Details for: PTP4A1

Gene ID: 7803

Symbol: PTP4A1

Ensembl ID: ENSG00000112245

Description: protein tyrosine phosphatase 4A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 243.4662
    Cell Significance Index: -37.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.8572
    Cell Significance Index: -35.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 108.7031
    Cell Significance Index: -44.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.4231
    Cell Significance Index: -35.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.8175
    Cell Significance Index: -39.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.1240
    Cell Significance Index: -39.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.0940
    Cell Significance Index: -36.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.6776
    Cell Significance Index: -40.2900
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 17.0897
    Cell Significance Index: 50.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.4792
    Cell Significance Index: -33.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 10.5580
    Cell Significance Index: 177.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.4193
    Cell Significance Index: -41.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 9.8698
    Cell Significance Index: 1150.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.8020
    Cell Significance Index: -27.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 7.2622
    Cell Significance Index: 122.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.3190
    Cell Significance Index: 169.3200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 5.8991
    Cell Significance Index: 22.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.0371
    Cell Significance Index: 801.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8237
    Cell Significance Index: -6.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2364
    Cell Significance Index: 166.6800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.8319
    Cell Significance Index: 4.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6377
    Cell Significance Index: 894.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6318
    Cell Significance Index: 177.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5493
    Cell Significance Index: 12.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5306
    Cell Significance Index: 108.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5288
    Cell Significance Index: 40.2000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.2847
    Cell Significance Index: 18.0200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.2040
    Cell Significance Index: 4.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0869
    Cell Significance Index: 480.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0667
    Cell Significance Index: 137.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9648
    Cell Significance Index: 14.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9435
    Cell Significance Index: 19.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9191
    Cell Significance Index: 829.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8514
    Cell Significance Index: 54.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8295
    Cell Significance Index: 23.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6919
    Cell Significance Index: 41.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6811
    Cell Significance Index: 80.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6577
    Cell Significance Index: 7.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6308
    Cell Significance Index: 21.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5731
    Cell Significance Index: 15.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5696
    Cell Significance Index: 78.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5454
    Cell Significance Index: 37.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4614
    Cell Significance Index: 13.5500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3890
    Cell Significance Index: 2.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2508
    Cell Significance Index: 13.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2501
    Cell Significance Index: 47.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2202
    Cell Significance Index: 9.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1810
    Cell Significance Index: 9.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1646
    Cell Significance Index: 16.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1433
    Cell Significance Index: 23.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1246
    Cell Significance Index: 94.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0049
    Cell Significance Index: -3.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0087
    Cell Significance Index: -0.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0184
    Cell Significance Index: -34.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0231
    Cell Significance Index: -0.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0277
    Cell Significance Index: -5.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0289
    Cell Significance Index: -53.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0309
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0314
    Cell Significance Index: -23.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0339
    Cell Significance Index: -52.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0390
    Cell Significance Index: -1.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0406
    Cell Significance Index: -55.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0497
    Cell Significance Index: -8.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0592
    Cell Significance Index: -33.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0606
    Cell Significance Index: -38.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0649
    Cell Significance Index: -18.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0666
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0722
    Cell Significance Index: -45.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0816
    Cell Significance Index: -1.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0902
    Cell Significance Index: -40.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1093
    Cell Significance Index: -3.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1115
    Cell Significance Index: -39.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1390
    Cell Significance Index: -2.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1593
    Cell Significance Index: -2.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1595
    Cell Significance Index: -2.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1757
    Cell Significance Index: -31.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1873
    Cell Significance Index: -21.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2124
    Cell Significance Index: -44.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2228
    Cell Significance Index: -5.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2343
    Cell Significance Index: -3.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2363
    Cell Significance Index: -14.5300
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.2411
    Cell Significance Index: -1.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2473
    Cell Significance Index: -35.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2853
    Cell Significance Index: -35.0800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3399
    Cell Significance Index: -2.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3466
    Cell Significance Index: -11.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3629
    Cell Significance Index: -9.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3738
    Cell Significance Index: -17.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3935
    Cell Significance Index: -40.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4259
    Cell Significance Index: -33.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4917
    Cell Significance Index: -13.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5412
    Cell Significance Index: -33.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5432
    Cell Significance Index: -6.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5525
    Cell Significance Index: -42.4000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.5757
    Cell Significance Index: -6.3100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.5974
    Cell Significance Index: -3.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6125
    Cell Significance Index: -11.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6171
    Cell Significance Index: -10.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6259
    Cell Significance Index: -42.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6627
    Cell Significance Index: -9.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PTP4A1 is a non-receptor tyrosine phosphatase, specifically classified as a type IVA phosphatase. It exhibits a unique structure, consisting of two catalytic domains separated by a long linker region. This architecture allows PTP4A1 to interact with multiple protein partners, facilitating its regulatory functions. The gene is highly expressed in various cell types, including epithelial cells, stem cells, and cells of the nervous system. **Pathways and Functions:** PTP4A1 is involved in several critical signaling pathways, including: 1. **Positive Regulation of Cell Migration:** PTP4A1 modulates the activity of tyrosine kinases, such as FAK and Src, which are essential for cell migration. By dephosphorylating and inactivating these kinases, PTP4A1 promotes cell migration and invasion. 2. **Cell Cycle Regulation:** PTP4A1 interacts with cyclin-dependent kinases (CDKs) and cyclins, regulating the cell cycle progression. Its activity is essential for the proper progression of the cell cycle and the maintenance of genomic stability. 3. **Protein Binding and Phosphatase Activity:** PTP4A1 exhibits high specificity for tyrosine and serine/threonine phosphates, making it a key regulator of protein function. Its phosphatase activity is essential for the dephosphorylation and inactivation of protein kinases, thereby modulating signal transduction pathways. **Clinical Significance:** PTP4A1 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of PTP4A1 has been observed in several types of cancer, including breast, lung, and colon cancer. Its overexpression is often associated with poor prognosis and increased metastatic potential. 2. **Neurological Disorders:** PTP4A1 has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Its dysregulation is thought to contribute to the development of these diseases. 3. **Cardiovascular Disease:** PTP4A1 has been implicated in the development of cardiovascular disease, including atherosclerosis and hypertension. Its dysregulation is thought to contribute to the pathogenesis of these diseases. In conclusion, PTP4A1 is a critical enzyme involved in various cellular processes, including cell migration, proliferation, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of PTP4A1.

Genular Protein ID: 3419539966

Symbol: TP4A1_HUMAN

Name: Protein tyrosine phosphatase type IVA 1

UniProtKB Accession Codes:

Q93096 B2R6C8 O00648 Q49A54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9018080

Title: Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases.

PubMed ID: 9018080

DOI: 10.1016/s0304-3835(96)04459-x

PubMed ID: 9642300

Title: The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer.

PubMed ID: 9642300

DOI: 10.1074/jbc.273.27.17286

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9633825

Title: Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38.

PubMed ID: 9633825

PubMed ID: 10940933

Title: Subcellular localization of intracellular protein tyrosine phosphatases in T cells.

PubMed ID: 10940933

DOI: 10.1002/1521-4141(2000)30:8<2412::aid-immu2412>3.0.co;2-j

PubMed ID: 12235145

Title: The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis.

PubMed ID: 12235145

DOI: 10.1074/jbc.m206407200

PubMed ID: 12516958

Title: Pentamidine is an inhibitor of PRL phosphatases with anticancer activity.

PubMed ID: 12516958

PubMed ID: 14643450

Title: Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases.

PubMed ID: 14643450

DOI: 10.1016/s0304-3835(03)00517-2

PubMed ID: 12782572

Title: PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.

PubMed ID: 12782572

PubMed ID: 15501285

Title: Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach.

PubMed ID: 15501285

DOI: 10.1016/j.toxicon.2004.07.018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15571731

Title: Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms.

PubMed ID: 15571731

DOI: 10.1016/j.jmb.2004.10.061

Sequence Information:

  • Length: 173
  • Mass: 19815
  • Checksum: 702008013D3F3835
  • Sequence:
    • MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK 
EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI 
EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.