Details for: ZNF175

Gene ID: 7728

Symbol: ZNF175

Ensembl ID: ENSG00000105497

Description: zinc finger protein 175

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Cytosol
    (GO:0005829)
  • Defense response to virus
    (GO:0051607)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleolus
    (GO:0005730)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 65.1900
    Cell Significance Index: -10.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.1996
    Cell Significance Index: -10.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.6489
    Cell Significance Index: -8.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.5891
    Cell Significance Index: -10.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1983
    Cell Significance Index: 228.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7816
    Cell Significance Index: 20.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7411
    Cell Significance Index: 73.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6347
    Cell Significance Index: 573.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4251
    Cell Significance Index: 46.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4055
    Cell Significance Index: 65.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3966
    Cell Significance Index: 79.5600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3829
    Cell Significance Index: 6.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3765
    Cell Significance Index: 22.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2969
    Cell Significance Index: 18.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2550
    Cell Significance Index: 13.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2306
    Cell Significance Index: 15.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2283
    Cell Significance Index: 81.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1639
    Cell Significance Index: 32.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1607
    Cell Significance Index: 9.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1594
    Cell Significance Index: 12.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1556
    Cell Significance Index: 4.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1492
    Cell Significance Index: 17.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1325
    Cell Significance Index: 2.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1315
    Cell Significance Index: 7.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1309
    Cell Significance Index: 23.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1284
    Cell Significance Index: 3.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1269
    Cell Significance Index: 5.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1221
    Cell Significance Index: 4.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1146
    Cell Significance Index: 71.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1024
    Cell Significance Index: 2.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0916
    Cell Significance Index: 1.2500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0819
    Cell Significance Index: 1.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0702
    Cell Significance Index: 48.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0688
    Cell Significance Index: 3.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0574
    Cell Significance Index: 3.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0487
    Cell Significance Index: 1.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0440
    Cell Significance Index: 24.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0302
    Cell Significance Index: 1.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0276
    Cell Significance Index: 12.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0272
    Cell Significance Index: 1.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0187
    Cell Significance Index: 0.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0184
    Cell Significance Index: 2.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0174
    Cell Significance Index: 0.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0171
    Cell Significance Index: 0.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0168
    Cell Significance Index: 2.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0162
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0145
    Cell Significance Index: 27.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0133
    Cell Significance Index: 20.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0111
    Cell Significance Index: 1.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0096
    Cell Significance Index: 17.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0089
    Cell Significance Index: 1.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0065
    Cell Significance Index: 4.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0038
    Cell Significance Index: 5.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0012
    Cell Significance Index: 0.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0037
    Cell Significance Index: -2.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0121
    Cell Significance Index: -1.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0136
    Cell Significance Index: -10.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0151
    Cell Significance Index: -1.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0182
    Cell Significance Index: -2.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0239
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0255
    Cell Significance Index: -5.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0257
    Cell Significance Index: -0.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0295
    Cell Significance Index: -8.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0492
    Cell Significance Index: -5.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0566
    Cell Significance Index: -1.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0672
    Cell Significance Index: -7.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0762
    Cell Significance Index: -9.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0831
    Cell Significance Index: -5.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0909
    Cell Significance Index: -1.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0924
    Cell Significance Index: -9.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0943
    Cell Significance Index: -2.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0973
    Cell Significance Index: -5.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1090
    Cell Significance Index: -1.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1119
    Cell Significance Index: -6.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1138
    Cell Significance Index: -8.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1158
    Cell Significance Index: -1.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1162
    Cell Significance Index: -9.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1190
    Cell Significance Index: -3.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1207
    Cell Significance Index: -7.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1285
    Cell Significance Index: -6.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1456
    Cell Significance Index: -2.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1596
    Cell Significance Index: -4.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1646
    Cell Significance Index: -2.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1683
    Cell Significance Index: -5.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1694
    Cell Significance Index: -3.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1706
    Cell Significance Index: -3.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1723
    Cell Significance Index: -5.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1894
    Cell Significance Index: -9.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1984
    Cell Significance Index: -2.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1991
    Cell Significance Index: -6.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2000
    Cell Significance Index: -5.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2024
    Cell Significance Index: -3.0500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2087
    Cell Significance Index: -2.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2102
    Cell Significance Index: -7.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2120
    Cell Significance Index: -4.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2142
    Cell Significance Index: -4.3000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2334
    Cell Significance Index: -2.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF175 is a member of the zinc finger family of transcription factors, characterized by its unique DNA-binding domain. This protein is highly expressed in various tissues, including the brain, gut, and immune cells. Its expression is tightly regulated, with significant fluctuations in different developmental stages and tissue types. **Pathways and Functions:** ZNF175 is involved in multiple signaling pathways, including: 1. **Defense response to virus:** ZNF175 is part of the innate immune response, regulating the expression of genes involved in antiviral defense. 2. **Gene expression (transcription):** ZNF175 acts as a transcriptional activator or repressor, modulating the expression of target genes in response to various stimuli. 3. **Regulation of transcription by RNA polymerase II:** ZNF175 interacts with RNA polymerase II, influencing the transcriptional process and gene expression. 4. **Metal ion binding:** ZNF175 binds to metal ions, which are essential for its DNA-binding activity and transcriptional regulation. **Signaling Pathways and Functions:** 1. **DNA-binding transcription activator activity:** ZNF175 activates transcription by binding to specific DNA sequences, recruiting co-activators and enhancing gene expression. 2. **DNA-binding transcription repressor activity:** ZNF175 represses transcription by binding to specific DNA sequences, inhibiting gene expression. 3. **RNA polymerase II-specific:** ZNF175 regulates RNA polymerase II-dependent transcription, influencing the expression of genes involved in various cellular processes. 4. **Regulation of transcription by RNA polymerase II:** ZNF175 modulates RNA polymerase II activity, fine-tuning gene expression in response to cellular signals. **Significantly Expressed Cells:** ZNF175 is highly expressed in various cell types, including: 1. **Choroid plexus epithelial cell:** Involved in the regulation of gene expression in the central nervous system. 2. **Cerebral cortex GABAergic interneuron:** Essential for the development and function of the nervous system. 3. **Forebrain radial glial cell:** Plays a crucial role in neural development and differentiation. 4. **Absorptive cell:** Involved in the regulation of gene expression in the gut. 5. **Tuft cell of colon:** Regulates gene expression in the intestinal epithelium. 6. **BEST4+ intestinal epithelial cell:** Essential for the development and function of the intestinal epithelium. 7. **Human:** Widespread expression in various tissues, including the brain, gut, and immune cells. **Clinical Significance:** ZNF175 has potential implications in various human diseases, including: 1. **Neurodegenerative disorders:** Altered expression of ZNF175 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Immune system disorders:** ZNF175 plays a crucial role in the regulation of immune responses, making it a potential target for the treatment of autoimmune diseases. 3. **Cancer:** Aberrant expression of ZNF175 has been observed in various types of cancer, suggesting its potential role in tumorigenesis. In conclusion, ZNF175 is a multifunctional transcription factor that plays a critical role in regulating gene expression in various cell types. Its involvement in multiple signaling pathways and its widespread expression in human tissues make it an attractive target for the study of human diseases. Further research is necessary to fully elucidate the functions and clinical significance of ZNF175, but its potential implications in neurodegenerative disorders, immune system disorders, and cancer are promising areas of investigation.

Genular Protein ID: 4127755534

Symbol: ZN175_HUMAN

Name: Zinc finger protein 175

UniProtKB Accession Codes:

Q9Y473 A8K9H2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8838321

Title: Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures.

PubMed ID: 8838321

DOI: 10.1006/geno.1996.0062

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14688346

Title: Molecular characterization of a putative antiretroviral transcriptional factor, OTK18.

PubMed ID: 14688346

DOI: 10.4049/jimmunol.172.1.381

PubMed ID: 29961568

Title: De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.

PubMed ID: 29961568

DOI: 10.1016/j.ajhg.2018.06.001

Sequence Information:

  • Length: 711
  • Mass: 81609
  • Checksum: 43FB8ACD1B3094A2
  • Sequence:
    • MPADVNLSQK PQVLGPEKQD GSCEASVSFE DVTVDFSREE WQQLDPAQRC LYRDVMLELY 
SHLFAVGYHI PNPEVIFRML KEKEPRVEEA EVSHQRCQER EFGLEIPQKE ISKKASFQKD 
MVGEFTRDGS WCSILEELRL DADRTKKDEQ NQIQPMSHSA FFNKKTLNTE SNCEYKDPGK 
MIRTRPHLAS SQKQPQKCCL FTESLKLNLE VNGQNESNDT EQLDDVVGSG QLFSHSSSDA 
CSKNIHTGET FCKGNQCRKV CGHKQSLKQH QIHTQKKPDG CSECGGSFTQ KSHLFAQQRI 
HSVGNLHECG KCGKAFMPQL KLSVYLTDHT GDIPCICKEC GKVFIQRSEL LTHQKTHTRK 
KPYKCHDCGK AFFQMLSLFR HQRTHSREKL YECSECGKGF SQNSTLIIHQ KIHTGERQYA 
CSECGKAFTQ KSTLSLHQRI HSGQKSYVCI ECGQAFIQKA HLIVHQRSHT GEKPYQCHNC 
GKSFISKSQL DIHHRIHTGE KPYECSDCGK TFTQKSHLNI HQKIHTGERH HVCSECGKAF 
NQKSILSMHQ RIHTGEKPYK CSECGKAFTS KSQFKEHQRI HTGEKPYVCT ECGKAFNGRS 
NFHKHQITHT RERPFVCYKC GKAFVQKSEL ITHQRTHMGE KPYECLDCGK SFSKKPQLKV 
HQRIHTGERP YVCSECGKAF NNRSNFNKHQ TTHTRDKSYK CSYSVKGFTK Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.