Details for: MALL

Gene ID: 7851

Symbol: MALL

Ensembl ID: ENSG00000144063

Description: mal, T cell differentiation protein like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.4850
    Cell Significance Index: -16.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6110
    Cell Significance Index: -17.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.5789
    Cell Significance Index: 185.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7649
    Cell Significance Index: 31.4100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.2306
    Cell Significance Index: 13.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9701
    Cell Significance Index: 34.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8343
    Cell Significance Index: 225.5400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.6038
    Cell Significance Index: 22.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5730
    Cell Significance Index: 45.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2070
    Cell Significance Index: 26.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1826
    Cell Significance Index: 17.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1094
    Cell Significance Index: 120.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0955
    Cell Significance Index: 141.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0497
    Cell Significance Index: 170.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0177
    Cell Significance Index: 100.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8274
    Cell Significance Index: 37.5100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6866
    Cell Significance Index: 5.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6523
    Cell Significance Index: 588.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6312
    Cell Significance Index: 113.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5364
    Cell Significance Index: 37.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5240
    Cell Significance Index: 11.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3562
    Cell Significance Index: 3.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3394
    Cell Significance Index: 39.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3389
    Cell Significance Index: 256.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3128
    Cell Significance Index: 59.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2619
    Cell Significance Index: 143.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1911
    Cell Significance Index: 6.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1095
    Cell Significance Index: 3.0600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1066
    Cell Significance Index: 1.1000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0994
    Cell Significance Index: 1.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0791
    Cell Significance Index: 49.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0738
    Cell Significance Index: 3.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0583
    Cell Significance Index: 11.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0569
    Cell Significance Index: 4.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0042
    Cell Significance Index: -0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0078
    Cell Significance Index: -14.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0133
    Cell Significance Index: -20.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0177
    Cell Significance Index: -7.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0215
    Cell Significance Index: -15.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0248
    Cell Significance Index: -15.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0278
    Cell Significance Index: -0.8900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0314
    Cell Significance Index: -0.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0317
    Cell Significance Index: -6.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0320
    Cell Significance Index: -11.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0349
    Cell Significance Index: -7.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0367
    Cell Significance Index: -4.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0386
    Cell Significance Index: -17.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0440
    Cell Significance Index: -2.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0498
    Cell Significance Index: -6.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0546
    Cell Significance Index: -15.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0619
    Cell Significance Index: -7.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0659
    Cell Significance Index: -1.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0816
    Cell Significance Index: -3.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0883
    Cell Significance Index: -9.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0904
    Cell Significance Index: -12.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0988
    Cell Significance Index: -2.4700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0995
    Cell Significance Index: -1.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1088
    Cell Significance Index: -15.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1268
    Cell Significance Index: -5.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1424
    Cell Significance Index: -14.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1488
    Cell Significance Index: -9.1300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1741
    Cell Significance Index: -1.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1970
    Cell Significance Index: -13.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2015
    Cell Significance Index: -15.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2179
    Cell Significance Index: -16.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2198
    Cell Significance Index: -14.7800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2225
    Cell Significance Index: -2.9100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.2600
    Cell Significance Index: -2.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2939
    Cell Significance Index: -8.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2972
    Cell Significance Index: -18.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2994
    Cell Significance Index: -5.0100
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.3015
    Cell Significance Index: -2.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3092
    Cell Significance Index: -17.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3138
    Cell Significance Index: -11.5200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.3251
    Cell Significance Index: -2.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3271
    Cell Significance Index: -6.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3280
    Cell Significance Index: -9.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3482
    Cell Significance Index: -18.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3486
    Cell Significance Index: -15.1600
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.3689
    Cell Significance Index: -2.3100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3699
    Cell Significance Index: -5.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3799
    Cell Significance Index: -13.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3942
    Cell Significance Index: -13.7000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4038
    Cell Significance Index: -9.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4068
    Cell Significance Index: -13.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4130
    Cell Significance Index: -18.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4252
    Cell Significance Index: -10.6200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4536
    Cell Significance Index: -4.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4807
    Cell Significance Index: -15.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4811
    Cell Significance Index: -12.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4817
    Cell Significance Index: -18.2400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4842
    Cell Significance Index: -7.0300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.4871
    Cell Significance Index: -3.5400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.4968
    Cell Significance Index: -3.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4993
    Cell Significance Index: -12.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MALL is a protein-coding gene that belongs to the mal family of proteins, which are characterized by their ability to modulate T cell differentiation and myelination. The gene's protein product, MALL_HUMAN, shares a high degree of sequence similarity with other mal family members, suggesting a conserved evolutionary function. The expression of MALL is widespread, with significant levels detected in enterocytes, colon epithelial cells, and epithelial cells of the lung, esophagus, and urethra. This broad tissue distribution underscores the gene's potential role in maintaining tissue homeostasis and regulating cellular processes. **Pathways and Functions:** MALL's involvement in various cellular pathways is a testament to its multifaceted role in maintaining cellular homeostasis. The gene's protein product is implicated in: 1. **Cholesterol homeostasis:** MALL is involved in regulating cholesterol levels within cells, which is crucial for maintaining cellular membrane integrity and function. 2. **Protein binding:** MALL's protein product interacts with other proteins, modulating their activity and regulating cellular processes. 3. **Myelination:** MALL is essential for the structural maintenance of the myelin sheath, which is critical for the proper functioning of the nervous system. 4. **Clathrin-coated vesicle and cytoplasmic vesicle formation:** MALL's protein product is involved in the regulation of vesicle formation and transport, which is essential for cellular homeostasis. **Clinical Significance:** The MALL gene's role in T cell differentiation and myelination has significant implications for our understanding of various diseases. Dysregulation of MALL has been implicated in: 1. **Autoimmune diseases:** Alterations in MALL expression and function may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Neurological disorders:** MALL's involvement in myelination and cholesterol homeostasis makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** MALL's protein product has been implicated in cancer progression and metastasis, highlighting its potential as a therapeutic target. In conclusion, the MALL gene is a complex protein-coding gene that plays a pivotal role in T cell differentiation, myelination, and cholesterol homeostasis. Its widespread expression and implication in various cellular pathways underscore its importance in maintaining tissue homeostasis. Further research is needed to fully elucidate the mechanisms by which MALL regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 908137104

Symbol: MALL_HUMAN

Name: MAL-like protein

UniProtKB Accession Codes:

Q13021 B3KWR6 Q9BTU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7622049

Title: Searching for non-V kappa transcripts from the human immunoglobulin kappa locus.

PubMed ID: 7622049

DOI: 10.1016/0378-1119(95)00161-x

Sequence Information:

  • Length: 153
  • Mass: 17350
  • Checksum: 83B30F1D950C5745
  • Sequence:
    • MASPDPPATS YAPSDVPSGV ALFLTIPFAF FLPELIFGFL VWTMVAATHI VYPLLQGWVM 
YVSLTSFLIS LMFLLSYLFG FYKRFESWRV LDSLYHGTTG ILYMSAAVLQ VHATIVSEKL 
LDPRIYYINS AASFFAFIAT LLYILHAFSI YYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.