Details for: ZKSCAN8

Gene ID: 7745

Symbol: ZKSCAN8

Ensembl ID: ENSG00000198315

Description: zinc finger with KRAB and SCAN domains 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.9271
    Cell Significance Index: -13.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.8588
    Cell Significance Index: -12.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.6887
    Cell Significance Index: -11.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.2389
    Cell Significance Index: -11.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1196
    Cell Significance Index: -13.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9013
    Cell Significance Index: -13.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1544
    Cell Significance Index: -12.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5276
    Cell Significance Index: -13.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0013
    Cell Significance Index: -4.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6981
    Cell Significance Index: 18.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6299
    Cell Significance Index: 125.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5960
    Cell Significance Index: 119.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5905
    Cell Significance Index: 96.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5223
    Cell Significance Index: 31.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4435
    Cell Significance Index: 24.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4425
    Cell Significance Index: 51.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3461
    Cell Significance Index: 65.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3332
    Cell Significance Index: 23.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2913
    Cell Significance Index: 104.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2353
    Cell Significance Index: 14.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2254
    Cell Significance Index: 40.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2125
    Cell Significance Index: 16.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1638
    Cell Significance Index: 16.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1616
    Cell Significance Index: 145.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1472
    Cell Significance Index: 3.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1360
    Cell Significance Index: 74.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1298
    Cell Significance Index: 17.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1187
    Cell Significance Index: 2.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1159
    Cell Significance Index: 3.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1109
    Cell Significance Index: 2.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1040
    Cell Significance Index: 2.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1019
    Cell Significance Index: 1.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0907
    Cell Significance Index: 40.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0812
    Cell Significance Index: 4.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0634
    Cell Significance Index: 7.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0578
    Cell Significance Index: 2.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0478
    Cell Significance Index: 3.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0440
    Cell Significance Index: 1.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0392
    Cell Significance Index: 1.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0217
    Cell Significance Index: 40.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0165
    Cell Significance Index: 0.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0079
    Cell Significance Index: 5.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0072
    Cell Significance Index: 11.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0067
    Cell Significance Index: 12.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0046
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0041
    Cell Significance Index: 5.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0026
    Cell Significance Index: 1.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0079
    Cell Significance Index: -0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0101
    Cell Significance Index: -0.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0111
    Cell Significance Index: -1.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0112
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0144
    Cell Significance Index: -1.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0145
    Cell Significance Index: -10.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0152
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0208
    Cell Significance Index: -11.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0242
    Cell Significance Index: -15.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0312
    Cell Significance Index: -8.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0333
    Cell Significance Index: -0.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0343
    Cell Significance Index: -0.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0344
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0390
    Cell Significance Index: -4.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0636
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0695
    Cell Significance Index: -14.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0711
    Cell Significance Index: -9.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0788
    Cell Significance Index: -5.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0863
    Cell Significance Index: -2.3500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0928
    Cell Significance Index: -1.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0935
    Cell Significance Index: -0.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0974
    Cell Significance Index: -3.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0975
    Cell Significance Index: -7.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0994
    Cell Significance Index: -5.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1031
    Cell Significance Index: -4.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1061
    Cell Significance Index: -3.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1084
    Cell Significance Index: -1.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1117
    Cell Significance Index: -11.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1293
    Cell Significance Index: -2.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1384
    Cell Significance Index: -3.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1450
    Cell Significance Index: -5.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1505
    Cell Significance Index: -9.2300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1600
    Cell Significance Index: -1.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1720
    Cell Significance Index: -2.0500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1797
    Cell Significance Index: -2.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1802
    Cell Significance Index: -4.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1809
    Cell Significance Index: -3.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1873
    Cell Significance Index: -9.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2181
    Cell Significance Index: -7.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2266
    Cell Significance Index: -11.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2280
    Cell Significance Index: -2.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2318
    Cell Significance Index: -3.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2440
    Cell Significance Index: -7.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2445
    Cell Significance Index: -3.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2475
    Cell Significance Index: -3.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2520
    Cell Significance Index: -3.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2526
    Cell Significance Index: -8.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2627
    Cell Significance Index: -6.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2745
    Cell Significance Index: -5.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2974
    Cell Significance Index: -5.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger structure:** ZKSCAN8 possesses a unique zinc finger structure, comprising a KRAB domain and a SCAN domain, which are essential for its DNA-binding and transcriptional regulatory functions. 2. **Diverse expression patterns:** ZKSCAN8 is expressed in various cell types, including germ cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, intestinal crypt stem cells, and BEST4+ intestinal epithelial cells. 3. **Metal ion binding:** ZKSCAN8 exhibits metal ion binding capabilities, which may contribute to its role in transcriptional regulation and protein-protein interactions. **Pathways and Functions:** 1. **Transcriptional regulation:** ZKSCAN8 acts as a transcription factor, regulating gene expression by binding to specific DNA sequences and interacting with RNA polymerase II. 2. **Generic transcription pathway:** ZKSCAN8 participates in the generic transcription pathway, which is essential for the expression of essential genes involved in cellular development and function. 3. **Metal ion binding:** ZKSCAN8's metal ion binding capabilities may contribute to its role in transcriptional regulation and protein-protein interactions. 4. **Protein-protein interactions:** ZKSCAN8 interacts with other proteins, including RNA polymerase II, to regulate gene expression and transcriptional processes. **Clinical Significance:** 1. **Germ cell development:** ZKSCAN8's expression in germ cells suggests its involvement in the regulation of germ cell development and fertility. 2. **Neurological disorders:** The expression of ZKSCAN8 in cerebral cortex GABAergic interneurons and forebrain radial glial cells may contribute to the development of neurological disorders, such as autism and schizophrenia. 3. **Intestinal disorders:** ZKSCAN8's expression in intestinal epithelial cells and crypt stem cells may be involved in the regulation of intestinal development and function, and may contribute to the development of intestinal disorders, such as inflammatory bowel disease. 4. **Cancer:** ZKSCAN8's role in transcriptional regulation and protein-protein interactions may contribute to its potential involvement in cancer development and progression. In conclusion, ZKSCAN8 is a multifunctional zinc finger transcription factor with diverse expression patterns, involved in transcriptional regulation, metal ion binding, and protein-protein interactions. Its clinical significance is evident in its potential involvement in germ cell development, neurological disorders, intestinal disorders, and cancer. Further research is necessary to elucidate the intricate mechanisms underlying ZKSCAN8's biological functions and its potential therapeutic applications.

Genular Protein ID: 4106941190

Symbol: ZKSC8_HUMAN

Name: Zinc finger protein with KRAB and SCAN domains 8

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9244436

Title: Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain.

PubMed ID: 9244436

DOI: 10.1006/geno.1997.4806

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8673473

Title: A strategy for cloning the hereditary hemochromatosis gene.

PubMed ID: 8673473

DOI: 10.1006/bcmd.1995.0024

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 578
  • Mass: 65816
  • Checksum: 0A4FCA610DFF31F2
  • Sequence:
  • MAEESRKPSA PSPPDQTPEE DLVIVKVEED HGWDQESSLH ESNPLGQEVF RLRFRQLRYQ 
    ETLGPREALI QLRALCHQWL RPDLNTKEQI LELLVLEQFL TILPEELQTL VKEHQLENGE 
    EVVTLLEDLE RQIDILGRPV SARVHGHRVL WEEVVHSASA PEPPNTQLQS EATQHKSPVP 
    QESQERAMST SQSPTRSQKG SSGDQEMTAT LLTAGFQTLE KIEDMAVSLI REEWLLDPSQ 
    KDLCRDNRPE NFRNMFSLGG ETRSENRELA SKQVISTGIQ PHGETAAKCN GDVIRGLEHE 
    EARDLLGRLE RQRGNPTQER RHKCDECGKS FAQSSGLVRH WRIHTGEKPY QCNVCGKAFS 
    YRSALLSHQD IHNKVKRYHC KECGKAFSQN TGLILHQRIH TGEKPYQCNQ CGKAFSQSAG 
    LILHQRIHSG ERPYECNECG KAFSHSSHLI GHQRIHTGEK PYECDECGKT FRRSSHLIGH 
    QRSHTGEKPY KCNECGRAFS QKSGLIEHQR IHTGERPYKC KECGKAFNGN TGLIQHLRIH 
    TGEKPYQCNE CGKAFIQRSS LIRHQRIHSG EKSESISV

Genular Protein ID: 2722665497

Symbol: Q59HG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 441
  • Mass: 49855
  • Checksum: C24F731DA64C2D71
  • Sequence:
  • KEVSARVHGH RVLWEEVVHS ASAPEPPNTQ LQSEATQHKS PVPQESQERA MSTSQSPTRS 
    QKGSSGDQEM TATLLTAGFQ TLEKIEDMAV SLIREEWLLD PSQKDLCRDN RPENFRNMFS 
    LGGETRSENR ELASKQVIST GIQPHGETAA KCNGDVIRGL EHEEARDLLG RLERQRGNPT 
    QERRHKCDEC GKSFAQSSGL VRHWRIHTGE KPYQCNVCGK AFSYRSALLS HQDIHNKVKR 
    YHCKECGKAF SQNTGLILHQ RIHTGEKPYQ CNQCGKAFSQ SAGLILHQRI HSGERPYECN 
    ECGKAFSHSS HLIGHQRIHT GEKPYECDEC GKTFRRSSHL IGHQRSHTGE KPYKCNECGR 
    AFSQKSGLIE HQRIHTGERP YKCKECGKAF NGNTGLIQHL RIHTGEKPYQ CNECGKAFIQ 
    RSSLIRHQRI HSGEKSESIS V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.