Details for: ZNF223

Gene ID: 7766

Symbol: ZNF223

Ensembl ID: ENSG00000178386

Description: zinc finger protein 223

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9523
    Cell Significance Index: -5.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3418
    Cell Significance Index: 255.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6297
    Cell Significance Index: 13.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4800
    Cell Significance Index: 47.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4630
    Cell Significance Index: 27.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4218
    Cell Significance Index: 380.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3685
    Cell Significance Index: 40.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2616
    Cell Significance Index: 42.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2123
    Cell Significance Index: 11.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2068
    Cell Significance Index: 4.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2052
    Cell Significance Index: 41.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2021
    Cell Significance Index: 13.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2013
    Cell Significance Index: 12.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1690
    Cell Significance Index: 19.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1307
    Cell Significance Index: 10.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1234
    Cell Significance Index: 22.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1163
    Cell Significance Index: 3.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1163
    Cell Significance Index: 7.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1090
    Cell Significance Index: 39.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0821
    Cell Significance Index: 3.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0685
    Cell Significance Index: 3.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0681
    Cell Significance Index: 2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0554
    Cell Significance Index: 2.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0538
    Cell Significance Index: 6.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0409
    Cell Significance Index: 2.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0403
    Cell Significance Index: 1.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0350
    Cell Significance Index: 0.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0340
    Cell Significance Index: 0.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0259
    Cell Significance Index: 11.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0201
    Cell Significance Index: 10.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0061
    Cell Significance Index: 0.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0033
    Cell Significance Index: 0.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0075
    Cell Significance Index: -4.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0081
    Cell Significance Index: -5.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0082
    Cell Significance Index: -0.1700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0096
    Cell Significance Index: -0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0102
    Cell Significance Index: -1.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0115
    Cell Significance Index: -5.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0167
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0206
    Cell Significance Index: -3.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0246
    Cell Significance Index: -2.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0251
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0268
    Cell Significance Index: -5.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0293
    Cell Significance Index: -0.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0296
    Cell Significance Index: -0.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0333
    Cell Significance Index: -0.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0334
    Cell Significance Index: -4.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0345
    Cell Significance Index: -5.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0370
    Cell Significance Index: -2.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0433
    Cell Significance Index: -5.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0472
    Cell Significance Index: -3.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0511
    Cell Significance Index: -3.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0513
    Cell Significance Index: -2.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0550
    Cell Significance Index: -2.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0596
    Cell Significance Index: -4.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0609
    Cell Significance Index: -1.9400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0625
    Cell Significance Index: -1.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0637
    Cell Significance Index: -0.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0664
    Cell Significance Index: -4.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0684
    Cell Significance Index: -2.2400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0711
    Cell Significance Index: -0.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0717
    Cell Significance Index: -1.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0724
    Cell Significance Index: -1.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0734
    Cell Significance Index: -1.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0763
    Cell Significance Index: -2.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0770
    Cell Significance Index: -2.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0814
    Cell Significance Index: -2.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0895
    Cell Significance Index: -1.9000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0930
    Cell Significance Index: -1.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0967
    Cell Significance Index: -2.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1002
    Cell Significance Index: -1.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1015
    Cell Significance Index: -1.4600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1022
    Cell Significance Index: -2.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1022
    Cell Significance Index: -2.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1108
    Cell Significance Index: -2.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1238
    Cell Significance Index: -2.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1273
    Cell Significance Index: -2.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1347
    Cell Significance Index: -2.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1358
    Cell Significance Index: -5.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1390
    Cell Significance Index: -3.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1395
    Cell Significance Index: -5.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1400
    Cell Significance Index: -1.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1456
    Cell Significance Index: -4.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1496
    Cell Significance Index: -1.8600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1502
    Cell Significance Index: -2.4100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1524
    Cell Significance Index: -1.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1593
    Cell Significance Index: -4.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1608
    Cell Significance Index: -4.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1621
    Cell Significance Index: -7.0500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1656
    Cell Significance Index: -3.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF223 is a small, non-coding protein that belongs to the zinc finger protein family, which is characterized by the presence of a zinc finger domain. This domain is responsible for DNA binding and is highly conserved among members of this family. ZNF223 is specifically expressed in various epithelial cells, including goblet cells, kidney proximal convoluted tubule epithelial cells, absorptive cells, and intestinal epithelial cells. Its expression is also observed in stem cells and transit amplifying cells within the intestinal crypt, indicating a potential role in maintaining tissue homeostasis. **Pathways and Functions:** ZNF223 is involved in multiple cellular pathways, including: 1. **Gene Expression (Transcription):** ZNF223 acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. Its primary function is to modulate the transcription of genes involved in epithelial homeostasis, cell differentiation, and response to cellular stress. 2. **DNA-Binding Transcription Factor Activity:** ZNF223's DNA-binding domain allows it to interact with specific DNA sequences, influencing transcriptional activity and gene expression. 3. **Metal Ion Binding:** ZNF223's zinc finger domain is also capable of binding metal ions, which may play a role in its interaction with DNA and other proteins. 4. **Regulation of DNA-templated Transcription:** ZNF223 regulates the transcription of genes involved in DNA replication and repair, ensuring the integrity of the genome. **Clinical Significance:** Dysregulation of ZNF223 has been implicated in various diseases, including: 1. **Inflammatory Bowel Disease (IBD):** Alterations in ZNF223 expression have been observed in patients with IBD, suggesting a potential role in the pathogenesis of this disease. 2. **Cancer:** ZNF223 has been identified as a tumor suppressor gene, with its expression reduced in various types of cancer, including colorectal and breast cancer. 3. **Respiratory Diseases:** ZNF223 has been implicated in the regulation of gene expression in respiratory epithelial cells, making it a potential target for the treatment of respiratory diseases. In conclusion, ZNF223 is a critical regulator of gene expression in epithelial cells, playing a vital role in maintaining tissue homeostasis and responding to cellular stress. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of ZNF223 and its potential therapeutic applications.

Genular Protein ID: 2006316408

Symbol: ZN223_HUMAN

Name: Zinc finger protein 223

UniProtKB Accession Codes:

Q9UK11 Q15736 Q8TBJ3 Q9HCA9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617494

Title: Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7.

PubMed ID: 8617494

DOI: 10.1006/geno.1996.0166

Sequence Information:

  • Length: 482
  • Mass: 55763
  • Checksum: 2543E98D86F55E51
  • Sequence:
    • MTMSKEAVTF KDVAVVFTEE ELGLLDLAQR KLYRDVMLEN FRNLLSVGHQ PFHRDTFHFL 
REEKFWMMDI ATQREGNSGG KIQPEMKTFP EAGPHEGWSC QQIWEEIASD LTRPQDSTIK 
SSQFFEQGDA HSQVEEGLSI MHTGQKPSNC GKCKQSFSDM SIFDLPQQIR SAEKSHSCDE 
CGKSFCYISA LHIHQRVHLG EKLFKCDVCG KEFSQSLHLQ THQRVHTGEK PFKCEQCGRG 
FRCRSALTVH CKLHMGEKHY NCEACGRAFI HDFQLQKHQR IHTGEKPFKC EICSVSFRLR 
SSLNRHCVVH TGKKPNSTGE YGKGFIRRLD LCKHQTIHTG EKPYNCKECG KSFRRSSYLL 
IHQRVHTGEK PYKCDKCGKS YITKSGLDLH HRAHTGERPY NCDDCGKSFR QASSILNHKR 
LHCRKKPFKC EDCGKKLVYR SYRKDQQKNH SGENPSKCED CGKRYKRRLN LDIILSLFLN 
DT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.