Details for: ZNF229

Gene ID: 7772

Symbol: ZNF229

Ensembl ID: ENSG00000278318

Description: zinc finger protein 229

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8411
    Cell Significance Index: 13.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6897
    Cell Significance Index: 43.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4871
    Cell Significance Index: 92.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3679
    Cell Significance Index: 7.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2631
    Cell Significance Index: 7.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2475
    Cell Significance Index: 14.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2467
    Cell Significance Index: 28.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2268
    Cell Significance Index: 22.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2238
    Cell Significance Index: 9.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2139
    Cell Significance Index: 8.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2036
    Cell Significance Index: 40.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2033
    Cell Significance Index: 22.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1944
    Cell Significance Index: 175.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1866
    Cell Significance Index: 66.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1625
    Cell Significance Index: 26.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1613
    Cell Significance Index: 12.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1457
    Cell Significance Index: 7.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1321
    Cell Significance Index: 8.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1175
    Cell Significance Index: 4.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1140
    Cell Significance Index: 2.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0766
    Cell Significance Index: 5.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0764
    Cell Significance Index: 41.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0759
    Cell Significance Index: 4.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0715
    Cell Significance Index: 0.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0615
    Cell Significance Index: 11.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0580
    Cell Significance Index: 1.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0568
    Cell Significance Index: 11.4000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0463
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0257
    Cell Significance Index: 2.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0237
    Cell Significance Index: 2.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0176
    Cell Significance Index: 0.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0164
    Cell Significance Index: 7.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0147
    Cell Significance Index: 0.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0102
    Cell Significance Index: 1.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0102
    Cell Significance Index: 0.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0077
    Cell Significance Index: 0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0071
    Cell Significance Index: 0.9700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0052
    Cell Significance Index: -8.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0073
    Cell Significance Index: -1.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0109
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0118
    Cell Significance Index: -7.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0250
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0311
    Cell Significance Index: -6.5600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0406
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0409
    Cell Significance Index: -5.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0468
    Cell Significance Index: -6.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0504
    Cell Significance Index: -3.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0545
    Cell Significance Index: -6.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0554
    Cell Significance Index: -1.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0656
    Cell Significance Index: -4.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0686
    Cell Significance Index: -4.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0720
    Cell Significance Index: -1.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0728
    Cell Significance Index: -7.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0732
    Cell Significance Index: -1.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0820
    Cell Significance Index: -4.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0826
    Cell Significance Index: -6.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0831
    Cell Significance Index: -3.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0862
    Cell Significance Index: -3.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0864
    Cell Significance Index: -4.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0882
    Cell Significance Index: -2.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0928
    Cell Significance Index: -4.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0977
    Cell Significance Index: -2.7300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1092
    Cell Significance Index: -1.3600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1103
    Cell Significance Index: -2.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1180
    Cell Significance Index: -2.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1182
    Cell Significance Index: -3.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1211
    Cell Significance Index: -7.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1264
    Cell Significance Index: -3.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1300
    Cell Significance Index: -4.1400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1314
    Cell Significance Index: -1.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1371
    Cell Significance Index: -3.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1388
    Cell Significance Index: -3.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1419
    Cell Significance Index: -4.9700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1427
    Cell Significance Index: -1.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1476
    Cell Significance Index: -2.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1497
    Cell Significance Index: -2.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1510
    Cell Significance Index: -1.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1549
    Cell Significance Index: -6.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1579
    Cell Significance Index: -2.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1644
    Cell Significance Index: -3.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1664
    Cell Significance Index: -4.1500
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1750
    Cell Significance Index: -1.3600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1793
    Cell Significance Index: -1.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1809
    Cell Significance Index: -4.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1861
    Cell Significance Index: -4.0200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1940
    Cell Significance Index: -1.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1966
    Cell Significance Index: -5.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1975
    Cell Significance Index: -7.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2045
    Cell Significance Index: -2.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2096
    Cell Significance Index: -2.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2099
    Cell Significance Index: -4.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF229 is a transcriptional activator that regulates the expression of genes involved in intestinal homeostasis. It binds to specific DNA sequences, thereby modulating the transcription of target genes. 2. **RNA Polymerase II Specificity:** ZNF229 interacts with RNA polymerase II, a critical enzyme involved in the transcription of protein-coding genes. This interaction is essential for the regulation of gene expression in intestinal epithelial cells. 3. **Metal Ion Binding:** ZNF229 contains a metal ion-binding motif, which is necessary for its DNA-binding activity. This motif allows the protein to interact with specific DNA sequences, enabling the regulation of transcription. 4. **Expression Pattern:** ZNF229 is expressed in various epithelial cells lining the gut, including goblet cells, enterocytes, colon goblet cells, and intestinal crypt stem cells. This expression pattern suggests a critical role in maintaining intestinal homeostasis. **Pathways and Functions:** 1. **DNA-Binding Transcription Activation:** ZNF229 binds to specific DNA sequences, thereby activating transcription of target genes involved in intestinal homeostasis. 2. **RNA Polymerase II-Dependent Transcription:** ZNF229 interacts with RNA polymerase II, a critical enzyme involved in the transcription of protein-coding genes. 3. **Metal Ion-Dependent DNA Binding:** ZNF229's metal ion-binding motif enables its DNA-binding activity, allowing the protein to regulate transcription. 4. **Regulation of Intestinal Homeostasis:** ZNF229's dysregulation has been implicated in various intestinal disorders, highlighting its importance in maintaining gut health. **Clinical Significance:** 1. **Intestinal Disorders:** Dysregulation of ZNF229 has been implicated in various intestinal disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and colon cancer. 2. **Gut Microbiome:** ZNF229's expression in intestinal epithelial cells suggests a role in regulating the gut microbiome, which is essential for maintaining gut health. 3. **Cancer Progression:** ZNF229's dysregulation may contribute to cancer progression by disrupting normal transcriptional regulation. 4. **Therapeutic Targeting:** ZNF229's role in regulating intestinal homeostasis makes it a potential therapeutic target for the treatment of intestinal disorders. In conclusion, the zinc finger protein 229 is a critical transcriptional regulator involved in maintaining intestinal homeostasis. Its dysregulation has been implicated in various intestinal disorders, highlighting the importance of this gene in maintaining gut health. Further research is necessary to fully elucidate the role of ZNF229 in intestinal homeostasis and its potential as a therapeutic target.

Genular Protein ID: 2903189948

Symbol: ZN229_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 825
  • Mass: 93767
  • Checksum: 01058F57650097BC
  • Sequence:
  • METLTSRHEK RALHSQASAI SQDREEKIMS QEPLSFKDVA VVFTEEELEL LDSTQRQLYQ 
    DVMQENFRNL LSVGERNPLG DKNGKDTEYI QDEELRFFSH KELSSCKIWE EVAGELPGSQ 
    DCRVNLQGKD FQFSEDAAPH QGWEGASTPC FPIENFLDSL QGDGLIGLEN QQFPAWRAIR 
    PIPIQGSWAK AFVNQLGDVQ ERCKNLDTED TVYKCNWDDD SFCWISCHVD HRFPEIDKPC 
    GCNKCRKDCI KNSVLHRINP GENGLKSNEY RNGFRDDADL PPHPRVPLKE KLCQYDEFSE 
    GLRHSAHLNR HQRVPTGEKS VKSLERGRGV RQNTHIRNHP RAPVGDMPYR CDVCGKGFRY 
    KSVLLIHQGV HTGRRPYKCE ECGKAFGRSS NLLVHQRVHT GEKPYKCSEC GKGFSYSSVL 
    QVHQRLHTGE KPYTCSECGK GFCAKSALHK HQHIHPGEKP YSCGECGKGF SCSSHLSSHQ 
    KTHTGERPYQ CDKCGKGFSH NSYLQAHQRV HMGQHLYKCN VCGKSFSYSS GLLMHQRLHT 
    GEKPYKCECG KSFGRSSDLH IHQRVHTGEK PYKCSECGKG FRRNSDLHSH QRVHTGERPY 
    VCDVCGKGFI YSSDLLIHQR VHTGEKPYKC AECGKGFSYS SGLLIHQRVH TGEKPYRCQE 
    CGKGFRCTSS LHKHQRVHTG KKPYTCDQCG KGFSYGSNLR THQRLHTGEK PYTCCECGKG 
    FRYGSGLLSH KRVHTGEKPY RCHVCGKGYS QSSHLQGHQR VHTGEKPYKC EECGKGFGRN 
    SCLHVHQRVH TGEKPYTCGV CGKGFSYTSG LRNHQRVHLG ENPYK

Genular Protein ID: 1013092568

Symbol: A0A087WVZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 819
  • Mass: 93101
  • Checksum: 316FC5C2FC9A3D4D
  • Sequence:
  • METLTSRHEK RALHSQASAI SQDREEKIMS QEPLSFKDVA VVFTEEELEL LDSTQRQLYQ 
    DVMQENFRNL LSVGDKNGKD TEYIQDEELR FFSHKELSSC KIWEEVAGEL PGSQDCRVNL 
    QGKDFQFSED AAPHQGWEGA STPCFPIENF LDSLQGDGLI GLENQQFPAW RAIRPIPIQG 
    SWAKAFVNQL GDVQERCKNL DTEDTVYKCN WDDDSFCWIS CHVDHRFPEI DKPCGCNKCR 
    KDCIKNSVLH RINPGENGLK SNEYRNGFRD DADLPPHPRV PLKEKLCQYD EFSEGLRHSA 
    HLNRHQRVPT GEKSVKSLER GRGVRQNTHI RNHPRAPVGD MPYRCDVCGK GFRYKSVLLI 
    HQGVHTGRRP YKCEECGKAF GRSSNLLVHQ RVHTGEKPYK CSECGKGFSY SSVLQVHQRL 
    HTGEKPYTCS ECGKGFCAKS ALHKHQHIHP GEKPYSCGEC GKGFSCSSHL SSHQKTHTGE 
    RPYQCDKCGK GFSHNSYLQA HQRVHMGQHL YKCNVCGKSF SYSSGLLMHQ RLHTGEKPYK 
    CECGKSFGRS SDLHIHQRVH TGEKPYKCSE CGKGFRRNSD LHSHQRVHTG ERPYVCDVCG 
    KGFIYSSDLL IHQRVHTGEK PYKCAECGKG FSYSSGLLIH QRVHTGEKPY RCQECGKGFR 
    CTSSLHKHQR VHTGKKPYTC DQCGKGFSYG SNLRTHQRLH TGEKPYTCCE CGKGFRYGSG 
    LLSHKRVHTG EKPYRCHVCG KGYSQSSHLQ GHQRVHTGEK PYKCEECGKG FGRNSCLHVH 
    QRVHTGEKPY TCGVCGKGFS YTSGLRNHQR VHLGENPYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.