Details for: ZNF221

Gene ID: 7638

Symbol: ZNF221

Ensembl ID: ENSG00000159905

Description: zinc finger protein 221

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 31.8235
    Cell Significance Index: -4.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.5747
    Cell Significance Index: -4.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.0715
    Cell Significance Index: -5.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3138
    Cell Significance Index: 19.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3127
    Cell Significance Index: 59.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2397
    Cell Significance Index: 5.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2176
    Cell Significance Index: 13.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2037
    Cell Significance Index: 1.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1777
    Cell Significance Index: 35.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1593
    Cell Significance Index: 15.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1402
    Cell Significance Index: 27.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1382
    Cell Significance Index: 15.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1288
    Cell Significance Index: 2.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1101
    Cell Significance Index: 39.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1088
    Cell Significance Index: 4.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0970
    Cell Significance Index: 87.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0850
    Cell Significance Index: 13.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0812
    Cell Significance Index: 2.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0535
    Cell Significance Index: 3.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0535
    Cell Significance Index: 1.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0424
    Cell Significance Index: 2.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0418
    Cell Significance Index: 2.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0372
    Cell Significance Index: 4.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0355
    Cell Significance Index: 1.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0353
    Cell Significance Index: 24.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0198
    Cell Significance Index: 0.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0185
    Cell Significance Index: 0.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0181
    Cell Significance Index: 1.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0174
    Cell Significance Index: 2.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0166
    Cell Significance Index: 9.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0112
    Cell Significance Index: 0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0088
    Cell Significance Index: 1.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0033
    Cell Significance Index: 0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0027
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0004
    Cell Significance Index: 0.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0002
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0025
    Cell Significance Index: -0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0027
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0048
    Cell Significance Index: -2.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0061
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0098
    Cell Significance Index: -0.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0100
    Cell Significance Index: -0.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0106
    Cell Significance Index: -3.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0166
    Cell Significance Index: -2.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0169
    Cell Significance Index: -0.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0191
    Cell Significance Index: -0.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0204
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0218
    Cell Significance Index: -2.6800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0279
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0286
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0298
    Cell Significance Index: -5.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0309
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0337
    Cell Significance Index: -3.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0347
    Cell Significance Index: -3.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0367
    Cell Significance Index: -1.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0390
    Cell Significance Index: -4.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0416
    Cell Significance Index: -5.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0420
    Cell Significance Index: -1.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0463
    Cell Significance Index: -2.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0470
    Cell Significance Index: -4.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0491
    Cell Significance Index: -3.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0501
    Cell Significance Index: -3.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0510
    Cell Significance Index: -2.5800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0520
    Cell Significance Index: -0.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0565
    Cell Significance Index: -1.5800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0613
    Cell Significance Index: -0.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0626
    Cell Significance Index: -4.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0672
    Cell Significance Index: -5.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0743
    Cell Significance Index: -1.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0831
    Cell Significance Index: -5.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0879
    Cell Significance Index: -4.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0964
    Cell Significance Index: -3.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0974
    Cell Significance Index: -1.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1005
    Cell Significance Index: -3.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1065
    Cell Significance Index: -3.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1124
    Cell Significance Index: -1.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1187
    Cell Significance Index: -3.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1240
    Cell Significance Index: -2.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1296
    Cell Significance Index: -2.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1328
    Cell Significance Index: -3.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1331
    Cell Significance Index: -3.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1371
    Cell Significance Index: -3.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1378
    Cell Significance Index: -4.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1386
    Cell Significance Index: -2.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1387
    Cell Significance Index: -4.8200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1429
    Cell Significance Index: -4.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1435
    Cell Significance Index: -3.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1466
    Cell Significance Index: -5.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1469
    Cell Significance Index: -3.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1508
    Cell Significance Index: -3.2000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1509
    Cell Significance Index: -1.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF221 is a small, cysteine-rich protein that belongs to the zinc finger protein family. Its primary function is to bind to specific DNA sequences, thereby regulating gene expression. The protein consists of a zinc finger domain, which is responsible for DNA binding, and a C-terminal domain that interacts with RNA polymerase II. ZNF221 is highly expressed in various human tissues, including the colon, cerebral cortex, and small intestine, where it plays a crucial role in regulating the transcription of specific genes. **Pathways and Functions:** ZNF221 is involved in multiple pathways, including DNA-binding transcription factor activity, RNA polymerase II-specific transcription, and regulation of DNA-templated transcription. The protein's ability to bind to specific DNA sequences allows it to regulate the transcription of target genes, which are involved in various cellular processes, such as cell differentiation, proliferation, and survival. In the context of the colon, ZNF221 has been shown to regulate the expression of genes involved in goblet cell differentiation and intestinal epithelial cell function. Similarly, in the cerebral cortex, ZNF221 has been implicated in the regulation of gene expression in GABAergic interneurons. **Clinical Significance:** ZNF221 has been implicated in various human diseases, including colon cancer, where it has been shown to be overexpressed in tumor tissues. The protein's ability to regulate gene expression in intestinal epithelial cells makes it a potential target for the development of novel therapeutic strategies for colon cancer. Additionally, ZNF221 has been linked to neurological disorders, such as epilepsy, where it has been shown to be involved in the regulation of gene expression in GABAergic interneurons. Further studies are needed to fully elucidate the role of ZNF221 in human disease and to explore its potential as a therapeutic target. **Significantly Expressed Cells:** ZNF221 is highly expressed in various human tissues, including: * Colon goblet cell * Cerebral cortex GABAergic interneuron * Forebrain radial glial cell * Absorptive cell * Tuft cell of colon * BEST4+ intestinal epithelial cell * Human * Intestinal crypt stem cell of colon * Transit amplifying cell * Intestinal crypt stem cell of small intestine * Small intestine goblet cell In conclusion, ZNF221 is a transcription factor that plays a crucial role in regulating gene expression in various human tissues. Its ability to bind to specific DNA sequences allows it to regulate the transcription of target genes, which are involved in various cellular processes. Further studies are needed to fully elucidate the role of ZNF221 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 584181421

Symbol: ZN221_HUMAN

Name: Zinc finger protein 221

UniProtKB Accession Codes:

Q9UK13 A0A087WT08 B2RAI6 K7EIT6 Q2M2H2 Q9P1U8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 617
  • Mass: 71197
  • Checksum: 0E27FCDEDA0EC1D4
  • Sequence:
    • MISPSLELLH SGLCKFPEVE GKMTTFKEAV TFKDVAVVFT EEELGLLDPA QRKLYRDVML 
ENFRNLLSVG NQPFHQDTFH FLGKEKFWKM KTTSQREGNS GGKIQIEMET VPEAGPHEEW 
SCQQIWEQIA SDLTRSQNSI RNSSQFFKEG DVPCQIEARL SISHVQQKPY RCNECKQSFS 
DVSVFDLHQQ SHSGEKSHTC GECGKSFCYS PALHIHQRVH MGEKCYKCDV CGKEFNQSSH 
LQTHQRVHTG EKPFKCGQCG KGFHSRSALN VHCKLHTGEK PYNCEECGKA FIHDSQLQEH 
QRIHTGEKPF KCDICGKSFR VRSRLNRHSM VHTGEKPFRC DTCGKNFRQR SALNSHSMVH 
IEEKPYKCEQ CGKGFICRRD FCKHQMVHTG EKPYNCKECG KTFRWSSCLL NHQQVHSGQK 
SFKCEECGKG FYTNSRRSSH QRSHNGEKPY NCEECGKDYK RRLDLEFHQR VHTGERPYNC 
KECGKSFGWA SCLLKHQRLH SGEKPFKCEE CGKRFTQSSQ LHSHQTCHTG EKLYKCEQCE 
KGYNSKFNLD MHQRVHGGER PYNCKECGKS FGWASCLLKH QRLHSGEKPL KSGVWEEIYS 
EFTASFTSVS LCGRKAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.