Details for: ZNF85

Gene ID: 7639

Symbol: ZNF85

Ensembl ID: ENSG00000105750

Description: zinc finger protein 85

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.6605
    Cell Significance Index: -7.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.4742
    Cell Significance Index: -6.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9346
    Cell Significance Index: -8.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2514
    Cell Significance Index: -8.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9194
    Cell Significance Index: 19.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8019
    Cell Significance Index: 45.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7064
    Cell Significance Index: 69.8800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6489
    Cell Significance Index: 4.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4941
    Cell Significance Index: 29.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4538
    Cell Significance Index: 49.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4260
    Cell Significance Index: 384.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3805
    Cell Significance Index: 61.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3638
    Cell Significance Index: 18.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2812
    Cell Significance Index: 33.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2800
    Cell Significance Index: 6.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2757
    Cell Significance Index: 52.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2300
    Cell Significance Index: 46.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2299
    Cell Significance Index: 82.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1993
    Cell Significance Index: 23.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1961
    Cell Significance Index: 13.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1954
    Cell Significance Index: 38.7800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1938
    Cell Significance Index: 3.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1776
    Cell Significance Index: 4.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1722
    Cell Significance Index: 4.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1618
    Cell Significance Index: 10.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1376
    Cell Significance Index: 24.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1269
    Cell Significance Index: 8.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1174
    Cell Significance Index: 8.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1092
    Cell Significance Index: 15.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1087
    Cell Significance Index: 13.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1033
    Cell Significance Index: 45.6700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0937
    Cell Significance Index: 1.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0822
    Cell Significance Index: 51.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0811
    Cell Significance Index: 2.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0795
    Cell Significance Index: 4.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0746
    Cell Significance Index: 12.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0556
    Cell Significance Index: 30.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0524
    Cell Significance Index: 6.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0466
    Cell Significance Index: 1.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0294
    Cell Significance Index: 1.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0248
    Cell Significance Index: 0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0209
    Cell Significance Index: 39.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0192
    Cell Significance Index: 1.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0181
    Cell Significance Index: 0.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0167
    Cell Significance Index: 0.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0086
    Cell Significance Index: 3.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0084
    Cell Significance Index: 0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0064
    Cell Significance Index: 11.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0053
    Cell Significance Index: 0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0041
    Cell Significance Index: 2.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0019
    Cell Significance Index: 2.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0007
    Cell Significance Index: 0.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0090
    Cell Significance Index: -0.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0106
    Cell Significance Index: -8.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0108
    Cell Significance Index: -0.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0111
    Cell Significance Index: -0.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0170
    Cell Significance Index: -0.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0191
    Cell Significance Index: -1.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0198
    Cell Significance Index: -2.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0233
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0235
    Cell Significance Index: -4.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0236
    Cell Significance Index: -0.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0293
    Cell Significance Index: -3.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0299
    Cell Significance Index: -0.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0399
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0446
    Cell Significance Index: -5.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0616
    Cell Significance Index: -4.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0704
    Cell Significance Index: -0.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0714
    Cell Significance Index: -7.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0759
    Cell Significance Index: -3.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0773
    Cell Significance Index: -3.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0784
    Cell Significance Index: -2.5100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0972
    Cell Significance Index: -1.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0973
    Cell Significance Index: -5.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0999
    Cell Significance Index: -7.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1006
    Cell Significance Index: -3.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1075
    Cell Significance Index: -2.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1265
    Cell Significance Index: -4.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1289
    Cell Significance Index: -4.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1407
    Cell Significance Index: -1.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1450
    Cell Significance Index: -3.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1548
    Cell Significance Index: -3.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1587
    Cell Significance Index: -5.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1605
    Cell Significance Index: -3.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1651
    Cell Significance Index: -3.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1688
    Cell Significance Index: -1.7500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1727
    Cell Significance Index: -2.7400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1738
    Cell Significance Index: -1.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1771
    Cell Significance Index: -3.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1805
    Cell Significance Index: -3.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1805
    Cell Significance Index: -3.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1852
    Cell Significance Index: -5.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1944
    Cell Significance Index: -2.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2010
    Cell Significance Index: -3.1100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2069
    Cell Significance Index: -4.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2129
    Cell Significance Index: -6.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF85 contains a characteristic zinc finger domain, which is essential for its DNA-binding activity. This domain allows ZNF85 to recognize and bind to specific DNA sequences, thereby regulating gene expression. 2. **Transcriptional Regulation:** ZNF85 acts as a transcriptional repressor, negatively regulating the activity of RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. This regulation is crucial for maintaining gene expression homeostasis and preventing aberrant transcription. 3. **Cell-Type Specificity:** ZNF85 expression is observed in various cell types, including germ cells, mural cells, and intestinal epithelial cells, suggesting its involvement in specific cellular processes and tissue development. 4. **Metal Ion Binding:** ZNF85's ability to bind metal ions, such as zinc and copper, is essential for its function as a transcriptional regulator. This binding event is crucial for maintaining the protein's structural integrity and facilitating its interaction with DNA. **Pathways and Functions:** ZNF85 is involved in several key pathways, including: 1. **DNA-templated transcription:** ZNF85 regulates the transcription of genes involved in DNA replication, repair, and recombination. 2. **RNA polymerase II-specific transcription:** ZNF85 negatively regulates the activity of RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. 3. **Negative regulation of transcription by RNA polymerase II:** ZNF85's ability to repress RNA polymerase II activity is crucial for maintaining gene expression homeostasis and preventing aberrant transcription. 4. **Metal ion binding:** ZNF85's binding of metal ions is essential for its function as a transcriptional regulator and maintaining its structural integrity. **Clinical Significance:** The dysregulation of ZNF85 has been implicated in various diseases, including: 1. **Cancer:** ZNF85's role in regulating gene expression and maintaining genome stability makes it a potential target for cancer therapy. 2. **Neurological disorders:** ZNF85's involvement in DNA-templated transcription and RNA polymerase II-specific transcription suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders:** ZNF85's expression in germ cells and its role in regulating gene expression make it a potential target for immunological disorders, such as autoimmune diseases. In conclusion, ZNF85 is a multifaceted regulator of transcription and gene expression, playing a crucial role in various cellular processes and tissue development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 990570312

Symbol: ZNF85_HUMAN

Name: Zinc finger protein 85

UniProtKB Accession Codes:

Q03923 B9ZVP4 Q6NVI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 6 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9839802

Title: Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family.

PubMed ID: 9839802

DOI: 10.1089/dna.1998.17.931

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2023909

Title: The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

PubMed ID: 2023909

DOI: 10.1073/pnas.88.9.3608

Sequence Information:

  • Length: 595
  • Mass: 68736
  • Checksum: F21FA8927C28DE90
  • Sequence:
    • MGPLTFRDVA IEFSLKEWQC LDTAQRNLYR NVMLENYRNL VFLGITVSKP DLITCLEQGK 
EAWSMKRHEI MVAKPTVMCS HFAQDLWPEQ NIKDSFQKVT LKRYGKCRHE NLPLRKGCES 
MDECKMHKGG CNGLNQCLTA TQSKIFQCDK YVKVAHKFSN SNRHEIRHTK KKPFKCTKCG 
KSFGMISCLT EHSRIHTRVN FYKCEECGKA FNWSSTLTKH KRIHTGEKPY KCEECGKAFN 
QSSNLIKHKK IHTGEKPYKC EECGKTFNRF STLTTHKIIH TGEKPYKCKE CGKAFNRSST 
LTTHRKIHTG EKPYKCEECG KAFKQSSNLT THKIIHTGEK PYKCKKCGKA FNQSAHLTTH 
EVIHTGEKPY KCEKCGKAFN HFSHLTTHKI IHTGEKPYKC KECGKAFKHS STLTKHKIIH 
TGEKPYKCKE CEKAFNQSSK LTEHKKIHTG EKPYECEKCG KAFNQSSNLT RHKKSHTEEK 
PYKCEECGKG FKWPSTLTIH KIIHTGEKPY KCEECGKAFN QSSKLTKHKK IHTGEKPYTC 
EECGKAFNQS SNLTKHKRIH TGEKPYKCEE CDKAFKWSSV LTKHKIIHTG EKLQI

Genular Protein ID: 913571722

Symbol: Q49A12_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q49A12

Database IDs:

BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 Gene3D 1 HGNC 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 RefSeq 4 SMART 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 536
  • Mass: 61692
  • Checksum: 20A4F7552856428A
  • Sequence:
    • MSLSAQPSSS FYKPVSEVMC SHFAQDLWPE QNIKDSFQKV TLKRYGKCRH ENLPLRKGCE 
SMDECKMHKG GCNGLNQCLT ATQSKIFQCD KYVKVAHKFS NSNRHEIRHT KKKPFKCTKC 
GKSFGMISCL TEHSRIHTRV NFYKCEECGK AFNWSSTLTK HKRIHTGEKP YKCEECGKAF 
NQSSNLIKHK KIHTGEKPYK CEECGKTFNR FSTLTTHKII HTGEKPYKCK ECGKAFNRSS 
TLTTHRKIHT GEKPYKCEEC GKAFKQSSNL TTHKIIHTGE KPYKCKKCGK AFNQSAHLTT 
HEVIHTGEKP YKCEKCGKAF NHFSHLTTHK IIHTGEKPYK CKECGKAFKH SSTLTKHKII 
HTGEKPYKCK ECEKAFNQSS KLTEHKKIHT GEKPYECEKC GKAFNQSSNL TRHKKSHTEE 
KPYKCEECGK GFKWPSTLTI HKIIHTGEKP YKCEECGKAF NQSSKLTKHK KIHTGEKPYT 
CEECGKAFNQ SSNLTKHKRI HTGEKPYKCE ECDKAFKWSS VLTKHKIIHT GEKLQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.