Details for: ZSCAN9

Gene ID: 7746

Symbol: ZSCAN9

Ensembl ID: ENSG00000137185

Description: zinc finger and SCAN domain containing 9

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 72.1012
    Cell Significance Index: -11.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.4612
    Cell Significance Index: -10.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.2611
    Cell Significance Index: -9.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.8980
    Cell Significance Index: -9.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.3718
    Cell Significance Index: -11.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7777
    Cell Significance Index: -10.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9574
    Cell Significance Index: -11.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2107
    Cell Significance Index: -6.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9053
    Cell Significance Index: -4.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.4409
    Cell Significance Index: 29.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9024
    Cell Significance Index: 146.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7598
    Cell Significance Index: 686.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5948
    Cell Significance Index: 37.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5809
    Cell Significance Index: 63.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5655
    Cell Significance Index: 33.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4208
    Cell Significance Index: 11.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3447
    Cell Significance Index: 19.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2743
    Cell Significance Index: 18.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2436
    Cell Significance Index: 11.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2313
    Cell Significance Index: 22.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2235
    Cell Significance Index: 44.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2181
    Cell Significance Index: 150.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1934
    Cell Significance Index: 14.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1752
    Cell Significance Index: 20.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1640
    Cell Significance Index: 5.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1634
    Cell Significance Index: 8.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1607
    Cell Significance Index: 4.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1314
    Cell Significance Index: 25.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1279
    Cell Significance Index: 25.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1249
    Cell Significance Index: 2.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1246
    Cell Significance Index: 22.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1060
    Cell Significance Index: 2.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1004
    Cell Significance Index: 14.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0925
    Cell Significance Index: 33.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0848
    Cell Significance Index: 5.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0778
    Cell Significance Index: 10.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0762
    Cell Significance Index: 33.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0680
    Cell Significance Index: 8.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0634
    Cell Significance Index: 34.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0419
    Cell Significance Index: 1.1400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0398
    Cell Significance Index: 0.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0374
    Cell Significance Index: 4.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0332
    Cell Significance Index: 1.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0228
    Cell Significance Index: 1.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0110
    Cell Significance Index: 0.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0096
    Cell Significance Index: 0.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0072
    Cell Significance Index: 0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0030
    Cell Significance Index: 1.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0020
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0088
    Cell Significance Index: -12.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0098
    Cell Significance Index: -7.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0125
    Cell Significance Index: -9.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0142
    Cell Significance Index: -10.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0173
    Cell Significance Index: -1.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0190
    Cell Significance Index: -10.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0214
    Cell Significance Index: -13.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0248
    Cell Significance Index: -4.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0277
    Cell Significance Index: -7.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0291
    Cell Significance Index: -2.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0292
    Cell Significance Index: -0.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0303
    Cell Significance Index: -0.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0310
    Cell Significance Index: -0.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0346
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0370
    Cell Significance Index: -4.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0434
    Cell Significance Index: -1.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0437
    Cell Significance Index: -1.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0452
    Cell Significance Index: -5.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0470
    Cell Significance Index: -5.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0470
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0631
    Cell Significance Index: -13.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0685
    Cell Significance Index: -3.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0721
    Cell Significance Index: -2.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0742
    Cell Significance Index: -4.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0752
    Cell Significance Index: -3.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1078
    Cell Significance Index: -11.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1094
    Cell Significance Index: -1.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1253
    Cell Significance Index: -3.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1273
    Cell Significance Index: -10.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1502
    Cell Significance Index: -9.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1643
    Cell Significance Index: -1.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1652
    Cell Significance Index: -11.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1705
    Cell Significance Index: -1.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1785
    Cell Significance Index: -2.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1830
    Cell Significance Index: -4.3900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1860
    Cell Significance Index: -1.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1891
    Cell Significance Index: -4.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1940
    Cell Significance Index: -4.8500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2036
    Cell Significance Index: -1.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2258
    Cell Significance Index: -1.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2441
    Cell Significance Index: -6.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2498
    Cell Significance Index: -7.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2586
    Cell Significance Index: -8.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2663
    Cell Significance Index: -3.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2796
    Cell Significance Index: -10.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2813
    Cell Significance Index: -5.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger and SCAN Domain Structure:** ZSCAN9 contains a zinc finger domain, a SCAN domain, and a C-terminal tail, which confer its ability to bind to DNA and regulate transcription. 2. **Transcriptional Regulation:** ZSCAN9 acts as a transcription factor, specifically binding to RNA polymerase II-cis-regulatory regions to regulate gene expression. 3. **Cellular Expression:** ZSCAN9 is expressed in a wide range of cell types, including epithelial cells, germ cells, and neural cells, indicating its broad functional significance. 4. **Metal Ion Binding:** ZSCAN9's metal ion-binding capabilities suggest its potential involvement in redox reactions and DNA repair processes. **Pathways and Functions:** 1. **DNA Binding and Transcriptional Regulation:** ZSCAN9 binds to specific DNA sequences, recruiting RNA polymerase II and regulating the transcription of target genes. 2. **RNA Polymerase II-Specific Activity:** ZSCAN9 interacts with RNA polymerase II, modulating its activity and influencing the transcriptional output. 3. **Metal Ion Binding and Redox Reactions:** ZSCAN9's metal ion-binding capabilities may participate in redox reactions, influencing gene expression and cellular processes. 4. **Regulation of Transcription by RNA Polymerase II:** ZSCAN9 modulates the activity of RNA polymerase II, which is essential for the transcription of protein-coding genes. **Clinical Significance:** 1. **Disease Association:** Abnormal expression of ZSCAN9 has been linked to various diseases, including cancer, neurodevelopmental disorders, and metabolic disorders. 2. **Gene Therapy and Cancer:** ZSCAN9's role in transcriptional regulation makes it a potential target for gene therapy in cancer treatment. 3. **Neurological Disorders:** ZSCAN9's involvement in neural cell development and function suggests its potential role in neurological disorders, such as autism and schizophrenia. 4. **Metabolic Disorders:** ZSCAN9's expression in absorptive cells and intestinal epithelial cells implies its potential involvement in metabolic disorders, such as diabetes and obesity. In conclusion, ZSCAN9 is a crucial gene that regulates transcriptional processes in various cell types. Its involvement in DNA binding, RNA polymerase II-specific activity, and metal ion binding highlights its importance in maintaining cellular homeostasis. Further research on ZSCAN9's functions and clinical significance will provide valuable insights into its role in human health and disease.

Genular Protein ID: 1698340700

Symbol: ZSC9_HUMAN

Name: Zinc finger and SCAN domain-containing protein 9

UniProtKB Accession Codes:

O15535 B4E1W6 E7EVQ2 Q2TTR1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9244436

Title: Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain.

PubMed ID: 9244436

DOI: 10.1006/geno.1997.4806

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 24658003

Title: TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.

PubMed ID: 24658003

DOI: 10.1038/ng.2929

Sequence Information:

  • Length: 394
  • Mass: 45954
  • Checksum: 4CEC2BBC3E39EA40
  • Sequence:
    • MNTNSKEVLS LGVQVPEAWE ELLTMKVEAK SHLQWQESRL KRSNPLAREI FRRHFRQLCY 
QETPGPREAL TRLQELCYQW LRPHVSTKEQ ILDLLVLEQF LSILPKELQG WVREHCPESG 
EEAVILLEDL ERELDEPQHE MVAHRHRQEV LCKEMVPLAE QTPLTLQSQP KEPQLTCDSA 
QKCHSIGETD EVTKTEDREL VLRKDCPKIV EPHGKMFNEQ TWEVSQQDPS HGEVGEHKDR 
IERQWGNLLG EGQHKCDECG KSFTQSSGLI RHQRIHTGER PYECNECGKA FSRSSGLFNH 
RGIHNIQKRY HCKECGKVFS QSAGLIQHQR IHKGEKPYQC SQCSKSYSRR SFLIEHQRSH 
TGERPHQCIE CGKSFNRHCN LIRHQKIHTV AELV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.