Details for: AKAP17A

Gene ID: 8227

Symbol: AKAP17A

Ensembl ID: ENSG00000197976

Description: A-kinase anchoring protein 17A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.6637
    Cell Significance Index: -21.4000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.4730
    Cell Significance Index: -23.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.3624
    Cell Significance Index: -24.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.9119
    Cell Significance Index: -21.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2983
    Cell Significance Index: -22.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8051
    Cell Significance Index: -17.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1289
    Cell Significance Index: -11.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 5.0574
    Cell Significance Index: 104.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.2665
    Cell Significance Index: 148.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.7444
    Cell Significance Index: 37.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.5524
    Cell Significance Index: 54.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4224
    Cell Significance Index: 91.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2618
    Cell Significance Index: 36.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1867
    Cell Significance Index: 32.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0217
    Cell Significance Index: 111.1400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.9396
    Cell Significance Index: 5.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9061
    Cell Significance Index: 179.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8936
    Cell Significance Index: 23.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8273
    Cell Significance Index: 28.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7271
    Cell Significance Index: 9.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7182
    Cell Significance Index: 10.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6772
    Cell Significance Index: 18.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6398
    Cell Significance Index: 115.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6378
    Cell Significance Index: 87.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6201
    Cell Significance Index: 17.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5641
    Cell Significance Index: 69.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5484
    Cell Significance Index: 37.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5005
    Cell Significance Index: 6.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4892
    Cell Significance Index: 267.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4826
    Cell Significance Index: 22.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4659
    Cell Significance Index: 12.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4326
    Cell Significance Index: 12.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3874
    Cell Significance Index: 28.8700
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.3873
    Cell Significance Index: 2.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3618
    Cell Significance Index: 68.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3497
    Cell Significance Index: 5.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2887
    Cell Significance Index: 41.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2813
    Cell Significance Index: 36.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2741
    Cell Significance Index: 32.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2587
    Cell Significance Index: 33.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2463
    Cell Significance Index: 108.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2331
    Cell Significance Index: 4.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2257
    Cell Significance Index: 22.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2135
    Cell Significance Index: 192.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1488
    Cell Significance Index: 6.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1479
    Cell Significance Index: 7.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1472
    Cell Significance Index: 7.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1350
    Cell Significance Index: 3.1200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1265
    Cell Significance Index: 0.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0914
    Cell Significance Index: 15.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0853
    Cell Significance Index: 30.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0771
    Cell Significance Index: 5.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0271
    Cell Significance Index: 18.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0262
    Cell Significance Index: 49.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0225
    Cell Significance Index: 34.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0190
    Cell Significance Index: 34.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0142
    Cell Significance Index: 8.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0138
    Cell Significance Index: 0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0065
    Cell Significance Index: -1.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0084
    Cell Significance Index: -1.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0164
    Cell Significance Index: -7.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0178
    Cell Significance Index: -0.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0302
    Cell Significance Index: -17.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0341
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0412
    Cell Significance Index: -25.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0467
    Cell Significance Index: -2.4500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0634
    Cell Significance Index: -0.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0638
    Cell Significance Index: -3.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0715
    Cell Significance Index: -20.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0736
    Cell Significance Index: -5.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0968
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1039
    Cell Significance Index: -21.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1188
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1266
    Cell Significance Index: -14.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1957
    Cell Significance Index: -20.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2129
    Cell Significance Index: -5.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2253
    Cell Significance Index: -5.7900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2439
    Cell Significance Index: -1.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2633
    Cell Significance Index: -4.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2644
    Cell Significance Index: -2.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2665
    Cell Significance Index: -21.1100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2681
    Cell Significance Index: -1.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2892
    Cell Significance Index: -5.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2904
    Cell Significance Index: -4.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2994
    Cell Significance Index: -4.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3092
    Cell Significance Index: -7.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3273
    Cell Significance Index: -8.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3393
    Cell Significance Index: -15.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3507
    Cell Significance Index: -21.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3556
    Cell Significance Index: -4.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4003
    Cell Significance Index: -15.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4107
    Cell Significance Index: -4.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4212
    Cell Significance Index: -4.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4408
    Cell Significance Index: -6.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4434
    Cell Significance Index: -3.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4470
    Cell Significance Index: -9.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Localization:** AKAP17A is predominantly found in the cytosol and nucleus of immune cells, where it regulates PKA activity and modulates gene expression. 2. **Protein Interaction:** AKAP17A interacts with PKA and other proteins, such as RNA-binding proteins, to regulate gene expression and signal transduction. 3. **Expression Pattern:** AKAP17A is expressed in a wide range of immune cells, including T cells, dendritic cells, B cells, and monocytes, highlighting its broad role in immune regulation. 4. **Regulatory Function:** AKAP17A regulates gene expression by interacting with RNA-binding proteins and modulating the activity of PKA, which is involved in various signaling pathways, including those involved in immune cell activation and differentiation. **Pathways and Functions:** 1. **B Cell Activation:** AKAP17A regulates B cell activation by modulating PKA activity and influencing gene expression, which is essential for B cell development and function. 2. **Cytosol:** AKAP17A interacts with PKA and other proteins in the cytosol to regulate signal transduction pathways, including those involved in immune cell activation and differentiation. 3. **Nuclear Speck:** AKAP17A is also involved in the regulation of nuclear speck formation, which is a critical step in the regulation of gene expression and immune cell function. 4. **RNA Splicing:** AKAP17A regulates RNA splicing by interacting with RNA-binding proteins, which is essential for the proper processing of RNA and gene expression. **Clinical Significance:** 1. **Immune Cell Dysfunction:** Dysregulation of AKAP17A has been linked to immune cell dysfunction, including impaired T cell activation and B cell development. 2. **Autoimmune Diseases:** Alterations in AKAP17A expression and function have been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** AKAP17A has been identified as a potential biomarker for cancer, as its expression is often altered in cancer cells, including those of T cells and B cells. 4. **Therapeutic Target:** AKAP17A is a potential therapeutic target for the treatment of immune-related disorders, including autoimmune diseases and cancer. In conclusion, AKAP17A plays a critical role in regulating immune cell function, gene expression, and signal transduction. Its dysregulation has been implicated in various immune-related disorders, highlighting its potential as a therapeutic target for the treatment of autoimmune diseases and cancer. Further research is needed to fully elucidate the mechanisms by which AKAP17A regulates immune cell function and to explore its potential as a therapeutic target.

Genular Protein ID: 895867562

Symbol: AK17A_HUMAN

Name: A-kinase anchor protein 17A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1302606

Title: Structure and expression of the human pseudoautosomal gene XE7.

PubMed ID: 1302606

DOI: 10.1093/hmg/1.9.782-a

PubMed ID: 1438229

Title: Cloning and sequencing of a trophoblast-endothelial-activated lymphocyte surface protein: cDNA sequence and genomic structure.

PubMed ID: 1438229

DOI: 10.1073/pnas.89.21.10425

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12176931

Title: Large-scale proteomic analysis of the human spliceosome.

PubMed ID: 12176931

DOI: 10.1101/gr.473902

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16982639

Title: XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265.

PubMed ID: 16982639

DOI: 10.1093/nar/gkl660

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19840947

Title: Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments.

PubMed ID: 19840947

DOI: 10.1074/jbc.m109.056465

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 695
  • Mass: 80735
  • Checksum: 639E88ECA8006CF2
  • Sequence:
  • MAAATIVHDT SEAVELCPAY GLYLKPITKM TISVALPQLK QPGKSISNWE VMERLKGMVQ 
    NHQFSTLRIS KSTMDFIRFE GEVENKSLVK SFLACLDGKT IKLSGFSDIL KVRAAEFKID 
    FPTRHDWDSF FRDAKDMNET LPGERPDTIH LEGLPCKWFA LKESGSEKPS EDVLVKVFEK 
    FGEIRNVDIP MLDPYREEMT GRNFHTFSFG GHLNFEAYVQ YREYMGFIQA MSALRGMKLM 
    YKGEDGKAVA CNIKVSFDST KHLSDASIKK RQLERQKLQE LEQQREEQKR REKEAEERQR 
    AEERKQKELE ELERERKREE KLRKREQKQR DRELRRNQKK LEKLQAEEQK QLQEKIKLEE 
    RKLLLAQRNL QSIRLIAELL SRAKAVKLRE QEQKEEKLRL QQQEERRRLQ EAELRRVEEE 
    KERALGLQRK ERELRERLLS ILLSKKPDDS HTHDELGVAH ADLLQPVLDI LQTVSSGCVS 
    ATTLHPLGGQ PPAGAPKESP AHPEADGAPK SVNGSVAEEA PCKEVQSSCR VVPEDGSPEK 
    RCPGGVLSCI PDNNQQPKGI PACEQNVSRK DTRSEQDKCN REPSKGRGRA TGDGLADRHK 
    RERSRARRAS SREDGRPRKE RRPHKKHAYK DDSPRRRSTS PDHTRSRRSH SKDRHRRERS 
    RERRGSASRK HSRHRRRSER SRSRSPSRHR STWNR

Genular Protein ID: 1233926324

Symbol: Q05DA9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 292
  • Mass: 33555
  • Checksum: 5AC4B076D707794C
  • Sequence:
  • MAAATIVHDT SEAVELCPAY GLYLKPITKM TISVALPQLK QPGKSISNWE VMERLKGMVQ 
    NHQFSTLRIS KSTMDFIRFE GEVENKSLVK SFLACLDGKT IKLSGFSDIL KVRAAEFKID 
    FPTRHDWDSF FRDAKDMNET LPGERPDTIH LEGLPCKWFA LKESGSEKPS EDVLVKVFEK 
    FGEIRNVDIP MLDPYREEMT GRNFHTFSFG GHLNFEAYVQ YREYMGFIQA MSALRGMKLM 
    YKGEDGKAVA CNIKVSFDST KHLSDASIKK RQLERQKLQE LEQQREEQKK KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.