marker Score: 370
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3821
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.61
    Marker Score: 1449
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.6
    Marker Score: 243
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.6
    Marker Score: 1005
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.59
    Marker Score: 2285
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.59
    Marker Score: 371
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.57
    Marker Score: 1922
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.57
    Marker Score: 136
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.57
    Marker Score: 328
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.57
    Marker Score: 115
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 361
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.56
    Marker Score: 381
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.56
    Marker Score: 279
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.55
    Marker Score: 609
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.55
    Marker Score: 909
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.55
    Marker Score: 286

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Other Information

**Key Characteristics:** GPR137B is a member of the G protein-coupled receptor family, characterized by its seven transmembrane domains and its ability to interact with G-proteins. Its expression is widespread, with significant levels detected in various tissues, including the eye, kidney, and immune cells. Notably, GPR137B exhibits a unique expression pattern in lens epithelial cells, where it plays a crucial role in maintaining lens homeostasis. **Pathways and Functions:** GPR137B modulates multiple signaling pathways, including: 1. **Autophagy:** GPR137B regulates autophagy by interacting with key autophagy-related proteins, thereby influencing cellular homeostasis and survival. 2. **Osteoclast differentiation:** GPR137B negatively regulates osteoclast differentiation, which is essential for maintaining bone health and preventing excessive bone resorption. 3. **Macrophage activation:** GPR137B modulates macrophage activation, influencing their role in immune responses and tissue repair. 4. **TorC1 signaling:** GPR137B positively regulates TorC1 signaling, which is crucial for protein synthesis and cell growth. 5. **Protein localization to lysosome:** GPR137B regulates the localization of proteins to lysosomes, influencing cellular trafficking and homeostasis. **Clinical Significance:** GPR137B's dysregulation has been implicated in various diseases, including: 1. **Osteoporosis:** Abnormal GPR137B expression has been linked to osteoporosis, a condition characterized by excessive bone resorption and decreased bone density. 2. **Inflammatory diseases:** GPR137B's role in regulating macrophage activation makes it a potential target for treating inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 3. **Eye diseases:** GPR137B's expression in lens epithelial cells and its role in maintaining lens homeostasis make it a potential target for treating eye diseases, such as cataracts and age-related macular degeneration. In conclusion, GPR137B is a multifunctional receptor that plays a critical role in regulating various cellular processes, including autophagy, osteoclast differentiation, and macrophage activation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its clinical significance and potential therapeutic applications.

Genular Protein ID: 1099924895

Symbol: G137B_HUMAN

Name: Integral membrane protein GPR137B

UniProtKB Accession Codes:

O60478 Q53EK7 Q5TAE6 Q6FHI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9521871

Title: Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development.

PubMed ID: 9521871

DOI: 10.1006/geno.1997.5170

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22729905

Title: TM7SF1 (GPR137B): a novel lysosome integral membrane protein.

PubMed ID: 22729905

DOI: 10.1007/s11033-012-1755-0

PubMed ID: 31036939

Title: The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.

PubMed ID: 31036939

DOI: 10.1038/s41556-019-0321-6

Sequence Information:

  • Length: 399
  • Mass: 45599
  • Checksum: FE788D618A590604
  • Sequence:
    • MRPERPRPRG SAPGPMETPP WDPARNDSLP PTLTPAVPPY VKLGLTVVYT VFYALLFVFI 
YVQLWLVLRY RHKRLSYQSV FLFLCLFWAS LRTVLFSFYF KDFVAANSLS PFVFWLLYCF 
PVCLQFFTLT LMNLYFTQVI FKAKSKYSPE LLKYRLPLYL ASLFISLVFL LVNLTCAVLV 
KTGNWERKVI VSVRVAINDT LFVLCAVSLS ICLYKISKMS LANIYLESKG SSVCQVTAIG 
VTVILLYTSR ACYNLFILSF SQNKSVHSFD YDWYNVSDQA DLKNQLGDAG YVLFGVVLFV 
WELLPTTLVV YFFRVRNPTK DLTNPGMVPS HGFSPRSYFF DNPRRYDSDD DLAWNIAPQG 
LQGGFAPDYY DWGQQTNSFL AQAGTLQDST LDPDKPSLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.