Details for: ZNF76

Gene ID: 7629

Symbol: ZNF76

Ensembl ID: ENSG00000065029

Description: zinc finger protein 76

Associated with

  • Central nervous system development
    (GO:0007417)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of transcription by rna polymerase iii
    (GO:0006359)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.6659
    Cell Significance Index: -20.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.4566
    Cell Significance Index: -19.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.7500
    Cell Significance Index: -18.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.2512
    Cell Significance Index: -21.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4379
    Cell Significance Index: -19.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4327
    Cell Significance Index: -11.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4307
    Cell Significance Index: -21.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2434
    Cell Significance Index: -16.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0205
    Cell Significance Index: 27.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9530
    Cell Significance Index: 11.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8920
    Cell Significance Index: 12.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8874
    Cell Significance Index: 178.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6716
    Cell Significance Index: 51.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6598
    Cell Significance Index: 130.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6495
    Cell Significance Index: 105.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6365
    Cell Significance Index: 69.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5720
    Cell Significance Index: 108.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5287
    Cell Significance Index: 31.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4897
    Cell Significance Index: 10.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4723
    Cell Significance Index: 20.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4649
    Cell Significance Index: 166.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4384
    Cell Significance Index: 16.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4179
    Cell Significance Index: 11.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3877
    Cell Significance Index: 8.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3570
    Cell Significance Index: 41.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3323
    Cell Significance Index: 9.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3015
    Cell Significance Index: 20.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2792
    Cell Significance Index: 12.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2535
    Cell Significance Index: 11.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2325
    Cell Significance Index: 27.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2207
    Cell Significance Index: 13.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2093
    Cell Significance Index: 20.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2067
    Cell Significance Index: 10.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1925
    Cell Significance Index: 10.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1904
    Cell Significance Index: 2.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1696
    Cell Significance Index: 20.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1508
    Cell Significance Index: 7.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1385
    Cell Significance Index: 3.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1369
    Cell Significance Index: 94.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1288
    Cell Significance Index: 23.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1211
    Cell Significance Index: 8.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1197
    Cell Significance Index: 65.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1153
    Cell Significance Index: 4.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1151
    Cell Significance Index: 15.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0804
    Cell Significance Index: 151.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0760
    Cell Significance Index: 1.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0626
    Cell Significance Index: 27.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0605
    Cell Significance Index: 38.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0535
    Cell Significance Index: 24.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0346
    Cell Significance Index: 63.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0339
    Cell Significance Index: 52.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0185
    Cell Significance Index: 2.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0163
    Cell Significance Index: 0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0067
    Cell Significance Index: 0.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0054
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0045
    Cell Significance Index: 6.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0077
    Cell Significance Index: -1.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0088
    Cell Significance Index: -1.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0257
    Cell Significance Index: -1.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0363
    Cell Significance Index: -22.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0384
    Cell Significance Index: -4.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0405
    Cell Significance Index: -0.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0440
    Cell Significance Index: -4.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0553
    Cell Significance Index: -3.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0625
    Cell Significance Index: -17.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0665
    Cell Significance Index: -4.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0761
    Cell Significance Index: -1.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0786
    Cell Significance Index: -1.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0998
    Cell Significance Index: -1.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1018
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1027
    Cell Significance Index: -21.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1159
    Cell Significance Index: -13.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1202
    Cell Significance Index: -5.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1221
    Cell Significance Index: -3.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1437
    Cell Significance Index: -5.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1462
    Cell Significance Index: -15.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1502
    Cell Significance Index: -10.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1587
    Cell Significance Index: -4.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1894
    Cell Significance Index: -6.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2124
    Cell Significance Index: -5.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2221
    Cell Significance Index: -17.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2306
    Cell Significance Index: -5.0500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2390
    Cell Significance Index: -2.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2470
    Cell Significance Index: -15.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2753
    Cell Significance Index: -8.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2856
    Cell Significance Index: -2.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3191
    Cell Significance Index: -16.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3279
    Cell Significance Index: -6.9600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3375
    Cell Significance Index: -4.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3480
    Cell Significance Index: -8.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3701
    Cell Significance Index: -9.9000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3742
    Cell Significance Index: -9.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3787
    Cell Significance Index: -12.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3862
    Cell Significance Index: -5.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3897
    Cell Significance Index: -9.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4038
    Cell Significance Index: -4.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF76 acts as a transcriptional activator, binding to specific DNA sequences and regulating the expression of target genes involved in various cellular processes, including immune responses and CNS development. 2. **Cell-Specific Expression:** ZNF76 is expressed in neural progenitor cells, GABAergic neurons, and other cell types involved in immune responses, indicating its role in regulating specific cellular processes. 3. **Metal Ion Binding:** ZNF76 contains zinc finger domains, which are essential for binding to metal ions and facilitating its transcriptional activity. 4. **RNA Polymerase II-Specific:** ZNF76 interacts with RNA polymerase II, a key enzyme involved in transcriptional regulation, to activate the expression of target genes. **Pathways and Functions:** 1. **Central Nervous System Development:** ZNF76 plays a crucial role in regulating the development and function of the CNS, particularly in the context of neural progenitor cells and GABAergic neurons. 2. **Immune Regulation:** ZNF76 is involved in regulating immune-related processes, including the expression of genes involved in immune responses and the development of immune cells. 3. **Transcriptional Regulation:** ZNF76 acts as a transcriptional activator, regulating the expression of target genes involved in various cellular processes, including immune responses and CNS development. 4. **Gene Expression:** ZNF76 regulates the expression of specific genes involved in immune responses, such as those involved in the development of GABAergic neurons and dopaminergic neurons. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in ZNF76 expression have been linked to various neurological disorders, including autism spectrum disorder, schizophrenia, and bipolar disorder. 2. **Immune-Related Diseases:** ZNF76 may play a role in regulating immune-related processes, potentially contributing to the development of immune-related diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** ZNF76 has been implicated in cancer development and progression, particularly in the context of neural tumors and immune-related cancers. 4. **Personalized Medicine:** Further research on ZNF76 may lead to the development of personalized therapeutic strategies for patients with neurological and immune-related disorders. In conclusion, ZNF76 is a crucial transcription factor involved in regulating gene expression in various cell types, including neural progenitor cells, GABAergic neurons, and cardiac myocytes. Its role in immune regulation and CNS development makes it an important target for further research, particularly in the context of neurological and immune-related disorders.

Genular Protein ID: 3475042558

Symbol: ZNF76_HUMAN

Name: Zinc finger protein 76

UniProtKB Accession Codes:

P36508 Q9BQB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1427894

Title: A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the T-complex gene tcp-11.

PubMed ID: 1427894

DOI: 10.1016/s0888-7543(05)80167-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 570
  • Mass: 61831
  • Checksum: 333C99E0E79D86C2
  • Sequence:
    • MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ KEALSFEDGQ 
PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH PVAVPSESTI LAVQTEVGLE 
DLAAEDDEGF SADAVVALEQ YASKVLHDSQ IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH 
HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG 
DLQKHVRTHT GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC GKTYRQTSTL 
AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK RPRIAYLSEV KEERDDIPAQ 
VAMVTEEDGA PQVALITQDG AQQVSLSPED LQALGSAISM VTQHGSTTLT IPSPDADLAT 
SGTHTVTMVS ADGTQTQPVT IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ 
QTLEEAINVA TAAMQQGAVT LETTVSESGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.