Details for: VAV2

Gene ID: 7410

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: VAV2

Ensembl ID: ENSG00000160293

Description: vav guanine nucleotide exchange factor 2

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • hepatocyte CL0000182
    CSI 14.37
    rCSI 25.73%
    PRS 85.32
  • renal principal cell CL0005009
    CSI 12.41
    rCSI 32.24%
    PRS 85.9
  • glial cell CL0000125
    CSI 6.78
    rCSI 25.8%
    PRS 78.34
  • centrilobular region hepatocyte CL0019029
    CSI 6.46
    rCSI 16.86%
    PRS 83.16
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 5.71
    rCSI 7.32%
    PRS 82.53
  • glioblast CL0000030
    CSI 5.7
    rCSI 9.09%
    PRS 78.19
  • neural crest cell CL0011012
    CSI 5.64
    rCSI 4.46%
    PRS 77.16
  • alveolar adventitial fibroblast CL4028006
    CSI 5.31
    rCSI 8.38%
    PRS 87.16
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 5.07
    rCSI 15.63%
    PRS 88.88
  • Kupffer cell CL0000091
    CSI 4.5
    rCSI 10.28%
    PRS 87.1
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.85
    rCSI 11.41%
    PRS 92.82
  • extravillous trophoblast CL0008036
    CSI 3.8
    rCSI 4.7%
    PRS 84.48
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.73
    rCSI 8.37%
    PRS 71.42
  • naive B cell CL0000788
    CSI 3.64
    rCSI 3.12%
    PRS 90.63
  • paneth cell of epithelium of small intestine CL1000343
    CSI 3.62
    rCSI 10.14%
    PRS 90.64
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.56
    rCSI 4.3%
    PRS 92.17
  • melanocyte CL0000148
    CSI 3.49
    rCSI 2.58%
    PRS 81.14
  • midbrain dopaminergic neuron CL2000097
    CSI 3.32
    rCSI 21.24%
    PRS 81.05
  • periportal region hepatocyte CL0019026
    CSI 3.1
    rCSI 12.07%
    PRS 84.06
  • glutamatergic neuron CL0000679
    CSI 3.08
    rCSI 6.33%
    PRS 73.68
  • alveolar macrophage CL0000583
    CSI 3
    rCSI 4.95%
    PRS 89.03
  • blood vessel endothelial cell CL0000071
    CSI 2.99
    rCSI 6.21%
    PRS 83.57
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 2.98
    rCSI 4.99%
    PRS 70.58
  • fibroblast of cardiac tissue CL0002548
    CSI 2.91
    rCSI 13.92%
    PRS 86.48
  • enteroendocrine cell of small intestine CL0009006
    CSI 2.8
    rCSI 6.16%
    PRS 90.84
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.6
    rCSI 2.85%
    PRS 87.71
  • stem cell CL0000034
    CSI 2.59
    rCSI 2.5%
    PRS 81.04
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.57
    rCSI 3.31%
    PRS 71.76
  • midzonal region hepatocyte CL0019028
    CSI 2.56
    rCSI 6.01%
    PRS 84.71
  • intrahepatic cholangiocyte CL0002538
    CSI 2.55
    rCSI 6.11%
    PRS 88.03
  • intestinal epithelial cell CL0002563
    CSI 2.52
    rCSI 2.64%
    PRS 83.7
  • vascular leptomeningeal cell CL4023051
    CSI 2.52
    rCSI 4.42%
    PRS 81.38
  • hepatic stellate cell CL0000632
    CSI 2.51
    rCSI 9.41%
    PRS 80.07
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.51
    rCSI 2.9%
    PRS 78.68
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.45
    rCSI 4.45%
    PRS 78.62
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.43
    rCSI 6.27%
    PRS 82.55
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.29
    rCSI 2.85%
    PRS 68.4
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.25
    rCSI 5.86%
    PRS 87.46
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.21
    rCSI 3.13%
    PRS 83.38
  • intermediate monocyte CL0002393
    CSI 2.19
    rCSI 3.31%
    PRS 90.68
  • BEST4+ enteroycte CL4030026
    CSI 2.17
    rCSI 2.7%
    PRS 86.38
  • kidney collecting duct principal cell CL1001431
    CSI 2.17
    rCSI 10.92%
    PRS 82.54
  • GABAergic neuron CL0000617
    CSI 2.14
    rCSI 7.16%
    PRS 71.16
  • inhibitory interneuron CL0000498
    CSI 2.12
    rCSI 4.89%
    PRS 75.68
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.1
    rCSI 5.32%
    PRS 78.28
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.09
    rCSI 3.7%
    PRS 70.11
  • fibroblast of lung CL0002553
    CSI 2.07
    rCSI 1.92%
    PRS 87.01
  • chondrocyte CL0000138
    CSI 2.05
    rCSI 3.26%
    PRS 80.39
  • type L enteroendocrine cell CL0002279
    CSI 2.05
    rCSI 3.85%
    PRS 89.7
  • lung secretory cell CL1000272
    CSI 2.04
    rCSI 5.05%
    PRS 86.67
  • colon epithelial cell CL0011108
    CSI 2
    rCSI 2.09%
    PRS 83.7
  • CD14-positive monocyte CL0001054
    CSI 1.97
    rCSI 2.46%
    PRS 93.06
  • cerebral cortex endothelial cell CL1001602
    CSI 1.9
    rCSI 3.28%
    PRS 79.3
  • colonocyte CL1000347
    CSI 1.89
    rCSI 2.71%
    PRS 85.29
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.85
    rCSI 2.21%
    PRS 70.74
  • renal beta-intercalated cell CL0002201
    CSI 1.82
    rCSI 4.33%
    PRS 86.15
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.81
    rCSI 1.39%
    PRS 89.29
  • parietal epithelial cell CL1000452
    CSI 1.78
    rCSI 4.75%
    PRS 79.34
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.62
    rCSI 5.07%
    PRS 74.21
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.62
    rCSI 2.6%
    PRS 71.94
  • epithelial cell of proximal tubule CL0002306
    CSI 1.59
    rCSI 3.87%
    PRS 78.94
  • pancreatic acinar cell CL0002064
    CSI 1.55
    rCSI 2.07%
    PRS 90.23
  • choroid plexus epithelial cell CL0000706
    CSI 1.54
    rCSI 2.52%
    PRS 77.43
  • neural progenitor cell CL0011020
    CSI 1.53
    rCSI 6.75%
    PRS 74.81
  • renal interstitial pericyte CL1001318
    CSI 1.34
    rCSI 3.69%
    PRS 82.39
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.22
    rCSI 3.8%
    PRS 72.07
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.07
    rCSI 2.89%
    PRS 89.18
  • dopaminergic neuron CL0000700
    CSI 1.01
    rCSI 5.7%
    PRS 73.81
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.96
    rCSI 2.34%
    PRS 68.42
  • podocyte CL0000653
    CSI 0.87
    rCSI 3.87%
    PRS 86.77
  • retinal ganglion cell CL0000740
    CSI 0.81
    rCSI 1.8%
    PRS 73.8
  • blood vessel smooth muscle cell CL0019018
    CSI 0.78
    rCSI 6.38%
    PRS 81.94
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.63
    rCSI 2.38%
    PRS 70.92
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.62
    rCSI 2.23%
    PRS 68.55
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.52
    rCSI 3.05%
    PRS 71.09
  • central nervous system neuron CL2000029
    CSI 0.5
    rCSI 3.68%
    PRS 75.51
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.4
    rCSI 4.29%
    PRS 82.39

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [VAV2](/details-gene/7410) is a protein-coding gene located on chromosome 9q34.2 that encodes the vav guanine nucleotide exchange factor 2. This protein functions as a crucial activator for Rho family GTPases, including Rac and Rho, thereby acting as a key node in intracellular signal transduction. Its primary role involves translating signals from cell surface receptors into changes in the actin cytoskeleton, cell migration, and proliferation. While historically studied in the context of the immune system, expression data indicate that **Overall**, [VAV2](/details-gene/7410) shows the highest significance in non-hematopoietic cells such as [hepatocytes](/details-cell/CL0000182) and [renal principal cells](/details-cell/CL0005009), suggesting it plays a broad and fundamental role in the biology of diverse tissues. Clinically, it has been associated with OMIM entry [600428](https://omim.org/entry/600428). ## Cellular Roles and Expression Landscape The expression profile of [VAV2](/details-gene/7410) highlights its widespread importance across multiple cellular lineages. **Overall**, the gene exhibits the highest significance in metabolic and transport-specialized epithelial cells, with top ranks in [hepatocytes](/details-cell/CL0000182) (CSI: 14.37) and [renal principal cells](/details-cell/CL0005009) (CSI: 12.41). This suggests a critical, though not fully elucidated, function in liver and kidney physiology. Beyond these top cell types, [VAV2](/details-gene/7410) is also significant in the nervous system, as evidenced by its expression in [glial cells](/details-cell/CL0000125), [neuroblasts](/details-cell/CL0000031), and [astrocytes of the cerebral cortex](/details-cell/CL0002605). This is consistent with its known role in pathways like [Axon guidance](/details-reactome/R-HSA-422475). Furthermore, its expression in mesenchymal cell types like [alveolar adventitial fibroblasts](/details-cell/CL4028006) and vascular cells like [endothelial cell of pericentral hepatic sinusoid](/details-cell/CL0019022) underscores its involvement in tissue structure, repair, and angiogenesis. Finally, its well-established role in immunity is reflected by its significance in professional phagocytes like the [Kupffer cell](/details-cell/CL0000091) and in lymphocytes such as the [naive B cell](/details-cell/CL0000788). The broad expression pattern across these disparate cell types indicates that [VAV2](/details-gene/7410) is a pleiotropic signaling molecule central to fundamental cellular processes. ## Pathways and Molecular Function The molecular function of [VAV2](/details-gene/7410) is centered on its [Guanyl-nucleotide exchange factor activity](/details-go/GO:0005085), which enables it to activate small GTP-binding proteins. This activity is the nexus for its involvement in a vast array of signaling cascades, primarily those under the umbrella of [Signaling by rho gtpases](/details-reactome/R-HSA-194315). It participates in the activation cycles of multiple GTPases, including the [Cdc42 gtpase cycle](/details-reactome/R-HSA-9013148), [Rac1 gtpase cycle](/details-reactome/R-HSA-9013149), and [Rhoa gtpase cycle](/details-reactome/R-HSA-8980692). This core function links [VAV2](/details-gene/7410) to numerous biological processes. Its role in cytoskeletal dynamics is highlighted by its involvement in [Lamellipodium assembly](/details-go/GO:0030032) and [Regulation of actin dynamics for phagocytic cup formation](/details-reactome/R-HSA-2029482). This is critical for its functions in [Cell migration](/details-go/GO:0016477) and immune processes like [Fc-gamma receptor signaling pathway involved in phagocytosis](/details-go/GO:0038096), consistent with its expression in [Kupffer cells](/details-cell/CL0000091). [VAV2](/details-gene/7410) also acts as an integrator for signals from receptor tyrosine kinases, as shown by its involvement in the [Vascular endothelial growth factor receptor signaling pathway](/details-go/GO:0048010) and its ability to bind the [Epidermal growth factor receptor](/details-go/GO:0005154) [Link](https://doi.org/10.1074/jbc.m207555200). These connections are consistent with its role in [Angiogenesis](/details-go/GO:0001525) and its expression in endothelial cells. Moreover, its participation in pathways such as [Platelet activation](/details-go/GO:0030168) and [Hemostasis](/details-reactome/R-HSA-109582) further broadens its physiological scope. ## Research Directions The diverse expression profile and pleiotropic functions of [VAV2](/details-gene/7410) present multiple avenues for future investigation, particularly regarding its prominent role in non-immune cells. **Proposed Hypotheses:** 1. Given its top-ranking significance in [hepatocytes](/details-cell/CL0000182) and its annotated role in [Regulation of cell size](/details-go/GO:0008361) and [Cellular response to xenobiotic stimulus](/details-go/GO:0071466), [VAV2](/details-gene/7410) may function as a master regulator of hepatocyte volume homeostasis and metabolic capacity, potentially mediating cytoskeletal responses to osmotic stress and influencing the efficiency of drug metabolism. 2. Considering its high significance in [renal principal cells](/details-cell/CL0005009) and its function in Rho GTPase-mediated actin remodeling, [VAV2](/details-gene/7410) likely plays a critical role in the regulation of water and electrolyte balance by controlling the cytoskeletal trafficking and membrane localization of key ion channels and aquaporins in the kidney's collecting duct system. **Experimental Approach:** To test the first hypothesis, a conditional knockout of [VAV2](/details-gene/7410) specifically in mouse [hepatocytes](/details-cell/CL0000182) could be generated. These mice, along with wild-type controls, could be subjected to challenges such as a high-fat diet or administration of a model hepatotoxin like acetaminophen. The resulting liver phenotype could be assessed using a combination of techniques: histology to measure hepatocyte size and liver damage, RNA-seq to profile changes in metabolic gene expression (e.g., cytochrome P450 enzymes), and functional assays to measure liver enzyme levels in the serum. This would directly test the necessity of [VAV2](/details-gene/7410) for maintaining hepatocyte integrity and metabolic function under stress. **Therapeutic Potential:** As an intracellular signaling protein, [VAV2](/details-gene/7410) represents a potentially druggable target, likely via small molecule inhibitors targeting its GEF activity. However, its widespread expression across critical cell types, including [hepatocytes](/details-cell/CL0000182), [renal cells](/details-cell/CL0005009), and [neurons](/details-cell/CL0000031), raises a significant concern for on-target toxicity with systemic administration. Therapeutic strategies would likely require either the development of highly targeted delivery systems (e.g., lipid nanoparticles directed to specific tissues) or application in diseases where [VAV2](/details-gene/7410) is aberrantly overexpressed or activated, such as in certain cancers. In these contexts, inhibition of [VAV2](/details-gene/7410) could be a viable strategy to reduce tumor cell migration and proliferation.

Genular Protein ID: 2068471867

Symbol: VAV2_HUMAN

Name: Guanine nucleotide exchange factor VAV2

UniProtKB Accession Codes:

P52735 A2RUM4 A8MQ12 B6ZDF5 Q5SYV3 Q5SYV4 Q5SYV5 Q6N012 Q6PIJ9 Q6Q317

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 7 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 GO 21 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 21 RefSeq 3 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7762982

Title: Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.

PubMed ID: 7762982

DOI: 10.1111/j.1469-1809.1995.tb01603.x

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12454019

Title: Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.

PubMed ID: 12454019

DOI: 10.1074/jbc.m207555200

PubMed ID: 15561106

Title: The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.

PubMed ID: 15561106

DOI: 10.1016/j.yexcr.2004.09.005

PubMed ID: 15618286

Title: Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.

PubMed ID: 15618286

DOI: 10.1210/me.2004-0443

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 878
  • Mass: 101289
  • Checksum: C186911605FD5B73
  • Sequence:
    • MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 
AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV 
QQPMIRYMQK MGMTEDDKRN CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV 
FINLEDLIKV HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL 
LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK 
EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH 
TKQDRYLFLF DKVVIVCKRK GYSYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY 
LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC 
KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN 
PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR 
PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI 
KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR 
SPASCASYNF SFLSPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG 
DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ