Details for: GPR137B

Gene ID: 7107

Symbol: GPR137B

Ensembl ID: ENSG00000077585

Description: G protein-coupled receptor 137B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 189.0768
    Cell Significance Index: -29.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.3588
    Cell Significance Index: -29.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.9408
    Cell Significance Index: -30.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.4327
    Cell Significance Index: -25.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.5031
    Cell Significance Index: -28.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.1382
    Cell Significance Index: -25.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.8532
    Cell Significance Index: -29.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1872
    Cell Significance Index: -27.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4404
    Cell Significance Index: -29.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8250
    Cell Significance Index: -10.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.7471
    Cell Significance Index: 76.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.0316
    Cell Significance Index: 254.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.8624
    Cell Significance Index: 23.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.6829
    Cell Significance Index: 244.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2252
    Cell Significance Index: 121.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.2043
    Cell Significance Index: 9.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0843
    Cell Significance Index: 979.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0131
    Cell Significance Index: 62.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8120
    Cell Significance Index: 42.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7574
    Cell Significance Index: 28.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7558
    Cell Significance Index: 151.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7524
    Cell Significance Index: 33.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6567
    Cell Significance Index: 15.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6499
    Cell Significance Index: 34.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6408
    Cell Significance Index: 43.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6194
    Cell Significance Index: 222.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6120
    Cell Significance Index: 110.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6105
    Cell Significance Index: 830.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5979
    Cell Significance Index: 97.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5408
    Cell Significance Index: 374.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5245
    Cell Significance Index: 57.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5076
    Cell Significance Index: 38.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4216
    Cell Significance Index: 83.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4064
    Cell Significance Index: 10.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4002
    Cell Significance Index: 49.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3913
    Cell Significance Index: 21.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3812
    Cell Significance Index: 586.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3681
    Cell Significance Index: 7.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3021
    Cell Significance Index: 568.7400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.2986
    Cell Significance Index: 5.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2362
    Cell Significance Index: 44.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2235
    Cell Significance Index: 13.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2160
    Cell Significance Index: 14.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1992
    Cell Significance Index: 20.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1858
    Cell Significance Index: 25.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1816
    Cell Significance Index: 21.4200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.1666
    Cell Significance Index: 2.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1652
    Cell Significance Index: 304.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1521
    Cell Significance Index: 4.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1470
    Cell Significance Index: 80.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1007
    Cell Significance Index: 44.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0683
    Cell Significance Index: 8.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0522
    Cell Significance Index: 6.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0448
    Cell Significance Index: 1.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0310
    Cell Significance Index: 0.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0231
    Cell Significance Index: 0.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0100
    Cell Significance Index: 0.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0088
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0161
    Cell Significance Index: -10.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0247
    Cell Significance Index: -2.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0247
    Cell Significance Index: -0.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0248
    Cell Significance Index: -18.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0318
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0353
    Cell Significance Index: -6.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0370
    Cell Significance Index: -16.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0374
    Cell Significance Index: -21.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0416
    Cell Significance Index: -31.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0649
    Cell Significance Index: -2.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0841
    Cell Significance Index: -24.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0948
    Cell Significance Index: -19.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1042
    Cell Significance Index: -0.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1268
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1484
    Cell Significance Index: -17.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1511
    Cell Significance Index: -7.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1547
    Cell Significance Index: -3.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1574
    Cell Significance Index: -20.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1605
    Cell Significance Index: -11.9600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1664
    Cell Significance Index: -1.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1834
    Cell Significance Index: -12.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1873
    Cell Significance Index: -8.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2194
    Cell Significance Index: -25.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3215
    Cell Significance Index: -7.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3243
    Cell Significance Index: -25.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3276
    Cell Significance Index: -4.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3293
    Cell Significance Index: -15.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3408
    Cell Significance Index: -7.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4017
    Cell Significance Index: -24.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4054
    Cell Significance Index: -11.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4193
    Cell Significance Index: -13.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4287
    Cell Significance Index: -27.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5115
    Cell Significance Index: -7.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5207
    Cell Significance Index: -8.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5718
    Cell Significance Index: -18.7200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5739
    Cell Significance Index: -8.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5859
    Cell Significance Index: -18.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5992
    Cell Significance Index: -12.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6112
    Cell Significance Index: -21.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR137B is a member of the G protein-coupled receptor family, characterized by its seven transmembrane domains and its ability to interact with G-proteins. Its expression is widespread, with significant levels detected in various tissues, including the eye, kidney, and immune cells. Notably, GPR137B exhibits a unique expression pattern in lens epithelial cells, where it plays a crucial role in maintaining lens homeostasis. **Pathways and Functions:** GPR137B modulates multiple signaling pathways, including: 1. **Autophagy:** GPR137B regulates autophagy by interacting with key autophagy-related proteins, thereby influencing cellular homeostasis and survival. 2. **Osteoclast differentiation:** GPR137B negatively regulates osteoclast differentiation, which is essential for maintaining bone health and preventing excessive bone resorption. 3. **Macrophage activation:** GPR137B modulates macrophage activation, influencing their role in immune responses and tissue repair. 4. **TorC1 signaling:** GPR137B positively regulates TorC1 signaling, which is crucial for protein synthesis and cell growth. 5. **Protein localization to lysosome:** GPR137B regulates the localization of proteins to lysosomes, influencing cellular trafficking and homeostasis. **Clinical Significance:** GPR137B's dysregulation has been implicated in various diseases, including: 1. **Osteoporosis:** Abnormal GPR137B expression has been linked to osteoporosis, a condition characterized by excessive bone resorption and decreased bone density. 2. **Inflammatory diseases:** GPR137B's role in regulating macrophage activation makes it a potential target for treating inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 3. **Eye diseases:** GPR137B's expression in lens epithelial cells and its role in maintaining lens homeostasis make it a potential target for treating eye diseases, such as cataracts and age-related macular degeneration. In conclusion, GPR137B is a multifunctional receptor that plays a critical role in regulating various cellular processes, including autophagy, osteoclast differentiation, and macrophage activation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its clinical significance and potential therapeutic applications.

Genular Protein ID: 1099924895

Symbol: G137B_HUMAN

Name: Integral membrane protein GPR137B

UniProtKB Accession Codes:

O60478 Q53EK7 Q5TAE6 Q6FHI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9521871

Title: Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development.

PubMed ID: 9521871

DOI: 10.1006/geno.1997.5170

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22729905

Title: TM7SF1 (GPR137B): a novel lysosome integral membrane protein.

PubMed ID: 22729905

DOI: 10.1007/s11033-012-1755-0

PubMed ID: 31036939

Title: The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.

PubMed ID: 31036939

DOI: 10.1038/s41556-019-0321-6

Sequence Information:

  • Length: 399
  • Mass: 45599
  • Checksum: FE788D618A590604
  • Sequence:
    • MRPERPRPRG SAPGPMETPP WDPARNDSLP PTLTPAVPPY VKLGLTVVYT VFYALLFVFI 
YVQLWLVLRY RHKRLSYQSV FLFLCLFWAS LRTVLFSFYF KDFVAANSLS PFVFWLLYCF 
PVCLQFFTLT LMNLYFTQVI FKAKSKYSPE LLKYRLPLYL ASLFISLVFL LVNLTCAVLV 
KTGNWERKVI VSVRVAINDT LFVLCAVSLS ICLYKISKMS LANIYLESKG SSVCQVTAIG 
VTVILLYTSR ACYNLFILSF SQNKSVHSFD YDWYNVSDQA DLKNQLGDAG YVLFGVVLFV 
WELLPTTLVV YFFRVRNPTK DLTNPGMVPS HGFSPRSYFF DNPRRYDSDD DLAWNIAPQG 
LQGGFAPDYY DWGQQTNSFL AQAGTLQDST LDPDKPSLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.