Details for: FZD8

Gene ID: 8325

Symbol: FZD8

Ensembl ID: ENSG00000177283

Description: frizzled class receptor 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.7622
    Cell Significance Index: -11.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7851
    Cell Significance Index: -10.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8479
    Cell Significance Index: 24.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5377
    Cell Significance Index: 11.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4914
    Cell Significance Index: 22.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4827
    Cell Significance Index: 10.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4571
    Cell Significance Index: 86.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3873
    Cell Significance Index: 38.3200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3415
    Cell Significance Index: 0.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2972
    Cell Significance Index: 34.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2537
    Cell Significance Index: 112.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2201
    Cell Significance Index: 13.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1962
    Cell Significance Index: 2.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1843
    Cell Significance Index: 29.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1819
    Cell Significance Index: 19.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1642
    Cell Significance Index: 148.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1608
    Cell Significance Index: 5.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1526
    Cell Significance Index: 9.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1098
    Cell Significance Index: 14.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0956
    Cell Significance Index: 52.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0832
    Cell Significance Index: 4.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0734
    Cell Significance Index: 2.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0539
    Cell Significance Index: 3.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0242
    Cell Significance Index: 4.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0157
    Cell Significance Index: 0.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0117
    Cell Significance Index: 8.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0116
    Cell Significance Index: 0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0062
    Cell Significance Index: 0.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0034
    Cell Significance Index: 0.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0042
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0075
    Cell Significance Index: -0.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0104
    Cell Significance Index: -6.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0115
    Cell Significance Index: -17.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0167
    Cell Significance Index: -0.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0175
    Cell Significance Index: -6.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0177
    Cell Significance Index: -13.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0219
    Cell Significance Index: -2.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0226
    Cell Significance Index: -12.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0251
    Cell Significance Index: -11.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0255
    Cell Significance Index: -1.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0294
    Cell Significance Index: -0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0312
    Cell Significance Index: -6.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0351
    Cell Significance Index: -5.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0477
    Cell Significance Index: -2.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0504
    Cell Significance Index: -6.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0507
    Cell Significance Index: -1.1100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0542
    Cell Significance Index: -0.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0557
    Cell Significance Index: -0.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0580
    Cell Significance Index: -7.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0598
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0635
    Cell Significance Index: -13.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0650
    Cell Significance Index: -4.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0673
    Cell Significance Index: -6.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0703
    Cell Significance Index: -3.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0720
    Cell Significance Index: -1.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0723
    Cell Significance Index: -4.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0794
    Cell Significance Index: -1.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0855
    Cell Significance Index: -4.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0892
    Cell Significance Index: -10.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1057
    Cell Significance Index: -8.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1074
    Cell Significance Index: -6.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1082
    Cell Significance Index: -11.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1346
    Cell Significance Index: -10.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1378
    Cell Significance Index: -3.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1410
    Cell Significance Index: -2.3600
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1460
    Cell Significance Index: -1.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1466
    Cell Significance Index: -7.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1468
    Cell Significance Index: -6.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1549
    Cell Significance Index: -8.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1597
    Cell Significance Index: -6.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1649
    Cell Significance Index: -11.0900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1705
    Cell Significance Index: -1.1600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1882
    Cell Significance Index: -2.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1898
    Cell Significance Index: -5.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1920
    Cell Significance Index: -2.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2078
    Cell Significance Index: -5.4700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2094
    Cell Significance Index: -1.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2147
    Cell Significance Index: -6.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2226
    Cell Significance Index: -4.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2263
    Cell Significance Index: -11.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2333
    Cell Significance Index: -6.2500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2427
    Cell Significance Index: -2.6300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2496
    Cell Significance Index: -2.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2566
    Cell Significance Index: -8.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2580
    Cell Significance Index: -11.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2692
    Cell Significance Index: -4.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2701
    Cell Significance Index: -9.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2757
    Cell Significance Index: -10.1200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2807
    Cell Significance Index: -1.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2935
    Cell Significance Index: -7.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3024
    Cell Significance Index: -11.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3210
    Cell Significance Index: -10.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3281
    Cell Significance Index: -10.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3290
    Cell Significance Index: -7.9700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3300
    Cell Significance Index: -4.2700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3370
    Cell Significance Index: -2.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FZD8 is a single-pass transmembrane receptor that belongs to the Frizzled family of receptors, which are characterized by the presence of a seven-transmembrane domain structure. The receptor is composed of two extracellular cysteine-rich domains, which are essential for the recognition and binding of Wnt ligands. FZD8 is highly expressed in various tissues, including the brain, kidneys, and intestinal epithelium, where it plays a crucial role in the regulation of cell proliferation, differentiation, and survival. **Pathways and Functions:** FZD8 is involved in the canonical and non-canonical Wnt signaling pathways, which are essential for the regulation of various cellular processes, including cell proliferation, differentiation, and survival. The canonical Wnt signaling pathway involves the binding of Wnt ligands to FZD8, which activates the transcription factor β-catenin, leading to the activation of target gene expression. The non-canonical Wnt signaling pathway involves the activation of the planar cell polarity (PCP) pathway, which regulates cell polarity and migration. FZD8 also interacts with other signaling molecules, including LRP5/6, which are co-receptors that facilitate the transduction of Wnt signals. The interaction between FZD8 and LRP5/6 is essential for the regulation of cell proliferation, differentiation, and survival in various tissues. **Clinical Significance:** Dysregulation of the Wnt signaling pathway, including the FZD8 receptor, has been implicated in various immunological disorders, including autoimmune diseases, cancer, and inflammatory diseases. For example, mutations in the FZD8 gene have been associated with an increased risk of developing certain types of cancer, including colorectal cancer. FZD8 has also been implicated in the regulation of immune cell function, including the differentiation and proliferation of T cells and dendritic cells. Dysregulation of FZD8 signaling has been associated with impaired immune responses and increased susceptibility to infection. In addition, FZD8 has been shown to play a role in the regulation of the gut-associated lymphoid tissue (GALT), which is essential for the development and maintenance of immune homeostasis in the gut. **Conclusion:** In conclusion, FZD8 is a critical component of the Wnt signaling pathway, which plays a pivotal role in various cellular processes, including cell proliferation, differentiation, and survival. Dysregulation of FZD8 signaling has been implicated in various immunological disorders, including autoimmune diseases, cancer, and inflammatory diseases. Further research is needed to fully understand the role of FZD8 in the regulation of immune responses and to develop novel therapeutic strategies to target this receptor in the treatment of immunological disorders.

Genular Protein ID: 1935599926

Symbol: FZD8_HUMAN

Name: Frizzled-8

UniProtKB Accession Codes:

Q9H461

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 2 Ensembl 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11295046

Title: Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2.

PubMed ID: 11295046

DOI: 10.3892/ijo.18.5.991

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 11448771

Title: Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

PubMed ID: 11448771

DOI: 10.1016/s0960-9822(01)00290-1

PubMed ID: 16882988

Title: Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin.

PubMed ID: 16882988

DOI: 10.1110/ps.062087506

PubMed ID: 22575959

Title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

PubMed ID: 22575959

DOI: 10.1038/nature11019

PubMed ID: 24496449

Title: Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling.

PubMed ID: 24496449

DOI: 10.1242/jcs.140871

Sequence Information:

  • Length: 694
  • Mass: 73300
  • Checksum: E740CBFDA2A233EF
  • Sequence:
    • MEWGYLLEVT SLLAALALLQ RSSGAAAASA KELACQEITV PLCKGIGYNY TYMPNQFNHD 
TQDEAGLEVH QFWPLVEIQC SPDLKFFLCS MYTPICLEDY KKPLPPCRSV CERAKAGCAP 
LMRQYGFAWP DRMRCDRLPE QGNPDTLCMD YNRTDLTTAA PSPPRRLPPP PPGEQPPSGS 
GHGRPPGARP PHRGGGRGGG GGDAAAPPAR GGGGGGKARP PGGGAAPCEP GCQCRAPMVS 
VSSERHPLYN RVKTGQIANC ALPCHNPFFS QDERAFTVFW IGLWSVLCFV STFATVSTFL 
IDMERFKYPE RPIIFLSACY LFVSVGYLVR LVAGHEKVAC SGGAPGAGGA GGAGGAAAGA 
GAAGAGAGGP GGRGEYEELG AVEQHVRYET TGPALCTVVF LLVYFFGMAS SIWWVILSLT 
WFLAAGMKWG NEAIAGYSQY FHLAAWLVPS VKSIAVLALS SVDGDPVAGI CYVGNQSLDN 
LRGFVLAPLV IYLFIGTMFL LAGFVSLFRI RSVIKQQDGP TKTHKLEKLM IRLGLFTVLY 
TVPAAVVVAC LFYEQHNRPR WEATHNCPCL RDLQPDQARR PDYAVFMLKY FMCLVVGITS 
GVWVWSGKTL ESWRSLCTRC CWASKGAAVG GGAGATAAGG GGGPGGGGGG GPGGGGGPGG 
GGGSLYSDVS TGLTWRSGTA SSVSYPKQMP LSQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.