Details for: ADAM12

Gene ID: 8038

Symbol: ADAM12

Ensembl ID: ENSG00000148848

Description: ADAM metallopeptidase domain 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 149.8600
    Cell Significance Index: -23.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.0584
    Cell Significance Index: -23.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.7376
    Cell Significance Index: -19.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.9382
    Cell Significance Index: -23.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 6.7772
    Cell Significance Index: 42.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4047
    Cell Significance Index: -9.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1186
    Cell Significance Index: -12.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.1625
    Cell Significance Index: 67.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.7130
    Cell Significance Index: 394.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.4575
    Cell Significance Index: 108.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0387
    Cell Significance Index: 77.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9343
    Cell Significance Index: 51.6500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.1396
    Cell Significance Index: 14.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.9074
    Cell Significance Index: 55.6300
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.7443
    Cell Significance Index: 6.0100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.7128
    Cell Significance Index: 3.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.7057
    Cell Significance Index: 448.2000
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.6589
    Cell Significance Index: 5.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6143
    Cell Significance Index: 1156.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3535
    Cell Significance Index: 7.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3422
    Cell Significance Index: 46.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3042
    Cell Significance Index: 57.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1930
    Cell Significance Index: 38.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1722
    Cell Significance Index: 22.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1711
    Cell Significance Index: 154.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1566
    Cell Significance Index: 4.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1544
    Cell Significance Index: 15.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0948
    Cell Significance Index: 65.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0938
    Cell Significance Index: 1.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0909
    Cell Significance Index: 32.6200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0853
    Cell Significance Index: 1.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0771
    Cell Significance Index: 42.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0602
    Cell Significance Index: 9.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0600
    Cell Significance Index: 3.7800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0276
    Cell Significance Index: 0.1200
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0208
    Cell Significance Index: 0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0190
    Cell Significance Index: 29.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0015
    Cell Significance Index: 2.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0031
    Cell Significance Index: -0.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0174
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0316
    Cell Significance Index: -23.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0362
    Cell Significance Index: -27.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0379
    Cell Significance Index: -28.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0388
    Cell Significance Index: -17.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0423
    Cell Significance Index: -26.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0476
    Cell Significance Index: -26.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0497
    Cell Significance Index: -0.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0513
    Cell Significance Index: -10.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0569
    Cell Significance Index: -2.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0611
    Cell Significance Index: -17.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0630
    Cell Significance Index: -6.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0739
    Cell Significance Index: -2.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0775
    Cell Significance Index: -1.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1168
    Cell Significance Index: -2.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1197
    Cell Significance Index: -14.7200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1214
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1398
    Cell Significance Index: -29.4400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1527
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1539
    Cell Significance Index: -26.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1718
    Cell Significance Index: -22.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1747
    Cell Significance Index: -11.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1773
    Cell Significance Index: -18.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1793
    Cell Significance Index: -3.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1872
    Cell Significance Index: -21.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1913
    Cell Significance Index: -8.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1941
    Cell Significance Index: -14.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2121
    Cell Significance Index: -9.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2191
    Cell Significance Index: -22.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2214
    Cell Significance Index: -7.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2255
    Cell Significance Index: -25.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2295
    Cell Significance Index: -27.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2324
    Cell Significance Index: -2.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2358
    Cell Significance Index: -16.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2523
    Cell Significance Index: -18.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2565
    Cell Significance Index: -15.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2716
    Cell Significance Index: -7.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2724
    Cell Significance Index: -3.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2725
    Cell Significance Index: -4.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2739
    Cell Significance Index: -15.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2774
    Cell Significance Index: -19.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2912
    Cell Significance Index: -17.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2932
    Cell Significance Index: -7.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3001
    Cell Significance Index: -23.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3215
    Cell Significance Index: -6.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3300
    Cell Significance Index: -7.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3745
    Cell Significance Index: -19.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3848
    Cell Significance Index: -19.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4077
    Cell Significance Index: -10.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4086
    Cell Significance Index: -26.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4089
    Cell Significance Index: -10.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4461
    Cell Significance Index: -23.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4534
    Cell Significance Index: -9.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4713
    Cell Significance Index: -24.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4836
    Cell Significance Index: -16.9400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4959
    Cell Significance Index: -8.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5147
    Cell Significance Index: -11.1200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.5248
    Cell Significance Index: -3.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5407
    Cell Significance Index: -15.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADAM12 is characterized by its ability to bind to various ligands, including collagen, laminin, and growth factors, such as epidermal growth factor (EGF) and fibroblast growth factor (FGF). This binding capacity enables ADAM12 to regulate cell adhesion, migration, and proliferation. The gene's expression is tissue-specific, with significant expression in trophoblast giant cells, corneal endothelial cells, and colon goblet cells. ADAM12's proteolytic activity is mediated by its metalloprotease domain, which cleaves various substrates, including growth factors, cytokines, and cell surface proteins. **Pathways and Functions:** ADAM12's involvement in multiple signaling pathways underscores its complexity. Some of the key pathways regulated by ADAM12 include: 1. **Cell adhesion:** ADAM12 interacts with integrins, laminins, and collagen, modulating cell adhesion and migration. 2. **Extracellular matrix organization:** ADAM12 regulates the remodeling of the extracellular matrix by cleaving components such as collagen and laminin. 3. **Invadopodia formation:** ADAM12's proteolytic activity is required for the formation of invadopodia, a specialized structure involved in cancer cell invasion. 4. **Angiogenesis:** ADAM12 promotes angiogenesis by regulating the release of growth factors, such as VEGF and EGF. 5. **Neurological functions:** ADAM12 has been implicated in the regulation of neuronal migration, synapse formation, and synaptic plasticity. **Clinical Significance:** ADAM12's dysregulation has been implicated in various diseases, including: 1. **Cancer:** ADAM12's overexpression has been associated with cancer progression, metastasis, and poor prognosis. 2. **Autoimmune diseases:** ADAM12's role in regulating immune cell adhesion and migration may contribute to autoimmune diseases, such as multiple sclerosis. 3. **Neurological disorders:** ADAM12's involvement in neuronal migration and synaptic plasticity may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive disorders:** ADAM12's expression in trophoblast giant cells and syncytiotrophoblast cells suggests its potential involvement in reproductive disorders, such as preeclampsia. In conclusion, ADAM12 is a multifaceted gene with far-reaching implications in immune regulation, disease, and tissue homeostasis. Further research is needed to fully elucidate the mechanisms by which ADAM12 regulates its downstream signaling pathways and to explore its therapeutic potential in various diseases.

Genular Protein ID: 3069883682

Symbol: ADA12_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 12

UniProtKB Accession Codes:

O43184 O60470 Q5JRP0 Q5JRP1 Q6P9E3 Q6UWB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9417060

Title: A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo.

PubMed ID: 9417060

DOI: 10.1074/jbc.273.1.157

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9642263

Title: Human ADAM 12 (meltrin alpha) is an active metalloprotease.

PubMed ID: 9642263

DOI: 10.1074/jbc.273.27.16993

PubMed ID: 10831617

Title: The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.

PubMed ID: 10831617

DOI: 10.1083/jcb.149.5.1143

PubMed ID: 12615925

Title: The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells.

PubMed ID: 12615925

DOI: 10.1074/jbc.m300267200

PubMed ID: 15574124

Title: FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation.

PubMed ID: 15574124

DOI: 10.1042/bc20040506

PubMed ID: 18621736

Title: RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.

PubMed ID: 18621736

DOI: 10.1074/jbc.m709829200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21618342

Title: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

PubMed ID: 21618342

DOI: 10.1002/humu.21477

Sequence Information:

  • Length: 909
  • Mass: 99542
  • Checksum: E28131C64C4304AB
  • Sequence:
    • MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG DLWIPVKSFD 
SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTVILGHCY 
YHGHVRGYSD SAVSLSTCSG LRGLIVFENE SYVLEPMKSA TNRYKLFPAK KLKSVRGSCG 
SHHNTPNLAA KNVFPPPSQT WARRHKRETL KATKYVELVI VADNREFQRQ GKDLEKVKQR 
LIEIANHVDK FYRPLNIRIV LVGVEVWNDM DKCSVSQDPF TSLHEFLDWR KMKLLPRKSH 
DNAQLVSGVY FQGTTIGMAP IMSMCTADQS GGIVMDHSDN PLGAAVTLAH ELGHNFGMNH 
DTLDRGCSCQ MAVEKGGCIM NASTGYPFPM VFSSCSRKDL ETSLEKGMGV CLFNLPEVRE 
SFGGQKCGNR FVEEGEECDC GEPEECMNRC CNATTCTLKP DAVCAHGLCC EDCQLKPAGT 
ACRDSSNSCD LPEFCTGASP HCPANVYLHD GHSCQDVDGY CYNGICQTHE QQCVTLWGPG 
AKPAPGICFE RVNSAGDPYG NCGKVSKSSF AKCEMRDAKC GKIQCQGGAS RPVIGTNAVS 
IETNIPLQQG GRILCRGTHV YLGDDMPDPG LVLAGTKCAD GKICLNRQCQ NISVFGVHEC 
AMQCHGRGVC NNRKNCHCEA HWAPPFCDKF GFGGSTDSGP IRQADNQGLT IGILVTILCL 
LAAGFVVYLK RKTLIRLLFT NKKTTIEKLR CVRPSRPPRG FQPCQAHLGH LGKGLMRKPP 
DSYPPKDNPR RLLQCQNVDI SRPLNGLNVP QPQSTQRVLP PLHRAPRAPS VPARPLPAKP 
ALRQAQGTCK PNPPQKPLPA DPLARTTRLT HALARTPGQW ETGLRLAPLR PAPQYPHQVP 
RSTHTAYIK

Genular Protein ID: 2703900937

Symbol: Q5JRP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5JRP2 U5NE98

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 6 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 9 MANE-Select 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 3 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 24116070

Title: Alternative mRNA Splicing Generates Two Distinct ADAM12 Prodomain Variants.

PubMed ID: 24116070

Sequence Information:

  • Length: 906
  • Mass: 99217
  • Checksum: 123529DAF0A11D91
  • Sequence:
    • MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG DLWIPVKSFD 
SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTGHCYYHG 
HVRGYSDSAV SLSTCSGLRG LIVFENESYV LEPMKSATNR YKLFPAKKLK SVRGSCGSHH 
NTPNLAAKNV FPPPSQTWAR RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE 
IANHVDKFYR PLNIRIVLVG VEVWNDMDKC SVSQDPFTSL HEFLDWRKMK LLPRKSHDNA 
QLVSGVYFQG TTIGMAPIMS MCTADQSGGI VMDHSDNPLG AAVTLAHELG HNFGMNHDTL 
DRGCSCQMAV EKGGCIMNAS TGYPFPMVFS SCSRKDLETS LEKGMGVCLF NLPEVRESFG 
GQKCGNRFVE EGEECDCGEP EECMNRCCNA TTCTLKPDAV CAHGLCCEDC QLKPAGTACR 
DSSNSCDLPE FCTGASPHCP ANVYLHDGHS CQDVDGYCYN GICQTHEQQC VTLWGPGAKP 
APGICFERVN SAGDPYGNCG KVSKSSFAKC EMRDAKCGKI QCQGGASRPV IGTNAVSIET 
NIPLQQGGRI LCRGTHVYLG DDMPDPGLVL AGTKCADGKI CLNRQCQNIS VFGVHECAMQ 
CHGRGVCNNR KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ ADNQGLTIGI LVTILCLLAA 
GFVVYLKRKT LIRLLFTNKK TTIEKLRCVR PSRPPRGFQP CQAHLGHLGK GLMRKPPDSY 
PPKDNPRRLL QCQNVDISRP LNGLNVPQPQ STQRVLPPLH RAPRAPSVPA RPLPAKPALR 
QAQGTCKPNP PQKPLPADPL ARTTRLTHAL ARTPGQWETG LRLAPLRPAP QYPHQVPRST 
HTAYIK

Genular Protein ID: 3914254176

Symbol: A8K6G4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6G4

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 3 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 2 SAM 2 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 735
  • Mass: 80230
  • Checksum: CD0F7616961ED240
  • Sequence:
    • MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVRSG DLWIPVKSFD 
SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTGHCYYHG 
HVRGYSDSAV SLSTCSGLRG LIVFENESYV LEPMKSATNR YKLFPAKKLK SVRGSCGSHH 
NTPNLAAKNV FPPPSQTWAR RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE 
IANHVDKFYR PLNIRIVLVG VEVWNDMDKC SVSQDPFTSL HEFLDWRKMK LLPRKSHDNA 
QLVSGVYFQG TTIGMAPIMS MCTADQSGGI VMDHSDNPLG AAVTLAHELG HNFGMNHDTL 
DRGCSCQMAV EKGGCIMNAS TGYPFPMVFS SCSRKDLETS LEKGMGVCLF NLPEVRESFG 
GQKCGNRFVE EGEECDCGEP EECMNRCCNA TTCTLKPDAV CAHGLCCEDR QLKPAGTACR 
DSSNSCDLPE FCTGASPHCP ANVYLHDGHS CQDVDGYCYN GICQTHEQQC VTLWGPGAKP 
APGICFERVN SAGDPYGNCG KVSKSSFAKC EMRDAKCGKI QCQGGASRPV IGTNAVSIET 
NIPLQQGGRI LCRGTHVYLG DDMPDPGLVL AGTKCADGKI CLNRQCQNIS VFGVHECAMQ 
CHGRGVCNNR KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ AEARQEAAES NRERGQGQEP 
VGSQEHASTA SLTLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.