Details for: ZIC2

Gene ID: 7546

Symbol: ZIC2

Ensembl ID: ENSG00000043355

Description: Zic family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 7.5847
    Cell Significance Index: 129.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.1422
    Cell Significance Index: 67.1700
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.2253
    Cell Significance Index: 13.9500
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.9431
    Cell Significance Index: 10.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4081
    Cell Significance Index: 22.9000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.3337
    Cell Significance Index: 3.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2191
    Cell Significance Index: 13.8100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1196
    Cell Significance Index: 1.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0882
    Cell Significance Index: 56.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0614
    Cell Significance Index: 1.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0546
    Cell Significance Index: 102.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0098
    Cell Significance Index: -4.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0192
    Cell Significance Index: -13.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0239
    Cell Significance Index: -17.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0275
    Cell Significance Index: -15.0000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0303
    Cell Significance Index: -0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0339
    Cell Significance Index: -19.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0342
    Cell Significance Index: -15.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0513
    Cell Significance Index: -2.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0524
    Cell Significance Index: -18.7900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0538
    Cell Significance Index: -0.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0564
    Cell Significance Index: -2.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0607
    Cell Significance Index: -17.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0834
    Cell Significance Index: -14.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0837
    Cell Significance Index: -16.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0916
    Cell Significance Index: -16.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0936
    Cell Significance Index: -19.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0953
    Cell Significance Index: -13.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1001
    Cell Significance Index: -20.0800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1051
    Cell Significance Index: -0.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1262
    Cell Significance Index: -15.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1266
    Cell Significance Index: -17.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1525
    Cell Significance Index: -17.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1569
    Cell Significance Index: -17.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1724
    Cell Significance Index: -17.9500
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.2101
    Cell Significance Index: -2.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2553
    Cell Significance Index: -11.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2974
    Cell Significance Index: -20.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3304
    Cell Significance Index: -20.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3511
    Cell Significance Index: -7.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3991
    Cell Significance Index: -7.7900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4001
    Cell Significance Index: -4.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4139
    Cell Significance Index: -21.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4419
    Cell Significance Index: -20.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4641
    Cell Significance Index: -20.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5032
    Cell Significance Index: -8.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5060
    Cell Significance Index: -16.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5422
    Cell Significance Index: -20.5300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.5455
    Cell Significance Index: -6.8700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.5501
    Cell Significance Index: -7.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5694
    Cell Significance Index: -16.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5799
    Cell Significance Index: -20.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5973
    Cell Significance Index: -18.8900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6152
    Cell Significance Index: -9.7600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.6182
    Cell Significance Index: -7.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6203
    Cell Significance Index: -20.3100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.6207
    Cell Significance Index: -8.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6262
    Cell Significance Index: -16.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6490
    Cell Significance Index: -20.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6573
    Cell Significance Index: -17.8900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6630
    Cell Significance Index: -13.4900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.6821
    Cell Significance Index: -9.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6987
    Cell Significance Index: -20.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7000
    Cell Significance Index: -7.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7019
    Cell Significance Index: -20.0300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.7043
    Cell Significance Index: -8.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7057
    Cell Significance Index: -17.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7147
    Cell Significance Index: -19.1500
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.7522
    Cell Significance Index: -6.9600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.7607
    Cell Significance Index: -7.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7678
    Cell Significance Index: -20.1900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.7860
    Cell Significance Index: -7.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7897
    Cell Significance Index: -28.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8154
    Cell Significance Index: -20.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8220
    Cell Significance Index: -20.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.8443
    Cell Significance Index: -20.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8963
    Cell Significance Index: -21.5000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.8965
    Cell Significance Index: -7.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9386
    Cell Significance Index: -19.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.9406
    Cell Significance Index: -15.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9424
    Cell Significance Index: -20.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9654
    Cell Significance Index: -20.4900
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.9719
    Cell Significance Index: -7.7200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.9779
    Cell Significance Index: -14.6300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.9792
    Cell Significance Index: -16.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0024
    Cell Significance Index: -20.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0140
    Cell Significance Index: -16.9700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.0141
    Cell Significance Index: -19.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0145
    Cell Significance Index: -29.0800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0152
    Cell Significance Index: -24.7700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.0274
    Cell Significance Index: -16.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0304
    Cell Significance Index: -15.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -1.0316
    Cell Significance Index: -16.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0378
    Cell Significance Index: -20.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.0416
    Cell Significance Index: -20.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0526
    Cell Significance Index: -20.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.0530
    Cell Significance Index: -17.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.0553
    Cell Significance Index: -18.0400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -1.0617
    Cell Significance Index: -7.0700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.0625
    Cell Significance Index: -12.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription factor function:** ZIC2 is a transcription factor that regulates the expression of target genes involved in neural development, cell differentiation, and survival. 2. **DNA-binding specificity:** ZIC2 exhibits a high degree of specificity in binding to DNA sequences, particularly those involved in the regulation of neural-specific genes. 3. **Chromatin remodeling:** ZIC2 has been shown to interact with chromatin remodeling complexes, allowing for the regulation of gene expression through chromatin modification. 4. **Cell-type specificity:** ZIC2 expression is restricted to specific cell types within the CNS, including neurons, glial cells, and endothelial cells. **Pathways and Functions:** 1. **Brain development:** ZIC2 is essential for the development of the anterior neural plate and the formation of the cerebral cortex. 2. **Cell differentiation:** ZIC2 regulates the differentiation of neural cells into specific cell types, such as neurons and glial cells. 3. **Central nervous system development:** ZIC2 is involved in the development of the CNS, including the formation of the neural tube, the ventricular system, and the blood-brain barrier. 4. **Neural survival:** ZIC2 promotes the survival of neurons and other CNS cells by regulating the expression of anti-apoptotic genes. 5. **Visual perception:** ZIC2 has been implicated in the regulation of visual perception, particularly in the development and maintenance of the retina. **Clinical Significance:** 1. **Neurological disorders:** ZIC2 dysregulation has been implicated in several neurological disorders, including neuronal migration disorders, such as lissencephaly and subcortical band heterotopia. 2. **CNS cancer:** ZIC2 expression is often altered in CNS cancers, including glioblastoma and medulloblastoma, suggesting a potential role for ZIC2 as a tumor suppressor gene. 3. **Neurodevelopmental disorders:** ZIC2 has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, although the mechanisms underlying these associations are not fully understood. 4. **Therapeutic potential:** Targeting ZIC2 expression or function may offer a novel therapeutic strategy for the treatment of CNS disorders, particularly those involving neural cell proliferation and differentiation. In conclusion, the ZIC2 gene is a critical regulator of neural development and function, with significant implications for our understanding of CNS biology and disease. Further research is needed to fully elucidate the mechanisms by which ZIC2 regulates neural development and to explore its therapeutic potential.

Genular Protein ID: 2608943970

Symbol: ZIC2_HUMAN

Name: Zinc finger protein ZIC 2

UniProtKB Accession Codes:

O95409 Q5VYA9 Q9H309

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9771712

Title: Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.

PubMed ID: 9771712

DOI: 10.1038/2484

PubMed ID: 10984499

Title: ZIC2 and Sp3 repress Sp1-induced activation of the human D1A dopamine receptor gene.

PubMed ID: 10984499

DOI: 10.1074/jbc.m007906200

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 17251188

Title: ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A.

PubMed ID: 17251188

DOI: 10.1074/jbc.m610821200

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11285244

Title: Holoprosencephaly due to mutations in ZIC2: alanine tract expansion mutations may be caused by parental somatic recombination.

PubMed ID: 11285244

DOI: 10.1093/hmg/10.8.791

PubMed ID: 15221788

Title: Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: mutation review and genotype-phenotype correlations.

PubMed ID: 15221788

DOI: 10.1002/humu.20056

PubMed ID: 15590697

Title: In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation.

PubMed ID: 15590697

DOI: 10.1093/hmg/ddi037

PubMed ID: 19177455

Title: The full spectrum of holoprosencephaly-associated mutations within the ZIC2 gene in humans predicts loss-of-function as the predominant disease mechanism.

PubMed ID: 19177455

DOI: 10.1002/humu.20982

Sequence Information:

  • Length: 532
  • Mass: 55006
  • Checksum: BA3E6455DAF97EAC
  • Sequence:
    • MLLDAGPQFP AIGVGSFARH HHHSAAAAAA AAAEMQDREL SLAAAQNGFV DSAAAHMGAF 
KLNPGAHELS PGQSSAFTSQ GPGAYPGSAA AAAAAAALGP HAAHVGSYSG PPFNSTRDFL 
FRSRGFGDSA PGGGQHGLFG PGAGGLHHAH SDAQGHLLFP GLPEQHGPHG SQNVLNGQMR 
LGLPGEVFGR SEQYRQVASP RTDPYSAAQL HNQYGPMNMN MGMNMAAAAA HHHHHHHHHP 
GAFFRYMRQQ CIKQELICKW IDPEQLSNPK KSCNKTFSTM HELVTHVSVE HVGGPEQSNH 
VCFWEECPRE GKPFKAKYKL VNHIRVHTGE KPFPCPFPGC GKVFARSENL KIHKRTHTGE 
KPFQCEFEGC DRRFANSSDR KKHMHVHTSD KPYLCKMCDK SYTHPSSLRK HMKVHESSPQ 
GSESSPAASS GYESSTPPGL VSPSAEPQSS SNLSPAAAAA AAAAAAAAAA VSAVHRGGGS 
GSGGAGGGSG GGSGSGGGGG GAGGGGGGSS GGGSGTAGGH SGLSSNFNEW YV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.