Details for: TUB

Gene ID: 7275

Symbol: TUB

Ensembl ID: ENSG00000166402

Description: TUB bipartite transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.0877
    Cell Significance Index: -17.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.4515
    Cell Significance Index: -15.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.1685
    Cell Significance Index: 262.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0613
    Cell Significance Index: -6.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.4292
    Cell Significance Index: 77.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.9319
    Cell Significance Index: 23.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6822
    Cell Significance Index: 103.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6790
    Cell Significance Index: 336.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1169
    Cell Significance Index: 75.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9649
    Cell Significance Index: 14.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8708
    Cell Significance Index: 24.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7407
    Cell Significance Index: 28.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6169
    Cell Significance Index: 117.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5056
    Cell Significance Index: 11.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4807
    Cell Significance Index: 47.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4788
    Cell Significance Index: 171.7500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3921
    Cell Significance Index: 6.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2921
    Cell Significance Index: 263.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2779
    Cell Significance Index: 17.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2459
    Cell Significance Index: 40.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2435
    Cell Significance Index: 5.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2378
    Cell Significance Index: 18.2500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2253
    Cell Significance Index: 2.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1983
    Cell Significance Index: 137.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1779
    Cell Significance Index: 19.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1582
    Cell Significance Index: 8.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1284
    Cell Significance Index: 6.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1263
    Cell Significance Index: 5.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1260
    Cell Significance Index: 17.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0678
    Cell Significance Index: 125.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0676
    Cell Significance Index: 1.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0622
    Cell Significance Index: 95.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0578
    Cell Significance Index: 1.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0578
    Cell Significance Index: 3.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0422
    Cell Significance Index: 79.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0260
    Cell Significance Index: 0.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0185
    Cell Significance Index: 2.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0066
    Cell Significance Index: 0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0044
    Cell Significance Index: 6.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0019
    Cell Significance Index: 0.3800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0036
    Cell Significance Index: -0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0142
    Cell Significance Index: -7.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0157
    Cell Significance Index: -6.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0212
    Cell Significance Index: -15.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0215
    Cell Significance Index: -15.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0232
    Cell Significance Index: -3.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0263
    Cell Significance Index: -19.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0300
    Cell Significance Index: -16.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0326
    Cell Significance Index: -0.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0335
    Cell Significance Index: -0.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0335
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0358
    Cell Significance Index: -0.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0432
    Cell Significance Index: -1.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0506
    Cell Significance Index: -14.5600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0540
    Cell Significance Index: -0.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0542
    Cell Significance Index: -9.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0553
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0838
    Cell Significance Index: -14.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0861
    Cell Significance Index: -18.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1089
    Cell Significance Index: -11.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1221
    Cell Significance Index: -15.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1311
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1391
    Cell Significance Index: -15.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1394
    Cell Significance Index: -14.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1409
    Cell Significance Index: -18.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1418
    Cell Significance Index: -3.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1481
    Cell Significance Index: -17.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1548
    Cell Significance Index: -3.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1646
    Cell Significance Index: -5.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1653
    Cell Significance Index: -5.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1655
    Cell Significance Index: -19.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1748
    Cell Significance Index: -3.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1762
    Cell Significance Index: -3.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1769
    Cell Significance Index: -2.9600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1894
    Cell Significance Index: -2.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1958
    Cell Significance Index: -9.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2021
    Cell Significance Index: -14.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2047
    Cell Significance Index: -5.7200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2060
    Cell Significance Index: -1.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2239
    Cell Significance Index: -17.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2493
    Cell Significance Index: -18.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2521
    Cell Significance Index: -4.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2628
    Cell Significance Index: -3.8800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2674
    Cell Significance Index: -11.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2737
    Cell Significance Index: -14.2200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2813
    Cell Significance Index: -4.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2972
    Cell Significance Index: -10.4100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3277
    Cell Significance Index: -3.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3376
    Cell Significance Index: -15.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3379
    Cell Significance Index: -7.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3380
    Cell Significance Index: -9.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3464
    Cell Significance Index: -8.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3499
    Cell Significance Index: -10.0300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3513
    Cell Significance Index: -11.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4058
    Cell Significance Index: -10.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4149
    Cell Significance Index: -10.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bipartite structure**: TUB is a bipartite transcription factor, consisting of two distinct domains that interact with various cellular components to modulate gene expression. 2. **Ubiquitous expression**: TUB is expressed in a wide range of cell types, including dopaminergic neurons, conventional dendritic cells, kidney proximal straight tubule epithelial cells, and colon goblet cells. 3. **Regulation of phagocytosis**: TUB has been shown to positively regulate phagocytosis, a critical process for immune cell function and overall health. 4. **Photoreceptor maintenance**: TUB plays a crucial role in maintaining photoreceptor cells, which are essential for vision and sensory perception. **Pathways and Functions:** 1. **Intraciliary transport**: TUB is involved in regulating the transport of proteins and other molecules within the cilium, a crucial organelle in many cell types. 2. **G protein-coupled receptor signaling**: TUB modulates the activity of G protein-coupled receptors, which are essential for transmitting signals from the extracellular environment to the cell interior. 3. **Phagocytosis regulation**: TUB's positive regulation of phagocytosis is mediated through its interaction with specific signaling pathways, including the PI3K/Akt pathway. 4. **Photoreceptor cell maintenance**: TUB's role in maintaining photoreceptor cells involves regulating the expression of genes involved in phototransduction and visual cycle. **Clinical Significance:** 1. **Phagocytic disorders**: Dysregulation of TUB has been implicated in various phagocytic disorders, including chronic inflammatory diseases and autoimmune conditions. 2. **Visual impairments**: Mutations in TUB have been associated with visual impairments, including photoreceptor degeneration and vision loss. 3. **Sensory perception**: TUB's role in regulating sensory perception, particularly sound perception, highlights its importance in maintaining auditory function. 4. **Cancer and epithelial development**: TUB's expression in epithelial tissues and its role in regulating cellular processes make it an attractive target for cancer research and epithelial development studies. In conclusion, the study of TUB has revealed its intricate role in regulating various cellular processes, including phagocytosis, photoreceptor cell maintenance, and sensory perception. Further research is necessary to fully elucidate the mechanisms underlying TUB's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3773615461

Symbol: TUB_HUMAN

Name: Tubby protein homolog

UniProtKB Accession Codes:

P50607 D3DQU4 O00293 Q6B007

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8612280

Title: Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family.

PubMed ID: 8612280

DOI: 10.1016/s0092-8674(00)81104-6

PubMed ID: 9096357

Title: Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases.

PubMed ID: 9096357

DOI: 10.1073/pnas.94.7.3128

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19837063

Title: Identification of tubby and tubby-like protein 1 as eat-me signals by phage display.

PubMed ID: 19837063

DOI: 10.1016/j.yexcr.2009.10.008

PubMed ID: 24375934

Title: A homozygous mutation in the TUB gene associated with retinal dystrophy and obesity.

PubMed ID: 24375934

DOI: 10.1002/humu.22482

Sequence Information:

  • Length: 506
  • Mass: 55651
  • Checksum: B2A7D230795346C3
  • Sequence:
    • MTSKPHSDWI PYSVLDDEGR NLRQQKLDRQ RALLEQKQKK KRQEPLMVQA NADGRPRSRR 
ARQSEEQAPL VESYLSSSGS TSYQVQEADS LASVQLGATR PTAPASAKRT KAAATAGGQG 
GAARKEKKGK HKGTSGPAAL AEDKSEAQGP VQILTVGQSD HAQDAGETAA GGGERPSGQD 
LRATMQRKGI SSSMSFDEDE EDEEENSSSS SQLNSNTRPS SATSRKSVRE AASAPSPTAP 
EQPVDVEVQD LEEFALRPAP QGITIKCRIT RDKKGMDRGM YPTYFLHLDR EDGKKVFLLA 
GRKRKKSKTS NYLISVDPTD LSRGGDSYIG KLRSNLMGTK FTVYDNGVNP QKASSSTLES 
GTLRQELAAV CYETNVLGFK GPRKMSVIVP GMNMVHERVS IRPRNEHETL LARWQNKNTE 
SIIELQNKTP VWNDDTQSYV LNFHGRVTQA SVKNFQIIHG NDPDYIVMQF GRVAEDVFTM 
DYNYPLCALQ AFAIALSSFD SKLACE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.