VAV2 | ENSG00000160293 | NCBI 7410

Details for: VAV2

Gene ID: 7410

Symbol: VAV2

Ensembl ID: ENSG00000160293

Description: vav guanine nucleotide exchange factor 2

Associated with

Axon guidance
(R-HSA-422475)
Azathioprine adme
(R-HSA-9748787)
Cdc42 gtpase cycle
(R-HSA-9013148)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Death receptor signaling
(R-HSA-73887)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Drug adme
(R-HSA-9748784)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
G alpha (12/13) signalling events
(R-HSA-416482)
Gpcr downstream signalling
(R-HSA-388396)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
L1cam interactions
(R-HSA-373760)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Nervous system development
(R-HSA-9675108)
Nrage signals death through jnk
(R-HSA-193648)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhob gtpase cycle
(R-HSA-9013026)
Rhoc gtpase cycle
(R-HSA-9013106)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by gpcr
(R-HSA-372790)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction by l1
(R-HSA-445144)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Angiogenesis
(GO:0001525)
Cell migration
(GO:0016477)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epidermal growth factor receptor binding
(GO:0005154)
Fc-epsilon receptor signaling pathway
(GO:0038095)
Fc-gamma receptor signaling pathway involved in phagocytosis
(GO:0038096)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Immune response-regulating cell surface receptor signaling pathway
(GO:0002768)
Lamellipodium assembly
(GO:0030032)
Metal ion binding
(GO:0046872)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein binding
(GO:0005515)
Regulation of cell size
(GO:0008361)
Regulation of gtpase activity
(GO:0043087)
Regulation of small gtpase mediated signal transduction
(GO:0051056)
Signal transduction
(GO:0007165)
Small gtpase-mediated signal transduction
(GO:0007264)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 129.2872
Cell Significance Index: -20.1100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 80.0731
Cell Significance Index: -20.3100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 42.7685
Cell Significance Index: -17.3800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 30.2673
Cell Significance Index: -20.3100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 18.1567
Cell Significance Index: -17.3400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.3185
Cell Significance Index: -20.1200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.2718
Cell Significance Index: -19.4800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.1520
Cell Significance Index: -20.3300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.0117
Cell Significance Index: -8.7800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2233
Cell Significance Index: 441.2200
Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.4752
Cell Significance Index: 35.3800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2812
Cell Significance Index: 208.3800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.2370
Cell Significance Index: 76.0300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0754
Cell Significance Index: 106.3900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.9965
Cell Significance Index: 24.9100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9858
Cell Significance Index: 13.4500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9656
Cell Significance Index: 20.9200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9272
Cell Significance Index: 26.7200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7829
Cell Significance Index: 47.0000
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.7415
Cell Significance Index: 12.4900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7016
Cell Significance Index: 251.6600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6922
Cell Significance Index: 75.2900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5210
Cell Significance Index: 14.5600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4195
Cell Significance Index: 11.2400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4151
Cell Significance Index: 74.8300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3855
Cell Significance Index: 348.0600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3799
Cell Significance Index: 17.2200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.3567
Cell Significance Index: 7.6300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3523
Cell Significance Index: 19.7700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2634
Cell Significance Index: 50.1400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2594
Cell Significance Index: 179.4300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2093
Cell Significance Index: 322.1800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2039
Cell Significance Index: 14.1000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1842
Cell Significance Index: 100.6200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1242
Cell Significance Index: 15.2700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1195
Cell Significance Index: 6.2100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1182
Cell Significance Index: 23.7200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1121
Cell Significance Index: 152.4500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1075
Cell Significance Index: 2.2900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1049
Cell Significance Index: 17.9200
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0755
Cell Significance Index: 139.2300
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0246
Cell Significance Index: 0.4800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0240
Cell Significance Index: 1.1200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0202
Cell Significance Index: 38.1200
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0194
Cell Significance Index: 0.5100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0186
Cell Significance Index: 11.8400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0033
Cell Significance Index: 1.4800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0032
Cell Significance Index: 1.4700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0088
Cell Significance Index: -0.4600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0101
Cell Significance Index: -0.1500
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.0116
Cell Significance Index: -0.1500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0120
Cell Significance Index: -8.7900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0162
Cell Significance Index: -12.0400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0202
Cell Significance Index: -0.7100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0225
Cell Significance Index: -3.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0239
Cell Significance Index: -18.0800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0265
Cell Significance Index: -3.6400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0291
Cell Significance Index: -16.4200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0314
Cell Significance Index: -4.0300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0347
Cell Significance Index: -21.6800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0526
Cell Significance Index: -1.0400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0569
Cell Significance Index: -16.3700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0604
Cell Significance Index: -6.1700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0671
Cell Significance Index: -0.9900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0715
Cell Significance Index: -5.4900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0899
Cell Significance Index: -10.6000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0924
Cell Significance Index: -10.5900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0950
Cell Significance Index: -11.0700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0950
Cell Significance Index: -20.0100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1223
Cell Significance Index: -15.8000
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1371
Cell Significance Index: -2.9100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1425
Cell Significance Index: -9.2000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1466
Cell Significance Index: -6.8900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1509
Cell Significance Index: -10.6700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1641
Cell Significance Index: -17.0900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1701
Cell Significance Index: -4.6300
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.1766
Cell Significance Index: -2.9700
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1793
Cell Significance Index: -3.6000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1894
Cell Significance Index: -14.1200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1910
Cell Significance Index: -4.9100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2121
Cell Significance Index: -13.3700
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.2161
Cell Significance Index: -2.1800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2193
Cell Significance Index: -7.1800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2239
Cell Significance Index: -17.7300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2275
Cell Significance Index: -13.9500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2280
Cell Significance Index: -7.2600
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2630
Cell Significance Index: -2.1500
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2712
Cell Significance Index: -3.8600
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2719
Cell Significance Index: -3.3900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2847
Cell Significance Index: -19.1400
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2934
Cell Significance Index: -6.3400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3180
Cell Significance Index: -5.4500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3400
Cell Significance Index: -17.8500
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.3872
Cell Significance Index: -5.8900
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.3967
Cell Significance Index: -8.2800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4012
Cell Significance Index: -5.7700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4129
Cell Significance Index: -5.9300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4219
Cell Significance Index: -14.6600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4227
Cell Significance Index: -12.4500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4233
Cell Significance Index: -14.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** VAV2 is a guanine nucleotide exchange factor (GEF) that specifically activates Rac1 and RhoA, two members of the Rho GTPase family. The VAV2 GEF domain is responsible for exchanging GDP for GTP, activating the Rho GTPases, and regulating their downstream signaling pathways. VAV2 is also a phosphotyrosine residue-binding protein, allowing it to interact with and regulate various signaling proteins, including receptor tyrosine kinases and phosphatidylinositol 3-kinase. The gene is highly expressed in cells involved in immune responses, such as dendritic cells and macrophages, and has been shown to play a critical role in regulating immune cell function and cytokine production. **Pathways and Functions** VAV2 is involved in numerous signaling pathways, including: 1. **Rho GTPase cycle**: VAV2 activates Rac1 and RhoA, regulating their downstream signaling pathways, including cell migration, proliferation, and survival. 2. **Axon guidance**: VAV2 regulates axon guidance and neuronal development, influencing the formation of axonal projections and synaptic connections. 3. **Angiogenesis**: VAV2 is involved in angiogenesis, regulating the formation of new blood vessels and vascular permeability. 4. **Immune responses**: VAV2 regulates immune cell function, including dendritic cell and macrophage activation, cytokine production, and phagocytosis. 5. **Cell death signaling**: VAV2 is involved in cell death signaling pathways, including those mediated by the NRG1 receptor. **Clinical Significance** VAV2 has been implicated in several diseases, including: 1. **Cancer**: VAV2 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Autoimmune disorders**: VAV2 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious diseases**: VAV2 has been shown to play a critical role in regulating immune responses to infectious diseases, including Leishmania and HIV infections. 4. **Neurological disorders**: VAV2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, VAV2 is a critical regulator of various cellular processes, including cell migration, proliferation, and survival. Its involvement in numerous signaling pathways, including those involved in angiogenesis, immune responses, and cell death signaling, makes it a key player in the development and progression of various diseases. Further research is needed to fully elucidate the role of VAV2 in human disease and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide exchange factor VAV2

Genular Protein ID: 2068471867

Symbol: VAV2_HUMAN

Name: Guanine nucleotide exchange factor VAV2

UniProtKB Accession Codes:

P52735 A2RUM4 A8MQ12 B6ZDF5 Q5SYV3 Q5SYV4 Q5SYV5 Q6N012 Q6PIJ9 Q6Q317

Database IDs:

Citations:

PubMed ID: 7762982

Title: Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.

PubMed ID: 7762982

DOI: 10.1111/j.1469-1809.1995.tb01603.x

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12454019

Title: Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.

PubMed ID: 12454019

DOI: 10.1074/jbc.m207555200

PubMed ID: 15561106

Title: The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.

PubMed ID: 15561106

DOI: 10.1016/j.yexcr.2004.09.005

PubMed ID: 15618286

Title: Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.

PubMed ID: 15618286

DOI: 10.1210/me.2004-0443

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 878
Mass: 101289
Checksum: C186911605FD5B73
Sequence:

MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 
AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV 
QQPMIRYMQK MGMTEDDKRN CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV 
FINLEDLIKV HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL 
LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK 
EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH 
TKQDRYLFLF DKVVIVCKRK GYSYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY 
LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC 
KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN 
PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR 
PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI 
KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR 
SPASCASYNF SFLSPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG 
DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: VAV2

Associated with

Cells (max top 100)

Other Information

Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. PubMed ID: 7762982

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. PubMed ID: 12454019

The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. PubMed ID: 15561106

Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. PubMed ID: 15618286

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569