Details for: SLC30A3

Gene ID: 7781

Symbol: SLC30A3

Ensembl ID: ENSG00000115194

Description: solute carrier family 30 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.4170
    Cell Significance Index: -4.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.0675
    Cell Significance Index: -4.0900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 3.2331
    Cell Significance Index: 27.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1504
    Cell Significance Index: 77.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8766
    Cell Significance Index: 175.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8375
    Cell Significance Index: 23.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5003
    Cell Significance Index: 7.1700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3928
    Cell Significance Index: 5.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3836
    Cell Significance Index: 8.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2811
    Cell Significance Index: 55.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1661
    Cell Significance Index: 12.7500
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: 0.1391
    Cell Significance Index: 1.4300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1378
    Cell Significance Index: 1.1000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1083
    Cell Significance Index: 1.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0725
    Cell Significance Index: 1.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0424
    Cell Significance Index: 0.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0223
    Cell Significance Index: 7.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0075
    Cell Significance Index: 5.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0061
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0084
    Cell Significance Index: -4.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0097
    Cell Significance Index: -4.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0123
    Cell Significance Index: -2.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0138
    Cell Significance Index: -3.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0155
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0204
    Cell Significance Index: -3.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0250
    Cell Significance Index: -5.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0265
    Cell Significance Index: -1.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0291
    Cell Significance Index: -3.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0306
    Cell Significance Index: -3.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0317
    Cell Significance Index: -4.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0340
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0369
    Cell Significance Index: -0.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0382
    Cell Significance Index: -4.5100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0405
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0408
    Cell Significance Index: -4.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0414
    Cell Significance Index: -4.8200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0438
    Cell Significance Index: -0.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0460
    Cell Significance Index: -4.7000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0477
    Cell Significance Index: -0.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0479
    Cell Significance Index: -4.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0490
    Cell Significance Index: -1.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0507
    Cell Significance Index: -2.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0550
    Cell Significance Index: -1.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0585
    Cell Significance Index: -4.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0620
    Cell Significance Index: -3.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0641
    Cell Significance Index: -4.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0679
    Cell Significance Index: -4.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0699
    Cell Significance Index: -2.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0726
    Cell Significance Index: -1.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0728
    Cell Significance Index: -4.7000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0749
    Cell Significance Index: -0.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0756
    Cell Significance Index: -4.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0765
    Cell Significance Index: -2.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0770
    Cell Significance Index: -0.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0804
    Cell Significance Index: -2.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0836
    Cell Significance Index: -3.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0843
    Cell Significance Index: -3.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0859
    Cell Significance Index: -4.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0866
    Cell Significance Index: -4.0400
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0880
    Cell Significance Index: -0.9500
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.0912
    Cell Significance Index: -0.7200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0926
    Cell Significance Index: -1.0800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0981
    Cell Significance Index: -1.4300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0985
    Cell Significance Index: -1.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1003
    Cell Significance Index: -4.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1046
    Cell Significance Index: -3.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1110
    Cell Significance Index: -4.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1111
    Cell Significance Index: -2.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1242
    Cell Significance Index: -4.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1261
    Cell Significance Index: -4.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1297
    Cell Significance Index: -4.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1333
    Cell Significance Index: -3.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1375
    Cell Significance Index: -2.9700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1401
    Cell Significance Index: -1.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1409
    Cell Significance Index: -3.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1420
    Cell Significance Index: -2.8500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1426
    Cell Significance Index: -1.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1437
    Cell Significance Index: -1.9600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1447
    Cell Significance Index: -1.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1476
    Cell Significance Index: -3.8800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1481
    Cell Significance Index: -3.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1502
    Cell Significance Index: -4.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1546
    Cell Significance Index: -2.6500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1553
    Cell Significance Index: -3.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1569
    Cell Significance Index: -1.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1637
    Cell Significance Index: -4.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1645
    Cell Significance Index: -4.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1680
    Cell Significance Index: -4.2800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1690
    Cell Significance Index: -2.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1690
    Cell Significance Index: -1.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Metal Ion Transport:** SLC30A3 is a zinc transporter that facilitates the transport of zinc ions across cellular membranes, playing a crucial role in maintaining zinc homeostasis. 2. **Cellular Expression:** This gene is widely expressed in various cell types, including neurons, immune cells, and epithelial cells, indicating its importance in maintaining cellular homeostasis. 3. **Antiporter Activity:** SLC30A3 exhibits antiporter activity, allowing it to transport metal ions in exchange for other ions or molecules. 4. **Regulation of Transport:** The gene is regulated by various factors, including zinc ions, hormones, and transcription factors, which fine-tune its expression and activity. **Pathways and Functions:** 1. **Zinc Homeostasis:** SLC30A3 is essential for maintaining zinc homeostasis in cells, which is crucial for various cellular processes, including protein synthesis, enzyme activity, and immune function. 2. **Neurotransmission:** In neurons, SLC30A3 regulates the transport of zinc ions, which plays a critical role in neurotransmission and synaptic plasticity. 3. **Lysosomal Function:** SLC30A3 is involved in the transport of zinc ions into lysosomes, which is essential for lysosomal function and degradation of proteins. 4. **Immune Response:** This gene is expressed in immune cells, where it regulates the transport of metal ions, including zinc, which is essential for immune function and response. **Clinical Significance:** 1. **Neurodegenerative Diseases:** Abnormal expression or function of SLC30A3 has been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer:** SLC30A3 has been found to be overexpressed in certain types of cancer, including colon cancer, where it may contribute to tumor progression and metastasis. 3. **Cardiovascular Disease:** This gene has been linked to cardiovascular disease, where it may play a role in regulating zinc homeostasis and maintaining cardiovascular function. 4. **Therapeutic Potential:** Targeting SLC30A3 may offer a novel therapeutic strategy for treating neurodegenerative diseases, cancer, and cardiovascular disease. In conclusion, the SLC30A3 gene plays a critical role in regulating metal ion transport and maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the functional significance of SLC30A3 and its implications in human disease.

Genular Protein ID: 4201388723

Symbol: ZNT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99726 Q8TC03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 6 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8962159

Title: ZnT-3, a putative transporter of zinc into synaptic vesicles.

PubMed ID: 8962159

DOI: 10.1073/pnas.93.25.14934

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17349999

Title: Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes.

PubMed ID: 17349999

DOI: 10.1016/j.yexcr.2007.02.006

PubMed ID: 19521526

Title: SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.

PubMed ID: 19521526

DOI: 10.1371/journal.pone.0005896

PubMed ID: 36204728

Title: Transmembrane 163 (TMEM163) protein interacts with specific mammalian SLC30 zinc efflux transporter family members.

PubMed ID: 36204728

DOI: 10.1016/j.bbrep.2022.101362

PubMed ID: 26647834

Title: Loss of synaptic Zn2+ transporter function increases risk of febrile seizures.

PubMed ID: 26647834

DOI: 10.1038/srep17816

Sequence Information:

  • Length: 388
  • Mass: 41945
  • Checksum: D73DE65F46860FD8
  • Sequence:
    • MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM PFHHCHRDPL 
PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL AIMTDAAHLL ADVGSMMGSL 
FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM 
LLTASIAVCA NLLMAFVLHQ AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL 
GDLLQSFGVL AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV 
GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF 
GFSSCTLQVE QYQPEMAQCL RCQEPPQA

Genular Protein ID: 2730833146

Symbol: B4DXX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DXX8

Database IDs:

ARBA 19 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 383
  • Mass: 41734
  • Checksum: EA69A962AA9524E4
  • Sequence:
    • MRVAAGARGE NIEHLKLRLE ARPPTLLLFT EPSEPLPEES KPVEMPFHHC HRDPLPPPGL 
TPERLHARRQ LYAACAVCFV FMAGEVVGGY LAHSLAIMTD AAHLLADVGS MMGSLFSLWL 
STRPATRTMT FGWHRSETLG ALASVVSLWM VTGILLYLAF VRLLHSDYHI EGGAMLLTAS 
IAVCADLLMA FVLHQAGPPH SHGSRGAEYA PLEEGPEEPL PLGNTSVRAA FVHVLGDLLQ 
SFGVLAASIL IYFKPQYKAA DPISTFLFSI CALGSTAPTL RDVLRILMEG TPRNVGFEPV 
RDTLLSVPGV RATHELHLWA LTLTYHVASA HLAIDSTADP EAVLAEASSR LYSRFGFSSC 
TLQVEQYQPE MAQCLRCQEP PQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.