Details for: VIL1

Gene ID: 7429

Symbol: VIL1

Ensembl ID: ENSG00000127831

Description: villin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.2952
    Cell Significance Index: -5.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.8023
    Cell Significance Index: -5.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 9.3291
    Cell Significance Index: -6.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 6.4005
    Cell Significance Index: 184.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.2559
    Cell Significance Index: 283.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 5.5219
    Cell Significance Index: 119.6300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 5.1339
    Cell Significance Index: 51.7900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 3.4251
    Cell Significance Index: 37.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8781
    Cell Significance Index: -7.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.0125
    Cell Significance Index: 42.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.8269
    Cell Significance Index: 64.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6120
    Cell Significance Index: 319.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4676
    Cell Significance Index: 21.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.1126
    Cell Significance Index: 27.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.0730
    Cell Significance Index: 9.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9556
    Cell Significance Index: 7.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9466
    Cell Significance Index: 102.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7796
    Cell Significance Index: 703.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.6245
    Cell Significance Index: 6.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5767
    Cell Significance Index: 18.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5318
    Cell Significance Index: 52.6100
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.5027
    Cell Significance Index: 4.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4688
    Cell Significance Index: 76.2500
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.3900
    Cell Significance Index: 2.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3483
    Cell Significance Index: 66.2800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2345
    Cell Significance Index: 1.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1243
    Cell Significance Index: 3.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1223
    Cell Significance Index: 2.0600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.1144
    Cell Significance Index: 0.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1056
    Cell Significance Index: 1.8100
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.0801
    Cell Significance Index: 0.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0738
    Cell Significance Index: 12.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0619
    Cell Significance Index: 3.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0386
    Cell Significance Index: 6.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0364
    Cell Significance Index: 25.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0324
    Cell Significance Index: 6.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0271
    Cell Significance Index: 3.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0120
    Cell Significance Index: 1.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0067
    Cell Significance Index: 2.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0064
    Cell Significance Index: 2.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0041
    Cell Significance Index: 7.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0036
    Cell Significance Index: 5.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0031
    Cell Significance Index: 1.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0016
    Cell Significance Index: 2.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0013
    Cell Significance Index: 0.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0027
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0069
    Cell Significance Index: -4.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0073
    Cell Significance Index: -0.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0073
    Cell Significance Index: -1.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0083
    Cell Significance Index: -6.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0083
    Cell Significance Index: -4.7000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0100
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0106
    Cell Significance Index: -6.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0122
    Cell Significance Index: -5.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0146
    Cell Significance Index: -4.2100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0151
    Cell Significance Index: -0.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0228
    Cell Significance Index: -1.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0240
    Cell Significance Index: -0.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0245
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0247
    Cell Significance Index: -2.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0252
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0267
    Cell Significance Index: -5.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0285
    Cell Significance Index: -0.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0306
    Cell Significance Index: -4.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0315
    Cell Significance Index: -0.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0341
    Cell Significance Index: -2.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0397
    Cell Significance Index: -4.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0454
    Cell Significance Index: -1.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0457
    Cell Significance Index: -1.1800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0506
    Cell Significance Index: -0.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0513
    Cell Significance Index: -2.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0517
    Cell Significance Index: -2.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0524
    Cell Significance Index: -5.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0613
    Cell Significance Index: -7.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0677
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0686
    Cell Significance Index: -5.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0700
    Cell Significance Index: -4.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0707
    Cell Significance Index: -8.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0727
    Cell Significance Index: -4.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0780
    Cell Significance Index: -4.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0838
    Cell Significance Index: -1.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0868
    Cell Significance Index: -1.8000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0873
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0896
    Cell Significance Index: -2.4400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1004
    Cell Significance Index: -0.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1036
    Cell Significance Index: -7.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1051
    Cell Significance Index: -5.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1065
    Cell Significance Index: -2.2300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1100
    Cell Significance Index: -1.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1152
    Cell Significance Index: -7.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1168
    Cell Significance Index: -5.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1186
    Cell Significance Index: -6.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1266
    Cell Significance Index: -6.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1324
    Cell Significance Index: -3.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1333
    Cell Significance Index: -4.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1360
    Cell Significance Index: -4.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1370
    Cell Significance Index: -3.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Villin 1 exhibits several key characteristics that contribute to its function in regulating the actin cytoskeleton: 1. **Actin-binding properties**: Villin 1 binds to actin filaments, specifically to the barbed end, and regulates their dynamics through severing and capping. 2. **Severing activity**: Villin 1 has the ability to sever actin filaments, which is essential for regulating cell shape and motility. 3. **Capping activity**: Villin 1 can cap the barbed end of actin filaments, preventing their depolymerization and maintaining the integrity of the actin cytoskeleton. 4. **Regulation of cell migration**: Villin 1 plays a critical role in regulating cell migration by modulating the formation of filopodia and lamellipodia. 5. **Expression in epithelial cells**: Villin 1 is predominantly expressed in epithelial cells, including enterocytes, colon epithelial cells, and goblet cells. **Pathways and Functions** Villin 1 is involved in various cellular processes, including: 1. **Actin polymerization and depolymerization**: Villin 1 regulates the dynamics of actin filaments through severing and capping, which is essential for maintaining cell shape and motility. 2. **Cell migration**: Villin 1 plays a critical role in regulating cell migration by modulating the formation of filopodia and lamellipodia. 3. **Wound healing**: Villin 1 is involved in regulating the formation of the wound-healing response in epithelial cells. 4. **Epithelial cell differentiation**: Villin 1 regulates the differentiation of epithelial cells, including enterocytes and colon epithelial cells. 5. **Regulation of protein localization**: Villin 1 regulates the localization of proteins to the plasma membrane, which is essential for maintaining cellular processes. **Clinical Significance** Villin 1's dysregulation has been implicated in various diseases, including: 1. **Cancer**: Villin 1's overexpression has been observed in various types of cancer, including colorectal cancer. 2. **Neurological disorders**: Villin 1's dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Gastrointestinal disorders**: Villin 1's dysregulation has been observed in gastrointestinal disorders, such as inflammatory bowel disease. 4. **Wound healing disorders**: Villin 1's dysregulation has been implicated in wound healing disorders, such as diabetic foot ulcers. In conclusion, villin 1 is a critical actin-binding protein that plays a significant role in regulating the structure and dynamics of the actin cytoskeleton in epithelial cells. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation in maintaining cellular homeostasis.

Genular Protein ID: 1385122964

Symbol: VILI_HUMAN

Name: Villin-1

UniProtKB Accession Codes:

P09327 B2R9A7 Q53S11 Q96AC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 6 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2846586

Title: Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity.

PubMed ID: 2846586

DOI: 10.1083/jcb.107.5.1759

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3453110

Title: A human villin cDNA clone to investigate the differentiation of intestinal and kidney cells in vivo and in culture.

PubMed ID: 3453110

DOI: 10.1002/j.1460-2075.1986.tb04618.x

PubMed ID: 3087992

Title: Different calcium dependence of the capping and cutting activities of villin.

PubMed ID: 3087992

DOI: 10.1016/s0021-9258(18)67650-1

PubMed ID: 11500485

Title: Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeleton.

PubMed ID: 11500485

DOI: 10.1074/jbc.c100418200

PubMed ID: 12269817

Title: Regulation of actin dynamics by tyrosine phosphorylation: identification of tyrosine phosphorylation sites within the actin-severing domain of villin.

PubMed ID: 12269817

DOI: 10.1021/bi0263762

PubMed ID: 14550699

Title: Abnormalities in villin gene expression and canalicular microvillus structure in progressive cholestatic liver disease of childhood.

PubMed ID: 14550699

DOI: 10.1016/s0140-6736(03)14467-4

PubMed ID: 14594952

Title: Association of villin with phosphatidylinositol 4,5-bisphosphate regulates the actin cytoskeleton.

PubMed ID: 14594952

DOI: 10.1074/jbc.m308878200

PubMed ID: 15084600

Title: Identification of a functional switch for actin severing by cytoskeletal proteins.

PubMed ID: 15084600

DOI: 10.1074/jbc.c400110200

PubMed ID: 15272027

Title: Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin.

PubMed ID: 15272027

DOI: 10.1074/jbc.m405424200

PubMed ID: 15342783

Title: Regulation of cell motility by tyrosine phosphorylated villin.

PubMed ID: 15342783

DOI: 10.1091/mbc.e04-05-0431

PubMed ID: 16921170

Title: Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration.

PubMed ID: 16921170

DOI: 10.1074/jbc.m604323200

PubMed ID: 17229814

Title: Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.

PubMed ID: 17229814

DOI: 10.1152/ajpcell.00420.2006

PubMed ID: 17606613

Title: Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders.

PubMed ID: 17606613

DOI: 10.1074/jbc.m703617200

PubMed ID: 17182858

Title: Villin severing activity enhances actin-based motility in vivo.

PubMed ID: 17182858

DOI: 10.1091/mbc.e06-05-0423

PubMed ID: 18054784

Title: Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia.

PubMed ID: 18054784

DOI: 10.1016/j.yexcr.2007.10.028

PubMed ID: 18198174

Title: A novel role for villin in intestinal epithelial cell survival and homeostasis.

PubMed ID: 18198174

DOI: 10.1074/jbc.m707962200

PubMed ID: 19808673

Title: Differential effects of lysophosphatidic acid and phosphatidylinositol 4,5-bisphosphate on actin dynamics by direct association with the actin-binding protein villin.

PubMed ID: 19808673

DOI: 10.1074/jbc.c109.060830

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15096633

Title: Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements.

PubMed ID: 15096633

DOI: 10.1110/ps.03518104

PubMed ID: 19491107

Title: Helix straightening as an activation mechanism in the gelsolin superfamily of actin regulatory proteins.

PubMed ID: 19491107

DOI: 10.1074/jbc.m109.019760

Sequence Information:

  • Length: 827
  • Mass: 92695
  • Checksum: 96439B33B81E5F19
  • Sequence:
    • MTKLSAQVKG SLNITTPGLQ IWRIEAMQMV PVPSSTFGSF FDGDCYIILA IHKTASSLSY 
DIHYWIGQDS SLDEQGAAAI YTTQMDDFLK GRAVQHREVQ GNESEAFRGY FKQGLVIRKG 
GVASGMKHVE TNSYDVQRLL HVKGKRNVVA GEVEMSWKSF NRGDVFLLDL GKLIIQWNGP 
ESTRMERLRG MTLAKEIRDQ ERGGRTYVGV VDGENELASP KLMEVMNHVL GKRRELKAAV 
PDTVVEPALK AALKLYHVSD SEGNLVVREV ATRPLTQDLL SHEDCYILDQ GGLKIYVWKG 
KKANEQEKKG AMSHALNFIK AKQYPPSTQV EVQNDGAESA VFQQLFQKWT ASNRTSGLGK 
THTVGSVAKV EQVKFDATSM HVKPQVAAQQ KMVDDGSGEV QVWRIENLEL VPVDSKWLGH 
FYGGDCYLLL YTYLIGEKQH YLLYVWQGSQ ASQDEITASA YQAVILDQKY NGEPVQIRVP 
MGKEPPHLMS IFKGRMVVYQ GGTSRTNNLE TGPSTRLFQV QGTGANNTKA FEVPARANFL 
NSNDVFVLKT QSCCYLWCGK GCSGDEREMA KMVADTISRT EKQVVVEGQE PANFWMALGG 
KAPYANTKRL QEENLVITPR LFECSNKTGR FLATEIPDFN QDDLEEDDVF LLDVWDQVFF 
WIGKHANEEE KKAAATTAQE YLKTHPSGRD PETPIIVVKQ GHEPPTFTGW FLAWDPFKWS 
NTKSYEDLKA ELGNSRDWSQ ITAEVTSPKV DVFNANSNLS SGPLPIFPLE QLVNKPVEEL 
PEGVDPSRKE EHLSIEDFTQ AFGMTPAAFS ALPRWKQQNL KKEKGLF

Genular Protein ID: 1234011796

Symbol: Q53F91_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53F91

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 6 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SMART 2 SUPFAM 3

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 827
  • Mass: 92725
  • Checksum: 32E1D6DF92DB3F8D
  • Sequence:
    • MTKLSAQVKG SLNITTPGLQ IWRIEAMQMV PVPSSTFGSF FDGDCYIILA IHKTASSLSY 
DIHYWIGQDS SLDEQGAAAI YTTQMDDFLK GRAVQHREVQ GNESEAFRGY FKQGLVIRKG 
GVASGMKHVE TNSYDVQRLL HVKGKRNVVA GEVEMSWKSF NRGDVFLLDL GKLIIQWNGP 
ESTRMERLRG MTLAKEIRDQ ERGGRTYVGV VDGENELASP KLMEVMNHVL GKRRELKAAV 
PDTVVEPALK AALKLYHVSD SEGNLVVREV ATRPLTQDLL SHEDCYILDQ GGLKIYVWKG 
KKANEQEKKG AMSHALNFIK AKQYPPSTQV EVQNDGAESA VFQQLFQKWT ASNRTSGLGK 
THTVGSVAKV EQEKFDATSM HVKPQVAAQQ KMVDDGSGEV QVWRIENLEL VPVDSKWLGH 
FYGGDCYLLL YTYLIGEKQH YLLYVWQGSQ ASQDEITASA YQAVILDQKY NGEPVQIRVP 
MGKEPPHLMS IFKGRMVVYQ GGTSRTNNLE TGPSTRLFQV QGTGANNTKA FEVPARANFL 
NSNDVFVLKT QSCCYLWCGK GCSGDEREMA KMVADTISRT EKQVVVEGQE PANFWMALGG 
KAPYANTKRL QEENLVITPR LFECSNKTGR FLATEIPDFN QDDLEEDDVF LLDVWDQVFF 
WIGKHANEEE KKAAATTAQE YLKTHPSGRD PETPIIVVKQ GHEPPTFTGW FLAWDPFKWS 
NTKSYEDLKA ELGNSRDWSQ ITAEVTSPKV DVFNANSNLS SGPLPIFPLE QLVNKPVEEL 
PEGVDPSRKE EHLSIEDFTQ AFGMTPAAFS ALPRWKQQNL KKEKGLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.