Details for: ZNF157

Gene ID: 7712

Symbol: ZNF157

Ensembl ID: ENSG00000147117

Description: zinc finger protein 157

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.1501
    Cell Significance Index: -4.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5940
    Cell Significance Index: -1.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5891
    Cell Significance Index: 12.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3262
    Cell Significance Index: 5.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1756
    Cell Significance Index: 2.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1380
    Cell Significance Index: 27.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1266
    Cell Significance Index: 45.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1175
    Cell Significance Index: 81.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0591
    Cell Significance Index: 8.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0456
    Cell Significance Index: 2.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0165
    Cell Significance Index: 0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0100
    Cell Significance Index: 0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0050
    Cell Significance Index: 9.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0028
    Cell Significance Index: 0.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0021
    Cell Significance Index: 3.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0029
    Cell Significance Index: -1.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0035
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0057
    Cell Significance Index: -2.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0057
    Cell Significance Index: -4.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0060
    Cell Significance Index: -3.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0072
    Cell Significance Index: -1.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0086
    Cell Significance Index: -0.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0102
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0183
    Cell Significance Index: -3.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0203
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0214
    Cell Significance Index: -4.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0236
    Cell Significance Index: -1.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0260
    Cell Significance Index: -1.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0261
    Cell Significance Index: -3.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0340
    Cell Significance Index: -4.0100
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0346
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0365
    Cell Significance Index: -4.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0392
    Cell Significance Index: -4.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0392
    Cell Significance Index: -4.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0452
    Cell Significance Index: -0.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0455
    Cell Significance Index: -3.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0467
    Cell Significance Index: -1.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0523
    Cell Significance Index: -1.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0528
    Cell Significance Index: -1.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0529
    Cell Significance Index: -1.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0582
    Cell Significance Index: -1.1500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0611
    Cell Significance Index: -0.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0681
    Cell Significance Index: -2.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0702
    Cell Significance Index: -4.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0715
    Cell Significance Index: -2.3400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0717
    Cell Significance Index: -0.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0751
    Cell Significance Index: -3.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0774
    Cell Significance Index: -2.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0775
    Cell Significance Index: -4.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0790
    Cell Significance Index: -1.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0807
    Cell Significance Index: -3.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0835
    Cell Significance Index: -3.6300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0849
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0856
    Cell Significance Index: -2.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0861
    Cell Significance Index: -1.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0882
    Cell Significance Index: -4.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0937
    Cell Significance Index: -2.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1025
    Cell Significance Index: -3.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1056
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1058
    Cell Significance Index: -3.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1075
    Cell Significance Index: -1.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1119
    Cell Significance Index: -2.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1145
    Cell Significance Index: -3.3000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1157
    Cell Significance Index: -1.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1169
    Cell Significance Index: -2.4400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1194
    Cell Significance Index: -3.7800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1228
    Cell Significance Index: -1.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1237
    Cell Significance Index: -4.3000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1262
    Cell Significance Index: -1.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1277
    Cell Significance Index: -2.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1286
    Cell Significance Index: -4.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1299
    Cell Significance Index: -2.7200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1306
    Cell Significance Index: -1.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1308
    Cell Significance Index: -1.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1308
    Cell Significance Index: -3.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1358
    Cell Significance Index: -0.9200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1362
    Cell Significance Index: -2.6800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1387
    Cell Significance Index: -1.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1433
    Cell Significance Index: -4.2200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1434
    Cell Significance Index: -1.8800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1448
    Cell Significance Index: -1.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1465
    Cell Significance Index: -2.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1475
    Cell Significance Index: -3.6000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1521
    Cell Significance Index: -2.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1539
    Cell Significance Index: -4.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1542
    Cell Significance Index: -4.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1548
    Cell Significance Index: -4.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1566
    Cell Significance Index: -4.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1585
    Cell Significance Index: -4.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1660
    Cell Significance Index: -3.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1705
    Cell Significance Index: -2.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1718
    Cell Significance Index: -3.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1727
    Cell Significance Index: -4.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF157 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain that recognizes specific sequences of RNA polymerase II cis-regulatory regions. This domain allows ZNF157 to interact with RNA polymerase II and regulate transcriptional activity. The protein is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. ZNF157 exhibits tissue-specific expression, with high levels detected in retinal bipolar neurons, goblet cells, and intestinal crypt stem cells. Its expression is also observed in stem cells and progenitor cells, indicating its potential involvement in cell fate determination. **Pathways and Functions:** ZNF157 regulates gene expression through its interaction with RNA polymerase II, which is essential for transcriptional activity. The protein is involved in the regulation of transcription by RNA polymerase II, specifically in the context of RNA polymerase II cis-regulatory regions. ZNF157 also exhibits metal ion binding activity, which may be crucial for its DNA-binding function. Moreover, its expression is linked to various signaling pathways, including the Notch and Wnt signaling pathways, which are involved in cell fate determination and development. **Clinical Significance:** Dysregulation of ZNF157 has been implicated in various human diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. For instance, ZNF157 has been shown to act as a tumor suppressor in certain types of cancer, such as colon cancer. Its expression is also altered in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Furthermore, ZNF157 has been linked to cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. These findings suggest that ZNF157 may serve as a valuable biomarker for disease diagnosis and prognosis. In conclusion, ZNF157 is a transcriptional regulator that plays a critical role in maintaining cellular homeostasis and regulating cell fate determination. Its dysregulation has been implicated in various human diseases, highlighting its potential as a therapeutic target. Further studies are needed to elucidate the mechanisms underlying ZNF157's functions and to explore its clinical applications. **References:** * [Insert relevant references] Note: As this is a hypothetical article, the references section is not provided. However, in a real article, you would include relevant references to support the discussion and findings.

Genular Protein ID: 1742404086

Symbol: ZN157_HUMAN

Name: Zinc finger protein 157

UniProtKB Accession Codes:

P51786 Q96LE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8586441

Title: Cloning and characterization of a novel zinc finger gene in Xp11.2.

PubMed ID: 8586441

DOI: 10.1006/geno.1995.0031

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 506
  • Mass: 58291
  • Checksum: 59E1403E7F0CF944
  • Sequence:
    • MPANGTSPQR FPALIPGEPG RSFEGSVSFE DVAVDFTRQE WHRLDPAQRT MHKDVMLETY 
SNLASVGLCV AKPEMIFKLE RGEELWILEE ESSGHGYSGS LSLLCGNGSV GDNALRHDND 
LLHHQKIQTL DQNVEYNGCR KAFHEKTGFV RRKRTPRGDK NFECHECGKA YCRKSNLVEH 
LRIHTGERPY ECGECAKTFS ARSYLIAHQK THTGERPFEC NECGKSFGRK SQLILHTRTH 
TGERPYECTE CGKTFSEKAT LTIHQRTHTG EKPYECSECG KTFRVKISLT QHHRTHTGEK 
PYECGECGKN FRAKKSLNQH QRIHTGEKPY ECGECGKFFR MKMTLNNHQR THTGEKPYQC 
NECGKSFRVH SSLGIHQRIH TGEKPYECNE CGNAFYVKAR LIEHQRMHSG EKPYECSECG 
KIFSMKKSLC QHRRTHTGEK PYECSECGNA FYVKVRLIEH QRIHTGERPF ECQECGKAFC 
RKAHLTEHQR THIGWSWRCT MKKASH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.