Details for: AXIN1

Gene ID: 8312

Symbol: AXIN1

Ensembl ID: ENSG00000103126

Description: axin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.5355
    Cell Significance Index: -16.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.3961
    Cell Significance Index: -16.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.8486
    Cell Significance Index: -14.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.9045
    Cell Significance Index: -17.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.9310
    Cell Significance Index: -15.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.6582
    Cell Significance Index: -16.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3385
    Cell Significance Index: -16.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7697
    Cell Significance Index: -14.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3132
    Cell Significance Index: -17.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7467
    Cell Significance Index: -8.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2017
    Cell Significance Index: 140.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1800
    Cell Significance Index: 16.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0282
    Cell Significance Index: 206.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9732
    Cell Significance Index: 878.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9112
    Cell Significance Index: 41.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8137
    Cell Significance Index: 48.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7970
    Cell Significance Index: 86.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7665
    Cell Significance Index: 22.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6909
    Cell Significance Index: 112.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6048
    Cell Significance Index: 120.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5751
    Cell Significance Index: 12.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3985
    Cell Significance Index: 27.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3822
    Cell Significance Index: 10.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3558
    Cell Significance Index: 127.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3321
    Cell Significance Index: 229.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3288
    Cell Significance Index: 8.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3085
    Cell Significance Index: 7.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2672
    Cell Significance Index: 13.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2468
    Cell Significance Index: 10.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2044
    Cell Significance Index: 7.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1973
    Cell Significance Index: 10.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1694
    Cell Significance Index: 2.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1686
    Cell Significance Index: 10.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1623
    Cell Significance Index: 88.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1620
    Cell Significance Index: 4.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1554
    Cell Significance Index: 68.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1391
    Cell Significance Index: 13.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1345
    Cell Significance Index: 24.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1315
    Cell Significance Index: 4.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1249
    Cell Significance Index: 15.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1197
    Cell Significance Index: 2.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1052
    Cell Significance Index: 8.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0967
    Cell Significance Index: 2.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0789
    Cell Significance Index: 10.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0462
    Cell Significance Index: 2.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0456
    Cell Significance Index: 2.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0419
    Cell Significance Index: 1.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0414
    Cell Significance Index: 0.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0354
    Cell Significance Index: 2.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0282
    Cell Significance Index: 53.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0206
    Cell Significance Index: 38.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0161
    Cell Significance Index: 24.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0132
    Cell Significance Index: 0.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0044
    Cell Significance Index: 5.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0013
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0038
    Cell Significance Index: -0.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0153
    Cell Significance Index: -1.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0158
    Cell Significance Index: -7.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0181
    Cell Significance Index: -13.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0250
    Cell Significance Index: -1.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0282
    Cell Significance Index: -4.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0290
    Cell Significance Index: -16.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0300
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0306
    Cell Significance Index: -19.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0394
    Cell Significance Index: -4.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0460
    Cell Significance Index: -5.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0505
    Cell Significance Index: -14.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0568
    Cell Significance Index: -5.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0589
    Cell Significance Index: -1.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0622
    Cell Significance Index: -1.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0666
    Cell Significance Index: -7.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0704
    Cell Significance Index: -1.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0751
    Cell Significance Index: -1.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0855
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0885
    Cell Significance Index: -18.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0944
    Cell Significance Index: -2.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0981
    Cell Significance Index: -6.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1100
    Cell Significance Index: -3.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1380
    Cell Significance Index: -4.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1494
    Cell Significance Index: -15.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1589
    Cell Significance Index: -1.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2003
    Cell Significance Index: -15.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2290
    Cell Significance Index: -3.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2357
    Cell Significance Index: -14.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2455
    Cell Significance Index: -7.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2468
    Cell Significance Index: -5.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2598
    Cell Significance Index: -13.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2625
    Cell Significance Index: -5.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2733
    Cell Significance Index: -5.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2755
    Cell Significance Index: -7.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2804
    Cell Significance Index: -9.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2808
    Cell Significance Index: -5.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3328
    Cell Significance Index: -11.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3581
    Cell Significance Index: -2.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3643
    Cell Significance Index: -12.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3672
    Cell Significance Index: -13.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3694
    Cell Significance Index: -7.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AXIN1 exhibits several key characteristics that enable its regulatory function in cellular signaling: 1. **Armadillo repeat domain**: The AXIN1 protein contains an Armadillo repeat domain, which interacts with β-catenin and other Wnt signaling components. 2. **Destruction complex formation**: AXIN1 forms a complex with adenomatous polyposis coli (APC), glycogen synthase kinase 3β (GSK3β), and β-catenin, which regulates the degradation of β-catenin. 3. **Protein binding capabilities**: AXIN1 interacts with various proteins, including β-catenin, APC, GSK3β, and p53, to regulate signaling pathways. 4. **Regulation of Wnt signaling**: AXIN1 negatively regulates the canonical Wnt signaling pathway by promoting the degradation of β-catenin. **Pathways and Functions** AXIN1 is involved in various signaling pathways, including: 1. **Canonical Wnt signaling pathway**: AXIN1 regulates the degradation of β-catenin, which in turn modulates the transcription of target genes. 2. **Apoptotic process**: AXIN1 interacts with p53 to regulate apoptosis, a critical process for tissue homeostasis. 3. **Cell development**: AXIN1 is involved in the regulation of cell development, including axial mesoderm formation and head development. 4. **Signal transduction**: AXIN1 regulates signal transduction by interacting with various proteins, including growth factor receptors and second messengers. **Clinical Significance** Mutations in the AXIN1 gene have been implicated in several diseases, including: 1. **Colorectal cancer**: AXIN1 mutations have been associated with colorectal cancer, a disease characterized by uncontrolled cell growth and tumorigenesis. 2. **Osteoporosis**: AXIN1 mutations have been linked to osteoporosis, a disease characterized by bone loss and increased risk of fractures. 3. **Developmental disorders**: AXIN1 mutations have been implicated in developmental disorders, including neural tube defects and limb abnormalities. In conclusion, AXIN1 is a crucial protein that regulates various cellular processes, including Wnt signaling, apoptosis, and cell development. Mutations in the AXIN1 gene have been implicated in several diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which AXIN1 regulates cellular signaling and to explore its therapeutic potential in human disease.

Genular Protein ID: 1189531897

Symbol: AXIN1_HUMAN

Name: Axin-1

UniProtKB Accession Codes:

O15169 Q4TT26 Q4TT27 Q86YA7 Q8WVW6 Q96S28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 16 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 57 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 17 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9230313

Title: The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.

PubMed ID: 9230313

DOI: 10.1016/s0092-8674(00)80324-4

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9920888

Title: Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.

PubMed ID: 9920888

DOI: 10.1074/jbc.274.6.3439

PubMed ID: 10700176

Title: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.

PubMed ID: 10700176

DOI: 10.1038/73448

PubMed ID: 11336703

Title: Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

PubMed ID: 11336703

DOI: 10.1016/s1097-2765(01)00224-6

PubMed ID: 12192039

Title: I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.

PubMed ID: 12192039

DOI: 10.1128/mcb.22.18.6393-6405.2002

PubMed ID: 12805222

Title: Regulation of the Wnt signaling pathway by disabled-2 (Dab2).

PubMed ID: 12805222

DOI: 10.1093/emboj/cdg286

PubMed ID: 15262978

Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

PubMed ID: 15262978

DOI: 10.1074/jbc.m404598200

PubMed ID: 16773576

Title: Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.

PubMed ID: 16773576

DOI: 10.1086/505031

PubMed ID: 16601693

Title: Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.

PubMed ID: 16601693

DOI: 10.1038/sj.emboj.7601057

PubMed ID: 17210684

Title: Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

PubMed ID: 17210684

DOI: 10.1158/0008-5472.can-06-1671

PubMed ID: 17318175

Title: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.

PubMed ID: 17318175

DOI: 10.1038/sj.emboj.7601607

PubMed ID: 18632848

Title: SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability.

PubMed ID: 18632848

DOI: 10.1096/fj.08-113910

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19759537

Title: Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

PubMed ID: 19759537

DOI: 10.1038/nature08356

PubMed ID: 21383061

Title: The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling.

PubMed ID: 21383061

DOI: 10.1128/mcb.01094-10

PubMed ID: 21478859

Title: RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

PubMed ID: 21478859

DOI: 10.1038/ncb2222

PubMed ID: 21799911

Title: Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

PubMed ID: 21799911

DOI: 10.1371/journal.pone.0022595

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27098453

Title: WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

PubMed ID: 27098453

DOI: 10.1002/1873-3468.12180

PubMed ID: 28829046

Title: Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.

PubMed ID: 28829046

DOI: 10.1038/cr.2017.107

PubMed ID: 28546513

Title: The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling through mediating Wnt-induced Axin degradation.

PubMed ID: 28546513

DOI: 10.1101/gad.300053.117

PubMed ID: 10811618

Title: Structural basis of the axin-adenomatous polyposis coli interaction.

PubMed ID: 10811618

DOI: 10.1093/emboj/19.10.2270

PubMed ID: 12554650

Title: Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.

PubMed ID: 12554650

DOI: 10.1093/emboj/cdg068

PubMed ID: 12101426

Title: Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.

PubMed ID: 12101426

DOI: 10.1038/sj.onc.1205591

PubMed ID: 37582359

Title: AXIN1 bi-allelic variants disrupting the C-terminal DIX domain cause craniometadiaphyseal osteosclerosis with hip dysplasia.

PubMed ID: 37582359

DOI: 10.1016/j.ajhg.2023.07.011

Sequence Information:

  • Length: 862
  • Mass: 95635
  • Checksum: 10779173F5092F3F
  • Sequence:
    • MNIQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDPRPA SYSFCSGKGV GIKGETSTAT 
PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIS LFRTFLKQEG CADLLDFWFA 
CTGFRKLEPC DSNEEKRLKL ARAIYRKYIL DNNGIVSRQT KPATKSFIKG CIMKQLIDPA 
MFDQAQTEIQ ATMEENTYPS FLKSDIYLEY TRTGSESPKV CSDQSSGSGT GKGISGYLPT 
LNEDEEWKCD QDMDEDDGRD AAPPGRLPQK LLLETAAPRV SSSRRYSEGR EFRYGSWREP 
VNPYYVNAGY ALAPATSAND SEQQSLSSDA DTLSLTDSSV DGIPPYRIRK QHRREMQESV 
QVNGRVPLPH IPRTYRVPKE VRVEPQKFAE ELIHRLEAVQ RTREAEEKLE ERLKRVRMEE 
EGEDGDPSSG PPGPCHKLPP APAWHHFPPR CVDMGCAGLR DAHEENPESI LDEHVQRVLR 
TPGRQSPGPG HRSPDSGHVA KMPVALGGAA SGHGKHVPKS GAKLDAAGLH HHRHVHHHVH 
HSTARPKEQV EAEATRRAQS SFAWGLEPHS HGARSRGYSE SVGAAPNASD GLAHSGKVGV 
ACKRNAKKAE SGKSASTEVP GASEDAEKNQ KIMQWIIEGE KEISRHRRTG HGSSGTRKPQ 
PHENSRPLSL EHPWAGPQLR TSVQPSHLFI QDPTMPPHPA PNPLTQLEEA RRRLEEEEKR 
ASRAPSKQRY VQEVMRRGRA CVRPACAPVL HVVPAVSDME LSETETRSQR KVGGGSAQPC 
DSIVVAYYFC GEPIPYRTLV RGRAVTLGQF KELLTKKGSY RYYFKKVSDE FDCGVVFEEV 
REDEAVLPVF EEKIIGKVEK VD

Genular Protein ID: 3269126241

Symbol: A0A0S2Z4S3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4S3

Database IDs:

ARBA 14 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 6 Gene3D 3 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 4 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 826
  • Mass: 91653
  • Checksum: 4AA4187D70A5863D
  • Sequence:
    • MNIQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDPRPA SYSFCSGKGV GIKGETSTAT 
PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIS LFRTFLKQEG CADLLDFWFA 
CTGFRKLEPC DSNEEKRLKL ARAIYRKYIL DNNGIVSRQT KPATKSFIKG CIMKQLIDPA 
MFDQAQTEIQ ATMEENTYPS FLKSDIYLEY TRTGSESPKV CSDQSSGSGT GKGISGYLPT 
LNEDEEWKCD QDMDEDDGRD AAPPGRLPQK LLLETAAPRV SSSRRYSEGR EFRYGSWREP 
VNPYYVNAGY ALAPATSAND SEQQSLSSDA DTLSLTDSSV DGIPPYRIRK QHRREMQESV 
QVNGRVPLPH IPRTYRVPKE VRVEPQKFAE ELIHRLEAVQ RTREAEEKLE ERLKRVRMEE 
EGEDGDPSSG PPGPCHKLPP APAWHHFPPR CVDMGCAGLR DAHEENPESI LDEHVQRVLR 
TPGRQSPGPG HRSPDSGHVA KMPVALGGAA SGHGKHVPKS GAKLDAAGLH HHRHVHHHVH 
HSTARPKEQV EAEATRRAQS SFAWGLEPHS HGARSRGYSE SVGAAPNASD GLAHSGKVGV 
ACKRNAKKAE SGKSASTEVP GASEDAEKNQ KIMQWIIEGE KEISRHRRTG HGSSGTRKPQ 
PHENSRPLSL EHPWAGPQLR TSVQPSHLFI QDPTMPPHPA PNPLTQLEEA RRRLEEEEKR 
ASRAPSKQRT RSQRKVGGGS AQPCDSIVVA YYFCGEPIPY RTLVRGRAVT LGQFKELLTK 
KGSYRYYFKK VSDEFDCGVV FEEVREDEAV LPVFEEKIIG KVEKVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.