Details for: ZNF66

Gene ID: 7617

Symbol: ZNF66

Ensembl ID: ENSG00000160229

Description: zinc finger protein 66

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.6261
    Cell Significance Index: -10.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.5150
    Cell Significance Index: -10.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8324
    Cell Significance Index: -10.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7820
    Cell Significance Index: -3.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6392
    Cell Significance Index: 15.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9191
    Cell Significance Index: 174.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9065
    Cell Significance Index: 19.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8066
    Cell Significance Index: 45.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7717
    Cell Significance Index: 154.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.7335
    Cell Significance Index: 23.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6861
    Cell Significance Index: 67.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.6212
    Cell Significance Index: 15.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6054
    Cell Significance Index: 26.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5924
    Cell Significance Index: 106.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5688
    Cell Significance Index: 21.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5076
    Cell Significance Index: 26.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5012
    Cell Significance Index: 179.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4562
    Cell Significance Index: 27.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4357
    Cell Significance Index: 47.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4317
    Cell Significance Index: 389.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3739
    Cell Significance Index: 60.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3373
    Cell Significance Index: 5.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3204
    Cell Significance Index: 63.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2762
    Cell Significance Index: 7.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2603
    Cell Significance Index: 32.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2309
    Cell Significance Index: 66.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1969
    Cell Significance Index: 13.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1844
    Cell Significance Index: 4.6100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1810
    Cell Significance Index: 3.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1780
    Cell Significance Index: 11.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1619
    Cell Significance Index: 8.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1254
    Cell Significance Index: 8.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1242
    Cell Significance Index: 5.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1155
    Cell Significance Index: 13.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1024
    Cell Significance Index: 2.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0953
    Cell Significance Index: 179.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0741
    Cell Significance Index: 47.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0725
    Cell Significance Index: 1.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0527
    Cell Significance Index: 71.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0519
    Cell Significance Index: 1.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0372
    Cell Significance Index: 4.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0306
    Cell Significance Index: 4.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0242
    Cell Significance Index: 10.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0240
    Cell Significance Index: 36.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0222
    Cell Significance Index: 40.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0154
    Cell Significance Index: 8.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0140
    Cell Significance Index: 0.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0119
    Cell Significance Index: 0.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0105
    Cell Significance Index: 0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0048
    Cell Significance Index: 2.1900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0038
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0113
    Cell Significance Index: -8.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0133
    Cell Significance Index: -1.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0182
    Cell Significance Index: -10.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0188
    Cell Significance Index: -11.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0235
    Cell Significance Index: -1.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0260
    Cell Significance Index: -0.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0260
    Cell Significance Index: -1.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0285
    Cell Significance Index: -3.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0394
    Cell Significance Index: -2.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0410
    Cell Significance Index: -0.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0416
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0428
    Cell Significance Index: -7.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0459
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0495
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0545
    Cell Significance Index: -11.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0550
    Cell Significance Index: -5.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0785
    Cell Significance Index: -8.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0788
    Cell Significance Index: -10.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0798
    Cell Significance Index: -3.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0882
    Cell Significance Index: -2.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0922
    Cell Significance Index: -5.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0931
    Cell Significance Index: -2.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1060
    Cell Significance Index: -3.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1245
    Cell Significance Index: -9.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1355
    Cell Significance Index: -10.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1361
    Cell Significance Index: -2.7700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1416
    Cell Significance Index: -0.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1454
    Cell Significance Index: -4.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1465
    Cell Significance Index: -3.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1542
    Cell Significance Index: -4.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1673
    Cell Significance Index: -5.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1898
    Cell Significance Index: -2.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1927
    Cell Significance Index: -10.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1961
    Cell Significance Index: -5.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2046
    Cell Significance Index: -2.6200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2088
    Cell Significance Index: -2.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2149
    Cell Significance Index: -5.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2201
    Cell Significance Index: -3.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2326
    Cell Significance Index: -6.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2346
    Cell Significance Index: -2.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2447
    Cell Significance Index: -3.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2452
    Cell Significance Index: -5.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2478
    Cell Significance Index: -8.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2530
    Cell Significance Index: -5.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2666
    Cell Significance Index: -5.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2688
    Cell Significance Index: -6.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulation**: ZNF66 exhibits DNA-binding transcription factor activity, specifically through RNA polymerase II, which enables it to regulate gene expression by binding to cis-regulatory regions. 2. **Metal Ion Binding**: The protein's ability to bind metal ions, such as zinc, is essential for its structural integrity and functional activity. 3. **Cell Type Specificity**: ZNF66 is significantly expressed in various cell types, including colon goblet cells, germ cells, and neurons, which suggests its involvement in specific cellular processes. **Pathways and Functions** 1. **DNA-Binding Transcription Factor Activity**: ZNF66's ability to bind to DNA and regulate transcription by RNA polymerase II is crucial for its role in transcriptional regulation. 2. **Regulation of DNA-templated Transcription**: By controlling the expression of genes, ZNF66 plays a key role in the development and maintenance of specific cell types. 3. **Metal Ion Binding**: The binding of metal ions to ZNF66 is essential for its structural integrity and functional activity. 4. **Regulation of Transcription by RNA Polymerase II**: ZNF66's interaction with RNA polymerase II enables it to regulate transcription in response to environmental cues. **Clinical Significance** 1. **Cancer Research**: ZNF66's role in transcriptional regulation and cellular development makes it an attractive target for cancer research, particularly in the development of cancer therapies. 2. **Neurological Disorders**: The expression of ZNF66 in neurons and its involvement in transcriptional regulation suggest its potential role in neurological disorders, such as neurodegenerative diseases. 3. **Developmental Biology**: ZNF66's expression in germ cells and its role in transcriptional regulation highlight its importance in developmental biology, particularly in the development of specific cell types. 4. **Gene Therapy**: The understanding of ZNF66's function and regulation may lead to the development of gene therapies targeting specific cell types or diseases. In conclusion, ZNF66 is a transcription factor with a critical role in transcriptional regulation and cellular development. Its expression patterns and functional roles suggest its involvement in diverse cellular processes, making it an attractive target for research in cancer, neurological disorders, developmental biology, and gene therapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.