Details for: ZNF708

Gene ID: 7562

Symbol: ZNF708

Ensembl ID: ENSG00000182141

Description: zinc finger protein 708

Associated with

  • Epigenetic regulation of gene expression
    (R-HSA-212165)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Regulation of endogenous retroelements
    (R-HSA-9842860)
  • Regulation of endogenous retroelements by krab-zfp proteins
    (R-HSA-9843940)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.3913
    Cell Significance Index: -29.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.6635
    Cell Significance Index: -28.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.0646
    Cell Significance Index: -28.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.1651
    Cell Significance Index: -23.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.4859
    Cell Significance Index: -30.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2544
    Cell Significance Index: -27.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5790
    Cell Significance Index: -26.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7014
    Cell Significance Index: -30.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8400
    Cell Significance Index: -14.9700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 6.7934
    Cell Significance Index: 111.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3524
    Cell Significance Index: 133.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3376
    Cell Significance Index: 268.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.2973
    Cell Significance Index: 18.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1809
    Cell Significance Index: 66.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1358
    Cell Significance Index: 1025.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8749
    Cell Significance Index: 313.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8460
    Cell Significance Index: 52.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8252
    Cell Significance Index: 163.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7893
    Cell Significance Index: 18.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7873
    Cell Significance Index: 85.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7870
    Cell Significance Index: 15.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7483
    Cell Significance Index: 57.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7386
    Cell Significance Index: 44.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7326
    Cell Significance Index: 119.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6494
    Cell Significance Index: 24.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6162
    Cell Significance Index: 27.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3784
    Cell Significance Index: 51.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3768
    Cell Significance Index: 26.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3535
    Cell Significance Index: 23.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3009
    Cell Significance Index: 8.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2640
    Cell Significance Index: 358.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2637
    Cell Significance Index: 7.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2567
    Cell Significance Index: 29.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2414
    Cell Significance Index: 29.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2273
    Cell Significance Index: 40.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2239
    Cell Significance Index: 4.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1713
    Cell Significance Index: 8.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1709
    Cell Significance Index: 263.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1598
    Cell Significance Index: 294.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1322
    Cell Significance Index: 248.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1295
    Cell Significance Index: 8.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1206
    Cell Significance Index: 22.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1096
    Cell Significance Index: 6.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1064
    Cell Significance Index: 48.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0980
    Cell Significance Index: 62.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0861
    Cell Significance Index: 38.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0725
    Cell Significance Index: 39.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0572
    Cell Significance Index: 0.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0468
    Cell Significance Index: 1.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0370
    Cell Significance Index: 1.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0326
    Cell Significance Index: 3.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0177
    Cell Significance Index: 0.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0091
    Cell Significance Index: 0.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0155
    Cell Significance Index: -11.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0311
    Cell Significance Index: -3.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0356
    Cell Significance Index: -26.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0489
    Cell Significance Index: -30.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0706
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0755
    Cell Significance Index: -12.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0859
    Cell Significance Index: -24.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0884
    Cell Significance Index: -4.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1011
    Cell Significance Index: -2.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1043
    Cell Significance Index: -3.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1202
    Cell Significance Index: -13.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1230
    Cell Significance Index: -2.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1293
    Cell Significance Index: -13.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1395
    Cell Significance Index: -29.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1634
    Cell Significance Index: -7.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1725
    Cell Significance Index: -12.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1769
    Cell Significance Index: -22.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1790
    Cell Significance Index: -4.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1881
    Cell Significance Index: -9.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1904
    Cell Significance Index: -19.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2188
    Cell Significance Index: -2.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2548
    Cell Significance Index: -5.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2777
    Cell Significance Index: -4.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2819
    Cell Significance Index: -3.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2972
    Cell Significance Index: -18.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3022
    Cell Significance Index: -22.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3154
    Cell Significance Index: -24.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3782
    Cell Significance Index: -9.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3836
    Cell Significance Index: -20.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3974
    Cell Significance Index: -13.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4057
    Cell Significance Index: -12.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4249
    Cell Significance Index: -11.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4718
    Cell Significance Index: -10.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4926
    Cell Significance Index: -9.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4999
    Cell Significance Index: -6.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5046
    Cell Significance Index: -10.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5230
    Cell Significance Index: -16.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5373
    Cell Significance Index: -18.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5389
    Cell Significance Index: -6.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5504
    Cell Significance Index: -11.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5624
    Cell Significance Index: -12.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5652
    Cell Significance Index: -15.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5746
    Cell Significance Index: -16.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5986
    Cell Significance Index: -10.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF708 contains a zinc finger domain, which is a conserved structural motif that enables the protein to bind to DNA and regulate gene expression. 2. **Transcriptional Regulation:** ZNF708 has been implicated in the regulation of transcription, particularly in the context of RNA polymerase II-specific transcription. 3. **Metal Ion Binding:** The protein has been shown to bind to metal ions, which is essential for its transcriptional regulatory functions. 4. **Cellular Specificity:** ZNF708 is significantly expressed in various cell types, including secondary lens fiber, oligodendrocyte, lens epithelial cell, anterior lens cell, astrocyte of the cerebral cortex, cardiac neuron, and several types of cortical neurons. 5. **Gene Expression:** ZNF708 has been implicated in the regulation of gene expression, particularly in the context of DNA-templated transcription. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF708 acts as a DNA-binding transcription factor, regulating gene expression by binding to specific DNA sequences. 2. **RNA Polymerase II-Specific Transcription:** ZNF708 has been implicated in the regulation of RNA polymerase II-specific transcription, which is a crucial process in gene expression. 3. **Gene Expression (Transcription):** ZNF708 plays a role in regulating gene expression, particularly in the context of DNA-templated transcription. 4. **Regulation of DNA-Templated Transcription:** ZNF708 has been shown to regulate DNA-templated transcription, which is a critical process in gene expression. 5. **Metal Ion Binding:** The protein binds to metal ions, which is essential for its transcriptional regulatory functions. **Clinical Significance:** 1. **Lens Disorders:** ZNF708 has been implicated in lens disorders, such as cataracts, which highlights the importance of this gene in maintaining lens function. 2. **Neurological Disorders:** The protein's involvement in the regulation of gene expression in various neural cell types underscores its potential role in neurological disorders, such as neurodegenerative diseases. 3. **Cancer Research:** ZNF708's role in regulating gene expression and transcriptional regulation makes it a potential target for cancer research and therapy. 4. **Gene Therapy:** The understanding of ZNF708's function and regulation could lead to the development of gene therapy strategies for various diseases, including lens and neurological disorders. In conclusion, the zinc finger protein ZNF708 plays a crucial role in regulating gene expression and transcriptional regulation in various cell types. Its involvement in lens disorders, neurological disorders, cancer research, and gene therapy highlights its clinical significance and underscores the importance of further research into this gene.

Genular Protein ID: 625540854

Symbol: ZN708_HUMAN

Name: Zinc finger protein 15

UniProtKB Accession Codes:

P17019 Q6ZMR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 563
  • Mass: 64779
  • Checksum: 633BFC91E6DC40CD
  • Sequence:
    • MGPLTFMDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSNL DLITCLEQGK 
EPWNMKRHEM AAKPPAMCSH FAKDLRPEQY IKNSFQQVIL RRYGKCGYQK GCKSVDEHKL 
HKGGHKGLNR CVTTTQSKIV QCDKYVKVFH KYSNAKRHKI RHTGKNPFKC KECGKSFCML 
SQLTQHEIIH TGEKPYKCEE CGKAFKKSSN LTNHKIIHTG EKPYKCEECG KAFNQSSTLT 
RHKIIHTGEK LYKCEECGKA FNRSSNLTKH KIVHTGEKPY KCEECGKAFK QSSNLTNHKK 
IHTGEKPYKC GECGKAFTLS SHLTTHKRIH TGEKPYKCEE CGKAFSVFST LTKHKIIHTE 
EKPYKCEECG KAFNRSSHLT NHKVIHTGEK PYKCEECGKA FTKSSTLTYH KVIHTGKKPY 
KCEECGKAFS IFSILTKHKV IHTEDKPYKC EECGKTFNYS SNFTNHKKIH TGEKPYKCEE 
CGKSFILSSH LTTHKIIHTG EKPYKCKECG KAFNQSSTLM KHKIIHTGEK PYKCEECGKA 
FNQSPNLTKH KRIHTKEKPY KCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.