Details for: UCP1

Gene ID: 7350

Symbol: UCP1

Ensembl ID: ENSG00000109424

Description: uncoupling protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4836
    Cell Significance Index: 21.9200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.3610
    Cell Significance Index: 2.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2539
    Cell Significance Index: 3.7000
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.1864
    Cell Significance Index: 1.6300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1696
    Cell Significance Index: 1.9000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.1354
    Cell Significance Index: 1.4500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1264
    Cell Significance Index: 1.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1248
    Cell Significance Index: 1.8700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1032
    Cell Significance Index: 1.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0659
    Cell Significance Index: 1.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0570
    Cell Significance Index: 6.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0519
    Cell Significance Index: 3.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0254
    Cell Significance Index: 0.6100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0221
    Cell Significance Index: 0.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0221
    Cell Significance Index: 1.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0205
    Cell Significance Index: 0.5500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0183
    Cell Significance Index: 0.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0177
    Cell Significance Index: 3.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0160
    Cell Significance Index: 0.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0097
    Cell Significance Index: 0.7500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0096
    Cell Significance Index: 0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0054
    Cell Significance Index: 1.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0025
    Cell Significance Index: 0.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0015
    Cell Significance Index: 1.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0013
    Cell Significance Index: 0.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0009
    Cell Significance Index: 0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0003
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0003
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0025
    Cell Significance Index: -1.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0057
    Cell Significance Index: -0.2500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0073
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0074
    Cell Significance Index: -1.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0086
    Cell Significance Index: -1.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0101
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0104
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0105
    Cell Significance Index: -1.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0106
    Cell Significance Index: -0.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0106
    Cell Significance Index: -0.7900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0107
    Cell Significance Index: -0.1600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0111
    Cell Significance Index: -0.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0116
    Cell Significance Index: -1.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0120
    Cell Significance Index: -0.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0124
    Cell Significance Index: -0.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0128
    Cell Significance Index: -0.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0130
    Cell Significance Index: -0.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0139
    Cell Significance Index: -1.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0139
    Cell Significance Index: -0.2900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0150
    Cell Significance Index: -1.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0161
    Cell Significance Index: -0.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0167
    Cell Significance Index: -0.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0202
    Cell Significance Index: -0.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0209
    Cell Significance Index: -0.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0222
    Cell Significance Index: -0.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0222
    Cell Significance Index: -0.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0228
    Cell Significance Index: -0.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0232
    Cell Significance Index: -1.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0234
    Cell Significance Index: -0.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0242
    Cell Significance Index: -0.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0250
    Cell Significance Index: -0.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0259
    Cell Significance Index: -0.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0261
    Cell Significance Index: -0.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0265
    Cell Significance Index: -0.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0271
    Cell Significance Index: -0.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0282
    Cell Significance Index: -0.8300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0290
    Cell Significance Index: -0.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0299
    Cell Significance Index: -0.9800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0304
    Cell Significance Index: -0.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0314
    Cell Significance Index: -0.8800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0353
    Cell Significance Index: -0.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0354
    Cell Significance Index: -0.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0359
    Cell Significance Index: -0.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0370
    Cell Significance Index: -1.3600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0373
    Cell Significance Index: -0.4300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0383
    Cell Significance Index: -0.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0384
    Cell Significance Index: -0.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0385
    Cell Significance Index: -0.9600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0393
    Cell Significance Index: -0.8500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0398
    Cell Significance Index: -0.8100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0405
    Cell Significance Index: -0.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0421
    Cell Significance Index: -1.4800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0431
    Cell Significance Index: -0.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0437
    Cell Significance Index: -1.5200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0443
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0452
    Cell Significance Index: -1.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0473
    Cell Significance Index: -1.2700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0495
    Cell Significance Index: -0.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0506
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression and localization:** UCP1 is highly expressed in brown adipose tissue (BAT) and is also found in other tissues such as the brain, heart, and skeletal muscle. 2. **Function:** UCP1 acts as an uncoupling protein, allowing the mitochondria to dissipate excess energy as heat rather than ATP. 3. **Thermogenic activity:** UCP1 is responsible for the heat production by uncoupling proteins, which is essential for the regulation of body temperature. 4. **Regulation of reactive oxygen species:** UCP1 has been shown to regulate the production of reactive oxygen species (ROS) in the mitochondria. 5. **Cellular differentiation:** UCP1 is involved in the differentiation of brown adipocytes, the cells responsible for thermogenesis. **Pathways and Functions:** 1. **Adaptive thermogenesis:** UCP1 plays a crucial role in the regulation of adaptive thermogenesis, the process by which the body generates heat in response to cold stress. 2. **Brown fat cell differentiation:** UCP1 is involved in the differentiation of brown adipocytes, the cells responsible for thermogenesis. 3. **Cellular response to cold:** UCP1 is activated in response to cold stress, allowing the mitochondria to dissipate excess energy as heat. 4. **Cellular response to dehydroepiandrosterone:** UCP1 has been shown to regulate the response to dehydroepiandrosterone, a hormone involved in thermogenesis. 5. **Mitochondrial inner membrane:** UCP1 is embedded in the mitochondrial inner membrane, where it regulates the flow of protons and the production of ROS. **Clinical Significance:** 1. **Obesity and metabolic disorders:** UCP1 has been implicated in the regulation of energy expenditure and glucose metabolism, making it a potential target for the treatment of obesity and metabolic disorders. 2. **Thermoregulation:** UCP1 plays a crucial role in the regulation of body temperature, making it essential for individuals with temperature regulation disorders. 3. **Neurological disorders:** UCP1 has been implicated in the regulation of neuronal function and has been shown to be involved in various neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Cancer:** UCP1 has been shown to regulate the growth and metabolism of cancer cells, making it a potential target for cancer therapy. In conclusion, UCP1 is a crucial regulator of thermogenesis and mitochondrial function, and its dysregulation has been implicated in various physiological and pathological processes. Further research is needed to fully understand the role of UCP1 in human health and disease.

Genular Protein ID: 4104143932

Symbol: UCP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P25874 Q13218 Q4KMZ3 Q68G66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 4 Ensembl 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2380264

Title: Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.

PubMed ID: 2380264

DOI: 10.1002/jcb.240430306

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3165741

Title: Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe.

PubMed ID: 3165741

DOI: 10.1042/cs0750021

PubMed ID: 24196960

Title: Expression, folding, and proton transport activity of human uncoupling protein-1 (UCP1) in lipid membranes: evidence for associated functional forms.

PubMed ID: 24196960

DOI: 10.1074/jbc.m113.509935

PubMed ID: 23266187

Title: The mitochondrial transporter family SLC25: identification, properties and physiopathology.

PubMed ID: 23266187

DOI: 10.1016/j.mam.2012.05.005

PubMed ID: 11317671

Title: A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus.

PubMed ID: 11317671

DOI: 10.1007/s001250051629

PubMed ID: 12756473

Title: Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio.

PubMed ID: 12756473

DOI: 10.1007/s00109-003-0431-1

PubMed ID: 28781081

Title: Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid.

PubMed ID: 28781081

DOI: 10.1016/j.str.2017.07.005

Sequence Information:

  • Length: 307
  • Mass: 33005
  • Checksum: BCC99AB27171FC67
  • Sequence:
    • MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS SVIRYKGVLG 
TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ EFLTAGKETA PSLGSKILAG 
LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI KPRYTGTYNA YRIIATTEGL TGLWKGTTPN 
LMRSVIINCT ELVTYDLMKE AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF 
INSPPGQYKS VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR 
QTMDCAT

Genular Protein ID: 2199805794

Symbol: Q4KMT7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4KMT7

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 GO 12 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 306
  • Mass: 32933
  • Checksum: F50C0A60A7C11DB3
  • Sequence:
    • MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS SVIRYKGVLG 
TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ EFLTAGKETP SLGSKILAGL 
TTGGVAVFIG QPTEVVKVRL QAQSHLHGIK PRYTGTYNAY RIIATTEGLT GLWKGTTPNL 
MRSVIINCTE LVTYDLMKEA FVKNNILADD VPCHLVSALI AGFCATAMSS PVDVVKTRFI 
NSPPGQYKSV PNCAMKVFTN EGPTAFFKGL VPSFLRLGSW NVIMFVCFEQ LKRELSKSRQ 
TMDCAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.