Details for: GTPBP6

Gene ID: 8225

Symbol: GTPBP6

Ensembl ID: ENSG00000178605

Description: GTP binding protein 6 (putative)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.0506
    Cell Significance Index: -23.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 48.9261
    Cell Significance Index: -20.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.0246
    Cell Significance Index: -23.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.3640
    Cell Significance Index: -23.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 10.9068
    Cell Significance Index: 494.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3016
    Cell Significance Index: -19.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4681
    Cell Significance Index: -16.8000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 4.8594
    Cell Significance Index: 61.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5417
    Cell Significance Index: -9.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.3171
    Cell Significance Index: 124.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2758
    Cell Significance Index: 34.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.1040
    Cell Significance Index: 44.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6869
    Cell Significance Index: 45.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.4079
    Cell Significance Index: 49.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2851
    Cell Significance Index: 82.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0703
    Cell Significance Index: 8.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0114
    Cell Significance Index: 69.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8732
    Cell Significance Index: 25.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8149
    Cell Significance Index: 735.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7094
    Cell Significance Index: 140.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6994
    Cell Significance Index: 381.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6932
    Cell Significance Index: 95.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6487
    Cell Significance Index: 30.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6258
    Cell Significance Index: 112.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5762
    Cell Significance Index: 70.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4847
    Cell Significance Index: 47.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4648
    Cell Significance Index: 21.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4263
    Cell Significance Index: 31.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4202
    Cell Significance Index: 71.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4168
    Cell Significance Index: 53.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4168
    Cell Significance Index: 184.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4151
    Cell Significance Index: 9.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4130
    Cell Significance Index: 4.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4110
    Cell Significance Index: 82.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3781
    Cell Significance Index: 26.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3413
    Cell Significance Index: 10.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3372
    Cell Significance Index: 4.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2881
    Cell Significance Index: 6.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2524
    Cell Significance Index: 8.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2348
    Cell Significance Index: 6.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2149
    Cell Significance Index: 27.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1849
    Cell Significance Index: 66.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1743
    Cell Significance Index: 1.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1737
    Cell Significance Index: 33.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1539
    Cell Significance Index: 4.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1517
    Cell Significance Index: 4.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1509
    Cell Significance Index: 7.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1409
    Cell Significance Index: 22.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1148
    Cell Significance Index: 16.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1027
    Cell Significance Index: 2.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0859
    Cell Significance Index: 4.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0843
    Cell Significance Index: 9.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0821
    Cell Significance Index: 1.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0623
    Cell Significance Index: 4.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0268
    Cell Significance Index: 0.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0151
    Cell Significance Index: 11.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0128
    Cell Significance Index: 24.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0119
    Cell Significance Index: 8.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0091
    Cell Significance Index: 16.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0052
    Cell Significance Index: 8.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0048
    Cell Significance Index: 3.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0016
    Cell Significance Index: -0.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0218
    Cell Significance Index: -15.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0253
    Cell Significance Index: -14.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0324
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0444
    Cell Significance Index: -5.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0607
    Cell Significance Index: -17.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0657
    Cell Significance Index: -6.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0907
    Cell Significance Index: -2.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1005
    Cell Significance Index: -4.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1062
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1074
    Cell Significance Index: -22.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1240
    Cell Significance Index: -1.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1292
    Cell Significance Index: -2.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1296
    Cell Significance Index: -1.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1434
    Cell Significance Index: -5.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1652
    Cell Significance Index: -13.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1912
    Cell Significance Index: -19.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1928
    Cell Significance Index: -2.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1977
    Cell Significance Index: -5.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2473
    Cell Significance Index: -15.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2727
    Cell Significance Index: -4.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2851
    Cell Significance Index: -4.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3095
    Cell Significance Index: -5.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3275
    Cell Significance Index: -3.3900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3380
    Cell Significance Index: -2.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3718
    Cell Significance Index: -15.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4108
    Cell Significance Index: -14.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4123
    Cell Significance Index: -13.1300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4156
    Cell Significance Index: -10.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4221
    Cell Significance Index: -13.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4269
    Cell Significance Index: -7.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4645
    Cell Significance Index: -3.5800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4944
    Cell Significance Index: -6.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4971
    Cell Significance Index: -18.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5089
    Cell Significance Index: -8.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5190
    Cell Significance Index: -11.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5218
    Cell Significance Index: -15.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GTPBP6 is a putative GTP-binding protein, which implies that it possesses the ability to bind guanosine triphosphate (GTP). This characteristic suggests that GTPBP6 may be involved in various cellular processes, including signal transduction, protein regulation, and membrane trafficking. The gene is highly expressed in specific cell types, such as tracheal goblet cells, pancreatic A and D cells, and erythroid progenitor cells, which may indicate its role in maintaining cellular homeostasis and function. **Pathways and Functions:** The expression patterns of GTPBP6 in various cell types suggest that it may be involved in several cellular pathways. The gene's association with cytoplasmic localization, GTP binding, metal ion binding, and ribosome binding further implicates its role in protein regulation, signal transduction, and membrane trafficking. Some potential pathways that GTPBP6 may be involved in include: 1. **GTPase signaling pathways**: GTPBP6's ability to bind GTP suggests that it may be involved in GTPase signaling pathways, which regulate various cellular processes, including cell growth, differentiation, and survival. 2. **Metal ion homeostasis**: The gene's association with metal ion binding may indicate its role in maintaining metal ion homeostasis, which is crucial for various cellular processes, including protein function and cell signaling. 3. **Ribosome biogenesis**: The gene's association with ribosome binding may suggest that GTPBP6 is involved in ribosome biogenesis, which is essential for protein synthesis and cell growth. **Clinical Significance:** Despite its widespread expression, the functional significance of GTPBP6 remains unclear. However, its association with specific cell types and pathways suggests that it may play a role in various diseases. Some potential clinical implications of GTPBP6 include: 1. **Pancreatic disorders**: The gene's expression in pancreatic A and D cells suggests that GTPBP6 may be involved in pancreatic function and regulation. Dysregulation of GTPBP6 may contribute to pancreatic disorders, such as diabetes and pancreatitis. 2. **Erythropoiesis**: The gene's expression in erythroid progenitor cells suggests that GTPBP6 may be involved in erythropoiesis, which is essential for red blood cell production. Dysregulation of GTPBP6 may contribute to anemia and other erythropoietic disorders. 3. **Cancer**: The gene's expression in various cell types suggests that GTPBP6 may be involved in cancer development and progression. Dysregulation of GTPBP6 may contribute to tumorigenesis and metastasis. In conclusion, GTPBP6 is a putative GTP-binding protein with widespread expression in various cell types. While its functional significance remains unclear, its association with specific pathways and cell types suggests that it may play a role in various diseases. Further research is needed to elucidate the role of GTPBP6 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3304056391

Symbol: GTPB6_HUMAN

Name: Putative GTP-binding protein 6

UniProtKB Accession Codes:

O43824 H0Y2S1 Q53F77 Q5HYX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 Ensembl 2 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 9466997

Title: A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere.

PubMed ID: 9466997

DOI: 10.1093/hmg/7.3.407

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 516
  • Mass: 56897
  • Checksum: 0BCF19A88FB5A984
  • Sequence:
    • MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP WGGGRGLRAD 
GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL VHPDVKWGPG KSQMTRAEWQ 
VAEATALVHT LDGWSVVQTM VVSTKTPDRK LIFGKGNFEH LTEKIRGSPD ITCVFLNVER 
MAAPTKKELE AAWGVEVFDR FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL 
YRGVGSRYIM GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV 
GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT IGFLSQLPHG 
LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL RGLQLPAPLL DSMVEVHNKV 
DLVPGYSPTE PNVVPVSALR GHGLQELKAE LDAAVLKATG RQILTLRVRL AGAQLSWLYK 
EATVQEVDVI PEDGAADVRV IISNSAYGKF RKLFPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.