Details for: SCG2

Gene ID: 7857

Symbol: SCG2

Ensembl ID: ENSG00000171951

Description: secretogranin II

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 64.8626
    Cell Significance Index: -26.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 8.0100
    Cell Significance Index: 61.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 5.2061
    Cell Significance Index: 319.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.2234
    Cell Significance Index: 34.4000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.8890
    Cell Significance Index: 16.6400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.6077
    Cell Significance Index: 20.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5814
    Cell Significance Index: 567.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5581
    Cell Significance Index: 49.9100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.5555
    Cell Significance Index: 12.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4163
    Cell Significance Index: 269.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3315
    Cell Significance Index: 16.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.9208
    Cell Significance Index: 105.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9047
    Cell Significance Index: 55.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7822
    Cell Significance Index: 706.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7650
    Cell Significance Index: 153.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7583
    Cell Significance Index: 75.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6864
    Cell Significance Index: 30.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5375
    Cell Significance Index: 12.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5147
    Cell Significance Index: 19.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4431
    Cell Significance Index: 306.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4345
    Cell Significance Index: 70.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4003
    Cell Significance Index: 43.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3800
    Cell Significance Index: 8.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2289
    Cell Significance Index: 13.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1531
    Cell Significance Index: 8.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1502
    Cell Significance Index: 10.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1334
    Cell Significance Index: 2.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0257
    Cell Significance Index: 0.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0220
    Cell Significance Index: 1.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0083
    Cell Significance Index: 6.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0020
    Cell Significance Index: 0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0105
    Cell Significance Index: -6.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0137
    Cell Significance Index: -25.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0167
    Cell Significance Index: -25.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0191
    Cell Significance Index: -25.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0248
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0306
    Cell Significance Index: -5.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0340
    Cell Significance Index: -25.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0356
    Cell Significance Index: -26.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0365
    Cell Significance Index: -0.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0402
    Cell Significance Index: -21.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0497
    Cell Significance Index: -5.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0559
    Cell Significance Index: -25.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0607
    Cell Significance Index: -2.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0661
    Cell Significance Index: -19.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1011
    Cell Significance Index: -2.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1179
    Cell Significance Index: -21.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1245
    Cell Significance Index: -24.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1435
    Cell Significance Index: -20.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1577
    Cell Significance Index: -21.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1744
    Cell Significance Index: -21.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1863
    Cell Significance Index: -24.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1961
    Cell Significance Index: -22.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1994
    Cell Significance Index: -5.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2245
    Cell Significance Index: -4.8500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2250
    Cell Significance Index: -2.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2274
    Cell Significance Index: -23.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2276
    Cell Significance Index: -23.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2803
    Cell Significance Index: -5.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2834
    Cell Significance Index: -4.2700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3052
    Cell Significance Index: -3.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3207
    Cell Significance Index: -24.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3226
    Cell Significance Index: -24.0400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3597
    Cell Significance Index: -3.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3762
    Cell Significance Index: -23.7100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4076
    Cell Significance Index: -8.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4124
    Cell Significance Index: -23.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4170
    Cell Significance Index: -26.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4447
    Cell Significance Index: -23.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4575
    Cell Significance Index: -14.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4584
    Cell Significance Index: -9.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5429
    Cell Significance Index: -11.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6002
    Cell Significance Index: -21.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6142
    Cell Significance Index: -19.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6162
    Cell Significance Index: -15.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6199
    Cell Significance Index: -29.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6249
    Cell Significance Index: -12.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6471
    Cell Significance Index: -33.6200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6747
    Cell Significance Index: -9.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6761
    Cell Significance Index: -31.5300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6798
    Cell Significance Index: -8.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6987
    Cell Significance Index: -25.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7401
    Cell Significance Index: -18.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7420
    Cell Significance Index: -21.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.7583
    Cell Significance Index: -12.0300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.7639
    Cell Significance Index: -9.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7669
    Cell Significance Index: -26.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7675
    Cell Significance Index: -16.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7717
    Cell Significance Index: -13.2300
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.7889
    Cell Significance Index: -8.0200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7903
    Cell Significance Index: -15.7600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7909
    Cell Significance Index: -9.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8065
    Cell Significance Index: -11.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8260
    Cell Significance Index: -17.2900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8379
    Cell Significance Index: -26.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8811
    Cell Significance Index: -23.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SCG2 is a member of the secretogranin family, which is composed of proteins that are stored in the secretory granules of neurons, endocrine cells, and other cells. SCG2 is a 45-kDa protein that is highly expressed in sympathetic neurons, endothelial cells, and other cell types. It is characterized by its ability to bind to various proteins, including insulin-like growth factor binding proteins (IGFBPs), and its involvement in the regulation of protein secretion. **Pathways and Functions** SCG2 is involved in several key pathways, including: 1. **Angiogenesis**: SCG2 promotes angiogenesis by regulating the expression of vascular endothelial growth factor (VEGF) and other pro-angiogenic factors. 2. **Cytokine activity**: SCG2 modulates the activity of various cytokines, including interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), which are involved in the regulation of immune responses. 3. **Endoplasmic reticulum lumen**: SCG2 is transported to the endoplasmic reticulum lumen, where it regulates the processing and secretion of proteins. 4. **Inflammatory response**: SCG2 plays a role in the regulation of the inflammatory response by modulating the expression of pro-inflammatory cytokines. 5. **Metabolism of proteins**: SCG2 is involved in the regulation of protein metabolism, including the degradation of proteins and the regulation of protein synthesis. **Clinical Significance** SCG2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: SCG2 has been shown to be involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: SCG2 has been found to be overexpressed in various types of cancer, including breast cancer and lung cancer, and has been implicated in tumor progression and metastasis. 3. **Inflammatory disorders**: SCG2 has been shown to be involved in the regulation of the inflammatory response in various inflammatory disorders, including rheumatoid arthritis and asthma. 4. **Neurological disorders**: SCG2 has been implicated in the regulation of synaptic plasticity and neuronal excitability, and has been found to be involved in various neurological disorders, including epilepsy and multiple sclerosis. In conclusion, SCG2 is a multifunctional protein that plays a critical role in various physiological processes, including immune responses, angiogenesis, and cellular proliferation. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease. **Significantly expressed cells** The following cell types have been found to express SCG2: * Sympathetic neuron * Blood vessel endothelial cell * PP cell * Type A enteroendocrine cell * Primary sensory neuron (sensu Teleostei) * Chromaffin cell * GABAergic amacrine cell * Caudal ganglionic eminence derived GABAergic cortical interneuron * Dopaminergic neuron * Chandelier pvalb GABAergic cortical interneuron **Proteins** The only protein listed is SCG2_HUMAN, which refers to the human version of the SCG2 protein. In conclusion, SCG2 is a critical regulator of various physiological processes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 3621823055

Symbol: SCG2_HUMAN

Name: Secretogranin-2

UniProtKB Accession Codes:

P13521 B2R662 Q53T11 Q8TBH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2745426

Title: The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation.

PubMed ID: 2745426

DOI: 10.1016/s0021-9258(18)80167-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9654353

Title: Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains.

PubMed ID: 9654353

DOI: 10.1016/s0304-3940(98)00345-0

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 19357184

Title: Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC.

PubMed ID: 19357184

DOI: 10.1677/joe-08-0531

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 617
  • Mass: 70941
  • Checksum: A81C9C091DE9DF6B
  • Sequence:
    • MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF PSPEMIRALE 
YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP ERDSLSEEDW MRIILEALRQ 
AENEPQSAPK ENKPYALNSE KNFPMDMSDD YETQQWPERK LKHMQFPPMY EENSRDNPFK 
RTNEIVEEQY TPQSLATLES VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA 
YEDVVGGEDW NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK 
DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ LIEISRNLQI 
PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD HPDLFQNRML SKSGYPKTPG 
RAGTEALPDG LSVEDILNLL GMESAANQKT SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK 
AAWIPHVENR QMAYENLNDK DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE 
EQIEQAIKEH LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE 
KAEKGREHIA KRAMENM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.