Details for: UCP1

Gene ID: 7350

Symbol: UCP1

Ensembl ID: ENSG00000109424

Description: uncoupling protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.48
    Marker Score: 30379
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.88
    Marker Score: 3809
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.04
    Marker Score: 2129
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 3.95
    Marker Score: 4928.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.92
    Marker Score: 2226
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.61
    Marker Score: 10707.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.23
    Marker Score: 3095.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.15
    Marker Score: 26598
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 2.61
    Marker Score: 7603
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.25
    Marker Score: 2264.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2191
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.89
    Marker Score: 789
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.76
    Marker Score: 1215
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2102
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2417
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.89
    Marker Score: 1160
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 651
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 509
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.71
    Marker Score: 1141
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.66
    Marker Score: 384
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 474
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8843
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.56
    Marker Score: 339
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.5
    Marker Score: 1043
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.43
    Marker Score: 211
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 883
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 417
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.3
    Marker Score: 183
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.27
    Marker Score: 260
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 146
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 127
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 110
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.22
    Marker Score: 630
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.21
    Marker Score: 128
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 105
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.16
    Marker Score: 31
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.14
    Marker Score: 237
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.13
    Marker Score: 193
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 100
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 56
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 135
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 228
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.1
    Marker Score: 181
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 80
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.09
    Marker Score: 93
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 83
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 26.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.06
    Marker Score: 25

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Other Information

**Key Characteristics:** 1. **Expression and localization:** UCP1 is highly expressed in brown adipose tissue (BAT) and is also found in other tissues such as the brain, heart, and skeletal muscle. 2. **Function:** UCP1 acts as an uncoupling protein, allowing the mitochondria to dissipate excess energy as heat rather than ATP. 3. **Thermogenic activity:** UCP1 is responsible for the heat production by uncoupling proteins, which is essential for the regulation of body temperature. 4. **Regulation of reactive oxygen species:** UCP1 has been shown to regulate the production of reactive oxygen species (ROS) in the mitochondria. 5. **Cellular differentiation:** UCP1 is involved in the differentiation of brown adipocytes, the cells responsible for thermogenesis. **Pathways and Functions:** 1. **Adaptive thermogenesis:** UCP1 plays a crucial role in the regulation of adaptive thermogenesis, the process by which the body generates heat in response to cold stress. 2. **Brown fat cell differentiation:** UCP1 is involved in the differentiation of brown adipocytes, the cells responsible for thermogenesis. 3. **Cellular response to cold:** UCP1 is activated in response to cold stress, allowing the mitochondria to dissipate excess energy as heat. 4. **Cellular response to dehydroepiandrosterone:** UCP1 has been shown to regulate the response to dehydroepiandrosterone, a hormone involved in thermogenesis. 5. **Mitochondrial inner membrane:** UCP1 is embedded in the mitochondrial inner membrane, where it regulates the flow of protons and the production of ROS. **Clinical Significance:** 1. **Obesity and metabolic disorders:** UCP1 has been implicated in the regulation of energy expenditure and glucose metabolism, making it a potential target for the treatment of obesity and metabolic disorders. 2. **Thermoregulation:** UCP1 plays a crucial role in the regulation of body temperature, making it essential for individuals with temperature regulation disorders. 3. **Neurological disorders:** UCP1 has been implicated in the regulation of neuronal function and has been shown to be involved in various neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Cancer:** UCP1 has been shown to regulate the growth and metabolism of cancer cells, making it a potential target for cancer therapy. In conclusion, UCP1 is a crucial regulator of thermogenesis and mitochondrial function, and its dysregulation has been implicated in various physiological and pathological processes. Further research is needed to fully understand the role of UCP1 in human health and disease.

Genular Protein ID: 4104143932

Symbol: UCP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P25874 Q13218 Q4KMZ3 Q68G66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 3 Ensembl 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2380264

Title: Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.

PubMed ID: 2380264

DOI: 10.1002/jcb.240430306

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3165741

Title: Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe.

PubMed ID: 3165741

DOI: 10.1042/cs0750021

PubMed ID: 24196960

Title: Expression, folding, and proton transport activity of human uncoupling protein-1 (UCP1) in lipid membranes: evidence for associated functional forms.

PubMed ID: 24196960

DOI: 10.1074/jbc.m113.509935

PubMed ID: 23266187

Title: The mitochondrial transporter family SLC25: identification, properties and physiopathology.

PubMed ID: 23266187

DOI: 10.1016/j.mam.2012.05.005

PubMed ID: 11317671

Title: A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus.

PubMed ID: 11317671

DOI: 10.1007/s001250051629

PubMed ID: 12756473

Title: Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio.

PubMed ID: 12756473

DOI: 10.1007/s00109-003-0431-1

PubMed ID: 28781081

Title: Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid.

PubMed ID: 28781081

DOI: 10.1016/j.str.2017.07.005

Sequence Information:

  • Length: 307
  • Mass: 33005
  • Checksum: BCC99AB27171FC67
  • Sequence:
    • MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS SVIRYKGVLG 
TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ EFLTAGKETA PSLGSKILAG 
LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI KPRYTGTYNA YRIIATTEGL TGLWKGTTPN 
LMRSVIINCT ELVTYDLMKE AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF 
INSPPGQYKS VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR 
QTMDCAT

Genular Protein ID: 2199805794

Symbol: Q4KMT7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4KMT7

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 3 GO 13 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 RuleBase 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 306
  • Mass: 32933
  • Checksum: F50C0A60A7C11DB3
  • Sequence:
    • MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS SVIRYKGVLG 
TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ EFLTAGKETP SLGSKILAGL 
TTGGVAVFIG QPTEVVKVRL QAQSHLHGIK PRYTGTYNAY RIIATTEGLT GLWKGTTPNL 
MRSVIINCTE LVTYDLMKEA FVKNNILADD VPCHLVSALI AGFCATAMSS PVDVVKTRFI 
NSPPGQYKSV PNCAMKVFTN EGPTAFFKGL VPSFLRLGSW NVIMFVCFEQ LKRELSKSRQ 
TMDCAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.