Details for: ZNF230

Gene ID: 7773

Symbol: ZNF230

Ensembl ID: ENSG00000159882

Description: zinc finger protein 230

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.6172
    Cell Significance Index: -6.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.1641
    Cell Significance Index: -6.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.6582
    Cell Significance Index: -5.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.2949
    Cell Significance Index: -6.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9694
    Cell Significance Index: -7.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3629
    Cell Significance Index: -6.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8880
    Cell Significance Index: -7.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1880
    Cell Significance Index: -2.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6523
    Cell Significance Index: 64.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5008
    Cell Significance Index: 452.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4909
    Cell Significance Index: 29.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4400
    Cell Significance Index: 47.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3593
    Cell Significance Index: 58.4400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.3249
    Cell Significance Index: 2.0100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3221
    Cell Significance Index: 4.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3164
    Cell Significance Index: 36.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2624
    Cell Significance Index: 16.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2494
    Cell Significance Index: 1.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2459
    Cell Significance Index: 12.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2272
    Cell Significance Index: 15.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2213
    Cell Significance Index: 3.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1624
    Cell Significance Index: 7.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1310
    Cell Significance Index: 26.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1299
    Cell Significance Index: 24.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1211
    Cell Significance Index: 6.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1186
    Cell Significance Index: 2.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0963
    Cell Significance Index: 19.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0962
    Cell Significance Index: 1.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0760
    Cell Significance Index: 13.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0662
    Cell Significance Index: 1.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0660
    Cell Significance Index: 9.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0626
    Cell Significance Index: 27.6600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0623
    Cell Significance Index: 0.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0613
    Cell Significance Index: 7.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0562
    Cell Significance Index: 20.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0552
    Cell Significance Index: 1.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0537
    Cell Significance Index: 0.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0493
    Cell Significance Index: 26.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0438
    Cell Significance Index: 5.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0406
    Cell Significance Index: 5.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0309
    Cell Significance Index: 2.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0275
    Cell Significance Index: 0.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0240
    Cell Significance Index: 0.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0224
    Cell Significance Index: 0.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0171
    Cell Significance Index: 1.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0156
    Cell Significance Index: 0.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0112
    Cell Significance Index: 0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0052
    Cell Significance Index: 9.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0011
    Cell Significance Index: 0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0028
    Cell Significance Index: -1.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0030
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0040
    Cell Significance Index: -2.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0101
    Cell Significance Index: -5.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0126
    Cell Significance Index: -1.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0160
    Cell Significance Index: -4.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0179
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0185
    Cell Significance Index: -1.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0216
    Cell Significance Index: -1.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0226
    Cell Significance Index: -1.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0233
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0266
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0273
    Cell Significance Index: -3.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0296
    Cell Significance Index: -0.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0298
    Cell Significance Index: -0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0321
    Cell Significance Index: -1.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0337
    Cell Significance Index: -4.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0374
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0375
    Cell Significance Index: -7.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0535
    Cell Significance Index: -1.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0553
    Cell Significance Index: -1.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0611
    Cell Significance Index: -4.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0643
    Cell Significance Index: -6.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0720
    Cell Significance Index: -5.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0725
    Cell Significance Index: -1.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0818
    Cell Significance Index: -2.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0886
    Cell Significance Index: -3.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1003
    Cell Significance Index: -1.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1016
    Cell Significance Index: -3.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1151
    Cell Significance Index: -4.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1252
    Cell Significance Index: -3.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1521
    Cell Significance Index: -3.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1590
    Cell Significance Index: -4.6700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1601
    Cell Significance Index: -2.5400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1601
    Cell Significance Index: -2.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1656
    Cell Significance Index: -1.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1696
    Cell Significance Index: -5.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1704
    Cell Significance Index: -5.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1721
    Cell Significance Index: -6.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1730
    Cell Significance Index: -6.3500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1778
    Cell Significance Index: -1.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF230 is a transcription factor that binds to specific DNA sequences, thereby regulating the expression of target genes involved in cellular differentiation, development, and homeostasis. 2. **Zinc Finger Domain:** The protein's zinc finger domain is crucial for its DNA-binding activity, allowing it to interact with specific DNA sequences and modulate gene expression. 3. **Cell-Specific Expression:** ZNF230 is expressed in various cell types, including neural progenitor cells, mural cells, cerebral cortex GABAergic interneurons, and intestinal epithelial cells, highlighting its role in tissue-specific regulation. 4. **Metal Ion Binding:** The protein's ability to bind metal ions, such as zinc, is essential for its structural integrity and DNA-binding activity. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF230's ability to bind to specific DNA sequences enables it to regulate gene expression by controlling the transcription of target genes. 2. **Gene Expression (Transcription):** As a transcription factor, ZNF230 plays a critical role in regulating the expression of genes involved in cellular development, differentiation, and homeostasis. 3. **Generic Transcription Pathway:** ZNF230's involvement in the generic transcription pathway highlights its role in regulating the expression of genes involved in basic cellular processes. 4. **Metal Ion Binding:** The protein's ability to bind metal ions, such as zinc, is essential for its structural integrity and DNA-binding activity. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of ZNF230 has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease, highlighting its potential as a therapeutic target. 2. **Intestinal Health:** ZNF230's role in regulating intestinal homeostasis and immune function has significant implications for the treatment of intestinal disorders, such as inflammatory bowel disease. 3. **Cancer:** Aberrant expression of ZNF230 has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential as a biomarker and therapeutic target. 4. **Immunological Disorders:** ZNF230's involvement in immune function highlights its potential as a therapeutic target for immunological disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, ZNF230 is a critical transcription factor involved in regulating gene expression and transcriptional processes. Its role in neural development, intestinal homeostasis, and immune function highlights its importance in maintaining tissue homeostasis and overall health. Further research is necessary to fully elucidate the functional significance of ZNF230 and its potential as a therapeutic target for various diseases.

Genular Protein ID: 3200127025

Symbol: ZN230_HUMAN

Name: Zinc finger protein 230

UniProtKB Accession Codes:

Q9UIE0 O15322 Q504X7 Q86W84 Q9P1U6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 474
  • Mass: 54542
  • Checksum: 40DBFE785051451D
  • Sequence:
    • MTTFKEAVTF KDVAVFFTEE ELGLLDPAQR KLYQDVMLEN FTNLLSVGHQ PFHPFHFLRE 
EKFWMMETAT QREGNSGGKT IAEAGPHEDC PCQQIWEQTA SDLTQSQDSI INNSHFFEQG 
DVPSQVEAGL SIIHTGQKPS QNGKCKQSFS DVAIFDPPQQ FHSGEKSHTC NECGKSFCYI 
SALRIHQRVH LREKLSKCDM RGKEFSQSSC LQTRERVHTG EKPFKCEQCG KGFRCRAILQ 
VHCKLHTGEK PYICEKCGRA FIHDFQLQKH QIIHTGEKPF KCEICGKSFC LRSSLNRHCM 
VHTAEKLYKS EECGKGFTDS LDLHKHQIIH TGQKPYNCKE CGKSFRWSSY LLIHQRIHSG 
EKPYRCEECG KGYISKSGLN LHQRVHTGER PYNCKECGKS FSRASSILNH KKLHCRKKPF 
KCEDCGKRLV HRSFCKDQQG DHNGENSSKC EDCGKRYKRR LNLDIILSLF LNDM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.